Categorical Ontology of Complex Systems, Meta-Systems and Theory of Levels: The Emergence of Life, Human Consciousness and Society

Single cell interactomics in simpler organisms, as well as somatic cell interactomics in multicellular organisms, involve biomolecular interactions in complex signalling pathways that were recently represented in modular terms by quantum automata with ‘reversible behavior’ representing normal cell cycling and division. Other implications of such quantum automata, modular modeling of signaling pathways and cell differentiation during development are in the fields of neural plasticity and brain development leading to quantum-weave dynamic patterns and specific molecular processes underlying extensive memory, learning, anticipation mechanisms and the emergence of human consciousness during the early brain development in children. Cell interactomics is here represented for the first time as a mixture of ‘classical’ states that determine molecular dynamics subject to Boltzmann statistics and ‘steady-state’, metabolic (multi-stable) manifolds, together with ‘configuration’ spaces of metastable quantum states emerging from complex quantum dynamics of interacting networks of biomolecules, such as proteins and nucleic acids that are now collectively defined as quantum interactomics. On the other hand, the time dependent evolution over several generations of cancer cells --that are generally known to undergo frequent and extensive genetic mutations and, indeed, suffer genomic transformations at the chromosome level (such as extensive chromosomal aberrations found in many colon cancers)-- cannot be correctly represented in the ‘standard’ terms of quantum automaton modules, as the normal somatic cells can. This significant difference at the cancer cell genomic level is therefore reflected in major changes in cancer cell interactomics often from one cancer cell ‘cycle’ to the next, and thus it requires substantial changes in the modeling strategies, mathematical tools and experimental designs aimed at understanding cancer mechanisms. Novel solutions to this important problem in carcinogenesis are proposed and experimental validation procedures are suggested. From a medical research and clinical standpoint, this approach has important consequences for addressing and preventing the development of cancer resistance to medical therapy in ongoing clinical trials involving stage III cancer patients, as well as improving the designs of future clinical trials for cancer treatments.\ud \ud \ud KEYWORDS: Emergence of Life and Human Consciousness;\ud Proteomics; Artificial Intelligence; Complex Systems Dynamics; Quantum Automata models and Quantum Interactomics; quantum-weave dynamic patterns underlying human consciousness; specific molecular processes underlying extensive memory, learning, anticipation mechanisms and human consciousness; emergence of human consciousness during the early brain development in children; Cancer cell ‘cycling’; interacting networks of proteins and nucleic acids; genetic mutations and chromosomal aberrations in cancers, such as colon cancer; development of cancer resistance to therapy; ongoing clinical trials involving stage III cancer patients’ possible improvements of the designs for future clinical trials and cancer treatments. \ud \u

From Simple to Complex and Ultra-complex Systems:\ud A Paradigm Shift Towards Non-Abelian Systems Dynamics

Atoms, molecules, organisms distinguish layers of reality because of the causal links that govern their behavior, both horizontally (atom-atom, molecule-molecule, organism-organism) and vertically (atom-molecule-organism). This is the first intuition of the theory of levels. Even if the further development of the theory will require imposing a number of qualifications to this initial intuition, the idea of a series of entities organized on different levels of complexity will prove correct. Living systems as well as social systems and the human mind present features remarkably different from those characterizing non-living, simple physical and chemical systems. We propose that super-complexity requires at least four different categorical frameworks, provided by the theories of levels of reality, chronotopoids, (generalized) interactions, and anticipation

From Simple to Complex and Ultra-complex Systems:\ud A Paradigm Shift Towards Non-Abelian Systems Dynamics

Atoms, molecules, organisms distinguish layers of reality because of the causal links that govern their behavior, both horizontally (atom-atom, molecule-molecule, organism-organism) and vertically (atom-molecule-organism). This is the first intuition of the theory of levels. Even if the further development of the theory will require imposing a number of qualifications to this initial intuition, the idea of a series of entities organized on different levels of complexity will prove correct. Living systems as well as social systems and the human mind present features remarkably different from those characterizing non-living, simple physical and chemical systems. We propose that super-complexity requires at least four different categorical frameworks, provided by the theories of levels of reality, chronotopoids, (generalized) interactions, and anticipation

