Acquisition systems and decoding algorithms of peripheral neural signals for prosthetic applications

During the years, neuroprosthetic applications have obtained a great deal of attention by the international research, especially in the bioengineering field, thanks to the huge investments on several proposed projects funded by the political institutions which consider the treatment of this particular disease of fundamental importance for the global community. The aim of these projects is to find a possible solution to restore the functionalities lost by a patient subjected to an upper limb amputation trying to develop, according to physiological considerations, a communication link between the brain in which the significant signals are generated and a motor prosthesis device able to perform the desired action. Moreover, the designed system must be able to give back to the brain a sensory feedback about the surrounding world in terms of pressure or temperature acquired by tactile biosensors placed at the surface of the cybernetic hand. It in fact allows to execute involuntarymovements when for example the armcomes in contact with hot objects. The development of such a closed-loop architecture involves the need to address some critical issues which depend on the chosen approach. Several solutions have been proposed by the researches of the field, each one differing with respect to where the neural signals are acquired, either at the central nervous systemor at the peripheral one,most of themfollowing the former even that the latter is always considered by the amputees amore natural way to handle the artificial limb. This research work is based on the use of intrafascicular electrodes directly implanted in the residual peripheral nerves of the stump which represents a good compromise choice in terms of invasiveness and selectivity extracting electroneurographic (ENG) signals from which it is possible to identify the significant activity of a quite limited number of neuronal cells. In the perspective of the hardware implementation of the resulting solution which can work autonomously without any intervention by the amputee in an adaptive way according to the current characteristics of the processed signal and by using batteries as power source allowing portability, it is necessary to fulfill the tight constraints imposed by the application under consideration involved in each of the various phases which compose the considered closed-loop system. Regarding to the recording phase, the implementation must be able to remove the unwanted interferences mainly due to the electro-stimulations of themuscles placed near the electrodes featured by an order of magnitude much greater in comparison to that of the signals of interest amplifying the frequency components belonging to the significant bandwidth, and to convert them with a high resolution in order to obtain good performance at the next processing phases. To this aim, a recording module for peripheral neural signals will be presented, based on the use of a sigma-delta architecture which is composed by two main parts: an analog front-end stage for neural signal acquisition, pre-filtering and sigma-delta modulation and a digital unit for sigma-delta decimation and system configuration. Hardware/software cosimulations exploiting the Xilinx System Generator tool in Matlab Simulink environment and then transistor-level simulations confirmed that the system is capable of recording neural signals in the order of magnitude of tens of μV rejecting the huge low-frequency noise due to electromyographic interferences. The same architecture has been then exploited to implement a prototype of an 8-channel implantable electronic bi-directional interface between the peripheral nervous system and the neuro-controlled hand prosthesis. The solution includes a custom designed Integrated Circuit (0.35μm CMOS technology), responsible of the signal pre-filtering and sigma-delta modulation for each channel and the neural stimuli generation (in the opposite path) based on the directives sent by a digital control systemmapped on a low-cost Xilinx FPGA Spartan-3E 1600 development board which also involves the multi-channel sigma-delta decimation with a high-order band-pass filter as first stage in order to totally remove the unwanted interferences. In this way, the analog chip can be implanted near the electrodes thanks to its limited size avoiding to add a huge noise to theweak neural signals due to longwires connections and to cause heat-related infections, shifting the complexity to the digital part which can be hosted on a separated device in the stump of the amputeewithout using complex laboratory instrumentations. The system has been successfully tested from the electrical point of view and with in-vivo experiments exposing good results in terms of output resolution and noise