Special Session on Industry 4.0

No abstract available

Hybrid modeling and optimization of biological processes

Proß S. Hybrid modeling and optimization of biological processes. Bielefeld: Bielefeld University; 2013

EOOLT 2007 – Proceedings of the 1st International Workshop on Equation-Based Object-Oriented Languages and Tools

Computer aided modeling and simulation of complex systems, using components from multiple application domains, such as electrical, mechanical, hydraulic, control, etc., have in recent years witness0065d a significant growth of interest. In the last decade, novel equation-based object-oriented (EOO) modeling languages, (e.g. Mode- lica, gPROMS, and VHDL-AMS) based on acausal modeling using equations have appeared. Using such languages, it has become possible to model complex systems covering multiple application domains at a high level of abstraction through reusable model components. The interest in EOO languages and tools is rapidly growing in the industry because of their increasing importance in modeling, simulation, and specification of complex systems. There exist several different EOO language communities today that grew out of different application areas (multi-body system dynamics, electronic circuit simula- tion, chemical process engineering). The members of these disparate communities rarely talk to each other in spite of the similarities of their modeling and simulation needs. The EOOLT workshop series aims at bringing these different communities together to discuss their common needs and goals as well as the algorithms and tools that best support them. Despite the short deadlines and the fact that this is a new not very established workshop series, there was a good response to the call-for-papers. Thirteen papers and one presentation were accepted to the workshop program. All papers were subject to reviews by the program committee, and are present in these electronic proceedings. The workshop program started with a welcome and introduction to the area of equa- tion-based object-oriented languages, followed by paper presentations and discussion sessions after presentations of each set of related papers. On behalf of the program committee, the Program Chairmen would like to thank all those who submitted papers to EOOLT'2007. Special thanks go to David Broman who created the web page and helped with organization of the workshop. Many thanks to the program committee for reviewing the papers. EOOLT'2007 was hosted by the Technical University of Berlin, in conjunction with the ECOOP'2007 conference

New Software Tool for Modelling and Control of Discrete-Event and Hybrid Systems Using Petri Nets

The main aim of the proposed paper is to design a new software tool for modelling and control of discrete-event and hybrid systems using Arduino and similar microcontrollers. To accomplish these tasks a new tool called PN2ARDUINO based on Petri nets is proposed which is able to communicate with the microcontroller. Communication with the microcontroller is based on the modified Firmata protocol hence the control algorithm can be implemented on all microcontrollers that support this type of protocol. The developed software tool has been successfully verified in control of laboratory systems. It can also be used for education and research purposes as it offers a graphical environment for designing control algorithms for hybrid and mainly discrete-event systems. The proposed tool can improve education and practice in the field of cyber-physical systems (Industry 4.0)

Artificial intelligence and model checking methods for in silico clinical trials

Model-based approaches to safety and efficacy assessment of pharmacological treatments (In Silico Clinical Trials, ISCT) hold the promise to decrease time and cost for the needed experimentations, reduce the need for animal and human testing, and enable personalised medicine, where treatments tailored for each single patient can be designed before being actually administered. Research in Virtual Physiological Human (VPH) is harvesting such promise by developing quantitative mechanistic models of patient physiology and drugs. Depending on many parameters, such models define physiological differences among different individuals and different reactions to drug administrations. Value assignments to model parameters can be regarded as Virtual Patients (VPs). Thus, as in vivo clinical trials test relevant drugs against suitable candidate patients, ISCT simulate effect of relevant drugs against VPs covering possible behaviours that might occur in vivo. Having a population of VPs representative of the whole spectrum of human patient behaviours is a key enabler of ISCT. However, VPH models of practical relevance are typically too complex to be solved analytically or to be formally analysed. Thus, they are usually solved numerically within simulators. In this setting, Artificial Intelligence and Model Checking methods are typically devised. Indeed, a VP coupled together with a pharmacological treatment represents a closed-loop model where the VP plays the role of a physical subsystem and the treatment strategy plays the role of the control software. Systems with this structure are known as Cyber-Physical Systems (CPSs). Thus, simulation-based methodologies for CPSs can be employed within personalised medicine in order to compute representative VP populations and to conduct ISCT. In this thesis, we advance the state of the art of simulation-based Artificial Intelligence and Model Checking methods for ISCT in the following directions. First, we present a Statistical Model Checking (SMC) methodology based on hypothesis testing that, given a VPH model as input, computes a population of VPs which is representative (i.e., large enough to represent all relevant phenotypes, with a given degree of statistical confidence) and stratified (i.e., organised as a multi-layer hierarchy of homogeneous sub-groups). Stratification allows ISCT to adaptively focus on specific phenotypes, also supporting prioritisation of patient sub-groups in follow-up in vivo clinical trials. Second, resting on a representative VP population, we design an ISCT aiming at optimising a complex treatment for a patient digital twin, that is the virtual counterpart of that patient physiology defined by means of a set of VPs. Our ISCT employs an intelligent search driving a VPH model simulator to seek the lightest but still effective treatment for the input patient digital twin. Third, to enable interoperability among VPH models defined with different modelling and simulation environments and to increase efficiency of our ISCT, we also design an optimised simulator driver to speed-up backtracking-based search algorithms driving simulators. Finally, we evaluate the effectiveness of our presented methodologies on state-of-the-art use cases and validate our results on retrospective clinical data

Modeling and Control of the Ball and Beam Process

One of the most difficult problems that an engineer who works with modeling deals with, is the question about how to translate a physical phenomenon into a set of equations. It is usually difficult to capture all dynamics and phenomena, so one usually strives for a set of equations that describes the physical system approximately and adequately with the accuracy for the purpose. In our case, we model the dynamics relevant for control design. The topic of this thesis was to do an in-depth study of the Ball and Beam process. Two different experimental implementation of the Ball and Beam process have been considered, both available at the course lab at the Department of Automatic Control, Lund. The first step consisted of deriving the equations of motion, that is, to do the mathematical modeling of the process. In order to implement this model Modelica has been used. Modelica, which is a powerful language for modeling of physical systems, uses the tool Dymola. Another model was designed also with Modelica but with the help of the extension of the multi body library, which uses a methodology based on object orientation and symbolic manipulation of equations. With this last model it was possible to visualize an animation in real time 3D. The following step of the project was to do control design for the different models. The obtained simulations were shown in Dymola and Simulink. Finally experiments on the real process were developed, based on vision feedback

Special Session on Industry 4.0

No abstract available