The Observability Radius of Networks

This paper studies the observability radius of network systems, which measures the robustness of a network to perturbations of the edges. We consider linear networks, where the dynamics are described by a weighted adjacency matrix, and dedicated sensors are positioned at a subset of nodes. We allow for perturbations of certain edge weights, with the objective of preventing observability of some modes of the network dynamics. To comply with the network setting, our work considers perturbations with a desired sparsity structure, thus extending the classic literature on the observability radius of linear systems. The paper proposes two sets of results. First, we propose an optimization framework to determine a perturbation with smallest Frobenius norm that renders a desired mode unobservable from the existing sensor nodes. Second, we study the expected observability radius of networks with given structure and random edge weights. We provide fundamental robustness bounds dependent on the connectivity properties of the network and we analytically characterize optimal perturbations of line and star networks, showing that line networks are inherently more robust than star networks.Comment: 8 pages, 3 figure

Disrupted functional brain network organization in patients with obstructive sleep apnea.

IntroductionObstructive sleep apnea (OSA) subjects show impaired autonomic, affective, executive, sensorimotor, and cognitive functions. Brain injury in OSA subjects appears in multiple sites regulating these functions, but the integrity of functional networks within the regulatory sites remains unclear. Our aim was to examine the functional interactions and the complex network organization of these interactions across the whole brain in OSA, using regional functional connectivity (FC) and brain network topological properties.MethodsWe collected resting-state functional magnetic resonance imaging (MRI) data, using a 3.0-Tesla MRI scanner, from 69 newly diagnosed, treatment-naïve, moderate-to-severe OSA (age, 48.3 ± 9.2 years; body mass index, 31 ± 6.2 kg/m(2); apnea-hypopnea index (AHI), 35.6 ± 23.3 events/h) and 82 control subjects (47.6 ± 9.1 years; body mass index, 25.1 ± 3.5 kg/m(2)). Data were analyzed to examine FC in OSA over controls as interregional correlations and brain network topological properties.ResultsObstructive sleep apnea subjects showed significantly altered FC in the cerebellar, frontal, parietal, temporal, occipital, limbic, and basal ganglia regions (FDR, P < 0.05). Entire functional brain networks in OSA subjects showed significantly less efficient integration, and their regional topological properties of functional integration and specialization characteristics also showed declined trends in areas showing altered FC, an outcome which would interfere with brain network organization (P < 0.05; 10,000 permutations). Brain sites with abnormal topological properties in OSA showed significant relationships with AHI scores.ConclusionsOur findings suggest that the dysfunction extends to resting conditions, and the altered FC and impaired network organization may underlie the impaired responses in autonomic, cognitive, and sensorimotor functions. The outcomes likely result from the prominent structural changes in both axons and nuclear structures, which occur in the condition

Self-Healing Protocols for Connectivity Maintenance in Unstructured Overlays

In this paper, we discuss on the use of self-organizing protocols to improve the reliability of dynamic Peer-to-Peer (P2P) overlay networks. Two similar approaches are studied, which are based on local knowledge of the nodes' 2nd neighborhood. The first scheme is a simple protocol requiring interactions among nodes and their direct neighbors. The second scheme adds a check on the Edge Clustering Coefficient (ECC), a local measure that allows determining edges connecting different clusters in the network. The performed simulation assessment evaluates these protocols over uniform networks, clustered networks and scale-free networks. Different failure modes are considered. Results demonstrate the effectiveness of the proposal.Comment: The paper has been accepted to the journal Peer-to-Peer Networking and Applications. The final publication is available at Springer via http://dx.doi.org/10.1007/s12083-015-0384-

Cell death and life in cancer: mathematical modeling of cell fate decisions

Tumor development is characterized by a compromised balance between cell life and death decision mechanisms, which are tighly regulated in normal cells. Understanding this process provides insights for developing new treatments for fighting with cancer. We present a study of a mathematical model describing cellular choice between survival and two alternative cell death modalities: apoptosis and necrosis. The model is implemented in discrete modeling formalism and allows to predict probabilities of having a particular cellular phenotype in response to engagement of cell death receptors. Using an original parameter sensitivity analysis developed for discrete dynamic systems, we determine the critical parameters affecting cellular fate decision variables that appear to be critical in the cellular fate decision and discuss how they are exploited by existing cancer therapies

In the Shadow of a Willow Tree: A Community Garden Experiment in Decolonising, Multispecies Research

In 2014 I commenced a postdoctoral project that involved collaboratively planting and maintaining a community garden on a block of land that was once part of the East Armidale Aboriginal Reserve in the so-called New England Tableland region of New South Wales, Australia. At the edge of this block of land is an introduced, invasive willow tree. In this article I write with and alongside the willow tree to interrogate the potential and limitations of anticolonial projects undertaken from colonial subject positions predicated on relations of social and environmental privilege. Anticolonial scholarly activism demands a critique of individual and institutional complicity with ongoing colonial power structures. The following analysis offers a personal narrative of what it has been like to be involved in an anticolonial multispecies research project while working within the confines of the neoliberal university. Exploring the intersection of academic, social and environmental ecologies, I position the community garden as an alternative pedagogical and public environmental humanities research site that interrupts the reproduction of settler colonial power relations by cultivating tactics of collective resistance in alliance with the nonhuman world

Structure, mechanical properties and acoustic emissions of starch extrudates

Imperial Users onl

Incorporating Human Beliefs and Behaviors into Wildlife Ecology

Like much of the global biosphere, wildlife species have experienced rapid declines during the Anthropocene. Wildlife ecologists have responded to these crises by developing a range of technologies, techniques, and large datasets, which together have revolutionized the field, provided novel insights into the movements and behaviors of animals, and identified new risks and impacts to wildlife in a human-dominated world. While these advances have been vitally important, wildlife ecology has been slower to recognize and incorporate humans themselves into its new research domains. The chapters of this dissertation explore methods for better incorporating human behaviors, beliefs, actions, and infrastructure into the theories and approaches in wildlife ecology that have flourished in the last two decades. The research presented here demonstrates the importance of linking human beliefs and behaviors to wildlife ecology both by presenting novel findings and by showing the opportunities missed when narrow approaches are applied to complex socio-ecological problems.In Chapter 1, I provide a general introduction on the theories underlying this research, contextualize the research questions in light of the loss and recovery of large predators, and describe the research site where I collected much of the data for this dissertation. In Chapter 2, I apply the methods of movement ecology to some of the first fine-scale telemetry data collected on rifle hunters. I draw conclusions about their individual, site-level, and regional-level hunting behaviors and discuss the broad implications of these findings for hunting management. In Chapter 3, I examine livestock-predator conflict using approaches from both ecology and the social sciences. I describe a form of selection bias that is likely widespread but unreported due to the omission of social data from ecological models of conflict, and I offer guidelines for combining and translating ecological and social research on conflict. In Chapter 4, I explore the ecological impacts of one of the most globally widespread human constructions, the fence. I show for the first time the potential extent of fencing at large scales and discuss the wide variety of ecological effects of fences for both humans and ecosystems. I further highlight biases and gaps in fence research that have thus far limited a complete understanding of the environmental effects of these features. In Chapter 5, I conclude by making recommendations regarding how research might better incorporate human perceptions, decisions, and actions into ecology