The cultural epigenetics of psychopathology: The missing heritability of complex diseases found?

We extend a cognitive paradigm for gene expression based on the asymptotic limit theorems of information theory to the epigenetic epidemiology of mental disorders. In particular, we recognize the fundamental role culture plays in human biology, another heritage mechanism parallel to, and interacting with, the more familiar genetic and epigenetic systems. We do this via a model through which culture acts as another tunable epigenetic catalyst that both directs developmental trajectories, and becomes convoluted with individual ontology, via a mutually-interacting crosstalk mediated by a social interaction that is itself culturally driven. We call for the incorporation of embedding culture as an essential component of the epigenetic regulation of human mental development and its dysfunctions, bringing what is perhaps the central reality of human biology into the center of biological psychiatry. Current US work on gene-environment interactions in psychiatry must be extended to a model of gene-environment-culture interaction to avoid becoming victim of an extreme American individualism that threatens to create paradigms particular to that culture and that are, indeed, peculiar in the context of the world's cultures. The cultural and epigenetic systems of heritage may well provide the 'missing' heritability of complex diseases now under so much intense discussion

The role of socio-technical experiments in introducing sustainable Product-Service System innovations

This is the pre-print version of the chapter published in 2015 by Springer in the book “The Handbook of Service Innovation” (edited by Renu Agarwal, Willem Selen, Göran Roos and Roy Green). The final publication is available at Springer via http://dx.doi.org/10.1007/978-1-4471-6590-3_18Product-Service System (PSS) innovations represent a promising approach to sustainability, but their implementation and diffusion are hindered by several cultural, corporate, and regulative barriers. Hence, an important challenge is not only to conceive sustainable PSS concepts, but also to understand how to manage, support, and orient the introduction and diffusion of these concepts. Building upon insights from transition studies (in particular, the concepts of Strategic Niche Management and Transition Management), and through an action research project, the chapter investigates the role of design in introducing sustainable radical service innovations. A key role is given to the implementation of socio-technical experiments, partially protected spaces where innovations can be incubated and tested, become more mature, and potentially favor the implementation and scaling up process

Critical factors for implementing and diffusing sustainable Product-Service Systems: Insights from innovation studies and companies' experiences

This is the post-print version of the final paper published in Journal for Cleaner Production. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2012 Elsevier B.V.Eco-efficient Product-Service System (PSS) innovations represent a promising approach to sustainability. However the adoption of such business strategies is still very limited because it often involves significant corporate, cultural and regulatory barriers. An important challenge is not only to conceive eco-efficient PSS concepts, but also to understand the contextual conditions that facilitate their societal embedding, and which strategies and development pathways are the most appropriate. The combination of theoretical insights from innovation studies (in particular Strategic Niche Management and Transition Management) and a case studies research (exploring the innovation journeys made by six companies in introducing their eco-efficient PSS innovations in the market) is used to investigate the factors that influence the implementation and diffusion of this kind of innovations. The article provides a structured overview of these factors, grouping them in four clusters: implementation of socio-technical experiments; establishment of a broad network of actors; building up of a shared project vision; creation of room for broad and reflexive learning processes. Based on these results it is argued that a broader and more strategic system approach should be adopted by companies. Companies should focus not only on the PSS solution and its value chain, but also on the contextual conditions that may favour or hinder the societal embedding of the PSS itself. The article concludes by outlining a key area for future research

The societal embedding of sustainable Product-Service Systems: Looking for synergies between strategic design and transition studies

Copyright @ 2014 Greenleaf Publishing.Eco-efficient Product-Service System (PSS) innovations represent a promising approach to sustainability, but their implementation and diffusion is hindered by several cultural, corporate and regulative barriers. Hence, an important challenge is not only to conceive sustainable PSS concepts, but also to understand how to manage, support and orient the introduction and diffusion of these concepts. Building upon recent advances in the innovation studies field (in particular the contributions from transition studies) this chapter puts forward a conceptual framework for the introduction and scaling-up of eco-efficient PSSs. A key role is given to the implementation of socio-technical experiments: protected spaces where radical innovations can be tested, become more mature, and potentially challenge and change dominant socio-technical practices, habits and institutions. Starting from these considerations this chapter investigates the potential contribution that a strategic design approach can make to stimulating and supporting the societal embedding of eco-efficient PSS innovations. A new strategic design role thus emerges, a role in which the ideation and development of sustainable PSS concepts is coupled with the designing of appropriate transition paths to gradually incubate, introduce and diffuse these concepts. Starting from these considerations the chapter outlines and discusses the new design approach and capabilities required by strategic designers

How the design of socio-technical experiments can enable radical changes for sustainability

