249 research outputs found

    Effects of municipal smoke-free ordinances on secondhand smoke exposure in the Republic of Korea

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    ObjectiveTo reduce premature deaths due to secondhand smoke (SHS) exposure among non-smokers, the Republic of Korea (ROK) adopted changes to the National Health Promotion Act, which allowed local governments to enact municipal ordinances to strengthen their authority to designate smoke-free areas and levy penalty fines. In this study, we examined national trends in SHS exposure after the introduction of these municipal ordinances at the city level in 2010.MethodsWe used interrupted time series analysis to assess whether the trends of SHS exposure in the workplace and at home, and the primary cigarette smoking rate changed following the policy adjustment in the national legislation in ROK. Population-standardized data for selected variables were retrieved from a nationally representative survey dataset and used to study the policy action’s effectiveness.ResultsFollowing the change in the legislation, SHS exposure in the workplace reversed course from an increasing (18% per year) trend prior to the introduction of these smoke-free ordinances to a decreasing (−10% per year) trend after adoption and enforcement of these laws (β2 = 0.18, p-value = 0.07; β3 = −0.10, p-value = 0.02). SHS exposure at home (β2 = 0.10, p-value = 0.09; β3 = −0.03, p-value = 0.14) and the primary cigarette smoking rate (β2 = 0.03, p-value = 0.10; β3 = 0.008, p-value = 0.15) showed no significant changes in the sampled period. Although analyses stratified by sex showed that the allowance of municipal ordinances resulted in reduced SHS exposure in the workplace for both males and females, they did not affect the primary cigarette smoking rate as much, especially among females.ConclusionStrengthening the role of local governments by giving them the authority to enact and enforce penalties on SHS exposure violation helped ROK to reduce SHS exposure in the workplace. However, smoking behaviors and related activities seemed to shift to less restrictive areas such as on the streets and in apartment hallways, negating some of the effects due to these ordinances. Future studies should investigate how smoke-free policies beyond public places can further reduce the SHS exposure in ROK

    Computational Approaches to Drug Profiling and Drug-Protein Interactions

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    Despite substantial increases in R&D spending within the pharmaceutical industry, denovo drug design has become a time-consuming endeavour. High attrition rates led to a long period of stagnation in drug approvals. Due to the extreme costs associated with introducing a drug to the market, locating and understanding the reasons for clinical failure is key to future productivity. As part of this PhD, three main contributions were made in this respect. First, the web platform, LigNFam enables users to interactively explore similarity relationships between ‘drug like’ molecules and the proteins they bind. Secondly, two deep-learning-based binding site comparison tools were developed, competing with the state-of-the-art over benchmark datasets. The models have the ability to predict offtarget interactions and potential candidates for target-based drug repurposing. Finally, the open-source ScaffoldGraph software was presented for the analysis of hierarchical scaffold relationships and has already been used in multiple projects, including integration into a virtual screening pipeline to increase the tractability of ultra-large screening experiments. Together, and with existing tools, the contributions made will aid in the understanding of drug-protein relationships, particularly in the fields of off-target prediction and drug repurposing, helping to design better drugs faster

    Artificial Intelligence for detection and prevention of mold contamination in tomato processing

