380 research outputs found
Automated Home Oxygen Delivery for Patients with COPD and Respiratory Failure: A New Approach
Long-term oxygen therapy (LTOT) has become standard care for the treatment of patients with chronic obstructive pulmonary disease (COPD) and other severe hypoxemic lung diseases. The use of new portable O-2 concentrators (POC) in LTOT is being expanded. However, the issue of oxygen titration is not always properly addressed, since POCs rely on proper use by patients. The robustness of algorithms and the limited reliability of current oximetry sensors are hindering the effectiveness of new approaches to closed-loop POCs based on the feedback of blood oxygen saturation. In this study, a novel intelligent portable oxygen concentrator (iPOC) is described. The presented iPOC is capable of adjusting the O-2 flow automatically by real-time classifying the intensity of a patient's physical activity (PA). It was designed with a group of patients with COPD and stable chronic respiratory failure. The technical pilot test showed a weighted accuracy of 91.1% in updating the O-2 flow automatically according to medical prescriptions, and a general improvement in oxygenation compared to conventional POCs. In addition, the usability achieved was high, which indicated a significant degree of user satisfaction. This iPOC may have important benefits, including improved oxygenation, increased compliance with therapy recommendations, and the promotion of PA
Methods and Tools for Battery-free Wireless Networks
Embedding small wireless sensors into the environment allows for monitoring physical processes with high spatio-temporal resolutions. Today, these devices are equipped with a battery to supply them with power. Despite technological advances, the high maintenance cost and environmental impact of batteries prevent the widespread adoption of wireless sensors. Battery-free devices that store energy harvested from light, vibrations, and other ambient sources in a capacitor promise to overcome the drawbacks of (rechargeable) batteries, such as bulkiness, wear-out and toxicity. Because of low energy input and low storage capacity, battery-free devices operate intermittently; they are forced to remain inactive for most of the time charging their capacitor before being able to operate for a short time. While it is known how to deal with intermittency on a single device, the coordination and communication among groups of multiple battery-free devices remain largely unexplored. For the first time, the present thesis addresses this problem by proposing new methods and tools to investigate and overcome several fundamental challenges
Sensor System for Rescue Robots
A majority of rescue worker fatalities are a result of on-scene responses. Existing technologies help assist the first responders in scenarios of no light, and there even exist robots that can navigate radioactive areas. However, none are able to be both quickly deployable and enter hard to reach or unsafe areas in an emergency event such as an earthquake or storm that damages a structure. In this project we created a sensor platform system to augment existing robotic solutions so that rescue workers can search for people in danger while avoiding preventable injury or death and saving time and resources. Our results showed that we were able to map out a 2D map of the room with updates for robot motion on a display while also showing a live thermal image in front of the system. The system is also capable of taking a digital picture from a triggering event and then displaying it on the computer screen. We discovered that data transfer plays a huge role in making different programs like Arduino and Processing interact with each other. Consequently, this needs to be accounted for when improving our project. In particular our project is wired right now but should deliver data wirelessly to be of any practical use. Furthermore, we dipped our feet into SLAM technologies and if our project were to become autonomous, more research into the algorithms would make this autonomy feasible
Privacy in characterizing and recruiting patients for IoHT-aided digital clinical trials
Nowadays there is a tremendous amount of smart and connected devices that produce data. The so-called IoT is so pervasive that its devices (in particular the ones that we take with us during all the day - wearables, smartphones...) often provide some insights on our lives to third parties. People habitually exchange some of their private data in order to obtain services, discounts and advantages. Sharing personal data is commonly accepted in contexts like social networks but individuals suddenly become more than concerned if a third party is interested in accessing personal health data. The healthcare systems worldwide, however, begun to take advantage of the data produced by eHealth solutions. It is clear that while on one hand the technology proved to be a great ally in the modern medicine and can lead to notable benefits, on the other hand these processes pose serious threats to our privacy. The process of testing, validating and putting on the market a new drug or medical treatment is called clinical trial. These trials are deeply impacted by the technological advancements and greatly benefit from the use of eHealth solutions. The clinical research institutes are the entities in charge of leading the trials and need to access as much health data of the patients as possible. However, at any phase of a clinical trial, the personal information of the participants should be preserved and maintained private as long as possible. During this thesis, we will introduce an architecture that protects the privacy of personal data during the first phases of digital clinical trials (namely the characterization phase and the recruiting phase), allowing potential participants to freely join trials without disclosing their personal health information without a proper reward and/or prior agreement. We will illustrate what is the trusted environment that is the most used approach in eHealth and, later, we will dig into the untrusted environment where the concept of privacy is more challenging to protect while maintaining usability of data. Our architecture maintains the individuals in full control over the flow of their personal health data. Moreover, the architecture allows the clinical research institutes to characterize the population of potentiant users without direct access to their personal data. We validated our architecture with a proof of concept that includes all the involved entities from the low level hardware up to the end application. We designed and realized the hardware capable of sensing, processing and transmitting personal health data in a privacy preserving fashion that requires little to none maintenance
Enabling peer-to-peer remote experimentation in distributed online remote laboratories
Remote Access Laboratories (RALs) are online platforms that allow human user interaction with physical instruments over the Internet. Usually RALs follow a client-server paradigm. Dedicated providers create and maintain experiments and corresponding educational content. In contrast, this dissertation focuses on a Peer-to-Peer (P2P) service model for RALs where users are encouraged to host experiments at their location. This approach can be seen as an example of an Internet of Things (IoT) system. A set of smart devices work together providing a cyber-physical interface for users to run experiments remotely via the Internet.