Learning Computer Programs with the Bayesian Optimization Algorithm

The hierarchical Bayesian Optimization Algorithm (hBOA) [24, 25] learns bit-strings by constructing explicit centralized models of a population and using them to generate new instances. This thesis is concerned with extending hBOA to learning open-ended program trees. The new system, BOA programming (BOAP), improves on previous probabilistic model building GP systems (PMBGPs) in terms of the expressiveness and open-ended flexibility of the models learned, and hence control over the distribution of individuals generated. BOAP is studied empirically on a toy problem (learning linear functions) in various configurations, and further experimental results are presented for two real-world problems: prediction of sunspot time series, and human gene function inference

An adaptive stigmergy-based system for evaluating technological indicator dynamics in the context of smart specialization

Regional innovation is more and more considered an important enabler of welfare. It is no coincidence that the European Commission has started looking at regional peculiarities and dynamics, in order to focus Research and Innovation Strategies for Smart Specialization towards effective investment policies. In this context, this work aims to support policy makers in the analysis of innovation-relevant trends. We exploit a European database of the regional patent application to determine the dynamics of a set of technological innovation indicators. For this purpose, we design and develop a software system for assessing unfolding trends in such indicators. In contrast with conventional knowledge-based design, our approach is biologically-inspired and based on self-organization of information. This means that a functional structure, called track, appears and stays spontaneous at runtime when local dynamism in data occurs. A further prototyping of tracks allows a better distinction of the critical phenomena during unfolding events, with a better assessment of the progressing levels. The proposed mechanism works if structural parameters are correctly tuned for the given historical context. Determining such correct parameters is not a simple task since different indicators may have different dynamics. For this purpose, we adopt an adaptation mechanism based on differential evolution. The study includes the problem statement and its characterization in the literature, as well as the proposed solving approach, experimental setting and results.Comment: mail: [email protected]

OPTION: OPTImization Algorithm Benchmarking ONtology

Many optimization algorithm benchmarking platforms allow users to share their experimental data to promote reproducible and reusable research. However, different platforms use different data models and formats, which drastically complicates the identification of relevant datasets, their interpretation, and their interoperability. Therefore, a semantically rich, ontology-based, machine-readable data model that can be used by different platforms is highly desirable. In this paper, we report on the development of such an ontology, which we call OPTION (OPTImization algorithm benchmarking ONtology). Our ontology provides the vocabulary needed for semantic annotation of the core entities involved in the benchmarking process, such as algorithms, problems, and evaluation measures. It also provides means for automatic data integration, improved interoperability, and powerful querying capabilities, thereby increasing the value of the benchmarking data. We demonstrate the utility of OPTION, by annotating and querying a corpus of benchmark performance data from the BBOB collection of the COCO framework and from the Yet Another Black-Box Optimization Benchmark (YABBOB) family of the Nevergrad environment. In addition, we integrate features of the BBOB functional performance landscape into the OPTION knowledge base using publicly available datasets with exploratory landscape analysis. Finally, we integrate the OPTION knowledge base into the IOHprofiler environment and provide users with the ability to perform meta-analysis of performance data

