Advanced Applications of Rapid Prototyping Technology in Modern Engineering

Rapid prototyping (RP) technology has been widely known and appreciated due to its flexible and customized manufacturing capabilities. The widely studied RP techniques include stereolithography apparatus (SLA), selective laser sintering (SLS), three-dimensional printing (3DP), fused deposition modeling (FDM), 3D plotting, solid ground curing (SGC), multiphase jet solidification (MJS), laminated object manufacturing (LOM). Different techniques are associated with different materials and/or processing principles and thus are devoted to specific applications. RP technology has no longer been only for prototype building rather has been extended for real industrial manufacturing solutions. Today, the RP technology has contributed to almost all engineering areas that include mechanical, materials, industrial, aerospace, electrical and most recently biomedical engineering. This book aims to present the advanced development of RP technologies in various engineering areas as the solutions to the real world engineering problems

Linear array CMOS detectors for laser doppler blood flow imaging

Laser Doppler blood flow imaging is well established as a tool for clinical research. The technique has considerable potential as an aid to diagnosis and as a treatment aid in a number of situations. However, to make widespread clinical use of a blood flow imager feasible a number of refinements are required to make the device easy to use, accurate and safe. Existing LDBF systems consist of 2D imaging systems, and single point scanning systems. 2D imaging systems can offer fast image acquisition time, and hence high frame rate. However, these require high laser power to illuminate the entire target area with sufficient power. Single point scanning systems allow lower laser power to be used, but building up an image of flow in skin requires mechanical scanning of the laser, which results in a high image acquisition time, making the system awkward to use. A new approach developed here involves scanning a line along a target, and imaging the line with a 1D sensor array. This means that only one axis of mechanical scanning is required, reducing the scanning speed, and the laser power is vastly reduced from that required for a 2D system. This approach lends itself well to the use of integrated CMOS detectors, as the smaller pixel number means that a linear sensor array can be implemented on an IC which has integrated processing while keeping overall IC size, and hence cost, lower than equivalent 2D imaging systems. A number of front-end and processing circuits are investigated in terms of their suitability for this application. This is done by simulating a range of possible designs, including several logarithmic pixels, active pixel sensors and opamp-based linear front-ends. Where possible previously fabricated ICs using similar sensors were tested in a laser Doppler flowmetry system to verify simulation results. A first prototype IC (known as BVIPS1) implements a 64x1 array of buffered logarithmic pixels, chosen for their combination of sufficient gain and bandwidth and compact size. The IC makes use of the space available to include two front-end circuits per pixel, allowing other circuits to be prototyped. This allows a linear front-end based on opamps to be tested. It is found that both designs can detect changes in blood flow despite significant discrepancies between simulated and measured IC performance. However, the signal-noise ratio for flux readings is high, and the logarithmic pixel array suffers from high fixed pattern noise, and noise and distortion that makes vein location impossible. A second prototype IC (BVIPS2) consists of dual 64x1 arrays, and integrated processing. The sensor arrays are a logarithmic array, which addresses the problems of the first IC and uses alternative, individually selectable front-ends for each pixel to reduce fixed-pattern noise, and an array of opamp-based linear detectors. Simulation and initial testing is performed to show that this design operates as intended, and partially overcomes the problems found on the previous IC - the IC shows reduced fixed pattern noise and better spatial detection of blood flow changes, although there is still significant noise

A Flexible, Low-Power, Programmable Unsupervised Neural Network Based on Microcontrollers for Medical Applications

We present an implementation and laboratory tests of a winner takes all (WTA) artificial neural network (NN) on two microcontrollers (μC) with the ARM Cortex M3 and the AVR cores. The prospective application of this device is in wireless body sensor network (WBSN) in an on-line analysis of electrocardiograph (ECG) and electromyograph (EMG) biomedical signals. The proposed device will be used as a base station in the WBSN, acquiring and analysing the signals from the sensors placed on the human body. The proposed system is equiped with an analog-todigital converter (ADC), and allows for multi-channel acquisition of analog signals, preprocessing (filtering) and further analysis

Ophthalmic engineering:the development of novel instrumentation to further research in the field