The majority of traditional RAL learning activities focus on undergraduate education where hands-on experience such as building experiments, is not a major focus. In contrast this work is motivated by the need to improve Science, Technology, Engineering and Mathematics (STEM) education for school-aged children. Here physically constructing experiments forms a substantial part of the learning experience. In the proposed approach, experiments can be designed with relatively simple components such as LEGO Mindstorms or Arduinos. The user interface can be programed using SNAP!, a graphical programming tool.
While the motivation for the work is educational in nature, this thesis focuses on the technical details of experiment control in an opportunistic distributed environment. P2P RAL aims to enable any two random participants in the system - one in the role of maker creating and hosting an experiment and one in the role of learner using the experiment - to establish a communication session during which the learner runs the remote experiment through the Internet without requiring a centralized experiment or service provider. The makers need to have support to create the experiment according to a common web based programing interface. Thus, the P2P approach of RALs requires an architecture that provides a set of heterogeneous tools which can be used by makers to create a wide variety of experiments.
The core contribution of this dissertation is an automaton-based model (twin finite state automata) of the controller units and the controller interface of an experiment. This enables the creation of experiments based on a common platform, both in terms of software and hardware. This architecture enables further development of algorithms for evaluating and supporting the performance of users which is demonstrated through a number of algorithms. It can also ensure the safety of instruments with intelligent tools. The proposed network architecture for P2P RALs is designed to minimise latency to improve user satisfaction and learning experience. As experiment availability is limited for this approach of RALs, novel scheduling strategies are proposed.
Each of these contributions has been validated through either simulations, e.g. in case of network architecture and scheduling, or test-bed implementations, in case of the intelligent tools. Three example experiments are discussed along with users' feedback on their experience of creating an experiment and using others’ experimental setup. The focus of the thesis is mainly on the design and hosting of experiments and ensuring user accessibility to them. The main contributions of this thesis are in regards to machine learning and data mining techniques applied to IoT systems in order to realize the P2P RALs system.
This research has shown that a P2P architecture of RALs can provide a wide variety of experimental setups in a modular environment with high scalability. It can potentially enhance the user-learning experience while aiding the makers of experiments. It presents new aspects of learning analytics mechanisms to monitor and support users while running experiments, thus lending itself to further research. The proposed mathematical models are also applicable to other Internet of Things applications
Focal Spot, Summer/Fall 2007
https://digitalcommons.wustl.edu/focal_spot_archives/1106/thumbnail.jp
Portable High Throughput Digital Microfluidics and On-Chip Bacteria Cultures
An intelligent, portable, and high throughput digital microfluidic (DMF) system is developed. Chapter 1 introduces microfluidics and DMF systems. In Chapter 2, a low-cost and high resolution capacitive-to-digital converter integrated circuit is used for droplet position detection. A field-programmable gate array FPGA is used as the integrated logic hub of the system for highly reliable and efficient control of the circuit. In this chapter a fast-fabricating PCB (printed circuit board) substrate microfluidic system is proposed. Smaller actuation threshold voltages than those previously reported are obtained. Droplets (3 µL) are actuated using 200 V, 500 Hz DC pulses. Droplet positions can be detected and displayed on a PC-based 3D animation in real time. The actuators and the capacitance sensing circuits are implemented on one PCB to reduce the size of the system. In Chapter 3, an intelligent EWOD (electrowetting on dielectric) top plate control system is proposed. The dynamic top plate is controlled by a piezoelectric (PZT) cantilever structure. A high resolution laser displacement sensor is used to monitor the deflection of the top plate. The gap height optimization and the harmonic vibration significantly improve the droplet velocity and decrease the droplet minimum threshold actuation voltage. The top plate vibration induced actuation improvement is magnitude and frequency dependent. 