Tensor Analysis and Fusion of Multimodal Brain Images

Current high-throughput data acquisition technologies probe dynamical systems with different imaging modalities, generating massive data sets at different spatial and temporal resolutions posing challenging problems in multimodal data fusion. A case in point is the attempt to parse out the brain structures and networks that underpin human cognitive processes by analysis of different neuroimaging modalities (functional MRI, EEG, NIRS etc.). We emphasize that the multimodal, multi-scale nature of neuroimaging data is well reflected by a multi-way (tensor) structure where the underlying processes can be summarized by a relatively small number of components or "atoms". We introduce Markov-Penrose diagrams - an integration of Bayesian DAG and tensor network notation in order to analyze these models. These diagrams not only clarify matrix and tensor EEG and fMRI time/frequency analysis and inverse problems, but also help understand multimodal fusion via Multiway Partial Least Squares and Coupled Matrix-Tensor Factorization. We show here, for the first time, that Granger causal analysis of brain networks is a tensor regression problem, thus allowing the atomic decomposition of brain networks. Analysis of EEG and fMRI recordings shows the potential of the methods and suggests their use in other scientific domains.Comment: 23 pages, 15 figures, submitted to Proceedings of the IEE

Spectral methods for multimodal data analysis

Spectral methods have proven themselves as an important and versatile tool in a wide range of problems in the fields of computer graphics, machine learning, pattern recognition, and computer vision, where many important problems boil down to constructing a Laplacian operator and finding a few of its eigenvalues and eigenfunctions. Classical examples include the computation of diffusion distances on manifolds in computer graphics, Laplacian eigenmaps, and spectral clustering in machine learning. In many cases, one has to deal with multiple data spaces simultaneously. For example, clustering multimedia data in machine learning applications involves various modalities or ``views'' (e.g., text and images), and finding correspondence between shapes in computer graphics problems is an operation performed between two or more modalities. In this thesis, we develop a generalization of spectral methods to deal with multiple data spaces and apply them to problems from the domains of computer graphics, machine learning, and image processing. Our main construction is based on simultaneous diagonalization of Laplacian operators. We present an efficient numerical technique for computing joint approximate eigenvectors of two or more Laplacians in challenging noisy scenarios, which also appears to be the first general non-smooth manifold optimization method. Finally, we use the relation between joint approximate diagonalizability and approximate commutativity of operators to define a structural similarity measure for images. We use this measure to perform structure-preserving color manipulations of a given image