The principle theme of this thesis is the advancement and expansion of ophthalmic research via the collaboration between professional Engineers and professional Optometrists. The aim has been to develop new and novel approaches and solutions to contemporary problems in the field. The work is sub divided into three areas of investigation; 1) High technology systems, 2) Modification of current systems to increase functionality, and 3) Development of smaller more portable and cost effective systems. High Technology Systems: A novel high speed Optical Coherence Tomography (OCT) system with integrated simultaneous high speed photography was developed achieving better operational speed than is currently available commercially. The mechanical design of the system featured a novel 8 axis alignment system. A full set of capture, analysis, and post processing software was developed providing custom analysis systems for ophthalmic OCT imaging, expanding the current capabilities of the technology. A large clinical trial was undertaken to test the dynamics of contact lens edge interaction with the cornea in-vivo. The interaction between lens edge design, lens base curvature, post insertion times and edge positions was investigated. A novel method for correction of optical distortion when assessing lens indentation was also demonstrated. Modification of Current Systems: A commercial autorefractor, the WAM-5500, was modified with the addition of extra hardware and a custom software and firmware solution to produce a system that was capable of measuring dynamic accommodative response to various stimuli in real time. A novel software package to control the data capture process was developed allowing real time monitoring of data by the practitioner, adding considerable functionality of the instrument further to the standard system. The device was used to assess the accommodative response differences between subjects who had worn UV blocking contact lens for 5 years, verses a control group that had not worn UV blocking lenses. While the standard static measurement of accommodation showed no differences between the two groups, it was determined that the UV blocking group did show better accommodative rise and fall times (faster), thus demonstrating the benefits of the modification of this commercially available instrumentation. Portable and Cost effective Systems: A new instrument was developed to expand the capability of the now defunct Keeler Tearscope. A device was developed that provided a similar capability in allowing observation of the reflected mires from the tear film surface, but with the added advantage of being able to record the observations. The device was tested comparatively with the tearscope and other tear film break-up techniques, demonstrating its potential. In Conclusion: This work has successfully demonstrated the advantages of interdisciplinary research between engineering and ophthalmic research has provided new and novel instrumented solutions as well as having added to the sum of scientific understanding in the ophthalmic field

Design and implementation of an integrating modulated light camera

In optical experiments, replacing the usual constant intensity light source with one that has its intensity modulated at a fixed frequency gives a number of advantages, namely moving the signal of interest away from low frequency noise, allowing the signal to be detected even in the presence of background illumination, as well as being able to gain more information about the experiment by measuring any change in the phase of the modulation. A number of different types of integrating pixels have been simulated in Matlab with regard to their suitability for use as a modulated light detector, along with different methods for reconstructing the signal. The quadrature method of reconstruction was chosen as the best technique, where four samples are taken per modulated time period then all four samples are used in the I and Q channels of the demodulator. A modulated light detector has been implemented using a custom integrated circuit in a standard 0:35 micro m CMOS process, linked to a field programmable gate array. The custom circuits consists of a photodiode configured as an integrating type pixel, where the output of the pixel is connected to a comparator so that when coupled with a counter, the pixel can measure the amount of time taken for the photodiode to reach a particular voltage. A camera with 128 x 128 pixels has been implemented and characterised using a modulated laser as the input, with the results obtained compared to the Matlab simulations carried out. Images have been taken with the camera that show the camera is able to detect modulated light signals at a modulation depth of 1.39% and modulation frequency of 420 Hz. The camera has also been operated successfully for a modulation frequency of 2.5 kHz

Proof-of-concept of a single-point Time-of-Flight LiDAR system and guidelines towards integrated high-accuracy timing, advanced polarization sensing and scanning with a MEMS micromirror

