The compression chord capacity model for the shear design and assessment of reinforced and prestressed concrete beams

This is the accepted version of the following article: [Cladera, A., Marí, A., Bairán, J. M., Ribas, C., Oller, E. and Duarte, N. (2016), The compression chord capacity model for the shear design and assessment of reinforced and prestressed concrete beams. Structural Concrete, 17: 1017–1032. doi:10.1002/suco.201500214], which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/suco.201500214/fullA simplified mechanical model is presented for the shear strength prediction of reinforced and prestressed concrete members with and without transverse reinforcement, with I, T or rectangular cross-section. The model, derived with further simplifications from a previous one developed by the authors, incorporates the contributions of the concrete compression chord, the cracked web, the dowel action and the shear reinforcement in a compact formulation. The mechanical character of the model provides valuable information about the physics of the problem and incorporates the most relevant parameters governing the shear strength of structural concrete members. The predictions of the model fit very well the experimental results collected in the ACI-DAfStb databases of shear tests on slender reinforced and prestressed concrete beams with and without stirrups. Due to this fact and the simplicity of the derived equations it may become a very useful tool for structural design and assessment in engineering practice.Peer ReviewedPostprint (author's final draft

Chimpanzees demonstrate individual differences in social information use

Studies of transmission biases in social learning have greatly informed our understanding of how behaviour patterns may diffuse through animal populations, yet within-species inter-individual variation in social information use has received little attention and remains poorly understood. We have addressed this question by examining individual performances across multiple experiments with the same population of primates. We compiled a dataset spanning 16 social learning studies (26 experimental conditions) carried out at the same study site over a 12-year period, incorporating a total of 167 chimpanzees. We applied a binary scoring system to code each participant’s performance in each study according to whether they demonstrated evidence of using social information from conspecifics to solve the experimental task or not (Social Information Score—‘SIS’). Bayesian binomial mixed effects models were then used to estimate the extent to which individual differences influenced SIS, together with any effects of sex, rearing history, age, prior involvement in research and task type on SIS. An estimate of repeatability found that approximately half of the variance in SIS was accounted for by individual identity, indicating that individual differences play a critical role in the social learning behaviour of chimpanzees. According to the model that best fit the data, females were, depending on their rearing history, 15–24% more likely to use social information to solve experimental tasks than males. However, there was no strong evidence of an effect of age or research experience, and pedigree records indicated that SIS was not a strongly heritable trait. Our study offers a novel, transferable method for the study of individual differences in social learning

Optimización del diseño estructural de pavimentos asfálticos para calles y carreteras

gráficos, tablasThe construction of asphalt pavements in streets and highways is an activity that requires optimizing the consumption of significant economic and natural resources. Pavement design optimization meets contradictory objectives according to the availability of resources and users’ needs. This dissertation explores the application of metaheuristics to optimize the design of asphalt pavements using an incremental design based on the prediction of damage and vehicle operating costs (VOC). The costs are proportional to energy and resource consumption and polluting emissions. The evolution of asphalt pavement design and metaheuristic optimization techniques on this topic were reviewed. Four computer programs were developed: (1) UNLEA, a program for the structural analysis of multilayer systems. (2) PSO-UNLEA, a program that uses particle swarm optimization metaheuristic (PSO) for the backcalculation of pavement moduli. (3) UNPAVE, an incremental pavement design program based on the equations of the North American MEPDG and includes the computation of vehicle operating costs based on IRI. (4) PSO-PAVE, a PSO program to search for thicknesses that optimize the design considering construction and vehicle operating costs. The case studies show that the backcalculation and structural design of pavements can be optimized by PSO considering restrictions in the thickness and the selection of materials. Future developments should reduce the computational cost and calibrate the pavement performance and VOC models. (Texto tomado de la fuente)La construcción de pavimentos asfálticos en calles y carreteras es una actividad que requiere la optimización del consumo de cuantiosos recursos económicos y naturales. La optimización del diseño de pavimentos atiende objetivos contradictorios de acuerdo con la disponibilidad de recursos y las necesidades de los usuarios. Este trabajo explora el empleo de metaheurísticas para optimizar el diseño de pavimentos asfálticos empleando el diseño incremental basado en la predicción del deterioro y los costos de operación vehicular (COV). Los costos son proporcionales al consumo energético y de recursos y las emisiones contaminantes. Se revisó la evolución del diseño de pavimentos asfálticos y el desarrollo de técnicas metaheurísticas de optimización en este tema. Se desarrollaron cuatro programas de computador: (1) UNLEA, programa para el análisis estructural de sistemas multicapa. (2) PSO-UNLEA, programa que emplea la metaheurística de optimización con enjambre de partículas (PSO) para el cálculo inverso de módulos de pavimentos. (3) UNPAVE, programa de diseño incremental de pavimentos basado en las ecuaciones de la MEPDG norteamericana, y el cálculo de costos de construcción y operación vehicular basados en el IRI. (4) PSO-PAVE, programa que emplea la PSO en la búsqueda de espesores que permitan optimizar el diseño considerando los costos de construcción y de operación vehicular. Los estudios de caso muestran que el cálculo inverso y el diseño estructural de pavimentos pueden optimizarse mediante PSO considerando restricciones en los espesores y la selección de materiales. Los desarrollos futuros deben enfocarse en reducir el costo computacional y calibrar los modelos de deterioro y COV.DoctoradoDoctor en Ingeniería - Ingeniería AutomáticaDiseño incremental de pavimentosEléctrica, Electrónica, Automatización Y Telecomunicacione

The Expanding Landscape of Alternative Splicing Variation in Human Populations.

Alternative splicing is a tightly regulated biological process by which the number of gene products for any given gene can be greatly expanded. Genomic variants in splicing regulatory sequences can disrupt splicing and cause disease. Recent developments in sequencing technologies and computational biology have allowed researchers to investigate alternative splicing at an unprecedented scale and resolution. Population-scale transcriptome studies have revealed many naturally occurring genetic variants that modulate alternative splicing and consequently influence phenotypic variability and disease susceptibility in human populations. Innovations in experimental and computational tools such as massively parallel reporter assays and deep learning have enabled the rapid screening of genomic variants for their causal impacts on splicing. In this review, we describe technological advances that have greatly increased the speed and scale at which discoveries are made about the genetic variation of alternative splicing. We summarize major findings from population transcriptomic studies of alternative splicing and discuss the implications of these findings for human genetics and medicine