Adaptive Signal Processing Techniques for Extracting Abdominal Fetal Electrocardiogram

Import 03/11/2016Tato diplomová práce se zabývá problematikou snímání plodového elektrokardiogramu z transabdominálního záznamu. Ten by se v budoucnu mohl stát velmi účinným a nezbytným nástrojem v monitorování a diagnostice ohrožených plodů v průběhu těhotenství a během porodu. Největším problémem, se kterým se tento způsob monitorace potýká, je velké množství nežádoucích složek, které jsou snímány společně s užitečným signálem, zejména pak mateřský elektrokardiogram. Autorka se zaměřuje zejména na využití adaptivních metod pro extrakci plodového elektrokardiogramu z takto zarušeného transabdominálního záznamu. Tato práce obsahuje mimo jiné také obsáhlé shrnutí této poměrně nové problematiky, klasifikaci a popis vybraných adaptivních metod a zejména návrh a realizaci adaptivního systému pro potlačování „nežádoucího“ mateřského elektrokardiogramu. Ověření funkčnosti tohoto systému bylo provedeno na syntetických i reálných datech.This thesis focuses on the fetal electrocardiogram recorded transabdominally. This method could become very efficient and essential tool in monitoring and diagnosing endangered fetuses during the pregnancy and the delivery. The greatest challenge connected with this kind of monitoring is the amount of noise that is recorded within the desired signal. This thesis aims at the use of adaptive methods for extracting fetal electrocardiogram from such abdominal signal. This thesis includes among others an extensive summary of this relatively new issue, classification and description of selected linear adaptive methods, and in particular, the design and the implementation of adaptive system for suppressing the ‚undesirable‘ maternal electrocardiogram.450 - Katedra kybernetiky a biomedicínského inženýrstvívelmi dobř

Mathematical tools for identifying the fetal response to physical exercise during pregnancy

In the applied mathematics literature there exist a significant number of tools that can reveal the interaction between mother and fetus during rest and also during and after exercise. These tools are based on techniques from a number of areas such as signal processing, time series analysis, neural networks, heart rate variability as well as dynamical systems and chaos. We will briefly review here some of these methods, concentrating on a method of extracting the fetal heart rate from the mixed maternal-fetal heart rate signal, that is based on phase space reconstructio

Fetal Electrocardiogram Signal Extraction by ANFIS Trained with PSO Method

Studies indicate that the primary source of distress in pregnent mothers is their concerns about fetus’s condition and health. One way to know about condition of fetus is non-invasive fetal electrocardiogram signal extraction through which the components of fetal electrocardiogram signal are extracted from a signal recorded at abdominal area of mother which is a combination of fetal and maternal electrocardiogram signal and noise source components. The purpose of this study is to propose an algorithm to boost this extraction. To this end, we decomposed electrocardiogram signal to its Intrinsic Mode Functions (IMFs) thruogh Empirical Mode Decomposition algorithm; then, we removed the last and collected the other IMFs to reconstruct electrocardiogram signal without Baseline. Afterwards, we used Particle Swarm Optimization to train and adjust the parameters of Adaptive Neuro-Fuzzy Inference System to model the path that maternal electrocardiogram signal travel to reach abdominal area. Accordingly, we were able to distinguish and remove maternal electrocardiogram signal components from the recorded signal and hence we obtained a good approximation of fetal electrocardiogram signal. We implemented our algorithm and other algorithms on simulated and real signals and found out that, in most cases, the proposed algorithm improved the extraction of fetal electrocardiogram signal.DOI:http://dx.doi.org/10.11591/ijece.v2i2.23

Novel hybrid extraction systems for fetal heart rate variability monitoring based on non-invasive fetal electrocardiogram

This study focuses on the design, implementation and subsequent verification of a new type of hybrid extraction system for noninvasive fetal electrocardiogram (NI-fECG) processing. The system designed combines the advantages of individual adaptive and non-adaptive algorithms. The pilot study reviews two innovative hybrid systems called ICA-ANFIS-WT and ICA-RLS-WT. This is a combination of independent component analysis (ICA), adaptive neuro-fuzzy inference system (ANFIS) algorithm or recursive least squares (RLS) algorithm and wavelet transform (WT) algorithm. The study was conducted on clinical practice data (extended ADFECGDB database and Physionet Challenge 2013 database) from the perspective of non-invasive fetal heart rate variability monitoring based on the determination of the overall probability of correct detection (ACC), sensitivity (SE), positive predictive value (PPV) and harmonic mean between SE and PPV (F1). System functionality was verified against a relevant reference obtained by an invasive way using a scalp electrode (ADFECGDB database), or relevant reference obtained by annotations (Physionet Challenge 2013 database). The study showed that ICA-RLS-WT hybrid system achieve better results than ICA-ANFIS-WT. During experiment on ADFECGDB database, the ICA-RLS-WT hybrid system reached ACC > 80 % on 9 recordings out of 12 and the ICA-ANFIS-WT hybrid system reached ACC > 80 % only on 6 recordings out of 12. During experiment on Physionet Challenge 2013 database the ICA-RLS-WT hybrid system reached ACC > 80 % on 13 recordings out of 25 and the ICA-ANFIS-WT hybrid system reached ACC > 80 % only on 7 recordings out of 25. Both hybrid systems achieve provably better results than the individual algorithms tested in previous studies.Web of Science713178413175

