Explicit optimization of plan quality measures in intensity-modulated radiation therapy treatment planning

Conventional planning objectives in optimization of intensity-modulated radiotherapy treatment (IMRT) plans are designed to minimize the violation of dose-volume histogram (DVH) thresholds using penalty functions. Although successful in guiding the DVH curve towards these thresholds, conventional planning objectives offer limited control of the individual points on the DVH curve (doses-at-volume) used to evaluate plan quality. In this study, we abandon the usual penalty-function framework and propose planning objectives that more explicitly relate to DVH statistics. The proposed planning objectives are based on mean-tail-dose, resulting in convex optimization. We also demonstrate how to adapt a standard optimization method to the proposed formulation in order to obtain a substantial reduction in computational cost. We investigate the potential of the proposed planning objectives as tools for optimizing DVH statistics through juxtaposition with the conventional planning objectives on two patient cases. Sets of treatment plans with differently balanced planning objectives are generated using either the proposed or the conventional approach. Dominance in the sense of better distributed doses-at-volume is observed in plans optimized within the proposed framework, indicating that the DVH statistics are better optimized and more efficiently balanced using the proposed planning objectives

A new adaptive algorithm for convex quadratic multicriteria optimization

We present a new adaptive algorithm for convex quadratic multicriteria optimization. The algorithm is able to adaptively refine the approximation to the set of efficient points by way of a warm-start interior-point scalarization approach. Numerical results show that this technique is faster than a standard method used for this problem

A New Adaptive Algorithm for Convex Quadratic Multicriteria Optimization

We present a new adaptive algorithm for convex quadratic multicriteria optimization. The algorithm is able to adaptively refine the approximation to the set of efficient points by way of a warm-start interior-point scalarization approach. Numerical results show that this technique is an order of magnitude faster than a standard method used for this problem