596 research outputs found
On the accuracy of language trees
Historical linguistics aims at inferring the most likely language
phylogenetic tree starting from information concerning the evolutionary
relatedness of languages. The available information are typically lists of
homologous (lexical, phonological, syntactic) features or characters for many
different languages.
From this perspective the reconstruction of language trees is an example of
inverse problems: starting from present, incomplete and often noisy,
information, one aims at inferring the most likely past evolutionary history. A
fundamental issue in inverse problems is the evaluation of the inference made.
A standard way of dealing with this question is to generate data with
artificial models in order to have full access to the evolutionary process one
is going to infer. This procedure presents an intrinsic limitation: when
dealing with real data sets, one typically does not know which model of
evolution is the most suitable for them. A possible way out is to compare
algorithmic inference with expert classifications. This is the point of view we
take here by conducting a thorough survey of the accuracy of reconstruction
methods as compared with the Ethnologue expert classifications. We focus in
particular on state-of-the-art distance-based methods for phylogeny
reconstruction using worldwide linguistic databases.
In order to assess the accuracy of the inferred trees we introduce and
characterize two generalizations of standard definitions of distances between
trees. Based on these scores we quantify the relative performances of the
distance-based algorithms considered. Further we quantify how the completeness
and the coverage of the available databases affect the accuracy of the
reconstruction. Finally we draw some conclusions about where the accuracy of
the reconstructions in historical linguistics stands and about the leading
directions to improve it.Comment: 36 pages, 14 figure
The generalized Robinson-Foulds metric
The Robinson-Foulds (RF) metric is arguably the most widely used measure of
phylogenetic tree similarity, despite its well-known shortcomings: For example,
moving a single taxon in a tree can result in a tree that has maximum distance
to the original one; but the two trees are identical if we remove the single
taxon. To this end, we propose a natural extension of the RF metric that does
not simply count identical clades but instead, also takes similar clades into
consideration. In contrast to previous approaches, our model requires the
matching between clades to respect the structure of the two trees, a property
that the classical RF metric exhibits, too. We show that computing this
generalized RF metric is, unfortunately, NP-hard. We then present a simple
Integer Linear Program for its computation, and evaluate it by an
all-against-all comparison of 100 trees from a benchmark data set. We find that
matchings that respect the tree structure differ significantly from those that
do not, underlining the importance of this natural condition.Comment: Peer-reviewed and presented as part of the 13th Workshop on
Algorithms in Bioinformatics (WABI2013
Learning Latent Tree Graphical Models
We study the problem of learning a latent tree graphical model where samples
are available only from a subset of variables. We propose two consistent and
computationally efficient algorithms for learning minimal latent trees, that
is, trees without any redundant hidden nodes. Unlike many existing methods, the
observed nodes (or variables) are not constrained to be leaf nodes. Our first
algorithm, recursive grouping, builds the latent tree recursively by
identifying sibling groups using so-called information distances. One of the
main contributions of this work is our second algorithm, which we refer to as
CLGrouping. CLGrouping starts with a pre-processing procedure in which a tree
over the observed variables is constructed. This global step groups the
observed nodes that are likely to be close to each other in the true latent
tree, thereby guiding subsequent recursive grouping (or equivalent procedures)
on much smaller subsets of variables. This results in more accurate and
efficient learning of latent trees. We also present regularized versions of our
algorithms that learn latent tree approximations of arbitrary distributions. We
compare the proposed algorithms to other methods by performing extensive
numerical experiments on various latent tree graphical models such as hidden
Markov models and star graphs. In addition, we demonstrate the applicability of
our methods on real-world datasets by modeling the dependency structure of
monthly stock returns in the S&P index and of the words in the 20 newsgroups
dataset
Unfolding Latent Tree Structures using 4th Order Tensors
Discovering the latent structure from many observed variables is an important
yet challenging learning task. Existing approaches for discovering latent
structures often require the unknown number of hidden states as an input. In
this paper, we propose a quartet based approach which is \emph{agnostic} to
this number. The key contribution is a novel rank characterization of the
tensor associated with the marginal distribution of a quartet. This
characterization allows us to design a \emph{nuclear norm} based test for
resolving quartet relations. We then use the quartet test as a subroutine in a
divide-and-conquer algorithm for recovering the latent tree structure. Under
mild conditions, the algorithm is consistent and its error probability decays
exponentially with increasing sample size. We demonstrate that the proposed
approach compares favorably to alternatives. In a real world stock dataset, it
also discovers meaningful groupings of variables, and produces a model that
fits the data better
Exploring Complex Disease Gene Relationships Using Simultaneous Analysis
The characterization of complex diseases remains a great challenge for biomedical researchers due to the myriad interactions of genetic and environmental factors. Adaptation of phylogenomic techniques to increasingly available genomic data provides an evolutionary perspective that may elucidate important unknown features of complex diseases. Here an automated method is presented that leverages publicly available genomic data and phylogenomic techniques. The approach is tested with nine genes implicated in the development of Alzheimer Disease, a complex neurodegenerative syndrome.
The developed technique, which is an update to a previously described Perl script called “ASAP,” was implemented through a suite of Ruby scripts entitled “ASAP2,” first compiles a list of sequence-similarity based orthologues using PSI-BLAST and a recursive NCBI BLAST+ search strategy, then constructs maximum parsimony phylogenetic trees for each set of nucleotide and protein sequences, and calculates phylogenetic metrics (partitioned Bremer support values, combined branch scores, and Robinson-Foulds distance) to provide an empirical assessment of evolutionary conservation within a given genetic network.
This study demonstrates the potential for using automated simultaneous phylogenetic analysis to uncover previously unknown relationships among disease-associated genes that may not have been apparent using traditional, single-gene methods. Furthermore, the results provide the first integrated evolutionary history of an Alzheimer Disease gene network and identify potentially important co-evolutionary clustering around components of oxidative stress pathways
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