rejection even in case of critical conditions. The various output channels at the Nyquist sampling frequency coming from the acquisition system must be processed in order to decode the intentions of movements of the amputee, applying the correspondent electro-mechanical stimulation in input to the cybernetic hand in order to perform the desired motor action. Different decoding approaches have been presented in the past, the majority of them were conceived starting from the relative implementation and performance evaluation of their off-line version. At the end of the research, it is necessary to develop these solutions on embedded systems performing an online processing of the peripheral neural signals. However, it is often possible only by using complex hardware platforms clocked at very high operating frequencies which are not be compliant with the low-power requirements needed to allow portability for the prosthetic device. At present, in fact, the important aspect of the real-time implementation of sophisticated signal processing algorithms on embedded systems has been often overlooked, notwithstanding the impact that limited resources of the former may have on the efficiency/effectiveness of any given algorithm. In this research work it has been addressed the optimization of a state-of-the-art algorithmfor PNS signals decoding that is a step forward for its real-time, full implementation onto a floating-point Digital Signal Processor (DSP). Beyond low-level optimizations, different solutions have been proposed at an high level in order to find the best trade-off in terms of effectiveness/efficiency. A latency model, obtained through cycle accurate profiling of the different code sections, has been drawn in order to perform a fair performance assessment. The proposed optimized real-time algorithmachieves up to 96% of correct classification on real PNS signals acquired through tf-LIFE electrodes on animals, and performs as the best off-line algorithmfor spike clustering on a synthetic cortical dataset characterized by a reasonable dissimilarity between the spikemorphologies of different neurons. When the real-time requirements are joined to the fulfilment of area and power minimization for implantable/portable applications, such as for the target neuroprosthetic devices, only custom VLSI implementations can be adopted. In this case, every part of the algorithmshould be carefully tuned. To this aim, the first preprocessing stage of the decoding algorithmbased on the use of aWavelet Denoising solution able to remove also the in-band noise sources has been deeply analysed in order to obtain an optimal hardware implementation. In particular, the usually overlooked part related to threshold estimation has been evaluated in terms of required hardware resources and functionality, exploiting the commercial Xilinx System Generator tool for the design of the architecture and the co-simulation. The analysis has revealed how the widely used Median Absolute Deviation (MAD) could lead o hardware implementations highly inefficient compared to other dispersion estimators demonstrating better scalability, relatively to the specific application. Finally, two different hardware implementations of the reference decoding algorithm have been presented highlighting pros and cons of each one of them. Firstly, a novel approach based on high-level dataflow description and automatic hardware generation is presented and evaluated on the on-line template-matching spike sorting algorithmwhich represents the most complex processing stage. It starts from the identification of the single kernels with the greater computational complexity and using their dataflow description to generate the HDL implementation of a coarse-grained reconfigurable global kernel characterized by theminimumresources in order to reduce the area and the energy dissipation for the fulfilment of the low-power requirements imposed by the application. Results in the best case have revealed a 71%of area saving compared tomore traditional solutions,without any accuracy penalty. With respect to single kernels execution, better latency performance are achievable stillminimizing the number of adopted resources. The performance in terms of latency can also be improved by tuning the implemented parallelismin the light of a defined number of channels and real-time constraints, by using more than one reconfigurable global kernel in order that they can be exploited to perform the same or different kernels at the same time in a parallel way, due to the fact that each one can execute the relative processing only in a sequential way. For this reason, a second FPGA-based prototype has been proposed based on the use of aMulti-Processor System-on-Chip (MPSoC) embedded architecture. This prototype is capable of respecting the real-time constraints posed by the application when