Multistage Packet-Switching Fabrics for Data Center Networks

Recent applications have imposed stringent requirements within the Data Center Network (DCN) switches in terms of scalability, throughput and latency. In this thesis, the architectural design of the packet-switches is tackled in different ways to enable the expansion in both the number of connected endpoints and traffic volume. A cost-effective Clos-network switch with partially buffered units is proposed and two packet scheduling algorithms are described. The first algorithm adopts many simple and distributed arbiters, while the second approach relies on a central arbiter to guarantee an ordered packet delivery. For an improved scalability, the Clos switch is build using a Network-on-Chip (NoC) fabric instead of the common crossbar units. The Clos-UDN architecture made with Input-Queued (IQ) Uni-Directional NoC modules (UDNs) simplifies the input line cards and obviates the need for the costly Virtual Output Queues (VOQs). It also avoids the need for complex, and synchronized scheduling processes, and offers speedup, load balancing, and good path diversity. Under skewed traffic, a reliable micro load-balancing contributes to boosting the overall network performance. Taking advantage of the NoC paradigm, a wrapped-around multistage switch with fully interconnected Central Modules (CMs) is proposed. The architecture operates with a congestion-aware routing algorithm that proactively distributes the traffic load across the switching modules, and enhances the switch performance under critical packet arrivals. The implementation of small on-chip buffers has been made perfectly feasible using the current technology. This motivated the implementation of a large switching architecture with an Output-Queued (OQ) NoC fabric. The design merges assets of the output queuing, and NoCs to provide high throughput, and smooth latency variations. An approximate analytical model of the switch performance is also proposed. To further exploit the potential of the NoC fabrics and their modularity features, a high capacity Clos switch with Multi-Directional NoC (MDN) modules is presented. The Clos-MDN switching architecture exhibits a more compact layout than the Clos-UDN switch. It scales better and faster in port count and traffic load. Results achieved in this thesis demonstrate the high performance, expandability and programmability features of the proposed packet-switches which makes them promising candidates for the next-generation data center networking infrastructure

Multistage Packet-Switching Fabrics for Data Center Networks

Recent applications have imposed stringent requirements within the Data Center Network (DCN) switches in terms of scalability, throughput and latency. In this thesis, the architectural design of the packet-switches is tackled in different ways to enable the expansion in both the number of connected endpoints and traffic volume. A cost-effective Clos-network switch with partially buffered units is proposed and two packet scheduling algorithms are described. The first algorithm adopts many simple and distributed arbiters, while the second approach relies on a central arbiter to guarantee an ordered packet delivery. For an improved scalability, the Clos switch is build using a Network-on-Chip (NoC) fabric instead of the common crossbar units. The Clos-UDN architecture made with Input-Queued (IQ) Uni-Directional NoC modules (UDNs) simplifies the input line cards and obviates the need for the costly Virtual Output Queues (VOQs). It also avoids the need for complex, and synchronized scheduling processes, and offers speedup, load balancing, and good path diversity. Under skewed traffic, a reliable micro load-balancing contributes to boosting the overall network performance. Taking advantage of the NoC paradigm, a wrapped-around multistage switch with fully interconnected Central Modules (CMs) is proposed. The architecture operates with a congestion-aware routing algorithm that proactively distributes the traffic load across the switching modules, and enhances the switch performance under critical packet arrivals. The implementation of small on-chip buffers has been made perfectly feasible using the current technology. This motivated the implementation of a large switching architecture with an Output-Queued (OQ) NoC fabric. The design merges assets of the output queuing, and NoCs to provide high throughput, and smooth latency variations. An approximate analytical model of the switch performance is also proposed. To further exploit the potential of the NoC fabrics and their modularity features, a high capacity Clos switch with Multi-Directional NoC (MDN) modules is presented. The Clos-MDN switching architecture exhibits a more compact layout than the Clos-UDN switch. It scales better and faster in port count and traffic load. Results achieved in this thesis demonstrate the high performance, expandability and programmability features of the proposed packet-switches which makes them promising candidates for the next-generation data center networking infrastructure

Automatic synthesis and optimization of chip multiprocessors

The microprocessor technology has experienced an enormous growth during the last decades. Rapid downscale of the CMOS technology has led to higher operating frequencies and performance densities, facing the fundamental issue of power dissipation. Chip Multiprocessors (CMPs) have become the latest paradigm to improve the power-performance efficiency of computing systems by exploiting the parallelism inherent in applications. Industrial and prototype implementations have already demonstrated the benefits achieved by CMPs with hundreds of cores.CMP architects are challenged to take many complex design decisions. Only a few of them are:- What should be the ratio between the core and cache areas on a chip?- Which core architectures to select?- How many cache levels should the memory subsystem have?- Which interconnect topologies provide efficient on-chip communication?These and many other aspects create a complex multidimensional space for architectural exploration. Design Automation tools become essential to make the architectural exploration feasible under the hard time-to-market constraints. The exploration methods have to be efficient and scalable to handle future generation on-chip architectures with hundreds or thousands of cores.Furthermore, once a CMP has been fabricated, the need for efficient deployment of the many-core processor arises. Intelligent techniques for task mapping and scheduling onto CMPs are necessary to guarantee the full usage of the benefits brought by the many-core technology. These techniques have to consider the peculiarities of the modern architectures, such as availability of enhanced power saving techniques and presence of complex memory hierarchies.This thesis has several objectives. The first objective is to elaborate the methods for efficient analytical modeling and architectural design space exploration of CMPs. The efficiency is achieved by using analytical models instead of simulation, and replacing the exhaustive exploration with an intelligent search strategy. Additionally, these methods incorporate high-level models for physical planning. The related contributions are described in Chapters 3, 4 and 5 of the document.The second objective of this work is to propose a scalable task mapping algorithm onto general-purpose CMPs with power management techniques, for efficient deployment of many-core systems. This contribution is explained in Chapter 6 of this document.Finally, the third objective of this thesis is to address the issues of the on-chip interconnect design and exploration, by developing a model for simultaneous topology customization and deadlock-free routing in Networks-on-Chip. The developed methodology can be applied to various classes of the on-chip systems, ranging from general-purpose chip multiprocessors to application-specific solutions. Chapter 7 describes the proposed model.The presented methods have been thoroughly tested experimentally and the results are described in this dissertation. At the end of the document several possible directions for the future research are proposed

Development and application of quantitative proteomics strategies to analyze molecular mechanisms of neurodegeneration

Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis or Prion diseases are chronic, incurable and often fatal. A cardinal feature of all neurodegenerative disorders is the accumulation of misfolded and aggregated proteins. Depending on the disease, these aggregated proteins are cell type specific and have distinct cellular localizations, compositions and structures. Despite intensive research, the contribution of protein misfolding and aggregation to the cell type specific toxicity is not completely understood. In recent years, quantitative proteomics has matured into an exceptionally powerful technology providing accurate quantitative information on almost all cellular proteins as well as protein interactions, modifications, and subcellular localizations, which cannot be addressed by other omics technologies. The aim of this thesis is to investigate key features of neurodegeneration such as misfolded proteins and toxic protein aggregates with cutting edge proteomics, presenting a technological “proof of concept” and novel insights into the (patho)physiology of neurodegeneration