Sustainability requires radical innovations, but their introduction and diffusion usually encounter the opposition of existing socio-technical regimes. An important challenge is, therefore, to understand how to catalyse and support the process of transitioning towards these innovations. Building upon insights from transition studies (in particular the concepts of Strategic Niche Management and Transition Management), and through an action research project (aimed at designing, introducing and diffusing a sustainable mobility system in the suburban areas of Cape Town), the paper investigates the role of design in triggering and orienting societal transformations. A key role is given to the implementation of socio-technical experiments. A new socio-technical system design role emerges: a role in which the ideation and development of sustainable innovation concepts is coupled with the designing of appropriate transition paths to gradually incubate, introduce and diffuse these concepts

Embodiment, Cognition and the World Wide Web

Cognitive embodiment refers to the hypothesis that cognitive processes of all kinds are rooted in perception and action. Recent findings in cognitive neuroscience revealed that the motor cortex, long confined to the mere role of action programming and execution, in fact, plays a crucial role in complex cognitive abilities

Reading the story of law and embeddedness through a community lens: A Polanyi-meets-Cotterrell economic sociology of law?

In this article I propose that the role of law in Karl Polanyi’s concept of the “always embedded economy”1 can be enriched by the application of the “lens of community”2developed by Roger Cotterrell.3I begin with Polanyi’s suggestion that economic action and interaction are always “embedded” in wider social life. Reading through the lens of community, we can be more specific: any actor is at once engaged, to different degrees (from fleeting to stable), in multiple types (whether focusing on instrumental, traditional, affective and/or belief-based action) of social life. I then explore a second, implicit, cornerstone of Polanyi’s argument: that analytical and normative approaches to economy may become disembedded from wider social life. Reading through the lens of community we can again be more specific: in the transformation to a market society, the analytical and normative approaches that are central to economic actions and interactions are confused with, and privileged over, those that are central to non-economic actions and interactions. This confusion and privileging can have what we might call a performative effect on action and interaction. Finally, I explore Polanyi’s story of law as a facilitator both of disembedding movements and of re-embedding counter- movements. The application of a law-and-community lens suggests some additional details of that storyline and that there are additional plotlines to be pursued. The practical potential of this Polanyi-meets-Cotterrell economic sociology of law is briefly illustrated with references to two twenty-first-century cautionary tales: the World Bank’s investment climate programme and the 2008 financial crisis

Perceiving environmental structure from optical motion

Generally speaking, one of the most important sources of optical information about environmental structure is known to be the deforming optical patterns produced by the movements of the observer (pilot) or environmental objects. As an observer moves through a rigid environment, the projected optical patterns of environmental objects are systematically transformed according to their orientations and positions in 3D space relative to those of the observer. The detailed characteristics of these deforming optical patterns carry information about the 3D structure of the objects and about their locations and orientations relative to those of the observer. The specific geometrical properties of moving images that may constitute visually detected information about the shapes and locations of environmental objects is examined

A Global Workspace perspective on mental disorders

Recent developments in Global Workspace theory suggest that human consciousness can suffer interpenetrating dysfunctions of mutual and reciprocal interaction with embedding environments which will have early onset and often insidiously staged developmental progression, possibly according to a cancer model. A simple rate distortion argument implies that, if an external information source is pathogenic, then sufficient exposure to it is sure to write a sufficiently accurate image of it on mind and body in a punctuated manner so as to initiate or promote simililarly progressively punctuated developmental disorder. There can, thus, be no simple, reductionist brain chemical 'bug in the program' whose 'fix' can fully correct the problem. On the contrary, the growth of an individual over the life course, and the inevitable contact with a toxic physical, social, or cultural environment, can be expected to initiate developmental problems which will become more intrusive over time, most obviously according to some damage accumulation model, but likely according to far more subtle, highly punctuated, schemes analogous to tumorigenesis. The key intervention, at the population level, is clearly to limit such exposures, a question of proper environmental sanitation, in a large sense, a matter of social justice which has long been understood to be determined almost entirely by the interactions of cultural trajectory, group power relations, and economic structure, with public policy. Intervention at the individual level appears limited to triggering or extending periods of remission, as is the case with most cancers

Approaches to the embedding of sustainability into the engineering curriculum - where are we now, and how do our graduates become global engineers?

This paper presents a resume of how the topic of sustainability can become fully-integrated into the engineering curriculum in the UK, and how this needs to evolve toward consideration of how graduates could be better developed as global engineers. The paper begins by providing a justification as to why sustainability is an important feature of the already overcrowded engineering curriculum, and briefly reports, through illustrative examples, on alternative approaches which currently embed sustainability into the engineering curriculum. The paper makes the case that it is timely now to re-address the learning outcomes in order to enhance the students’ experience beyond just the inclusion of new curriculum content It does this by consideration of the identified drivers that range from the accrediting bodies and from the aspirations of employers, through revised approaches to embed sustainability, to the consideration of students’ own perceptions of sustainability and ultimately to their becoming employed as global engineers. The paper therefore discusses both the current and planned work toward supporting the development of engineering graduates into global citizens, with a greater emphasis upon their responsibility to ensure a sustainable future world, moving beyond sustainability awareness towards informed application of sustainability thinking