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    openIl presente elaborato si propone di analizzare l'uso dell'intelligenza artificiale attraverso il riconoscimento di immagini per rilevare la presenza di muffa nei pomodori durante il processo di essiccazione. La muffa nei pomodori rappresenta un rischio sia per la salute umana sia per l'industria alimentare, comportando, anche, una serie di problemi che vanno oltre l'aspetto estetico. Essa è causata principalmente da funghi che si diffondono rapidamente sulla superficie dei pomodori. Tale processo compromette così la qualità con la conseguente produzione di tossine che possono influire sulla salute umana. L'obiettivo sperimentale di questo lavoro è il problema dello spreco e della perdita di prodotto nell'industria alimentare. Quando i pomodori sono colpiti da muffe, infatti, diventano inadatti al consumo, con conseguente perdita di cibo. Lo spreco di pomodori a causa delle muffe rappresenta anche la perdita di preziose risorse, utili alla produzione, come terra, acqua, energia e tempo. Il proposito è testare, anche nella fase iniziale, la capacità di un algoritmo di rilevamento degli oggetti per identificare la muffa, e adottare misure preventive. L'analisi sperimentale ha previsto l'addestramento dell'algoritmo con un'ampia serie di foto, tra cui pomodori sani e rovinati di diversi tipi, forme e consistenze. Per etichettare le immagini e creare le epoche di addestramento è stato quindi utilizzato YOLOv7, l'algoritmo di rilevamento degli oggetti scelto, basato su reti neurali. Per valutare le prestazioni sono state utilizzate metriche di valutazione, tra cui “Precision” e “Recall”. L'ipotesi di applicazione dell'intelligenza artificiale in futuro sarà un grande potenziale per migliorare i processi di produzione alimentare, facilitando, così, l'identificazione delle muffe. Il rilevamento rapido delle muffe faciliterebbe la separazione tempestiva dei prodotti contaminati, riducendo così il rischio di diffusione delle tossine e preservando la qualità degli alimenti non contaminati. Questo approccio contribuirebbe a ridurre al minimo gli sprechi alimentari e le inefficienze delle risorse associate allo scarto di grandi quantità di prodotto. Inoltre, l'integrazione della computer vision nel contesto dell'HACCP (Hazard Analysis Critical Control Points) potrebbe migliorare i protocolli di sicurezza alimentare grazie a un rilevamento accurato e tempestivo. Questa tecnologia potrà offrire, dando priorità alla prevenzione, una promettente opportunità per migliorare la qualità, l'efficienza e la sostenibilità dei futuri processi di produzione alimentare.This study investigates the use of computer vision couples with artificial intelligence to detect mold in tomatoes during the drying process. Mold presence in tomatoes poses threats to human health and the food industry as it leads to several issues beyond appearance. It is primarily caused by fungi that spread rapidly over the tomato surface, compromising their quality, and potentially producing toxins that can harm human health. The experimental aim of this work focused on the issue of wastage and loss within the food industry. When tomatoes succumb to mold, they become unsuitable for consumption, resulting in a loss of food and resources. Considering that tomato production requires resources such as land, water, energy, and time, wasting tomatoes due to mold also represents a waste of these valuable resources. The goal was to evaluate the mold detection capabilities of an object detection algorithm, particularly in its early stages, to facilitate preventative measures. This experimental analysis entailed training the algorithm with an extensive array of images, encompassing a variety of healthy and spoiled tomatoes of different shapes, types, textures and drying stages. The chosen object detection algorithm, YOLOv7, is convolutional neural network-based and was utilized for image labeling and training epochs. Evaluation metrics, including precision and recall, were utilized to assess the algorithm's performance. The implementation of artificial intelligence in the future has significant potential for enhancing food production processes by streamlining mold identification. Prompt mold detection would expedite segregation of contaminated products, thus reducing the risk of toxin dissemination and preserving the quality of uncontaminated food. This approach could minimize food waste and resource inefficiencies linked to discarding significant product amounts. Furthermore, integrating computer vision in the HACCP (Hazard Analysis Critical Control Points) context could enhance food safety protocols via accurate and prompt detection. By prioritizing prevention, this technology offers a promising chance to optimize quality, efficiency, and sustainability of future food production processes

