A cycling state that can lead to glassy dynamics in intracellular transport

Power-law dwell times have been observed for molecular motors in living cells, but the origins of these trapped states are not known. We introduce a minimal model of motors moving on a two-dimensional network of filaments, and simulations of its dynamics exhibit statistics comparable to those observed experimentally. Analysis of the model trajectories, as well as experimental particle tracking data, reveals a state in which motors cycle unproductively at junctions of three or more filaments. We formulate a master equation for these junction dynamics and show that the time required to escape from this vortex-like state can account for the power-law dwell times. We identify trends in the dynamics with the motor valency for further experimental validation. We demonstrate that these trends exist in individual trajectories of myosin II on an actin network. We discuss how cells could regulate intracellular transport and, in turn, biological function, by controlling their cytoskeletal network structures locally

Mass, Light and Colour of the Cosmic Web in the Supercluster SCL2243-0935 (z=0.447)

Context: In 2.2m MPG-ESO/WFI data we discovered several mass peaks through weak lensing, forming a possible supercluster at redshift 0.45. Through multi-colour wide-field imaging with CFHT/Megaprime and INT/WFC we identify early-type galaxies and trace the supercluster network with them. Through EMMI/NTT multi-object spectroscopy we verify the initial shear-selected cluster candidates. Using weak lensing we obtain mass estimates for the supercluster centre and the filaments. Results: We identified the centre of the SCL2243-0935 supercluster, MACS J2243-0935, which was found independently by Ebeling et al. (2010). 13 more clusters or overdensities are embedded in a filamentary network, half of them are already spectroscopically confirmed. Three (5-15) Mpc filaments are detected, and we estimate the global size of SCL2243 to 45x15x50 Mpc, making it one of the largest superclusters known at intermediate redshifts. Weak lensing yields r_200=(2.06+/-0.13) Mpc and M_200=(1.54+/-0.29)x10^15 M_sun for MACS J2243 with M/L=428+/-82, very similar to results from size-richness cluster scaling relations. Integrating the weak lensing surface mass density over the supercluster network (defined by increased i-band luminosity or g-i colours), we find (1.53+/-1.01)x10^15 M_sun and M/L=305+/-201 for the three main filaments, consistant with theoretical predictions. The filaments' projected surface mass density is 0.007-0.012, corresponding to 10-100 times the critical density. The greatly varying density of the cosmic web is also reflected in the mean colour of galaxies. Conclusions: SCL2243 is significantly larger and much more richly structured than other known superclusters such as A901/902 or MS0302 studied with weak lensing before. It is a text-book supercluster with little contamination along the line of sight, making it a perfect sandbox for testing new techniques probing the cosmic web.Comment: 26 pages, 16 figures, accepted for publication Astronomy and Astrophysics. Minor corrections implemented as requested by the refere