7,041 research outputs found

    Algorithms for within-cluster searches using inverted files

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    Information retrieval over clustered document collections has two successive stages: first identifying the best-clusters and then the best-documents in these clusters that are most similar to the user query. In this paper, we assume that an inverted file over the entire document collection is used for the latter stage. We propose and evaluate algorithms for within-cluster searches, i.e., to integrate the best-clusters with the best-documents to obtain the final output including the highest ranked documents only from the best-clusters. Our experiments on a TREC collection including 210,158 documents with several query sets show that an appropriately selected integration algorithm based on the query length and system resources can significantly improve the query evaluation efficiency. © Springer-Verlag Berlin Heidelberg 2006

    The NASA Astrophysics Data System: Architecture

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    The powerful discovery capabilities available in the ADS bibliographic services are possible thanks to the design of a flexible search and retrieval system based on a relational database model. Bibliographic records are stored as a corpus of structured documents containing fielded data and metadata, while discipline-specific knowledge is segregated in a set of files independent of the bibliographic data itself. The creation and management of links to both internal and external resources associated with each bibliography in the database is made possible by representing them as a set of document properties and their attributes. To improve global access to the ADS data holdings, a number of mirror sites have been created by cloning the database contents and software on a variety of hardware and software platforms. The procedures used to create and manage the database and its mirrors have been written as a set of scripts that can be run in either an interactive or unsupervised fashion. The ADS can be accessed at http://adswww.harvard.eduComment: 25 pages, 8 figures, 3 table

    Scalable Similarity Search for Molecular Descriptors

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    Similarity search over chemical compound databases is a fundamental task in the discovery and design of novel drug-like molecules. Such databases often encode molecules as non-negative integer vectors, called molecular descriptors, which represent rich information on various molecular properties. While there exist efficient indexing structures for searching databases of binary vectors, solutions for more general integer vectors are in their infancy. In this paper we present a time- and space- efficient index for the problem that we call the succinct intervals-splitting tree algorithm for molecular descriptors (SITAd). Our approach extends efficient methods for binary-vector databases, and uses ideas from succinct data structures. Our experiments, on a large database of over 40 million compounds, show SITAd significantly outperforms alternative approaches in practice.Comment: To be appeared in the Proceedings of SISAP'1

    Discovery of large genomic inversions using long range information.

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    BackgroundAlthough many algorithms are now available that aim to characterize different classes of structural variation, discovery of balanced rearrangements such as inversions remains an open problem. This is mainly due to the fact that breakpoints of such events typically lie within segmental duplications or common repeats, which reduces the mappability of short reads. The algorithms developed within the 1000 Genomes Project to identify inversions are limited to relatively short inversions, and there are currently no available algorithms to discover large inversions using high throughput sequencing technologies.ResultsHere we propose a novel algorithm, VALOR, to discover large inversions using new sequencing methods that provide long range information such as 10X Genomics linked-read sequencing, pooled clone sequencing, or other similar technologies that we commonly refer to as long range sequencing. We demonstrate the utility of VALOR using both pooled clone sequencing and 10X Genomics linked-read sequencing generated from the genome of an individual from the HapMap project (NA12878). We also provide a comprehensive comparison of VALOR against several state-of-the-art structural variation discovery algorithms that use whole genome shotgun sequencing data.ConclusionsIn this paper, we show that VALOR is able to accurately discover all previously identified and experimentally validated large inversions in the same genome with a low false discovery rate. Using VALOR, we also predicted a novel inversion, which we validated using fluorescent in situ hybridization. VALOR is available at https://github.com/BilkentCompGen/VALOR

    Info Navigator: A visualization tool for document searching and browsing

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    In this paper we investigate the retrieval performance of monophonic and polyphonic queries made on a polyphonic music database. We extend the n-gram approach for full-music indexing of monophonic music data to polyphonic music using both rhythm and pitch information. We define an experimental framework for a comparative and fault-tolerance study of various n-gramming strategies and encoding levels. For monophonic queries, we focus in particular on query-by-humming systems, and for polyphonic queries on query-by-example. Error models addressed in several studies are surveyed for the fault-tolerance study. Our experiments show that different n-gramming strategies and encoding precision differ widely in their effectiveness. We present the results of our study on a collection of 6366 polyphonic MIDI-encoded music pieces
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