Design of a Simulator for Neonatal Multichannel EEG: Application to Time-Frequency Approaches for Automatic Artifact Removal and Seizure Detection

The electroencephalogram (EEG) is used to noninvasively monitor brain activities; it is the most utilized tool to detect abnormalities such as seizures. In recent studies, detection of neonatal EEG seizures has been automated to assist neurophysiologists in diagnosing EEG as manual detection is time consuming and subjective; however it still lacks the necessary robustness that is required for clinical implementation. Moreover, as EEG is intended to record the cerebral activities, extra-cerebral activities external to the brain are also recorded; these are called “artifacts” and can seriously degrade the accuracy of seizure detection. Seizures are one of the most common neurologic problems managed by hospitals occurring in 0.1%-0.5% livebirths. Neonates with seizures are at higher risk for mortality and are reported to be 55-70 times more likely to have severe cerebral-palsy. Therefore, early and accurate detection of neonatal seizures is important to prevent long-term neurological damage. Several attempts in modelling the neonatal EEG and artifacts have been done, but most did not consider the multichannel case. Furthermore, these models were used to test artifact or seizure detection separately, but not together. This study aims to design synthetic models that generate clean or corrupted multichannel EEG to test the accuracy of available artifact and seizure detection algorithms in a controlled environment. In this thesis, synthetic neonatal EEG model is constructed by using; single-channel EEG simulators, head model, 21-electrodes, and propagation equations, to produce clean multichannel EEG. Furthermore, neonatal EEG artifact model is designed using synthetic signals to corrupt EEG waveforms. After that, an automated EEG artifact detection and removal system is designed in both time and time-frequency domains. Artifact detection is optimised and removal performance is evaluated. Finally, an automated seizure detection technique is developed, utilising fused and extended multichannel features along a cross-validated SVM classifier. Results show that the synthetic EEG model mimics real neonatal EEG with 0.62 average correlation, and corrupted-EEG can degrade seizure detection average accuracy from 100% to 70.9%. They also show that using artifact detection and removal enhances the average accuracy to 89.6%, and utilising the extended features enhances it to 97.4% and strengthened its robustness.لمراقبة ورصد أنشطة واشارات المخ، دون الحاجة لأي عملیات (EEG) یستخدم الرسم أو التخطیط الكھربائي للدماغ للدماغجراحیة، وھي تعد الأداة الأكثر استخداما في الكشف عن أي شذوذأو نوبات غیر طبیعیة مثل نوبات الصرع. وقد أظھرت دراسات حدیثة، أن الكشف الآلي لنوبات حدیثي الولادة، ساعد علماء الفسیولوجیا العصبیة في تشخیص الاشارات الدماغیة بشكل أكبر من الكشف الیدوي، حیث أن الكشف الیدوي یحتاج إلى وقت وجھد أكبر وھوذو فعالیة أقل بكثیر، إلا أنھ لا یزال یفتقر إلى المتانة الضروریة والمطلوبة للتطبیق السریري.علاوة على ذلك؛ فكما یقوم الرسم الكھربائي بتسجیل الأنشطة والإشارات الدماغیة الداخلیة، فھو یسجل أیضا أي نشاط أو اشارات خارجیة، مما یؤدي إلى -(artifacts) :حدوث خلل في مدى دقة وفعالیة الكشف عن النوبات الدماغیة الداخلیة، ویطلق على تلك الاشارات مسمى (نتاج صنعي) . 0.5٪ولادة حدیثة في -٪تعد نوبات الصرع من أكثر المشكلات العصبیة انتشارا،ً وھي تصیب ما یقارب 0.1المستشفیات. حیث أن حدیثي الولادة المصابین بنوبات الصرع ھم أكثر عرضة للوفاة، وكما تشیر التقاریر الى أنھم 70مرة أكثر. لذا یعد الكشف المبكر والدقیق للنوبات الدماغیة -معرضین للإصابة بالشلل الدماغي الشدید بما یقارب 55لحدیثي الولادة مھم جدا لمنع الضرر العصبي على المدى الطویل. لقد تم القیام بالعدید من المحاولات التي كانتتھدف الى تصمیم نموذج التخطیط الكھربائي والنتاج الصنعي لدماغ حدیثي الولادة, إلا أن معظمھا لم یعر أي اھتمام الى قضیة تعدد القنوات. إضافة الى ذلك, استخدمت ھذه النماذج , كل على حدة, أو نوبات الصرع. تھدف ھذه الدراسة الى تصمیم نماذج مصطنعة من شأنھا (artifact) لإختبار كاشفات النتاج الصنعيأن تولد اشارات دماغیة متعددة القنوات سلیمة أو معطلة وذلك لفحص مدى دقة فعالیة خوارزمیات الكشف عن نوبات ضمن بیئة یمكن السیطرة علیھا. (artifact) الصرع و النتاج الصنعي في ھذه الأطروحة, یتكون نموذج الرسم الكھربائي المصطنع لحدیثي الولادة من : قناة محاكاة واحده للرسم الكھربائي, نموذج رأس, 21قطب كھربائي و معادلات إنتشار. حیث تھدف جمیعھا لإنتاج إشاراة سلیمة متعدده القنوات للتخطیط عن طریق استخدام اشارات مصطنعة (artifact) الكھربائي للدماغ.علاوة على ذلك, لقد تم تصمیم نموذجالنتاج الصنعيفي نطاقالوقت و (artifact) لإتلاف الرسم الكھربائي للدماغ. بعد ذلك تم انشاء برنامج لكشف و إزالةالنتاج الصناعينطاقالوقت و التردد المشترك. تم تحسین برنامج الكشف النتاج الصناعيالى ابعد ما یمكن بینما تمت عملیة تقییم أداء الإزالة. وفي الختام تم التمكن من تطویر تقنیة الكشف الآلي عن نوبات الصرع, وذلك بتوظیف صفات مدمجة و صفات الذي تم التأكد من صحتھ. (SVM) جدیدة للقنوات المتعددة لإستخدامھا للمصنفلقد أظھرت النتائج أن نموذج الرسم الكھربائي المصطنع لحدیثي الولادة یحاكي الرسمالكھربائي الحقیقي لحدیثي الولادة بمتوسط ترابط 0.62, و أنالرسم الكھربائي المتضرر للدماغ قد یؤدي الى حدوث ھبوطفي مدى دقة متوسط الكشف عن نوبات الصرع من 100%الى 70.9%. وقد أشارت أیضا الى أن استخدام الكشف والإزالة عن النتاج الصنعي (artifact) یؤدي الى تحسن مستوى الدقة الى نسبة 89.6 %, وأن توظیف الصفات الجدیدة للقنوات المتعددة یزید من تحسنھا لتصل الى نسبة 94.4 % مما یعمل على دعم متانتھا

