11,268 research outputs found
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
Multimodal Multipart Learning for Action Recognition in Depth Videos
The articulated and complex nature of human actions makes the task of action
recognition difficult. One approach to handle this complexity is dividing it to
the kinetics of body parts and analyzing the actions based on these partial
descriptors. We propose a joint sparse regression based learning method which
utilizes the structured sparsity to model each action as a combination of
multimodal features from a sparse set of body parts. To represent dynamics and
appearance of parts, we employ a heterogeneous set of depth and skeleton based
features. The proper structure of multimodal multipart features are formulated
into the learning framework via the proposed hierarchical mixed norm, to
regularize the structured features of each part and to apply sparsity between
them, in favor of a group feature selection. Our experimental results expose
the effectiveness of the proposed learning method in which it outperforms other
methods in all three tested datasets while saturating one of them by achieving
perfect accuracy
Learning Bodily and Temporal Attention in Protective Movement Behavior Detection
For people with chronic pain, the assessment of protective behavior during
physical functioning is essential to understand their subjective pain-related
experiences (e.g., fear and anxiety toward pain and injury) and how they deal
with such experiences (avoidance or reliance on specific body joints), with the
ultimate goal of guiding intervention. Advances in deep learning (DL) can
enable the development of such intervention. Using the EmoPain MoCap dataset,
we investigate how attention-based DL architectures can be used to improve the
detection of protective behavior by capturing the most informative temporal and
body configurational cues characterizing specific movements and the strategies
used to perform them. We propose an end-to-end deep learning architecture named
BodyAttentionNet (BANet). BANet is designed to learn temporal and bodily parts
that are more informative to the detection of protective behavior. The approach
addresses the variety of ways people execute a movement (including healthy
people) independently of the type of movement analyzed. Through extensive
comparison experiments with other state-of-the-art machine learning techniques
used with motion capture data, we show statistically significant improvements
achieved by using these attention mechanisms. In addition, the BANet
architecture requires a much lower number of parameters than the state of the
art for comparable if not higher performances.Comment: 7 pages, 3 figures, 2 tables, code available, accepted in ACII 201
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