100 µm and 200 µm vibrations are tested at 25 Hz. Vibration frequencies at 5 Hz, 10 Hz, and 20 Hz are tested while the magnitude is 200 µm. Results show greater improvements are achieved at larger vibration magnitudes and higher vibration frequencies. With a vibrated top plate, the largest reduction of the actuation voltage is 76 VRMS for a 2.0 µl DI water droplet. The maximum droplet instantaneous velocity is around 9.3 mm/s, which is almost 3 times faster than the droplet velocity without top plate vibration. Liquid that has different hysteresis such as acetonitrile with various concentrations are used as a control to show its compatibility with the proposed DMF chip. Contact line depinning under top plate vibration is observed, which indicates the underlying mechanism for the improvements in actuation velocity and threshold voltage. The top plate control technique reported in this study makes EWOD DMF chips more reliable for point of care diagnostics. In Chapter 4, the mechanisms of the improvements were investigated by observing the detailed changes in the contact angle hysteresis using both parallel and nonparallel top plates. In Chapter 5, on-chip cell cultures are used for anti-biotic resistant bacteria detection. The passively dispensed on-chip cell cultures realize the isolated micro environment electrochemistry measurement, shorten the culturing time, and reduce the required sample volume. The design of the next generation ultra-portable DMF system is covered in the Appendix. Detailed technical notes and hardware design is covered in the Appendix. The proposed portable and high throughput DMF system with on-chip cell cultures have a great potential to change the standards for micro-environment culturing technologies, which will significantly improve the efficiency of actuation, sensing, and detecting performance of the DMF systems
Design and Application of Wireless Body Sensors
Hörmann T. Design and Application of Wireless Body Sensors. Bielefeld: Universität Bielefeld; 2019
Wearable, low-power CMOS ISFETs and compensation circuits for on-body sweat analysis
Complementary metal-oxide-semiconductor (CMOS) technology has been a key driver behind the trend of reduced power consumption and increased integration of electronics in consumer devices and sensors. In the late 1990s, the integration of ion-sensitive field-effect transistors (ISFETs) into unmodified CMOS helped to create advancements in lab-on-chip technology through highly parallelised and low-cost designs. Using CMOS techniques to reduce power and size in chemical sensing applications has already aided the realisation of portable, battery-powered analysis platforms, however the possibility of integrating these sensors into wearable devices has until recently remained unexplored. This thesis investigates the use of CMOS ISFETs as wearable electrochemical sensors, specifically for on-body sweat analysis.
The investigation begins by evaluating the ISFET sensor for wearable applications, identifying the key advantages and challenges that arise in this pursuit. A key requirement for wearable devices is a low power consumption, to enable a suitable operational life and small form factor. From this perspective, ISFETs are investigated for low power operation, to determine the limitations when trying to push down the consumption of individual sensors. Batteryless ISFET operation is explored through the design and implementation of a 0.35 \si{\micro\metre} CMOS ISFET sensing array, operating in weak-inversion and consuming 6 \si{\micro\watt}. Using this application-specific integrated circuit (ASIC), the first ISFET array powered by body heat is demonstrated and the feasibility of using near-field communication (NFC) for wireless powering and data transfer is shown.
The thesis also presents circuits and systems for combatting three key non-ideal effects experienced by CMOS ISFETs, namely temperature variation, threshold voltage offset and drift. An improvement in temperature sensitivity by a factor of three compared to an uncompensated design is shown through measured results, while adding less than 70 \si{\nano\watt} to the design. A method of automatically biasing the sensors is presented and an approach to using spatial separation of sensors in arrays in applications with flowing fluids is proposed for distinguishing between signal and sensor drift. A wearable device using the ISFET-based system is designed and tested with both artificial and natural sweat, identifying the remaining challenges that exist with both the sensors themselves and accompanying components such as microfluidics and reference electrode. A new ASIC is designed based on the discoveries of this work and aimed at detecting multiple analytes on a single chip.
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Finally, the future directions of wearable electrochemical sensors is discussed with a look towards embedded machine learning to aid the interpretation of complex fluid with time-domain sensor arrays. The contributions of this thesis aim to form a foundation for the use of ISFETs in wearable devices to enable non-invasive physiological monitoring.Open Acces
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