Evaluating an Approach for mapping FHIR Profiles to Research Protocols

Observational studies and clinical trials have become increasingly important over recent years and play an essential role in advancing medical knowledge. In today’s world of clinical research, it is not possible to imagine trials without the founda-tion of a well-established it-infrastructure. Electronic capture and usage of data is pervasive. In practice, medical progress requires the ability to integrate data from different systems. An essential factor in enabling different actors, such as institutions and hospitals, to have their systems exchange structured data and make use of the information is the interoperability of the data and systems. FHIR (Fast Healthcare Interoperable Resources) is a free and easily customizable HL7 platform standard, based on 30 years of experience of HL7. It is focused on providing health-related information and defines a set of capabilities used in the health care process. This thesis will provide a conceptual approach for working with FHIR, as well as concrete approaches for working with FHIR profiles and for customizing the standard for particular use cases. It will be carried out in cooperation with the Medical Systems R&D, which is a service provider within the University Hospital of Cologne. The guiding request approach will focus on the evaluation of requirements for clini-cal trials and how clinical research protocols can be represented in an interoperable and machine-parsable format using FHIR

Emergency TeleOrthoPaedics m-health system for wireless communication links

For the first time, a complete wireless and mobile emergency TeleOrthoPaedics system with field trials and expert opinion is presented. The system enables doctors in a remote area to obtain a second opinion from doctors in the hospital using secured wireless telecommunication networks. Doctors can exchange securely medical images and video as well as other important data, and thus perform remote consultations, fast and accurately using a user friendly interface, via a reliable and secure telemedicine system of low cost. The quality of the transmitted compressed (JPEG2000) images was measured using different metrics and doctors opinions. The results have shown that all metrics were within acceptable limits. The performance of the system was evaluated successfully under different wireless communication links based on real data

On the Use of XML in Medical Imaging Web-Based Applications

The rapid growth of digital technology in medical fields over recent years has increased the need for applications able to manage patient medical records, imaging data, and chart information. Web-based applications are implemented with the purpose to link digital databases, storage and transmission protocols, management of large volumes of data and security concepts, allowing the possibility to read, analyze, and even diagnose remotely from the medical center where the information was acquired. The objective of this paper is to analyze the use of the Extensible Markup Language (XML) language in web-based applications that aid in diagnosis or treatment of patients, considering how this protocol allows indexing and exchanging the huge amount of information associated with each medical case. The purpose of this paper is to point out the main advantages and drawbacks of the XML technology in order to provide key ideas for future web-based applicationsPeer ReviewedPostprint (author's final draft

Interchanging lexical resources on the Semantic Web

Lexica and terminology databases play a vital role in many NLP applications, but currently most such resources are published in application-specific formats, or with custom access interfaces, leading to the problem that much of this data is in ‘‘data silos’’ and hence difficult to access. The Semantic Web and in particular the Linked Data initiative provide effective solutions to this problem, as well as possibilities for data reuse by inter-lexicon linking, and incorporation of data categories by dereferencable URIs. The Semantic Web focuses on the use of ontologies to describe semantics on the Web, but currently there is no standard for providing complex lexical information for such ontologies and for describing the relationship between the lexicon and the ontology. We present our model, lemon, which aims to address these gap

Grid Databases for Shared Image Analysis in the MammoGrid Project

The MammoGrid project aims to prove that Grid infrastructures can be used for collaborative clinical analysis of database-resident but geographically distributed medical images. This requires: a) the provision of a clinician-facing front-end workstation and b) the ability to service real-world clinician queries across a distributed and federated database. The MammoGrid project will prove the viability of the Grid by harnessing its power to enable radiologists from geographically dispersed hospitals to share standardized mammograms, to compare diagnoses (with and without computer aided detection of tumours) and to perform sophisticated epidemiological studies across national boundaries. This paper outlines the approach taken in MammoGrid to seamlessly connect radiologist workstations across a Grid using an "information infrastructure" and a DICOM-compliant object model residing in multiple distributed data stores in Italy and the UKComment: 10 pages, 5 figure

All-Payer Claims Database Development Manual: Establishing a Foundation for Health Care Transparency and Informed Decision Making

With support from the Gary and Mary West Health Policy Center, the APCD Council has developed a manual for states to develop all-payer claims databases. Titled All-Payer Claims Database Development Manual: Establishing a Foundation for Health Care Transparency and Informed Decision Making, the manual is a first-of its-kind resource that provides states with detailed guidance on common data standards, collection, aggregation and analysis involved with establishing these databases

Extending the Carrel system to mediate in the organ and tissue allocation processes: a first approach

In this paper we extend the formalization of Carrel, a virtual organization for the procurement of tissues for transplantation purposes, in order to model also the procurement of human organs for transplants. We will focus in the organ allocation process to show how it can be formalized with the ISLANDER formalism. Also we present a first mechanism to federate the institution in several geographically-distributed platforms.Postprint (published version

HoloDetect: Few-Shot Learning for Error Detection

We introduce a few-shot learning framework for error detection. We show that data augmentation (a form of weak supervision) is key to training high-quality, ML-based error detection models that require minimal human involvement. Our framework consists of two parts: (1) an expressive model to learn rich representations that capture the inherent syntactic and semantic heterogeneity of errors; and (2) a data augmentation model that, given a small seed of clean records, uses dataset-specific transformations to automatically generate additional training data. Our key insight is to learn data augmentation policies from the noisy input dataset in a weakly supervised manner. We show that our framework detects errors with an average precision of ~94% and an average recall of ~93% across a diverse array of datasets that exhibit different types and amounts of errors. We compare our approach to a comprehensive collection of error detection methods, ranging from traditional rule-based methods to ensemble-based and active learning approaches. We show that data augmentation yields an average improvement of 20 F1 points while it requires access to 3x fewer labeled examples compared to other ML approaches.Comment: 18 pages

Special Libraries, December 1975

Volume 66, Issue 12https://scholarworks.sjsu.edu/sla_sl_1975/1009/thumbnail.jp