Dwarna : a blockchain solution for dynamic consent in biobanking

Dynamic consent aims to empower research partners and facilitate active participation in the research process. Used within the context of biobanking, it gives individuals access to information and control to determine how and where their biospecimens and data should be used. We present Dwarna—a web portal for ‘dynamic consent’ that acts as a hub connecting the different stakeholders of the Malta Biobank: biobank managers, researchers, research partners, and the general public. The portal stores research partners’ consent in a blockchain to create an immutable audit trail of research partners’ consent changes. Dwarna’s structure also presents a solution to the European Union’s General Data Protection Regulation’s right to erasure—a right that is seemingly incompatible with the blockchain model. Dwarna’s transparent structure increases trustworthiness in the biobanking process by giving research partners more control over which research studies they participate in, by facilitating the withdrawal of consent and by making it possible to request that the biospecimen and associated data are destroyed.peer-reviewe

Hipster: hybrid task manager for latency-critical cloud workloads

In 2013, U. S. data centers accounted for 2.2% of the country's total electricity consumption, a figure that is projected to increase rapidly over the next decade. Many important workloads are interactive, and they demand strict levels of quality-of-service (QoS) to meet user expectations, making it challenging to reduce power consumption due to increasing performance demands. This paper introduces Hipster, a technique that combines heuristics and reinforcement learning to manage latency-critical workloads. Hipster's goal is to improve resource efficiency in data centers while respecting the QoS of the latency-critical workloads. Hipster achieves its goal by exploring heterogeneous multi-cores and dynamic voltage and frequency scaling (DVFS). To improve data center utilization and make best usage of the available resources, Hipster can dynamically assign remaining cores to batch workloads without violating the QoS constraints for the latency-critical workloads. We perform experiments using a 64-bit ARM big.LITTLE platform, and show that, compared to prior work, Hipster improves the QoS guarantee for Web-Search from 80% to 96%, and for Memcached from 92% to 99%, while reducing the energy consumption by up to 18%.Peer ReviewedPostprint (author's final draft

Scalable fleet monitoring and visualization for smart machine maintenance and industrial IoT applications

The wide adoption of smart machine maintenance in manufacturing is blocked by open challenges in the Industrial Internet of Things (IIoT) with regard to robustness, scalability and security. Solving these challenges is of uttermost importance to mission-critical industrial operations. Furthermore, effective application of predictive maintenance requires well-trained machine learning algorithms which on their turn require high volumes of reliable data. This paper addresses both challenges and presents the Smart Maintenance Living Lab, an open test and research platform that consists of a fleet of drivetrain systems for accelerated lifetime tests of rolling-element bearings, a scalable IoT middleware cloud platform for reliable data ingestion and persistence, and a dynamic dashboard application for fleet monitoring and visualization. Each individual component within the presented system is discussed and validated, demonstrating the feasibility of IIoT applications for smart machine maintenance. The resulting platform provides benchmark data for the improvement of machine learning algorithms, gives insights into the design, implementation and validation of a complete architecture for IIoT applications with specific requirements concerning robustness, scalability and security and therefore reduces the reticence in the industry to widely adopt these technologies

Virtualization techniques for memory resource exploitation

Cloud infrastructures have become indispensable in our daily lives with the rise of cloud-based services offered by companies like Facebook, Google, Amazon and many others. These cloud infrastructures use a large numbers of servers provisioned with their own computing resources. Each of these servers use a piece of software, called the Hypervisor (``HV''), that allows them to create multiple virtual instances of the server's physical computing resources and abstract them into "Virtual Machines'' (VMs). A VM runs an Operating System, which in turn runs the applications. The VMs within the servers generate varying memory demand behavior. When the demand increases, costly operations such as (virtual) disk accesses and/or VM migrations can occur. As a result, it is necessary to optimize the utilization of the local memory resources within a single computing server. However, pressure on the memory resources can still increase, making it necessary to migrate the VM to a different server with larger memory or add more memory to the same server. At this point, it is important to consider that some of the servers in the cloud infrastructure might have memory resources that they are not using. Considering the possibility to make memory available to the server, new architectures have been introduced that provide hardware support to enable servers to share their memory capacity. This thesis presents multiple contributions to the memory management problem. First, it addresses the problem of optimizing memory resources in a virtualized server through different types of memory abstractions. Two full contributions are presented for managing memory within a single server called SmarTmem and CARLEMM. In this respect, a third contribution is also presented, called CAVMem, that works as the foundation for CARLEMM. Second, this thesis presents two contributions for memory capacity aggregation across multiple servers, offering two mechanisms called GV-Tmem and vMCA, this latter being based on GV-Tmem but with significant enhancements. These mechanisms distribute the server's total memory within a single-server and globally across computing servers using a user-space process with high-level memory management policies.Las infraestructuras para la nube se han vuelto indispensables en nuestras vidas diarias con la proliferación de los servicios ofrecidos por compañías como Facebook, Google, Amazon entre otras. Estas infraestructuras utilizan una gran cantidad de servidores proveídos con sus propios recursos computacionales. Cada unos de estos servidores utilizan un software, llamado el Hipervisor (“HV”), que les permite crear múltiples instancias virtuales de los recursos físicos de computación del servidor y abstraerlos en “Máquinas Virtuales” (VMs). Una VM ejecuta un Sistema Operativo (OS), el cual a su vez ejecuta aplicaciones. Las VMs dentro de los servidores generan un comportamiento variable de demanda de memoria. Cuando la demanda de memoria aumenta, operaciones costosas como accesos al disco (virtual) y/o migraciones de VMs pueden ocurrir. Como resultado, es necesario optimizar la utilización de los recursos de memoria locales dentro del servidor. Sin embargo, la demanda por memoria puede seguir aumentando, haciendo necesario que la VM migre a otro servidor o que se añada más memoria al servidor. En este punto, es importante considerar que algunos servidores podrían tener recursos de memoria que no están utilizando. Considerando la posibilidad de hacer más memoria disponible a los servidores que lo necesitan, nuevas arquitecturas de servidores han sido introducidos que brindan el soporte de hardware necesario para habilitar que los servidores puedan compartir su capacidad de memoria. Esta tesis presenta múltiples contribuciones para el problema de manejo de memoria. Primero, se enfoca en el problema de optimizar los recursos de memoria en un servidor virtualizado a través de distintos tipos de abstracciones de memoria. Dos contribuciones son presentadas para administrar memoria de manera automática dentro de un servidor virtualizado, llamadas SmarTmem y CARLEMM. En este contexto, una tercera contribución es presentada, llamada CAVMem, que proporciona los fundamentos para el desarrollo de CARLEMM. Segundo, la tesis presenta dos contribuciones enfocadas en la agregación de capacidad de memoria a través de múltiples servidores, ofreciendo dos mecanismos llamados GV-Tmem y vMCA, siendo este último basado en GV-Tmem pero con mejoras significativas. Estos mecanismos administran la memoria total de un servidor a nivel local y de manera global a lo largo de los servidores de la infraestructura de nube utilizando un proceso de usuario que implementa políticas de manejo de ..

