E-infrastructures fostering multi-centre collaborative research into the intensive care management of patients with brain injury

Clinical research is becoming ever more collaborative with multi-centre trials now a common practice. With this in mind, never has it been more important to have secure access to data and, in so doing, tackle the challenges of inter-organisational data access and usage. This is especially the case for research conducted within the brain injury domain due to the complicated multi-trauma nature of the disease with its associated complex collation of time-series data of varying resolution and quality. It is now widely accepted that advances in treatment within this group of patients will only be delivered if the technical infrastructures underpinning the collection and validation of multi-centre research data for clinical trials is improved. In recognition of this need, IT-based multi-centre e-Infrastructures such as the Brain Monitoring with Information Technology group (BrainIT - www.brainit.org) and Cooperative Study on Brain Injury Depolarisations (COSBID - www.cosbid.de) have been formed. A serious impediment to the effective implementation of these networks is access to the know-how and experience needed to install, deploy and manage security-oriented middleware systems that provide secure access to distributed hospital based datasets and especially the linkage of these data sets across sites. The recently funded EU framework VII ICT project Advanced Arterial Hypotension Adverse Event prediction through a Novel Bayesian Neural Network (AVERT-IT) is focused upon tackling these challenges. This chapter describes the problems inherent to data collection within the brain injury medical domain, the current IT-based solutions designed to address these problems and how they perform in practice. We outline how the authors have collaborated towards developing Grid solutions to address the major technical issues. Towards this end we describe a prototype solution which ultimately formed the basis for the AVERT-IT project. We describe the design of the underlying Grid infrastructure for AVERT-IT and how it will be used to produce novel approaches to data collection, data validation and clinical trial design is also presented

Secure Large Scale Penetration of Electric Vehicles in the Power Grid

As part of the approaches used to meet climate goals set by international environmental agreements, policies are being applied worldwide for promoting the uptake of Electric Vehicles (EV)s. The resulting increase in EV sales and the accompanying expansion in the EV charging infrastructure carry along many challenges, mostly infrastructure-related. A pressing need arises to strengthen the power grid to handle and better manage the electricity demand by this mobile and geo-distributed load. Because the levels of penetration of EVs in the power grid have recently started increasing with the increase in EV sales, the real-time management of en-route EVs, before they connect to the grid, is quite recent and not many research works can be found in the literature covering this topic comprehensively. In this dissertation, advances and novel ideas are developed and presented, seizing the opportunities lying in this mobile load and addressing various challenges that arise in the application of public charging for EVs. A Bilateral Decision Support System (BDSS) is developed here for the management of en-route EVs. The BDSS is a middleware-based MAS that achieves a win-win situation for the EVs and the power grid. In this framework, the two are complementary in a way that the desired benefit of one cannot be achieved without attaining that of the other. A Fuzzy Logic based on-board module is developed for supporting the decision of the EV as to which charging station to charge at. GPU computing is used in the higher-end agents to handle the big amount of data resulting in such a large scale system with mobile and geo-distributed nodes. Cyber security risks that threaten the BDSS are assessed and measures are applied to revoke possible attacks. Furthermore, the Collective Distribution of Mobile Loads (CDML), a service with ancillary potential to the power system, is developed. It comprises a system-level optimization. In this service, the EVs requesting a public charging session are collectively redistributed onto charging stations with the objective of achieving the optimal and secure operation of the power system by reducing active power losses in normal conditions and mitigating line congestions in contingency conditions. The CDML uses the BDSS as an industrially viable tool to achieve the outcomes of the optimization in real time. By participating in this service, the EV is considered as an interacting node in the system-wide communication platform, providing both enhanced self-convenience in terms of access to public chargers, and contribution to the collective effort of providing benefit to the power system under the large scale uptake of EVs. On the EV charger level, several advantages have been reported favoring wireless charging of EVs over wired charging. Given that, new techniques are presented that facilitate the optimization of the magnetic link of wireless EV chargers while considering international EMC standards. The original techniques and developments presented in this dissertation were experimentally verified at the Energy Systems Research Laboratory at FIU

Automated tools and techniques for distributed Grid Software: Development of the testbed infrastructure

Grid technology is becoming more and more important as the new paradigm for sharing computational resources across different organizations in a secure way. The great powerfulness of this solution, requires the definition of a generic stack of services and protocols and this is the scope of the different Grid initiatives. As a result of international collaborations for its development, the Open Grid Forum created the Open Grid Services Architecture (OGSA) which aims to define the common set of services that will enable interoperability across the different implementations. This master thesis has been developed in this framework, as part of the two European-funded projects ETICS and OMII-Europe. The main objective is to contribute to the design and maintenance of large distributed development projects with the automated tool that enables to implement Software Engineering techniques oriented to achieve an acceptable level of quality at the release process. Specifically, this thesis develops the testbed concept as the virtual production-like scenario where to perform compliance tests. As proof of concept, the OGSA Basic Execution Service has been chosen in order to implement and execute conformance tests within the ETICS automated testbed framework