clocked at less than 50 MHz, in comparison to 300 MHz of the previous DSP implementation. Considering that the application workload is extremely data dependent and unpredictable due to the sparsity of the neural signals, the architecture has to be dimensioned taking into account critical worst-case operating conditions in order to always ensure the correct functionality. To compensate the resulting overprovisioning of the system architecture, a software-controllable power management based on the use of clock gating techniques has been integrated in order tominimize the dynamic power consumption of the resulting solution. Summarizing, this research work can be considered a sort of proof-of-concept for the proposed techniques considering all the design issues which characterize each stage of the closed-loop system in the perspective of a portable low-power real-time hardware implementation of the neuro-controlled prosthetic device

Contribution au domaine de la conception des Systèmes Embarqués et Pervasifs Faible Consommation

La première partie est consacré à l’Estimation de la Consommation des Architectures Logicel. Ce travail est en continuité de mes travaux de thèse et ont démarré avec le projet SPICES piloté par le Dr Eric Senn. Ce projet avait pour but, pour notre partie, de modéliser et d’estimer la consommation des services d’un système d’exploitation à haut niveau. Ces travaux ont fait l’objet de la thèse de Saadia Dhouib (2006-2009) co dirigée par Eric Senn et Jean Philippe Diguet.La seconde aborde le problème du placement des données en mémoire pour les architectures logiciel. L’idée de ces travaux était de permettre un placement optimum des structures de données d’une application dans une hiérarchie mémoire fixée. Ce travail a été le début de la collaboration avec Marc Sevaux et André Rossi sur ces aspects et ont été poursuivis dans la thèse réalisée par Maria Soto (2008-2011).La troisième présente les travaux autour de l’estimation et l’optimisation de la consommation des interconnexions dans les systèmes sur puce (SoC). Dans un système sur puce la consommation d’énergie générée par les interconnexions peut devenir non négligeable ; il devient donc indispensable de pouvoir optimiser cette consommation. Afin de pouvoir juger des optimisations proposées, un modèle d’estimation est nécessaire car le temps de conception et de simulation (au niveau électrique) est prohibitif. Ces travaux ont fait l’objet de la thèse d’Antoine Courtay (2005-2008) co dirigée par Olivier Sentieys et Nathalie Julien.Enfin la dernière aborde mes derniers travaux de recherche sur la conception de systèmes pervasifs pour le domaine maritime. Ces travaux aborde plusieurs sous thèmes comme: -la mesure de la performance pour la course au large ; travaux de thèse de Ronan Douguet (2010-2014)-l’utilisation de la réalité augmentée pour l’aide à la navigation ; travaux de thèse de Jean Christophe Morgère (2011-2015)-l’optimisation temps réel d’énergies renouvelables pour voilier du futur ; travaux de thèse de Mathilde Tréhin (2013- ?)-les algorithmes et plateforme faible consommation pour la conception d’un pilote automatique haute performance pour le nautisme ; travaux de thèse d’Hugo Kerhascoet (2014-2017

Design and Evaluation of a Hardware System for Online Signal Processing within Mobile Brain-Computer Interfaces

Brain-Computer Interfaces (BCIs) sind innovative Systeme, die eine direkte Kommunikation zwischen dem Gehirn und externen Geräten ermöglichen. Diese Schnittstellen haben sich zu einer transformativen Lösung nicht nur für Menschen mit neurologischen Verletzungen entwickelt, sondern auch für ein breiteres Spektrum von Menschen, das sowohl medizinische als auch nicht-medizinische Anwendungen umfasst. In der Vergangenheit hat die Herausforderung, dass neurologische Verletzungen nach einer anfänglichen Erholungsphase statisch bleiben, die Forscher dazu veranlasst, innovative Wege zu beschreiten. Seit den 1970er Jahren stehen BCIs an vorderster Front dieser Bemühungen. Mit den Fortschritten in der Forschung haben sich die BCI-Anwendungen erweitert und zeigen ein großes Potenzial für eine Vielzahl von Anwendungen, auch für weniger stark eingeschränkte (zum Beispiel im Kontext von Hörelektronik) sowie völlig gesunde Menschen (zum Beispiel in der Unterhaltungsindustrie). Die Zukunft der BCI-Forschung hängt jedoch auch von der Verfügbarkeit zuverlässiger BCI-Hardware ab, die den Einsatz in der realen Welt gewährleistet. Das im Rahmen dieser Arbeit konzipierte und implementierte CereBridge-System stellt einen bedeutenden Fortschritt in der Brain-Computer-Interface-Technologie dar, da es die gesamte Hardware zur Erfassung und Verarbeitung von EEG-Signalen in ein mobiles System integriert. Die Architektur der Verarbeitungshardware basiert auf einem FPGA mit einem ARM Cortex-M3 innerhalb eines heterogenen ICs, was Flexibilität