Improving Maternal and Fetal Cardiac Monitoring Using Artificial Intelligence

Early diagnosis of possible risks in the physiological status of fetus and mother during pregnancy and delivery is critical and can reduce mortality and morbidity. For example, early detection of life-threatening congenital heart disease may increase survival rate and reduce morbidity while allowing parents to make informed decisions. To study cardiac function, a variety of signals are required to be collected. In practice, several heart monitoring methods, such as electrocardiogram (ECG) and photoplethysmography (PPG), are commonly performed. Although there are several methods for monitoring fetal and maternal health, research is currently underway to enhance the mobility, accuracy, automation, and noise resistance of these methods to be used extensively, even at home. Artificial Intelligence (AI) can help to design a precise and convenient monitoring system. To achieve the goals, the following objectives are defined in this research: The first step for a signal acquisition system is to obtain high-quality signals. As the first objective, a signal processing scheme is explored to improve the signal-to-noise ratio (SNR) of signals and extract the desired signal from a noisy one with negative SNR (i.e., power of noise is greater than signal). It is worth mentioning that ECG and PPG signals are sensitive to noise from a variety of sources, increasing the risk of misunderstanding and interfering with the diagnostic process. The noises typically arise from power line interference, white noise, electrode contact noise, muscle contraction, baseline wandering, instrument noise, motion artifacts, electrosurgical noise. Even a slight variation in the obtained ECG waveform can impair the understanding of the patient's heart condition and affect the treatment procedure. Recent solutions, such as adaptive and blind source separation (BSS) algorithms, still have drawbacks, such as the need for noise or desired signal model, tuning and calibration, and inefficiency when dealing with excessively noisy signals. Therefore, the final goal of this step is to develop a robust algorithm that can estimate noise, even when SNR is negative, using the BSS method and remove it based on an adaptive filter. The second objective is defined for monitoring maternal and fetal ECG. Previous methods that were non-invasive used maternal abdominal ECG (MECG) for extracting fetal ECG (FECG). These methods need to be calibrated to generalize well. In other words, for each new subject, a calibration with a trustable device is required, which makes it difficult and time-consuming. The calibration is also susceptible to errors. We explore deep learning (DL) models for domain mapping, such as Cycle-Consistent Adversarial Networks, to map MECG to fetal ECG (FECG) and vice versa. The advantages of the proposed DL method over state-of-the-art approaches, such as adaptive filters or blind source separation, are that the proposed method is generalized well on unseen subjects. Moreover, it does not need calibration and is not sensitive to the heart rate variability of mother and fetal; it can also handle low signal-to-noise ratio (SNR) conditions. Thirdly, AI-based system that can measure continuous systolic blood pressure (SBP) and diastolic blood pressure (DBP) with minimum electrode requirements is explored. The most common method of measuring blood pressure is using cuff-based equipment, which cannot monitor blood pressure continuously, requires calibration, and is difficult to use. Other solutions use a synchronized ECG and PPG combination, which is still inconvenient and challenging to synchronize. The proposed method overcomes those issues and only uses PPG signal, comparing to other solutions. Using only PPG for blood pressure is more convenient since it is only one electrode on the finger where its acquisition is more resilient against error due to movement. The fourth objective is to detect anomalies on FECG data. The requirement of thousands of manually annotated samples is a concern for state-of-the-art detection systems, especially for fetal ECG (FECG), where there are few publicly available FECG datasets annotated for each FECG beat. Therefore, we will utilize active learning and transfer-learning concept to train a FECG anomaly detection system with the least training samples and high accuracy. In this part, a model is trained for detecting ECG anomalies in adults. Later this model is trained to detect anomalies on FECG. We only select more influential samples from the training set for training, which leads to training with the least effort. Because of physician shortages and rural geography, pregnant women's ability to get prenatal care might be improved through remote monitoring, especially when access to prenatal care is limited. Increased compliance with prenatal treatment and linked care amongst various providers are two possible benefits of remote monitoring. If recorded signals are transmitted correctly, maternal and fetal remote monitoring can be effective. Therefore, the last objective is to design a compression algorithm that can compress signals (like ECG) with a higher ratio than state-of-the-art and perform decompression fast without distortion. The proposed compression is fast thanks to the time domain B-Spline approach, and compressed data can be used for visualization and monitoring without decompression owing to the B-spline properties. Moreover, the stochastic optimization is designed to retain the signal quality and does not distort signal for diagnosis purposes while having a high compression ratio. In summary, components for creating an end-to-end system for day-to-day maternal and fetal cardiac monitoring can be envisioned as a mix of all tasks listed above. PPG and ECG recorded from the mother can be denoised using deconvolution strategy. Then, compression can be employed for transmitting signal. The trained CycleGAN model can be used for extracting FECG from MECG. Then, trained model using active transfer learning can detect anomaly on both MECG and FECG. Simultaneously, maternal BP is retrieved from the PPG signal. This information can be used for monitoring the cardiac status of mother and fetus, and also can be used for filling reports such as partogram

