Ergonomics of the Operative Field in Paediatric Minimal Access Surgery

Imperial Users onl

Robust visualization and discrimination of nanoparticles by interferometric imaging

Single-molecule and single-nanoparticle biosensors are a growing frontier in diagnostics. Digital biosensors are those which enumerate all specifically immobilized biomolecules or biological nanoparticles, and thereby achieve limits of detection usually beyond the reach of ensemble measurements. Here we review modern optical techniques for single nanoparticle detection and describe the single-particle interferometric reflectance imaging sensor (SP-IRIS). We present challenges associated with reliably detecting faint nanoparticles with SP-IRIS, and describe image acquisition processes and software modifications to address them. Specifically, we describe a image acquisition processing method for the discrimination and accurate counting of nanoparticles that greatly reduces both the number of false positives and false negatives. These engineering improvements are critical steps in the translation of SP-IRIS towards applications in medical diagnostics.R01 AI096159 - NIAID NIH HHSFirst author draf

DESIGN AND MICROFABRICATION OF EDGE-LIT OPTICAL LIGHT CURTAINS

Plastic optical light guides can be used for a variety of interior and exterior vehicle light curtains such as cabin illuminators and automotive tail lights. The edge-lit wave guide is an optically transparent substrate coupled with one or more energy efficient light emitting diodes (LEDs). The light rays from the source travel through the substrate based on the principle of total internal reflection. If a surface of the optical wave guide is patterned with optical microstructures then the light rays will scatter and refract throughout the medium, primarily exiting opposite to the patterned surface. Uniform illumination over this active surface region is a function of the individual optical microstructure\u27s shape and the spatial distribution of the microstructures. The goal of this research is to investigate the light dispersion characteristics in both smooth and micro-patterned optically transparent substrates, and utilize optical simulation software to develop viable design approaches for fabricating small and medium sized light curtains. The study first identifies an appropriate optical microstructure (i.e. cylindrical indentations) that can be reliably imprinted on the surface of an optically transparent polymethyl-methacrylate (PMMA) substrate using a multi-axis micromilling machine. The optical simulation software Light Tools is then used to determine the most appropriate microstructure radius and spatial positioning of elements for uniform light distribution. The key design and fabrication parameters for near optimal performance are summarized and used to establish the process plan for the high-speed precision micromilling operations. Experiments are performed on several 100 mm x 100 mm x 6 mm polymer light guide panels (LGPs) including a customized design with a hexagonal arrangement of microstructures. Both interior and boundary regions of the sample LGPs are investigated for intensity distribution, optical transmission efficiency, and light loss. Although the experiments involve relatively small flat PMMA LGPs, the optical design and microfabrication methods can be readily extended to larger surface areas or curved optically transparent polymer substrates for contoured light curtains

Direct illumination LED calibration for telescope photometry

Accepted by Nuclear Inst. and Methods in Physics Research, A NIMAA calibration method for telescope photometry, based on the direct illumination of a telescope with a calibrated light source regrouping multiple LEDs, is proposed. Its purpose is to calibrate the instrument response. The main emphasis of the proposed method is the traceability of the calibration process and a continuous monitoring of the instrument in order to maintain a 0.2% accuracy over a period of years. Its specificity is to map finely the response of the telescope and its camera as a function of all light ray parameters. This feature is essential to implement a computer model of the instrument representing the variation of the overall light collection efficiency of each pixel for various filter configurations. We report on hardware developments done for SNDICE, the first application of this direct illumination calibration system which will be installed in Canada France Hawaii telescope (CFHT) for its leading supernova experiment (SNLS)

Optically switched magnetism in photovoltaic perovskite CH3_3NH3_3(Mn:Pb)I3_3

The demand for ever-increasing density of information storage and speed of manipulation boosts an intense search for new magnetic materials and novel ways of controlling the magnetic bit. Here, we report the synthesis of a ferromagnetic photovoltaic CH$_3$NH$_3$(Mn:Pb)I$_3$ material in which the photo-excited electrons rapidly melt the local magnetic order through the Ruderman-Kittel-Kasuya-Yosida interactions without heating up the spin system. Our finding offers an alternative, very simple and efficient way of optical spin control, and opens an avenue for applications in low power, light controlling magnetic devices

Optical-to-optical interface device

An investigation was conducted to develop an optical-to-optical interface device capable of performing real-time incoherent-to-incoherent optical image conversion. The photoactivated liquid crystal light valve developed earlier represented a prototype liquid crystal light valve device capable of performing these functions. A device was developed which had high performance and extended lifetime

An Analysis of Optical Contributions to a Photo-Sensor's Ballistic Fingerprints

Lens aberrations have previously been used to determine the provenance of an image. However, this is not necessarily unique to an image sensor, as lens systems are often interchanged. Photo-response non-uniformity noise was proposed in 2005 by Luk\'a\v{s}, Goljan and Fridrich as a stochastic signal which describes a sensor uniquely, akin to a "ballistic" fingerprint. This method, however, did not account for additional sources of bias such as lens artefacts and temperature. In this paper, we propose a new additive signal model to account for artefacts previously thought to have been isolated from the ballistic fingerprint. Our proposed model separates sensor level artefacts from the lens optical system and thus accounts for lens aberrations previously thought to be filtered out. Specifically, we apply standard image processing theory, an understanding of frequency properties relating to the physics of light and temperature response of sensor dark current to classify artefacts. This model enables us to isolate and account for bias from the lens optical system and temperature within the current model.Comment: 16 pages, 9 figures, preprint for journal submission, paper is based on a thesis chapte

The design, construction and performance of the MICE scintillating fibre trackers

This is the Pre-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2011 ElsevierCharged-particle tracking in the international Muon Ionisation Cooling Experiment (MICE) will be performed using two solenoidal spectrometers, each instrumented with a tracking detector based on diameter scintillating fibres. The design and construction of the trackers is described along with the quality-assurance procedures, photon-detection system, readout electronics, reconstruction and simulation software and the data-acquisition system. Finally, the performance of the MICE tracker, determined using cosmic rays, is presented.This work was supported by the Science and Technology Facilities Council under grant numbers PP/E003214/1, PP/E000479/1, PP/E000509/1, PP/E000444/1, and through SLAs with STFC-supported laboratories. This work was also supportedby the Fermi National Accelerator Laboratory, which is operated by the Fermi Research Alliance, under contract No. DE-AC02-76CH03000 with the U.S. Department of Energy, and by the U.S. National Science Foundation under grants PHY-0301737,PHY-0521313, PHY-0758173 and PHY-0630052. The authors also acknowledge the support of the World Premier International Research Center Initiative (WPI Initiative), MEXT, Japan