    A Study of Geometric Semantic Genetic Programming with Linear Scaling

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    Dissertation presented as the partial requirement for obtaining a Master's degree in Data Science and Advanced Analytics, specialization in Data ScienceMachine Learning (ML) is a scientific discipline that endeavors to enable computers to learn without the need for explicit programming. Evolutionary Algorithms (EAs), a subset of ML algorithms, mimic Darwin’s Theory of Evolution by using natural selection mechanisms (i.e., survival of the fittest) to evolve a group of individuals (i.e., possible solutions to a given problem). Genetic Programming (GP) is the most recent type of EA and it evolves computer programs (i.e., individuals) to map a set of input data into known expected outputs. Geometric Semantic Genetic Programming (GSGP) extends this concept by allowing individuals to evolve and vary in the semantic space, where the output vectors are located, rather than being constrained by syntaxbased structures. Linear Scaling (LS) is a method that was introduced to facilitate the task of GP of searching for the best function matching a set of known data. GSGP and LS have both, independently, shown the ability to outperform standard GP for symbolic regression. GSGP uses Geometric Semantic Operators (GSOs), different from the standard ones, without altering the fitness, while LS modifies the fitness without altering the genetic operators. To the best of our knowledge, there has been no prior utilization of the combined methodology of GSGP and LS for classification problems. Furthermore, despite the fact that they have been used together in one practical regression application, a methodological evaluation of the advantages and disadvantages of integrating these methods for regression or classification problems has never been performed. In this dissertation, a study of a system that integrates both GSGP and LS (GSGP-LS) is presented. The performance of the proposed method, GSGPLS, was tested on six hand-tailored regression benchmarks, nine real-life regression problems and three real-life classification problems. The obtained results indicate that GSGP-LS outperforms GSGP in the majority of the cases, confirming the expected benefit of this integration. However, for some particularly hard regression datasets, GSGP-LS overfits training data, being outperformed by GSGP on unseen data. This contradicts the idea that LS is always beneficial for GP, warning the practitioners about its risk of overfitting in some specific cases.A Aprendizagem Automática (AA) é uma disciplina científica que se esforça por permitir que os computadores aprendam sem a necessidade de programação explícita. Algoritmos Evolutivos (AE),um subconjunto de algoritmos de ML, mimetizam a Teoria da Evolução de Darwin, usando a seleção natural e mecanismos de "sobrevivência dos mais aptos"para evoluir um grupo de indivíduos (ou seja, possíveis soluções para um problema dado). A Programação Genética (PG) é um processo algorítmico que evolui programas de computador (ou indivíduos) para ligar características de entrada e saída. A Programação Genética em Geometria Semântica (PGGS) estende esse conceito permitindo que os indivíduos evoluam e variem no espaço semântico, onde os vetores de saída estão localizados, em vez de serem limitados por estruturas baseadas em sintaxe. A Escala Linear (EL) é um método introduzido para facilitar a tarefa da PG de procurar a melhor função que corresponda a um conjunto de dados conhecidos. Tanto a PGGS quanto a EL demonstraram, independentemente, a capacidade de superar a PG padrão para regressão simbólica. A PGGS usa Operadores Semânticos Geométricos (OSGs), diferentes dos padrões, sem alterar o fitness, enquanto a EL modifica o fitness sem alterar os operadores genéticos. Até onde sabemos, não houve utilização prévia da metodologia combinada de PGGS e EL para problemas de classificação. Além disso, apesar de terem sido usados juntos em uma aplicação prática de regressão, nunca foi realizada uma avaliação metodológica das vantagens e desvantagens da integração desses métodos para problemas de regressão ou classificação. Nesta dissertação, é apresentado um estudo de um sistema que integra tanto a PGGS quanto a EL (PGGSEL). O desempenho do método proposto, PGGS-EL, foi testado em seis benchmarks de regressão personalizados, nove problemas de regressão da vida real e três problemas de classificação da vida real. Os resultados obtidos indicam que o PGGS-EL supera o PGGS na maioria dos casos, confirmando o benefício esperado desta integração. No entanto, para alguns conjuntos de dados de regressão particularmente difíceis, o PGGS-EL faz overfit aos dados de treino, obtendo piores resultados em comparação com PGGS em dados não vistos. Isso contradiz a ideia de que a EL é sempre benéfica para a PG, alertando os praticantes sobre o risco de overfitting em alguns casos específicos

    ATHENA Research Book, Volume 2

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    ATHENA European University is an association of nine higher education institutions with the mission of promoting excellence in research and innovation by enabling international cooperation. The acronym ATHENA stands for Association of Advanced Technologies in Higher Education. Partner institutions are from France, Germany, Greece, Italy, Lithuania, Portugal and Slovenia: University of Orléans, University of Siegen, Hellenic Mediterranean University, Niccolò Cusano University, Vilnius Gediminas Technical University, Polytechnic Institute of Porto and University of Maribor. In 2022, two institutions joined the alliance: the Maria Curie-Skłodowska University from Poland and the University of Vigo from Spain. Also in 2022, an institution from Austria joined the alliance as an associate member: Carinthia University of Applied Sciences. This research book presents a selection of the research activities of ATHENA University's partners. It contains an overview of the research activities of individual members, a selection of the most important bibliographic works of members, peer-reviewed student theses, a descriptive list of ATHENA lectures and reports from individual working sections of the ATHENA project. The ATHENA Research Book provides a platform that encourages collaborative and interdisciplinary research projects by advanced and early career researchers