Towards Power- and Energy-Efficient Datacenters

As the Internet evolves, cloud computing is now a dominant form of computation in modern lives. Warehouse-scale computers (WSCs), or datacenters, comprising the foundation of this cloud-centric web have been able to deliver satisfactory performance to both the Internet companies and the customers. With the increased focus and popularity of the cloud, however, datacenter loads rise and grow rapidly, and Internet companies are in need of boosted computing capacity to serve such demand. Unfortunately, power and energy are often the major limiting factors prohibiting datacenter growth: it is often the case that no more servers can be added to datacenters without surpassing the capacity of the existing power infrastructure. This dissertation aims to investigate the issues of power and energy usage in a modern datacenter environment. We identify the source of power and energy inefficiency at three levels in a modern datacenter environment and provides insights and solutions to address each of these problems, aiming to prepare datacenters for critical future growth. We start at the datacenter-level and find that the peak provisioning and improper service placement in multi-level power delivery infrastructures fragment the power budget inside production datacenters, degrading the compute capacity the existing infrastructure can support. We find that the heterogeneity among datacenter workloads is key to address this issue and design systematic methods to reduce the fragmentation and improve the utilization of the power budget. This dissertation then narrow the focus to examine the energy usage of individual servers running cloud workloads. Especially, we examine the power management mechanisms employed in these servers and find that the coarse time granularity of these mechanisms is one critical factor that leads to excessive energy consumption. We propose an intelligent and low overhead solution on top of the emerging finer granularity voltage/frequency boosting circuit to effectively pinpoints and boosts queries that are likely to increase the tail distribution and can reap more benefit from the voltage/frequency boost, improving energy efficiency without sacrificing the quality of services. The final focus of this dissertation takes a further step to investigate how using a fundamentally more efficient computing substrate, field programmable gate arrays (FPGAs), benefit datacenter power and energy efficiency. Different from other types of hardware accelerations, FPGAs can be reconfigured on-the-fly to provide fine-grain control over hardware resource allocation and presents a unique set of challenges for optimal workload scheduling and resource allocation. We aim to design a set coordinated algorithms to manage these two key factors simultaneously and fully explore the benefit of deploying FPGAs in the highly varying cloud environment.PHDComputer Science & EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/144043/1/hsuch_1.pd

Business Plan for Launching a Luxury Adventure Tour Operator Based in Canada

MOT Elite Travel Experiences (METE) is a tour operator and online travel agent start-up company based in Vancouver, British Columbia. METE is faced with the challenge of establishing itself as a business in the travel industry. However, recent advances in technology such as an increase in the number of broadband Internet users, search engine optimization, and the advent of smartphones have created an opportunity to capitalize on the growing popularity of online travel booking services. This trend towards online travel sales is stimulating new growth in the tourism industry and providing exciting opportunities for new entrants like METE. Analysis of current statistics and penetration rates for broadband internet and smartphone for countries travelling to Canada in the 25-44 year old age segment indicates that the United States, the United Kingdom (UK), Germany and France are the primary target markets for METE. Luxury travel has recovered from the recession of 2008-2009, and a growing, younger upper middle class and large proportion of High Net Worth Individuals (HNWI) in the under 45 year old segment in China are supporting a market for unique travel experience that METE plans to offer. The travel cycle introduces the inspiration, research, booking, experience, and sharing phases that comprise a framework to understand the relationship between travel and technology. METE plans to develop into competitive business as an on-line travel agent and tour operator that is able to deliver a comprehensive on-line and offline experience throughout the travel cycle