443 research outputs found

    Design of new algorithms for gene network reconstruction applied to in silico modeling of biomedical data

    Get PDF
    Programa de Doctorado en Biotecnología, Ingeniería y Tecnología QuímicaLínea de Investigación: Ingeniería, Ciencia de Datos y BioinformáticaClave Programa: DBICódigo Línea: 111The root causes of disease are still poorly understood. The success of current therapies is limited because persistent diseases are frequently treated based on their symptoms rather than the underlying cause of the disease. Therefore, biomedical research is experiencing a technology-driven shift to data-driven holistic approaches to better characterize the molecular mechanisms causing disease. Using omics data as an input, emerging disciplines like network biology attempt to model the relationships between biomolecules. To this effect, gene co- expression networks arise as a promising tool for deciphering the relationships between genes in large transcriptomic datasets. However, because of their low specificity and high false positive rate, they demonstrate a limited capacity to retrieve the disrupted mechanisms that lead to disease onset, progression, and maintenance. Within the context of statistical modeling, we dove deeper into the reconstruction of gene co-expression networks with the specific goal of discovering disease-specific features directly from expression data. Using ensemble techniques, which combine the results of various metrics, we were able to more precisely capture biologically significant relationships between genes. We were able to find de novo potential disease-specific features with the help of prior biological knowledge and the development of new network inference techniques. Through our different approaches, we analyzed large gene sets across multiple samples and used gene expression as a surrogate marker for the inherent biological processes, reconstructing robust gene co-expression networks that are simple to explore. By mining disease-specific gene co-expression networks we come up with a useful framework for identifying new omics-phenotype associations from conditional expression datasets.In this sense, understanding diseases from the perspective of biological network perturbations will improve personalized medicine, impacting rational biomarker discovery, patient stratification and drug design, and ultimately leading to more targeted therapies.Universidad Pablo de Olavide de Sevilla. Departamento de Deporte e Informátic

    Selection and sizing of the instrumentation in process industries

    Get PDF
    Abstract. Instrumentation engineering, that is selections and sizing of measuring and control instruments and methods, as well as the selection and design of their installation, is an important aspect of plant automation engineering. The aim of this master’s thesis was to produce a generally applicable, concise, and clear engineering guide for instrumentation that could be used in all industrial sectors. The research objectives were to explore factors influencing instrumentation, the selection and procurement process, as well as commonly used devices and methods and their properties. To achieve the objectives of the study, in addition to theoretical literature based research, and empirical research was conducted by interviewing professionals in the field. The selection of instrumentation is a sum of many factors, but by prioritizing these factors based on their flexibility and significance, the selection process can be rationalized. The selection and procurement process can be carried out either based on detailed process information in the final stages of design, or by establishing framework contracts with device suppliers in the early phases of the project, relying on preliminary design information and reference projects. Based on the results, it was concluded that instrumentation technology is continuously evolving but the associated literature stands the test of time. The physical phenomena behind the techniques remain the same. Research is not directly suitable for a project engineering guide, but it can be used as support for design work and as educational material.Instrumentoinnin valinta ja mitoitus prosessiteollisuudessa. Tiivistelmä. Instrumentointisuunnittelu, joka kattaa mittaus- ja säätöinstrumenttien valinnan ja mitoituksen, sekä niiden asennuksen valinnan ja suunnittelun, on tärkeä osa laitosautomaatiosuunnittelua. Tämän diplomityön tavoitteena oli tuottaa yleisesti soveltuva, tiivis ja selkeä suunnitteluohje instrumentointiin, jota voitaisiin käyttää kaikilla teollisuuden aloilla. Tutkimuksen tavoitteina oli selvittää instrumentointiin vaikuttavia tekijöitä, laitteiden valinta ja hankintaprosessia, sekä yleisesti käytettyjä laitteita ja menetelmiä, sekä niiden ominaisuuksia. Tutkimustavoitteiden saavuttamiseksi, teoreettisen kirjallisuuteen perustuvan tutkimuksen lisäksi toteutettiin empiirinen tutkimus haastattelemalla alan ammattilaisia. Instrumenttien valinta on monen tekijän summa, mutta priorisoimalla nämä tekijät niiden joustavuuden ja tärkeyden perusteella valintaprosessia voidaan järkeistää. Valinta- ja hankintaprosessi voidaan toteuttaa joko yksityiskohtaisten prosessitietojen perusteella suunnittelun loppuvaiheessa tai tekemällä raamisopimuksia laitetoimittajien kanssa projektin alkuvaiheessa esisuunnittelutietoihin ja referenssiprojekteihin perustuen. Tulosten perusteella voidaan päätellä instrumentointiteknologian kehittyvän jatkuvasti, mutta siihen liittyvän kirjallisuuden kestävän aikaa. Fysikaaliset ilmiöt, joihin tekniikat perustuvat, eivät muutu. Tämä tutkimus ei sovellu suoraan projektien suunnitteluohjeeksi, mutta sitä voidaan käyttää suunnittelutyön tukena ja opetusmateriaalin