Design of a Machine Learning-based Approach for Fragment Retrieval on Models

[ES] El aprendizaje automático (ML por sus siglas en inglés) es conocido como la rama de la inteligencia artificial que reúne algoritmos estadísticos, probabilísticos y de optimización, que aprenden empíricamente. ML puede aprovechar el conocimiento y la experiencia que se han generado durante años en las empresas para realizar automáticamente diferentes procesos. Por lo tanto, ML se ha aplicado a diversas áreas de investigación, que estudian desde la medicina hasta la ingeniería del software. De hecho, en el campo de la ingeniería del software, el mantenimiento y la evolución de un sistema abarca hasta un 80% de la vida útil del sistema. Las empresas, que se han dedicado al desarrollo de sistemas software durante muchos años, han acumulado grandes cantidades de conocimiento y experiencia. Por lo tanto, ML resulta una solución atractiva para reducir sus costos de mantenimiento aprovechando los recursos acumulados. Específicamente, la Recuperación de Enlaces de Trazabilidad, la Localización de Errores y la Ubicación de Características se encuentran entre las tareas más comunes y relevantes para realizar el mantenimiento de productos software. Para abordar estas tareas, los investigadores han propuesto diferentes enfoques. Sin embargo, la mayoría de las investigaciones se centran en métodos tradicionales, como la indexación semántica latente, que no explota los recursos recopilados. Además, la mayoría de las investigaciones se enfocan en el código, descuidando otros artefactos de software como son los modelos. En esta tesis, presentamos un enfoque basado en ML para la recuperación de fragmentos en modelos (FRAME). El objetivo de este enfoque es recuperar el fragmento del modelo que realiza mejor una consulta específica. Esto permite a los ingenieros recuperar el fragmento que necesita ser trazado, reparado o ubicado para el mantenimiento del software. Específicamente, FRAME combina la computación evolutiva y las técnicas ML. En FRAME, un algoritmo evolutivo es guiado por ML para extraer de manera eficaz distintos fragmentos de un modelo. Estos fragmentos son posteriormente evaluados mediante técnicas ML. Para aprender a evaluarlos, las técnicas ML aprovechan el conocimiento (fragmentos recuperados de modelos) y la experiencia que las empresas han generado durante años. Basándose en lo aprendido, las técnicas ML determinan qué fragmento del modelo realiza mejor una consulta. Sin embargo, la mayoría de las técnicas ML no pueden entender los fragmentos de los modelos. Por lo tanto, antes de aplicar las técnicas ML, el enfoque propuesto codifica los fragmentos a través de una codificación ontológica y evolutiva. En resumen, FRAME está diseñado para extraer fragmentos de un modelo, codificarlos y evaluar cuál realiza mejor una consulta específica. El enfoque ha sido evaluado a partir de un caso real proporcionado por nuestro socio industrial (CAF, un proveedor internacional de soluciones ferroviarias). Además, sus resultados han sido comparados con los resultados de los enfoques más comunes y recientes. Los resultados muestran que FRAME obtuvo los mejores resultados para la mayoría de los indicadores de rendimiento, proporcionando un valor medio de precisión igual a 59.91%, un valor medio de exhaustividad igual a 78.95%, una valor-F medio igual a 62.50% y un MCC (Coeficiente de Correlación Matthews) medio igual a 0.64. Aprovechando los fragmentos recuperados de los modelos, FRAME es menos sensible al conocimiento tácito y al desajuste de vocabulario que los enfoques basados en información semántica. Sin embargo, FRAME está limitado por la disponibilidad de fragmentos recuperados para llevar a cabo el aprendizaje automático. Esta tesis presenta una discusión más amplia de estos aspectos así como el análisis estadístico de los resultados, que evalúa la magnitud de la mejora en comparación con los otros enfoques.[CAT] L'aprenentatge automàtic (ML per les seues sigles en anglés) és conegut com la branca de la intel·ligència artificial que reuneix algorismes estadístics, probabilístics i d'optimització, que aprenen empíricament. ML pot aprofitar el coneixement i l'experiència que s'han generat durant anys en les empreses per a realitzar automàticament diferents processos. Per tant, ML s'ha aplicat a diverses àrees d'investigació, que estudien des de la medicina fins a l'enginyeria del programari. De fet, en el camp de l'enginyeria del programari, el manteniment i l'evolució d'un sistema abasta fins a un 80% de la vida útil del sistema. Les empreses, que s'han dedicat al desenvolupament de sistemes programari durant molts anys, han acumulat grans quantitats de coneixement i experiència. Per tant, ML resulta una solució atractiva per a reduir els seus costos de manteniment aprofitant els recursos acumulats. Específicament, la Recuperació d'Enllaços de Traçabilitat, la Localització d'Errors i la Ubicació de Característiques es troben entre les tasques més comunes i rellevants per a realitzar el manteniment de productes programari. Per a abordar aquestes tasques, els investigadors han proposat diferents enfocaments. No obstant això, la majoria de les investigacions se centren en mètodes tradicionals, com la indexació semàntica latent, que no explota els recursos recopilats. A més, la majoria de les investigacions s'enfoquen en el codi, descurant altres artefactes de programari com són els models. En aquesta tesi, presentem un enfocament basat en ML per a la recuperació de fragments en models (FRAME). L'objectiu d'aquest enfocament és recuperar el fragment del model que realitza millor una consulta específica. Això permet als enginyers recuperar el fragment que necessita ser traçat, reparat o situat per al manteniment del programari. Específicament, FRAME combina la computació evolutiva i les tècniques ML. En