Rotational Features Extraction for Ridge Detection

State-of-the-art approaches to detecting ridge-like structures in images rely on filters designed to respond to locally linear intensity features. While these approaches may be optimal for ridges whose appearance is close to being ideal, their performance degrades quickly in the presence of structured noise that corrupts the image signal, potentially to the point where it truly does not conform to the ideal model anymore. In this paper, we address this issue by introducing a learning framework that relies on rich, local, rotationally invariant image descriptors and demonstrate that we can outperform state-of-the-art ridge detectors in many different kinds of imagery. More specifically, our framework yields superior performance for the detection of blood vessel in retinal scans, dendrites in bright-field and confocal microscopy image-stacks, and streets in satellite imagery

Robust Physical Layer Security for Power Domain Non-Orthogonal Multiple Access-Based HetNets and HUDNs: SIC Avoidance at Eavesdroppers

In this paper, we investigate the physical layer security in downlink of Power Domain Non-Orthogonal Multiple Access (PD-NOMA)-based heterogeneous cellular network (HetNet). In this paper, we assume two categories of users are available: 1) Trusted users and 2) untrusted users (eavesdroppers) at which transparency of users is not clear for the BSs, i.e., they are potential eavesdroppers. Our aim is to maximize the sum secrecy rate of the network. To this end, we formulate joint subcarrier and power allocation optimization problems to increase sum secrecy rate. Moreover, we propose a novel scheme at which the eavesdroppers are prevented from doing Successive Interference Cancellation (SIC), while legitimate users are able to do it. In practical systems, perfectly availability of all eavesdroppers' Channel State Information (CSI) at legitimate transmitters are impractical. Also CSIs of legitimate users may be also imperfect due to the error of channel estimation. Hence, we study two cases of CSI availability: 1) Perfect CSI of nodes (legitimate users and eavesdroppers) are available at the BSs and 2) imperfect CSI of nodes are available at the BSs. Since the proposed optimization problems are non-convex, we adopt the well-known iterative algorithm called Alternative Search Method (ASM). In this algorithm, the optimization problems are converted to two subproblems, power allocation and subcarrier allocation. We solve the power allocation problem by the Successive Convex Approximation approach and solve the subcarrier allocation subproblem, by exploiting the Mesh Adaptive Direct Search algorithm (MADS). Moreover, in order to study the optimality gap of the proposed solution method, we apply the monotonic optimization method. Moreover, we evaluate the proposed scheme for secure massive connectivity in Heterogeneous Ultra Dense Networks (HUDNs). Furthermore, we investigate multiple antennas base stations scenario in this literature. Finally, we numerically compare the proposed scheme with the conventional case at which the eavesdroppers are able to apply SIC. Numerical results highlight that the proposed scheme significantly improves the sum secrecy rate compared with the conventional case