und Effizienz bei der EEG-Signalverarbeitung gewährleistet. Der modulare Aufbau des Systems, bestehend aus drei einzelnen Boards, gewährleistet die Anpassbarkeit an unterschiedliche Anforderungen. Das komplette System wird an der Kopfhaut befestigt, kann autonom arbeiten, benötigt keine externe Interaktion und wiegt einschließlich der 16-Kanal-EEG-Sensoren nur ca. 56 g. Der Fokus liegt auf voller Mobilität. Das vorgeschlagene anpassbare Datenflusskonzept erleichtert die Untersuchung und nahtlose Integration von Algorithmen und erhöht die Flexibilität des Systems. Dies wird auch durch die Möglichkeit unterstrichen, verschiedene Algorithmen auf EEG-Daten anzuwenden, um unterschiedliche Anwendungsziele zu erreichen. High-Level Synthesis (HLS) wurde verwendet, um die Algorithmen auf das FPGA zu portieren, was den Algorithmenentwicklungsprozess beschleunigt und eine schnelle Implementierung von Algorithmusvarianten ermöglicht. Evaluierungen haben gezeigt, dass das CereBridge-System in der Lage ist, die gesamte Signalverarbeitungskette zu integrieren, die für verschiedene BCI-Anwendungen erforderlich ist. Darüber hinaus kann es mit einer Batterie von mehr als 31 Stunden Dauerbetrieb betrieben werden, was es zu einer praktikablen Lösung für mobile Langzeit-EEG-Aufzeichnungen und reale BCI-Studien macht. Im Vergleich zu bestehenden Forschungsplattformen bietet das CereBridge-System eine bisher unerreichte Leistungsfähigkeit und Ausstattung für ein mobiles BCI. Es erfüllt nicht nur die relevanten Anforderungen an ein mobiles BCI-System, sondern ebnet auch den Weg für eine schnelle Übertragung von Algorithmen aus dem Labor in reale Anwendungen. Im Wesentlichen liefert diese Arbeit einen umfassenden Entwurf für die Entwicklung und Implementierung eines hochmodernen mobilen EEG-basierten BCI-Systems und setzt damit einen neuen Standard für BCI-Hardware, die in der Praxis eingesetzt werden kann.Brain-Computer Interfaces (BCIs) are innovative systems that enable direct communication between the brain and external devices. These interfaces have emerged as a transformative solution not only for individuals with neurological injuries, but also for a broader range of individuals, encompassing both medical and non-medical applications. Historically, the challenge of neurological injury being static after an initial recovery phase has driven researchers to explore innovative avenues. Since the 1970s, BCIs have been at one forefront of these efforts. As research has progressed, BCI applications have expanded, showing potential in a wide range of applications, including those for less severely disabled (e.g. in the context of hearing aids) and completely healthy individuals (e.g. entertainment industry). However, the future of BCI research also depends on the availability of reliable BCI hardware to ensure real-world application. The CereBridge system designed and implemented in this work represents a significant leap forward in brain-computer interface technology by integrating all EEG signal acquisition and processing hardware into a mobile system. The processing hardware architecture is centered around an FPGA with an ARM Cortex-M3 within a heterogeneous IC, ensuring flexibility and efficiency in EEG signal processing. The modular design of the system, consisting of three individual boards, ensures adaptability to different requirements. With a focus on full mobility, the complete system is mounted on the scalp, can operate autonomously, requires no external interaction, and weighs approximately 56g, including 16 channel EEG sensors. The proposed customizable dataflow concept facilitates the exploration and seamless integration of algorithms, increasing the flexibility of the system. This is further underscored by the ability to apply different algorithms to recorded EEG data to meet different application goals. High-Level Synthesis (HLS) was used to port algorithms to the FPGA, accelerating the algorithm development process and facilitating rapid implementation of algorithm variants. Evaluations have shown that the CereBridge system is capable of integrating the complete signal processing chain required for various BCI applications. Furthermore, it can operate continuously for more than 31 hours with a 1800mAh battery, making it a viable solution for long-term mobile EEG recording and real-world BCI studies. Compared to existing research platforms, the CereBridge system offers unprecedented performance and features for a mobile BCI. It not only meets the relevant requirements for a mobile BCI system, but also paves the way for the rapid transition of algorithms from the laboratory to real-world applications. In essence, this work provides a comprehensive blueprint for the development and implementation of a state-of-the-art mobile EEG-based BCI system, setting a new benchmark in BCI hardware for real-world applicability