    2018 GREAT Day Program

    Get PDF
    SUNY Geneseo’s Twelfth Annual GREAT Day.https://knightscholar.geneseo.edu/program-2007/1012/thumbnail.jp

    Changing Priorities. 3rd VIBRArch

    Full text link
    In order to warrant a good present and future for people around the planet and to safe the care of the planet itself, research in architecture has to release all its potential. Therefore, the aims of the 3rd Valencia International Biennial of Research in Architecture are: - To focus on the most relevant needs of humanity and the planet and what architectural research can do for solving them. - To assess the evolution of architectural research in traditionally matters of interest and the current state of these popular and widespread topics. - To deepen in the current state and findings of architectural research on subjects akin to post-capitalism and frequently related to equal opportunities and the universal right to personal development and happiness. - To showcase all kinds of research related to the new and holistic concept of sustainability and to climate emergency. - To place in the spotlight those ongoing works or available proposals developed by architectural researchers in order to combat the effects of the COVID-19 pandemic. - To underline the capacity of architectural research to develop resiliency and abilities to adapt itself to changing priorities. - To highlight architecture's multidisciplinarity as a melting pot of multiple approaches, points of view and expertise. - To open new perspectives for architectural research by promoting the development of multidisciplinary and inter-university networks and research groups. For all that, the 3rd Valencia International Biennial of Research in Architecture is open not only to architects, but also for any academic, practitioner, professional or student with a determination to develop research in architecture or neighboring fields.Cabrera Fausto, I. (2023). Changing Priorities. 3rd VIBRArch. Editorial Universitat Politècnica de València. https://doi.org/10.4995/VIBRArch2022.2022.1686

    Advanced Technologies for Biomass

    Get PDF
    The use of biomass and organic waste material as a primary resource for the production of fuels, chemicals, and electric power is of growing significance in light of the environmental issues associated with the use of fossil fuels. For this reason, it is vital that new and more efficient technologies for the conversion of biomass are investigated and developed. Today, various advanced methods can be used for the conversion of biomass. These methods are broadly classified into thermochemical conversion, biochemical conversion, and electrochemical conversion. This book collects papers that consider various aspects of sustainability in the conversion of biomass into valuable products, covering all the technical stages from biomass production to residue management. In particular, it focuses on experimental and simulation studies aiming to investigate new processes and technologies on the industrial, pilot, and bench scales

    Open reWall: Survey-to-production workflow for building renovation

    Get PDF
    A reabilitação de espaços interiores, num contexto de personalização em série, requer uma mudança na forma como os sistemas construtivos são desenhados, construídos e reutilizados. Recorrendo a plataformas digitais para a participação os arquitetos, em colaboração com outros atores na indústria AEC, podem desenvolver e oferecer soluções personalizadas e desmontáveis a utilizadores genéricos. Esta investigação propõe o uso de sistemas de construção personalizada em série (CPS) para fornecer sistemas de divisórias desmontáveis fabricadas digitalmente usando metodologias do levantamento à produção ligadas a configuradores online, em que os utilizadores co-projetam soluções para a reabilitação de espaços interiores. A metodologia de investigação socorre-se de pesquisa e análise teórica para definir critérios e objetivos a serem explorados em resolução de problemas de projeto. A partir destas experiências são sintetizados princípios e uma metodologia para a conceção de sistemas CPS de sistemas de divisórias personalizáveis e desmontáveis para a reabilitação. A metodologia clarifica os papeis dos atores, passos, e arquitetura do sistema para implementar um sistema CPS do levantamento à produção. A investigação demonstra que a metodologia de levantamento proposta é utilizável por utilizadores especialistas e não-especialistas, com os últimos a apresentarem em média melhores resultados, e que estes levantamentos têm precisão suficiente para processos do desenho à produção. Também se demonstra que a metodologia do levantamento à produção, a gramática genérica, e os critérios são úteis para os arquitetos conceberem sistemas de divisórias desmontáveis e personalizáveis para sistemas CPS abertos.Building renovation of interior spaces, in the context of mass customization, requires a shift in how construction systems are designed, built, and reused. Leveraging digital frameworks for user participation, architects in collaboration with other stakeholders in the AEC industry may design anddeliver customized and disassemble-able solutions to generic end-users. The research proposes mass customization construction (MCC) systems can deliver cost-effective digitally fabricated and disassemble-able construction systems using survey-to-production workflows deployed in web configurators for end-users to co-design solutions in building renovation. The research methodology uses theoretical inquiry and analysis to define criteria and objectives to be explored in design problem solving. From these experiments generalizable principles and a lowkey workflow for the design of MCC systems of customizable and disassemble-able partition wall construction systems for open building renovation are synthetized. The workflow clarifies stakeholder roles, steps, and system architecture to implement an MCC system from survey to production. This investigation demonstrates the proposed survey workflow is usable by non-expert and expert instance-designers, with the former having on-average better results, and that these can survey spaces with sufficient precision for design-to-production workflows. It is also shown the survey-to-production workflow, the generic grammar, and criteria are useful for architects to design customizable and disassemble-able partition wall systems for open MCC systems

