Efficient Management of Short-Lived Data

Motivated by the increasing prominence of loosely-coupled systems, such as mobile and sensor networks, which are characterised by intermittent connectivity and volatile data, we study the tagging of data with so-called expiration times. More specifically, when data are inserted into a database, they may be tagged with time values indicating when they expire, i.e., when they are regarded as stale or invalid and thus are no longer considered part of the database. In a number of applications, expiration times are known and can be assigned at insertion time. We present data structures and algorithms for online management of data tagged with expiration times. The algorithms are based on fully functional, persistent treaps, which are a combination of binary search trees with respect to a primary attribute and heaps with respect to a secondary attribute. The primary attribute implements primary keys, and the secondary attribute stores expiration times in a minimum heap, thus keeping a priority queue of tuples to expire. A detailed and comprehensive experimental study demonstrates the well-behavedness and scalability of the approach as well as its efficiency with respect to a number of competitors.Comment: switched to TimeCenter latex styl

Dynamic Range Majority Data Structures

Given a set $P$ of coloured points on the real line, we study the problem of answering range $\alpha$-majority (or "heavy hitter") queries on $P$. More specifically, for a query range $Q$, we want to return each colour that is assigned to more than an $\alpha$-fraction of the points contained in $Q$. We present a new data structure for answering range $\alpha$-majority queries on a dynamic set of points, where $\alpha \in (0,1)$. Our data structure uses O(n) space, supports queries in $O((\lg n) / \alpha)$ time, and updates in $O((\lg n) / \alpha)$ amortized time. If the coordinates of the points are integers, then the query time can be improved to $O(\lg n / (\alpha \lg \lg n) + (\lg(1/\alpha))/\alpha))$. For constant values of $\alpha$, this improved query time matches an existing lower bound, for any data structure with polylogarithmic update time. We also generalize our data structure to handle sets of points in d-dimensions, for $d \ge 2$, as well as dynamic arrays, in which each entry is a colour.Comment: 16 pages, Preliminary version appeared in ISAAC 201

The Wavelet Trie: Maintaining an Indexed Sequence of Strings in Compressed Space

An indexed sequence of strings is a data structure for storing a string sequence that supports random access, searching, range counting and analytics operations, both for exact matches and prefix search. String sequences lie at the core of column-oriented databases, log processing, and other storage and query tasks. In these applications each string can appear several times and the order of the strings in the sequence is relevant. The prefix structure of the strings is relevant as well: common prefixes are sought in strings to extract interesting features from the sequence. Moreover, space-efficiency is highly desirable as it translates directly into higher performance, since more data can fit in fast memory. We introduce and study the problem of compressed indexed sequence of strings, representing indexed sequences of strings in nearly-optimal compressed space, both in the static and dynamic settings, while preserving provably good performance for the supported operations. We present a new data structure for this problem, the Wavelet Trie, which combines the classical Patricia Trie with the Wavelet Tree, a succinct data structure for storing a compressed sequence. The resulting Wavelet Trie smoothly adapts to a sequence of strings that changes over time. It improves on the state-of-the-art compressed data structures by supporting a dynamic alphabet (i.e. the set of distinct strings) and prefix queries, both crucial requirements in the aforementioned applications, and on traditional indexes by reducing space occupancy to close to the entropy of the sequence

Succinct Representations of Dynamic Strings

The rank and select operations over a string of length n from an alphabet of size $\sigma$ have been used widely in the design of succinct data structures. In many applications, the string itself need be maintained dynamically, allowing characters of the string to be inserted and deleted. Under the word RAM model with word size $w=\Omega(\lg n)$, we design a succinct representation of dynamic strings using $nH_0 + o(n)\lg\sigma + O(w)$ bits to support rank, select, insert and delete in $O(\frac{\lg n}{\lg\lg n}(\frac{\lg \sigma}{\lg\lg n}+1))$ time. When the alphabet size is small, i.e. when \sigma = O(\polylog (n)), including the case in which the string is a bit vector, these operations are supported in $O(\frac{\lg n}{\lg\lg n})$ time. Our data structures are more efficient than previous results on the same problem, and we have applied them to improve results on the design and construction of space-efficient text indexes

A Complexity O(1) Priority Queue for Event Driven Molecular Dynamics Simulations

We propose and implement a priority queue suitable for use in event driven molecular dynamics simulations. All operations on the queue take on average O(1) time per collision. In comparison, previously studied queues for event driven molecular dynamics simulations require O(log $N$) time per collision for systems of $N$ particles.Comment: Accepted for publication in Journal of Computational Physic

Learning mutational graphs of individual tumour evolution from single-cell and multi-region sequencing data

Background. A large number of algorithms is being developed to reconstruct evolutionary models of individual tumours from genome sequencing data. Most methods can analyze multiple samples collected either through bulk multi-region sequencing experiments or the sequencing of individual cancer cells. However, rarely the same method can support both data types. Results. We introduce TRaIT, a computational framework to infer mutational graphs that model the accumulation of multiple types of somatic alterations driving tumour evolution. Compared to other tools, TRaIT supports multi-region and single-cell sequencing data within the same statistical framework, and delivers expressive models that capture many complex evolutionary phenomena. TRaIT improves accuracy, robustness to data-specific errors and computational complexity compared to competing methods. Conclusions. We show that the application of TRaIT to single-cell and multi-region cancer datasets can produce accurate and reliable models of single-tumour evolution, quantify the extent of intra-tumour heterogeneity and generate new testable experimental hypotheses

Engineering Top-Down Weight-Balanced Trees

Weight-balanced trees are a popular form of self-balancing binary search trees. Their popularity is due to desirable guarantees, for example regarding the required work to balance annotated trees. While usual weight-balanced trees perform their balancing operations in a bottom-up fashion after a modification to the tree is completed, there exists a top-down variant which performs these balancing operations during descend. This variant has so far received only little attention. We provide an in-depth analysis and engineering of these top-down weight-balanced trees, demonstrating their superior performance. We also gaining insights into how the balancing parameters necessary for a weight-balanced tree should be chosen - with the surprising observation that it is often beneficial to choose parameters which are not feasible in the sense of the correctness proofs for the rebalancing algorithm.Comment: Accepted for publication at ALENEX 202