The importance of attribute interactions in conjoint choice design and modeling.

Within the context of choice experimental designs, most authors have proposed designs for the multinomial logit model under the assumption that only the main effects matter. Very little attention has been paid to designs for the attribute interaction models. In this paper, we present Bayesian D-optimal interaction-effects designs for the multinomial logit models and compare their predictive performances with those of main-effects designs. We show that in situations where a researcher is not sure whether or not the attribute interaction effects are present, incorporating interaction effects into both design stage and model estimation stage is most robust against misspecification of the underlying model for making precise predictions.Bayesian; Choice; Interaction effects; Experimental design; Predictions; Multinomial logit;

Bayesian D-Optimal Design of Experiments with Quantitative and Qualitative Responses

Systems with both quantitative and qualitative responses are widely encountered in many applications. Design of experiment methods are needed when experiments are conducted to study such systems. Classic experimental design methods are unsuitable here because they often focus on one type of response. In this paper, we develop a Bayesian D-optimal design method for experiments with one continuous and one binary response. Both noninformative and conjugate informative prior distributions on the unknown parameters are considered. The proposed design criterion has meaningful interpretations regarding the D-optimality for the models for both types of responses. An efficient point-exchange search algorithm is developed to construct the local D-optimal designs for given parameter values. Global D-optimal designs are obtained by accumulating the frequencies of the design points in local D-optimal designs, where the parameters are sampled from the prior distributions. The performances of the proposed methods are evaluated through two examples

D-optimal plans in observational studies

This paper investigates the use of Design of Experiments in observational studies in order to select informative observations and features for classification. D-optimal plans are searched for in existing data and based on these plans the variables most relevant for classification are determined. The adapted models are then compared with respect to their predictive accuracy on an independent test sample. Eight different data sets are investigated by this method. --D-optimality,Genetic Algorithm,Prototypes,Feature Selection

Optimal Design of Experiments for Functional Responses

abstract: Functional or dynamic responses are prevalent in experiments in the fields of engineering, medicine, and the sciences, but proposals for optimal designs are still sparse for this type of response. Experiments with dynamic responses result in multiple responses taken over a spectrum variable, so the design matrix for a dynamic response have more complicated structures. In the literature, the optimal design problem for some functional responses has been solved using genetic algorithm (GA) and approximate design methods. The goal of this dissertation is to develop fast computer algorithms for calculating exact D-optimal designs. First, we demonstrated how the traditional exchange methods could be improved to generate a computationally efficient algorithm for finding G-optimal designs. The proposed two-stage algorithm, which is called the cCEA, uses a clustering-based approach to restrict the set of possible candidates for PEA, and then improves the G-efficiency using CEA. The second major contribution of this dissertation is the development of fast algorithms for constructing D-optimal designs that determine the optimal sequence of stimuli in fMRI studies. The update formula for the determinant of the information matrix was improved by exploiting the sparseness of the information matrix, leading to faster computation times. The proposed algorithm outperforms genetic algorithm with respect to computational efficiency and D-efficiency. The third contribution is a study of optimal experimental designs for more general functional response models. First, the B-spline system is proposed to be used as the non-parametric smoother of response function and an algorithm is developed to determine D-optimal sampling points of a spectrum variable. Second, we proposed a two-step algorithm for finding the optimal design for both sampling points and experimental settings. In the first step, the matrix of experimental settings is held fixed while the algorithm optimizes the determinant of the information matrix for a mixed effects model to find the optimal sampling times. In the second step, the optimal sampling times obtained from the first step is held fixed while the algorithm iterates on the information matrix to find the optimal experimental settings. The designs constructed by this approach yield superior performance over other designs found in literature.Dissertation/ThesisDoctoral Dissertation Industrial Engineering 201