Radio Communications

In the last decades the restless evolution of information and communication technologies (ICT) brought to a deep transformation of our habits. The growth of the Internet and the advances in hardware and software implementations modified our way to communicate and to share information. In this book, an overview of the major issues faced today by researchers in the field of radio communications is given through 35 high quality chapters written by specialists working in universities and research centers all over the world. Various aspects will be deeply discussed: channel modeling, beamforming, multiple antennas, cooperative networks, opportunistic scheduling, advanced admission control, handover management, systems performance assessment, routing issues in mobility conditions, localization, web security. Advanced techniques for the radio resource management will be discussed both in single and multiple radio technologies; either in infrastructure, mesh or ad hoc networks

Английский язык. "Reader"

УЧЕБНО-МЕТОДИЧЕСКИЕ ПОСОБИЯАНГЛИЙСКИЙ ЯЗЫКЧТЕНИЕПОСОБИЯПособие содержит текстовой материал по формированию различных навыков чтения (просмотрового, поискового, ознакомительного, изучающего). Пособие может быть использовано как для аудиторной, так и для самостоятельной работы студентов и магистрантов

Energy-efficient Communications in Cloud, Mobile Cloud and Fog Computing

This thesis studies the problem of energy efficiency of communications in distributed computing paradigms, including cloud computing, mobile cloud computing and fog/edge computing. Distributed computing paradigms have significantly changed the way of doing business. With cloud computing, companies and end users can access the vast majority services online through a virtualized environment in a pay-as-you-go basis. %Three are the main services typically consumed by cloud users are Infrastructure as a Service (IaaS), Platform as a Service (PaaS) and Software as a Service (SaaS). Mobile cloud and fog/edge computing are the natural extension of the cloud computing paradigm for mobile and Internet of Things (IoT) devices. Based on offloading, the process of outsourcing computing tasks from mobile devices to the cloud, mobile cloud and fog/edge computing paradigms have become popular techniques to augment the capabilities of the mobile devices and to reduce their battery drain. Being equipped with a number of sensors, the proliferation of mobile and IoT devices has given rise to a new cloud-based paradigm for collecting data, which is called mobile crowdsensing as for proper operation it requires a large number of participants. A plethora of communication technologies is applicable to distributing computing paradigms. For example, cloud data centers typically implement wired technologies while mobile cloud and fog/edge environments exploit wireless technologies such as 3G/4G, WiFi and Bluetooth. Communication technologies directly impact the performance and the energy drain of the system. This Ph.D. thesis analyzes from a global perspective the efficiency in using energy of communications systems in distributed computing paradigms. In particular, the following contributions are proposed: - A new framework of performance metrics for communication systems of cloud computing data centers. The proposed framework allows a fine-grain analysis and comparison of communication systems, processes, and protocols, defining their influence on the performance of cloud applications. - A novel model for the problem of computation offloading, which describes the workflow of mobile applications through a new Directed Acyclic Graph (DAG) technique. This methodology is suitable for IoT devices working in fog computing environments and was used to design an Android application, called TreeGlass, which performs recognition of trees using Google Glass. TreeGlass is evaluated experimentally in different offloading scenarios by measuring battery drain and time of execution as key performance indicators. - In mobile crowdsensing systems, novel performance metrics and a new framework for data acquisition, which exploits a new policy for user recruitment. Performance of the framework are validated through CrowdSenSim, which is a new simulator designed for mobile crowdsensing activities in large scale urban scenarios

Preclinincal development of Avaren-Fc: a novel lectin-Fc fusion protein targeting cancer-associated high-mannose glycans.

This dissertation explores the anticancer activity of Avaren-Fc (AvFc), a novel lectin-Fc fusion protein or “lectibody” targeting cancer and virus-associated high-mannose glycans. Previously, we have shown that AvFc recognizes a broad selection of established cancer cell lines from a wide array of tissue types, can potently induce antibody-dependent cell-mediated cytotoxicity (ADCC) against them, and exhibits anti-cancer activity in vivo. However, the exact mechanism of action remains elusive. We hypothesized that the primary mechanism of action is through Fc-mediated effector functions, and the purpose of this dissertation is to explore this question through the use of Fc variants that either increase or decrease ADCC activity relative to the WT molecule using the B16F10 murine melanoma model. Chapters 1 and 2 give a comprehensive overview of glycosylation and its role in cancer and disease, the molecule AvFc, the mechanism of action of the various Fc-mediated effector functions, and the current status of plant-made cancer biologics. Chapter 4 discusses the efficacy of AvFc in a human liver chimeric mouse model of HCV infection, which helped not only to establish AvFc’s activity in vivo but also demonstrated its safety and feasibility as a drug candidate. The bulk of the data obtained regarding the anticancer activity of AvFc are contained in Chapter 5, which establishes that Fc-mediated functions are the primary mechanisms of action and that AvFc administration is associated with the recruitment of FcγR-bearing cells to the tumor microenvironment. Interestingly, these studies also indicated that the presence of pre-existing immunity in the presence of anti-drug antibodies to AvFc did not obviate its activity in vivo. Further exploration of the anticancer activity of AvFc is detailed in Chapter 6, which discusses the use of AvFc as a therapeutic for ovarian cancer (OVCA) and details its in vitro and in vivo activities. The results presented herein provide evidence to suggest that cancer-associated high-mannose glycans may be a viable pharmacological target and that AvFc is a unique and potent first-in-class agent with significant anticancer capabilities through recognition of this glycobiomarker, warranting its further development as a therapeutic against cancers with limited therapeutic options such as OVCA

Telecommunications Networks

This book guides readers through the basics of rapidly emerging networks to more advanced concepts and future expectations of Telecommunications Networks. It identifies and examines the most pressing research issues in Telecommunications and it contains chapters written by leading researchers, academics and industry professionals. Telecommunications Networks - Current Status and Future Trends covers surveys of recent publications that investigate key areas of interest such as: IMS, eTOM, 3G/4G, optimization problems, modeling, simulation, quality of service, etc. This book, that is suitable for both PhD and master students, is organized into six sections: New Generation Networks, Quality of Services, Sensor Networks, Telecommunications, Traffic Engineering and Routing