FRAME, un algorisme evolutiu és guiat per ML per a extraure de manera eficaç diferents fragments d'un model. Aquests fragments són posteriorment avaluats mitjançant tècniques ML. Per a aprendre a avaluar-los, les tècniques ML aprofiten el coneixement (fragments recuperats de models) i l'experiència que les empreses han generat durant anys. Basant-se en l'aprés, les tècniques ML determinen quin fragment del model realitza millor una consulta. No obstant això, la majoria de les tècniques ML no poden entendre els fragments dels models. Per tant, abans d'aplicar les tècniques ML, l'enfocament proposat codifica els fragments a través d'una codificació ontològica i evolutiva. En resum, FRAME està dissenyat per a extraure fragments d'un model, codificar-los i avaluar quin realitza millor una consulta específica. L'enfocament ha sigut avaluat a partir d'un cas real proporcionat pel nostre soci industrial (CAF, un proveïdor internacional de solucions ferroviàries). A més, els seus resultats han sigut comparats amb els resultats dels enfocaments més comuns i recents. Els resultats mostren que FRAME va obtindre els millors resultats per a la majoria dels indicadors de rendiment, proporcionant un valor mitjà de precisió igual a 59.91%, un valor mitjà d'exhaustivitat igual a 78.95%, una valor-F mig igual a 62.50% i un MCC (Coeficient de Correlació Matthews) mig igual a 0.64. Aprofitant els fragments recuperats dels models, FRAME és menys sensible al coneixement tàcit i al desajustament de vocabulari que els enfocaments basats en informació semàntica. No obstant això, FRAME està limitat per la disponibilitat de fragments recuperats per a dur a terme l'aprenentatge automàtic. Aquesta tesi presenta una discussió més àmplia d'aquests aspectes així com l'anàlisi estadística dels resultats, que avalua la magnitud de la millora en comparació amb els altres enfocaments.[EN] Machine Learning (ML) is known as the branch of artificial intelligence that gathers statistical, probabilistic, and optimization algorithms, which learn empirically. ML can exploit the knowledge and the experience that have been generated for years to automatically perform different processes. Therefore, ML has been applied to a wide range of research areas, from medicine to software engineering. In fact, in software engineering field, up to an 80% of a system's lifetime is spent on the maintenance and evolution of the system. The companies, that have been developing these software systems for a long time, have gathered a huge amount of knowledge and experience. Therefore, ML is an attractive solution to reduce their maintenance costs exploiting the gathered resources. Specifically, Traceability Link Recovery, Bug Localization, and Feature Location are amongst the most common and relevant tasks when maintaining software products. To tackle these tasks, researchers have proposed a number of approaches. However, most research focus on traditional methods, such as Latent Semantic Indexing, which does not exploit the gathered resources. Moreover, most research targets code, neglecting other software artifacts such as models. In this dissertation, we present an ML-based approach for fragment retrieval on models (FRAME). The goal of this approach is to retrieve the model fragment which better realizes a specific query in a model. This allows engineers to retrieve the model fragment, which must be traced, fixed, or located for software maintenance. Specifically, the FRAME approach combines evolutionary computation and ML techniques. In the FRAME approach, an evolutionary algorithm is guided by ML to effectively extract model fragments from a model. These model fragments are then assessed through ML techniques. To learn how to assess them, ML techniques takes advantage of the companies' knowledge (retrieved model fragments) and experience. Then, based on what was learned, ML techniques determine which model fragment better realizes a query. However, model fragments are not understandable for most ML techniques. Therefore, the proposed approach encodes the model fragments through an ontological evolutionary encoding. In short, the FRAME approach is designed to extract model fragments, encode them, and assess which one better realizes a specific query. The approach has been evaluated in our industrial partner (CAF, an international provider of railway solutions) and compared to the most common and recent approaches. The results show that the FRAME approach achieved the best results for most performance indicators, providing a mean precision value of 59.91%, a recall value of 78.95%, a combined F-measure of 62.50%, and a MCC (Matthews correlation coefficient) value of 0.64. Leveraging retrieved model fragments, the FRAME approach is less sensitive to tacit knowledge and vocabulary mismatch than the approaches based on semantic information. However, the approach is limited by the availability of the retrieved model fragments to perform the learning. These aspects are further discussed, after the statistical analysis of the results, which assesses the magnitude of the improvement in comparison to the other approaches.Marcén Terraza, AC. (2020). Design of a Machine Learning-based Approach for Fragment Retrieval on Models [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/158617TESI

Ontology Alignment using Biologically-inspired Optimisation Algorithms

It is investigated how biologically-inspired optimisation methods can be used to compute alignments between ontologies. Independent of particular similarity metrics, the developed techniques demonstrate anytime behaviour and high scalability. Due to the inherent parallelisability of these population-based algorithms it is possible to exploit dynamically scalable cloud infrastructures - a step towards the provisioning of Alignment-as-a-Service solutions for future semantic applications