Dissertação de mestrado integrado em Engenharia Física (área de especialização em Dispositivos, Microssistemas e Nanotecnologias)The core focus of the work reported herein is the fulfillment of a functional Light Detection and Ranging (LiDAR) sensor to validate the direct Time-of-Flight (ToF) ranging concept and the acquisition of critical knowledge regarding pivotal aspects jeopardizing the sensor’s performance, for forthcoming improvements aiming a realistic sensor targeted towards automotive applications. Hereupon, the ToF LiDAR system is implemented through an architecture encompassing both optical and electronical functions and is subsequently characterized under a sequence of test procedures usually applied in benchmarking of LiDAR sensors. The design employs a hybrid edge-emitting laser diode (pulsed at 6kHz, 46ns temporal FWHM, 7ns rise-time; 919nm wavelength with 5nm FWHM), a PIN photodiode to detect the back-reflected radiation, a transamplification stage and two Time-to-Digital Converters (TDCs), with leading-edge discrimination electronics to mark the transit time between emission and detection events. Furthermore, a flexible modular design is adopted using two separate Printed Circuit Boards (PCBs), comprising the transmitter (TX) and the receiver (RX), i.e. detection and signal processing. The overall output beam divergence is 0.4º×1º and an optical peak power of 60W (87% overall throughput) is realized. The sensor is tested indoors from 0.56 to 4.42 meters, and the distance is directly estimated from the pulses transit time. The precision within these working distances ranges from 4cm to 7cm, reflected in a Signal-to-Noise Ratio (SNR) between 12dB and 18dB. The design requires a calibration procedure to correct systematic errors in the range measurements, induced by two sources: the timing offset due to architecture-inherent differences in the optoelectronic paths and a supplementary bias resulting from the design, which renders an intensity dependence and is denoted time-walk. The calibrated system achieves a mean accuracy of 1cm. Two distinct target materials are used for characterization and performance evaluation: a metallic automotive paint and a diffuse material. This selection is representative of two extremes of actual LiDAR applications. The optical and electronic characterization is thoroughly detailed, including the recognition of a good agreement between empirical observations and simulations in ZEMAX, for optical design, and in a SPICE software, for the electrical subsystem. The foremost meaningful limitation of the implemented design is identified as an outcome of the leading-edge discrimination. A proposal for a Constant Fraction Discriminator addressing sub-millimetric accuracy is provided to replace the previous signal processing element. This modification is mandatory to virtually eliminate the aforementioned systematic bias in range sensing due to the intensity dependency. A further crucial addition is a scanning mechanism to supply the required Field-of-View (FOV) for automotive usage. The opto-electromechanical guidelines to interface a MEMS micromirror scanner, achieving a 46º×17º FOV, with the LiDAR sensor are furnished. Ultimately, a proof-of-principle to the use of polarization in material classification for advanced processing is carried out, aiming to complement the ToF measurements. The original design is modified to include a variable wave retarder, allowing the simultaneous detection of orthogonal linear polarization states using a single detector. The material classification with polarization sensing is tested with the previously referred materials culminating in an 87% and 11% degree of linear polarization retention from the metallic paint and the diffuse material, respectively, computed by Stokes parameters calculus. The procedure was independently validated under the same conditions with a micro-polarizer camera (92% and 13% polarization retention).O intuito primordial do trabalho reportado no presente documento é o desenvolvimento de um sensor LiDAR funcional, que permita validar o conceito de medição direta do tempo de voo de pulsos óticos para a estimativa de distância, e a aquisição de conhecimento crítico respeitante a aspetos fundamentais que prejudicam a performance do sensor, ambicionando melhorias futuras para um sensor endereçado para aplicações automóveis. Destarte, o sistema LiDAR é implementado através de uma arquitetura que engloba tanto funções óticas como eletrónicas, sendo posteriormente caracterizado através de uma sequência de testes experimentais comumente aplicáveis em benchmarking de sensores LiDAR. O design tira partido de um díodo de laser híbrido (pulsado a 6kHz, largura temporal de 46ns; comprimento de onda de pico de 919nm e largura espetral de 5nm), um fotodíodo PIN para detetar a radiação refletida, um andar de transamplificação e dois conversores tempo-digital, com discriminação temporal com threshold constante para marcar o tempo de trânsito entre emissão e receção. Ademais, um design modular flexível é adotado através de duas PCBs independentes, compondo o transmissor e o recetor (deteção e processamento de sinal). A divergência global do feixe emitido para o ambiente circundante é 0.4º×1º, apresentando uma potência ótica de pico de 60W (eficiência de 87% na transmissão). O sensor é testado em ambiente fechado, entre 0.56 e 4.42 metros. A precisão dentro das distâncias de trabalho varia entre 4cm e 7cm, o que se reflete numa razão sinal-ruído entre 12dB e 18dB. O design requer calibração para corrigir erros sistemáticos nas distâncias adquiridas devido a duas fontes: o desvio no ToF devido a diferenças nos percursos optoeletrónicos, inerentes à arquitetura, e uma dependência adicional da intensidade do sinal refletido, induzida pela técnica de discriminação implementada e denotada time-walk. A exatidão do sistema pós-calibração perfaz um valor médio de 1cm. Dois alvos distintos são utilizados durante a fase de caraterização e avaliação performativa: uma tinta metálica aplicada em revestimentos de automóveis e um material difusor. Esta seleção é representativa de dois cenários extremos em aplicações reais do LiDAR. A caraterização dos subsistemas ótico e eletrónico é minuciosamente detalhada, incluindo a constatação de uma boa concordância entre observações empíricas e simulações óticas em ZEMAX e elétricas num software SPICE. O principal elemento limitante do design implementado é identificado como sendo a técnica de discriminação adotada. Por conseguinte, é proposta a substituição do anterior bloco por uma técnica de discriminação a uma fração constante do pulso de retorno, com exatidões da ordem sub-milimétrica. Esta modificação é imperativa para eliminar o offset sistemático nas medidas de distância, decorrente da dependência da intensidade do sinal. Uma outra inclusão de extrema relevância é um mecanismo de varrimento que assegura o cumprimento dos requisitos de campo de visão para aplicações automóveis. As diretrizes para a integração de um micro-espelho no sensor concebido são providenciadas, permitindo atingir um campo de visão de 46º×17º. Conclusivamente, é feita uma prova de princípio para a utilização da polarização como complemento das medições do tempo de voo, de modo a suportar a classificação de materiais em processamento avançado. A arquitetura original é modificada para incluir uma lâmina de atraso variável, permitindo a deteção de estados de polarização ortogonais com um único fotodetetor. A classificação de materiais através da aferição do estado de polarização da luz refletida é testada para os materiais supramencionados, culminando numa retenção de polarização de 87% (tinta metálica) e 11% (difusor), calculados através dos parâmetros de Stokes. O procedimento é independentemente validado com uma câmara polarimétrica nas mesmas condições (retenção de 92% e 13%)

The 1993 Shuttle Small Payloads Symposium

The 1993 Shuttle Small Payloads Symposium is a combined symposia of the Get Away Special (GAS), Hitchhiker, and Complex Autonomous Payloads (CAP) programs, and is proposed to continue as an annual conference. The focus of this conference is to educate potential Space Shuttle Payload Bay users as to the types of carrier systems provided and for current users to share experiment concepts