Queuing Models of Tertiary Storage

Large scale scientific projects generate and use large amounts of data. For example, the NASA Earth Observation System Data and Information System (EOSDIS) project is expected to archive one petabyte per year of raw satellite data. This data is made automatically available for processing into higher level data products and for dissemination to the scientific community. Such large volumes of data can only be stored in robotic storage libraries (RSL's) for near-line access. A characteristic of RSL's is the use of a robot arm that transfers media between a storage rack and the read/write drives, thus multiplying the capacity of the system. The performance of the RSL's can be a critical limiting factor for the performance of the archive system. However, the many interacting components of an RSL make a performance analysis difficult. In addition, different RSL components can have widely varying performance characteristics. This paper describes our work to develop performance models of an RSL in isolation. Next we show how the RSL model can be incorporated into a queuing network model. We use the models to make some example performance studies of archive systems. The models described in this paper, developed for the NASA EODIS project, are implemented in C with a well defined interface. The source code, accompanying documentation, and also sample JAVA applets are available at: http://www.cis.ufl.edu/~ted

Toward a Standardized Strategy of Clinical Metabolomics for the Advancement of Precision Medicine

Despite the tremendous success, pitfalls have been observed in every step of a clinical metabolomics workflow, which impedes the internal validity of the study. Furthermore, the demand for logistics, instrumentations, and computational resources for metabolic phenotyping studies has far exceeded our expectations. In this conceptual review, we will cover inclusive barriers of a metabolomics-based clinical study and suggest potential solutions in the hope of enhancing study robustness, usability, and transferability. The importance of quality assurance and quality control procedures is discussed, followed by a practical rule containing five phases, including two additional "pre-pre-" and "post-post-" analytical steps. Besides, we will elucidate the potential involvement of machine learning and demonstrate that the need for automated data mining algorithms to improve the quality of future research is undeniable. Consequently, we propose a comprehensive metabolomics framework, along with an appropriate checklist refined from current guidelines and our previously published assessment, in the attempt to accurately translate achievements in metabolomics into clinical and epidemiological research. Furthermore, the integration of multifaceted multi-omics approaches with metabolomics as the pillar member is in urgent need. When combining with other social or nutritional factors, we can gather complete omics profiles for a particular disease. Our discussion reflects the current obstacles and potential solutions toward the progressing trend of utilizing metabolomics in clinical research to create the next-generation healthcare system.11Ysciescopu

Aerospace medicine and biology: A continuing bibliography with indexes (supplement 355)

This bibliography lists 147 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during October, 1991. Subject coverage includes: aerospace medicine and psychology, life support systems and controlled environments, safety equipment, exobiology and extraterrestrial life, and flight crew behavior and performance

NASA SBIR abstracts of 1991 phase 1 projects

The objectives of 301 projects placed under contract by the Small Business Innovation Research (SBIR) program of the National Aeronautics and Space Administration (NASA) are described. These projects were selected competitively from among proposals submitted to NASA in response to the 1991 SBIR Program Solicitation. The basic document consists of edited, non-proprietary abstracts of the winning proposals submitted by small businesses. The abstracts are presented under the 15 technical topics within which Phase 1 proposals were solicited. Each project was assigned a sequential identifying number from 001 to 301, in order of its appearance in the body of the report. Appendixes to provide additional information about the SBIR program and permit cross-reference of the 1991 Phase 1 projects by company name, location by state, principal investigator, NASA Field Center responsible for management of each project, and NASA contract number are included

Design Space Exploration in Cyber-Physical Systems

Cyber physical systems (CPS) integrate a variety of engineering areas such as control, mechanical and computer engineering in a holistic design effort. While interdependencies between the different disciplines are key attributes of CPS design science, little is known about the impact of design decisions of the cyber part on the overall system qualities. To investigate these interdependencies, this paper proposes a simulation-based Design Space Exploration (DSE) framework that considers detailed cyber system parameters such as cache size, bus width, and voltage levels in addition to physical and control parameters of the CPS. We propose an exploration algorithm that surfs the parameter configurations in the cyber physical sub-systems, in order to approximate the Pareto-optimal design points with regards to the trade-os among the design objectives, such as energy consumption and control stability. We apply the proposed framework to a network control system for an inverted-pendulum application. The presented holistic evaluation of the identified Pareto-points reveals the presence of non-trivial trade-os, which are imposed by the control, physical, and detailed cyber parameters. For instance the identified energy and control optimal design points comprise configurations with a wide range of CPU speeds, sample times and cache configuration following non-trivial zig-zag patterns. The proposed framework could identify and manage those trade-os and, as a result, is an imperative rst step to automate the search for superior CSP configurations