Mapping the epileptic brain with EEG dynamical connectivity: established methods and novel approaches

Several algorithms rooted in statistical physics, mathematics and machine learning are used to analyze neuroimaging data from patients suffering from epilepsy, with the main goals of localizing the brain region where the seizure originates from and of detecting upcoming seizure activity in order to trigger therapeutic neurostimulation devices. Some of these methods explore the dynamical connections between brain regions, exploiting the high temporal resolution of the electroencephalographic signals recorded at the scalp or directly from the cortical surface or in deeper brain areas. In this paper we describe this specific class of algorithms and their clinical application, by reviewing the state of the art and reporting their application on EEG data from an epileptic patient

Adversarial Variational Embedding for Robust Semi-supervised Learning

Semi-supervised learning is sought for leveraging the unlabelled data when labelled data is difficult or expensive to acquire. Deep generative models (e.g., Variational Autoencoder (VAE)) and semisupervised Generative Adversarial Networks (GANs) have recently shown promising performance in semi-supervised classification for the excellent discriminative representing ability. However, the latent code learned by the traditional VAE is not exclusive (repeatable) for a specific input sample, which prevents it from excellent classification performance. In particular, the learned latent representation depends on a non-exclusive component which is stochastically sampled from the prior distribution. Moreover, the semi-supervised GAN models generate data from pre-defined distribution (e.g., Gaussian noises) which is independent of the input data distribution and may obstruct the convergence and is difficult to control the distribution of the generated data. To address the aforementioned issues, we propose a novel Adversarial Variational Embedding (AVAE) framework for robust and effective semi-supervised learning to leverage both the advantage of GAN as a high quality generative model and VAE as a posterior distribution learner. The proposed approach first produces an exclusive latent code by the model which we call VAE++, and meanwhile, provides a meaningful prior distribution for the generator of GAN. The proposed approach is evaluated over four different real-world applications and we show that our method outperforms the state-of-the-art models, which confirms that the combination of VAE++ and GAN can provide significant improvements in semisupervised classification.Comment: 9 pages, Accepted by Research Track in KDD 201

Performance Analysis of Deep-Learning and Explainable AI Techniques for Detecting and Predicting Epileptic Seizures

Epilepsy is one of the most common neurological diseases globally. Notably, people in low to middle-income nations could not get proper epilepsy treatment due to the cost and availability of medical infrastructure. The risk of sudden unpredicted death in Epilepsy is considerably high. Medical statistics reveal that people with Epilepsy die more prematurely than those without the disease. Early and accurately diagnosing diseases in the medical field is challenging due to the complex disease patterns and the need for time-sensitive medical responses to the patients. Even though numerous machine learning and advanced deep learning techniques have been employed for the seizure stages classification and prediction, understanding the causes behind the decision is difficult, termed a black box problem. Hence, doctors and patients are confronted with the black box decision-making to initiate the appropriate treatment and understand the disease patterns respectively. Owing to the scarcity of epileptic Electroencephalography (EEG) data, training the deep learning model with diversified epilepsy knowledge is still critical. Explainable Artificial intelligence has become a potential solution to provide the explanation and result interpretation of the learning models. By applying the explainable AI, there is a higher possibility of examining the features that influence the decision-making that either the patient recorded from epileptic or non-epileptic EEG signals. This paper reviews the various deep learning and Explainable AI techniques used for detecting and predicting epileptic seizures  using EEG data. It provides a comparative analysis of the different techniques based on their performance