Caracterização e estudo comparativo de exsudações de hidrocarbonetos e plays petrolíferos em bacias terrestres das regiões central do Irã e sudeste do Brasil usando sensoriamento remoto espectral

Orientador: Carlos Roberto de Souza FilhoTese (doutorado) - Universidade Estadual de Campinas, Instituto de GeociênciasResumo: O objetivo desta pesquisa foi explorar as assinaturas de exsudações de hidrocarbonetos na superfície usando a tecnologia de detecção remota espectral. Isso foi alcançado primeiro, realizando uma revisão abrangente das capacidades e potenciais técnicas de detecção direta e indireta. Em seguida, a técnica foi aplicada para investigar dois locais de teste localizados no Irã e no Brasil, conhecidos por hospedar sistemas ativos de micro-exsudações e afloramentos betuminosos, respectivamente. A primeira área de estudo está localizada perto da cidade de Qom (Irã), e está inserida no campo petrolífero Alborz, enterrado sob sedimentos datados do Oligoceno da Formação Upper Red. O segundo local está localizado perto da cidade de Anhembi (SP), na margem oriental da bacia do Paraná, no Brasil, e inclui acumulações de betume em arenitos triássicos da Formação Pirambóia. O trabalho na área de Qom integrou evidências de (i) estudos petrográficos e geoquímicos em laboratório, (ii) investigações de afloramentos em campo, e (iii) mapeamento de anomalia em larga escala através de conjuntos de dados multi-espectrais ASTER e Sentinel-2. O resultado deste estudo se trata de novos indicadores mineralógicos e geoquímicos para a exploração de micro-exsudações e um modelo de micro-exsudações atualizado. Durante este trabalho, conseguimos desenvolver novas metodologias para análise de dados espectroscópicos. Através da utilização de dados simulados, indicamos que o instrumento de satélite WorldView-3 tem potencial para detecção direta de hidrocarbonetos. Na sequência do estudo, dados reais sobre afloramentos de arenitos e óleo na área de Anhembi foram investigados. A área foi fotografada novamente no chão e usando o sistema de imagem hiperespectral AisaFENIX. Seguiu-se estudos e amostragem no campo,incluindo espectroscopia de alcance fechado das amostras no laboratório usando instrumentos de imagem (ou seja, sisuCHEMA) e não-imagem (ou seja, FieldSpec-4). O estudo demonstrou que uma abordagem espectroscópica multi-escala poderia fornecer uma imagem completa das variações no conteúdo e composição do betume e minerais de alteração que acompanham. A assinatura de hidrocarbonetos, especialmente a centrada em 2300 nm, mostrou-se consistente e comparável entre as escalas e capaz de estimar o teor de betume de areias de petróleo em todas as escalas de imagemAbstract: The objective of this research was to explore for the signatures of seeping hydrocarbons on the surface using spectral remote sensing technology. It was achieved firstly by conducting a comprehensive review of the capacities and potentials of the technique for direct and indirect seepage detection. Next, the technique was applied to investigate two distinctive test sites located in Iran and Brazil known to retain active microseepage systems and bituminous outcrops, respectively. The first study area is located near the city of Qom in Iran, and consists of Alborz oilfield buried under Oligocene sediments of the Upper-Red Formation. The second site is located near the town of Anhembi on the eastern edge of the Paraná Basin in Brazil and includes bitumen accumulations in the Triassic sandstones of the Pirambóia Formation. Our work in Qom area integrated evidence from (i) petrographic, spectroscopic, and geochemical studies in the laboratory, (ii) outcrop investigations in the field, and (iii) broad-scale anomaly mapping via orbital remote sensing data. The outcomes of this study was novel mineralogical and geochemical indicators for microseepage characterization and a classification scheme for the microseepage-induced alterations. Our study indicated that active microseepage systems occur in large parts of the lithofacies in Qom area, implying that the extent of the petroleum reservoir is much larger than previously thought. During this work, we also developed new methodologies for spectroscopic data analysis and processing. On the other side, by using simulated data, we indicated that WorldView-3 satellite instrument has the potential for direct hydrocarbon detection. Following this demonstration, real datasets were acquired over oil-sand outcrops of the Anhembi area. The area was further imaged on the ground and from the air by using an AisaFENIX hyperspectral imaging system. This was followed by outcrop studies and sampling in the field and close-range spectroscopy in the laboratory using both imaging (i.e. sisuCHEMA) and nonimaging instruments. The study demonstrated that a multi-scale spectroscopic approach could provide a complete picture of the variations in the content and composition of bitumen and associated alteration mineralogy. The oil signature, especially the one centered at 2300 nm, was shown to be consistent and comparable among scales, and capable of estimating the bitumen content of oil-sands at all imaging scalesDoutoradoGeologia e Recursos NaturaisDoutor em Geociências2015/06663-7FAPES