    Joe Pawsey and the Founding of Australian Radio Astronomy

    Get PDF
    This open access book is a biography of Joseph L. Pawsey. It examines not only his life but the birth and growth of the field of radio astronomy and the state of science itself in twentieth century Australia. The book explains how an isolated continent with limited resources grew to be one of the leaders in the study of radio astronomy and the design of instruments to do so. Pawsey made a name for himself in the international astronomy community within a decade after WWII and coined the term radio astronomy. His most valuable talent was his ability to recruit and support bright young scientists who became the technical and methodological innovators of the era, building new telescopes from the Mills Cross and Chris (Christiansen) Cross to the Parkes radio telescope. The development of aperture synthesis and the controversy surrounding the cosmological interpretation of the first major survey which resulted in the Sydney research group's disagreements with Nobel laureate Martin Ryle play major roles in this story. This book also shows the connections among prominent astronomers like Oort, Minkowski, Baade, Struve, famous scientists in the UK such as J.A. Ratcliffe, Edward Appleton and Henry Tizard, and the engineers and physicists in Australia who helped develop the field of radio astronomy. Pawsey was appointed the second Director of the National Radio Astronomy Observatory (Green Bank, West Virginia) in October 1961; he died in Sydney at the age of 54 in late November 1962. Upper level students, scientists and historians will find the information, much of it from primary sources, relevant to any study of Joseph L. Pawsey or radio astronomy. This is an open access book

    'As an emerald is green'. Waiting, poetry and affliction: Simone Weil's concept of attention

    Get PDF
    This research thesis explores the concept of attention as outlined and practised in the life of Simone Weil (1909-1943), a French woman variously described as a philosopher, mystic and activist yet someone who eludes categorisation or systematisation. It outlines the background to her life in a France between two world wars, and seeks to situate her within the context of the Christianity she claimed as her cultural backdrop. It explores the concept of attention as both a spiritual exercise and a practice in the life of Weil, something that then evolved into a core principle of her thinking. The central question here is the age-old one, harking back to ancient philosophy, concerning the living of a good life, particularly within the context of a lifelong acquaintanceship with Weil‘s work. As this study examines Weil‘s ideas on reading, it also interrogates how she is read, particularly by poets today, with a view to assessing her influence. Weil was a writer who loved poetry and wrote some herself. Poetry and the recitation of prayers played an important role in her mystical experiences. The role of affliction in her mysticism and in her life is important and it will be seen how her stance in the face of affliction is something that marks her thinking. The concept of attention today incorporates issues around the commodification of the attention span, as well as its deficits. This study examines some of these issues and draws forth from the life and work of Simone Weil a more expanded, practical, and reflective understanding of the idea of attentio

    AI as a Material for Design

    Get PDF
    From Netflix recommendations to Amazon Echos sitting proudly on kitchen countertops, artificial intelligence (AI) has been inserted into the mundane settings of our everyday lives. These ‘smart’ devices and services have given rise to the collection of data and processing within everyday objects, accumulating new challenges, particularly in legibility, agency, and negotiability of interactions. The emerging field of Human Data Interaction (HDI) recognises that these challenges go on to influence security, privacy, and accessibility protocols, while also encompassing socio-technical implications. Furthermore, these objects challenge designers’ traditional conventions of neutral interactions, which only work as instructed. However, these smart objects go beyond typical human-object relationships functioning in new and unexpected ways, creeping in function, and existing within independent and interdependent assemblages of human and non-human actants—demanding alternative considerations and design practice. This thesis aims to question the traditional practice of considering and designing for AI technology by arguing for a post-anthropocentric perspective of things with agency, by adopting the philosophical approach of Object Orientated Ontology with design research. This research ultimately presents and builds (a currently) unorthodox design approach of Human-AI Kinship that contests the design orthodoxies of human-centred design. Conclusively, this research seeks to bring into being AI as a material for design and justify through the case study of AI legibility. A More than Human Centered Design approach is established through a transdisciplinary and iterative Research through Design methodology, resulting in the design of AI iconography that attempts to communicate and signify AI’s ontology to human users. This thesis is concluded by testing the legibility of the icons themselves and discussing philosophy as an asset for design research
    corecore