    On the Hybridization of Geometric Semantic GP with Gradient-based Optimizers

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    Pietropolli, G., Manzoni, L., Paoletti, A., & Castelli, M. (2023). On the Hybridization of Geometric Semantic GP with Gradient-based Optimizers. Genetic Programming And Evolvable Machines, 24(2 Special Issue on Highlights of Genetic Programming 2022 Events), 1-20. [16]. https://doi.org/10.21203/rs.3.rs-2229748/v1, https://doi.org/10.1007/s10710-023-09463-1---Open access funding provided by Università degli Studi di Trieste within the CRUI-CARE Agreement. This work was supported by national funds through FCT (Fundação para a Ciência e a Tecnologia), under the Project—UIDB/04152/2020—Centro de Investigação em Gestão de Informação (MagIC)/NOVA IMSGeometric semantic genetic programming (GSGP) is a popular form of GP where the effect of crossover and mutation can be expressed as geometric operations on a semantic space. A recent study showed that GSGP can be hybridized with a standard gradient-based optimized, Adam, commonly used in training artificial neural networks.We expand upon that work by considering more gradient-based optimizers, a deeper investigation of their parameters, how the hybridization is performed, and a more comprehensive set of benchmark problems. With the correct choice of hyperparameters, this hybridization improves the performances of GSGP and allows it to reach the same fitness values with fewer fitness evaluations.publishersversionepub_ahead_of_prin

    Seventh International Symposium "Monitoring of Mediterranean Coastal Areas. Problems and Measurement Techniques"

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    The Seventh International Symposium Monitoring of Mediterranean Coastal Areas. Problems and Measurement Techniques (Livorno, Italy June 19-20-21, 2018) was organized by the CNR-IBIMET in collaboration with the City of Livorno, the LEM Foundation, the FCS Foundation and the Compagnia dei Portuali di Livorno, with the patronage by Accademia Nazionale dei Lincei, Accademia dei Georgofili, The University of Florence, the Tuscany Region and the North Tyrrhenian Sea Port System Authority. The Symposium, in which scholars from all over the Mediterranean basin participated, was an opportunity to illustrate new proposals and to promote actions to protect the Mediterranean coastal marine environment. In particular, the event was characterized by the search for technical and instrumental solutions to problems related to: energy production in the coastal area, morphology and evolution of coastlines, flora and fauna of the littoral system, management and integrated coastal protection, coastline geography, human influence on coastal landscape

    Improving Tree-based Pipeline Optimization Tool with Geometric Semantic Genetic Programming

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    Dissertation presented as the partial requirement for obtaining a Master's degree in Data Science and Advanced Analytics, specialization in Data ScienceMachine Learning (ML) is becoming part of our lives, from face recognition to sensors of the latest cars. However, the construction of its pipelines is a time-consuming and expensive process, even for experts that have the knowledge in ML algorithms, due to the several options for each step. To overcome this issue, Automated ML (AutoML) was introduced, automating some steps of this process. One of its recent algorithms is Tree-Based Pipeline Optimization Tool (TPOT), an Evolutionary Algorithm (EA) that automatically designs and optimizes ML pipelines using Genetic Programming (GP). Another recent algorithm is Geometric Semantic Genetic Programming (GSGP), an EA characterized by using the semantics, the vector of outputs of a program on the different training data, and by searching directly in the space of semantics of the program through geometric semantic operators, leading to a unimodal fitness landscape. In this work, a new version of TPOT was created, called TPOT-GSGP, where GSGP is one of the options for model selection. This new algorithm was implemented in Python, only for regression problems and using Negative Mean Absolute Error as measurement error. Five case studies were used to compare the performance of three algorithms: TPOT-GSGP, the original TPOT, and GSGP. Additionally, the statistical significance of the difference on the last generation’s score for each combination of two algorithms was checked with Wilcoxon tests. There was not a single algorithm that outperformed the others in all datasets, sometimes it was TPOT-GSGP and others TPOT, depending on the case study and on the score that was analysed (learning or test). It was concluded that every time GSGP is chosen as root 50% of the times or more, TPOT-GSGP outperformed TPOT on the test set. Therefore, the advantages of this new algorithm can be extraordinary with its development and adjustment in future work
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