Analysis of Martian Parental Melts and Thermal Infrared Studies of Putative Paleolake Basins on Mars

Both martian meteorites and remote sensing data allow us to study the geologic history of Mars. Martian meteorites can reveal information regarding partial melting of the Mars mantle and the surface processes that affected the meteorite following eruption (weathering, impact ejection, etc.). Remote sensing data can be used to investigate the local-, regional- or global-scale surface of Mars in terms of composition and geomorphology. A well-rounded approach is necessary to address fundamental questions regarding the geologic history of Mars. We studied melt inclusions in augite of the martian meteorite Nakhla to better understand the magma that produced this rock. This study used laboratory methods developed at the Virginia Tech Fluids Research Lab, electron microprobe analyses, and MELTS crystallization modeling. The result of this study was a new estimate of the Nakhla parent magma composition, which is basaltic in composition. Crystallization modeling of this composition provided the closest match to mineral abundances and composition observed within the nakhlites, suggesting an improved estimate. In addition, we studied thermal infrared data of martian craters that some workers suggest display geomorphic evidence that they once contained lakes. If in fact these craters did hold water, they may still contain evaporite minerals deposited in this environment and detectable within the thermal infrared. We used data acquired by TES (Thermal Emission Spectrometer aboard the Mars Global Surveyor) and THEMIS (Thermal Emission Imaging System aboard Mars Odyssey). Because of its higher spatial resolution, THEMIS is best viewed as a spectral unit mapper, whereas TES is better at mineral identification because of its higher spectral resolution. Both studies employed a linear deconvolution routine developed at Arizona State University, spectral ratios and newly-developed carbonate indices to search for local-scale deposits of evaporites within craters. In these studies, we did not find mineralogic evidence supporting a paleolake origin for the surficial deposits within any crater

Field theoretic formulation and empirical tracking of spatial processes

Spatial processes are attacked on two fronts. On the one hand, tools from theoretical and statistical physics can be used to understand behaviour in complex, spatially-extended multi-body systems. On the other hand, computer vision and statistical analysis can be used to study 4D microscopy data to observe and understand real spatial processes in vivo. On the rst of these fronts, analytical models are developed for abstract processes, which can be simulated on graphs and lattices before considering real-world applications in elds such as biology, epidemiology or ecology. In the eld theoretic formulation of spatial processes, techniques originating in quantum eld theory such as canonical quantisation and the renormalization group are applied to reaction-di usion processes by analogy. These techniques are combined in the study of critical phenomena or critical dynamics. At this level, one is often interested in the scaling behaviour; how the correlation functions scale for di erent dimensions in geometric space. This can lead to a better understanding of how macroscopic patterns relate to microscopic interactions. In this vein, the trace of a branching random walk on various graphs is studied. In the thesis, a distinctly abstract approach is emphasised in order to support an algorithmic approach to parts of the formalism. A model of self-organised criticality, the Abelian sandpile model, is also considered. By exploiting a bijection between recurrent con gurations and spanning trees, an e cient Monte Carlo algorithm is developed to simulate sandpile processes on large lattices. On the second front, two case studies are considered; migratory patterns of leukaemia cells and mitotic events in Arabidopsis roots. In the rst case, tools from statistical physics are used to study the spatial dynamics of di erent leukaemia cell lineages before and after a treatment. One key result is that we can discriminate between migratory patterns in response to treatment, classifying cell motility in terms of sup/super/di usive regimes. For the second case study, a novel algorithm is developed to processes a 4D light-sheet microscopy dataset. The combination of transient uorescent markers and a poorly localised specimen in the eld of view leads to a challenging tracking problem. A fuzzy registration-tracking algorithm is developed to track mitotic events so as to understand their spatiotemporal dynamics under normal conditions and after tissue damage.Open Acces