Non-invasive fetal monitoring: a maternal surface ECG electrode placement-based novel approach for optimization of adaptive filter control parameters using the LMS and RLS algorithms

This paper is focused on the design, implementation and verification of a novel method for the optimization of the control parameters (such as step size mu and filter order N) of LMS and RLS adaptive filters used for noninvasive fetal monitoring. The optimization algorithm is driven by considering the ECG electrode positions on the maternal body surface in improving the performance of these adaptive filters. The main criterion for optimal parameter selection was the Signal-to-Noise Ratio (SNR). We conducted experiments using signals supplied by the latest version of our LabVIEW-Based Multi-Channel Non-Invasive Abdominal Maternal-Fetal Electrocardiogram Signal Generator, which provides the flexibility and capability of modeling the principal distribution of maternal/fetal ECGs in the human body. Our novel algorithm enabled us to find the optimal settings of the adaptive filters based on maternal surface ECG electrode placements. The experimental results further confirmed the theoretical assumption that the optimal settings of these adaptive filters are dependent on the ECG electrode positions on the maternal body, and therefore, we were able to achieve far better results than without the use of optimization. These improvements in turn could lead to a more accurate detection of fetal hypoxia. Consequently, our approach could offer the potential to be used in clinical practice to establish recommendations for standard electrode placement and find the optimal adaptive filter settings for extracting high quality fetal ECG signals for further processing. Ultimately, diagnostic-grade fetal ECG signals would ensure the reliable detection of fetal hypoxia.Web of Science175art. no. 115

Extracting fetal heart beats from maternal abdominal recordings: Selection of the optimal principal components

This study presents a systematic comparison of different approaches to the automated selection of the principal components (PC) which optimise the detection of maternal and fetal heart beats from non-invasive maternal abdominal recordings. A public database of 75 4-channel non-invasive maternal abdominal recordings was used for training the algorithm. Four methods were developed and assessed to determine the optimal PC: (1) power spectral distribution, (2) root mean square, (3) sample entropy, and (4) QRS template. The sensitivity of the performance of the algorithm to large-amplitude noise removal (by wavelet de-noising) and maternal beat cancellation methods were also assessed. The accuracy of maternal and fetal beat detection was assessed against reference annotations and quantified using the detection accuracy score F1 [2*PPV*Se / (PPV + Se)], sensitivity (Se), and positive predictive value (PPV). The best performing implementation was assessed on a test dataset of 100 recordings and the agreement between the computed and the reference fetal heart rate (fHR) and fetal RR (fRR) time series quantified. The best performance for detecting maternal beats (F1 99.3%, Se 99.0%, PPV 99.7%) was obtained when using the QRS template method to select the optimal maternal PC and applying wavelet de-noising. The best performance for detecting fetal beats (F1 89.8%, Se 89.3%, PPV 90.5%) was obtained when the optimal fetal PC was selected using the sample entropy method and utilising a fixed-length time window for the cancellation of the maternal beats. The performance on the test dataset was 142.7 beats2/min2 for fHR and 19.9 ms for fRR, ranking respectively 14 and 17 (out of 29) when compared to the other algorithms presented at the Physionet Challenge 2013

Detection and Processing Techniques of FECG Signal for Fetal Monitoring

Fetal electrocardiogram (FECG) signal contains potentially precise information that could assist clinicians in making more appropriate and timely decisions during labor. The ultimate reason for the interest in FECG signal analysis is in clinical diagnosis and biomedical applications. The extraction and detection of the FECG signal from composite abdominal signals with powerful and advance methodologies are becoming very important requirements in fetal monitoring. The purpose of this review paper is to illustrate the various methodologies and developed algorithms on FECG signal detection and analysis to provide efficient and effective ways of understanding the FECG signal and its nature for fetal monitoring. A comparative study has been carried out to show the performance and accuracy of various methods of FECG signal analysis for fetal monitoring. Finally, this paper further focused some of the hardware implementations using electrical signals for monitoring the fetal heart rate. This paper opens up a passage for researchers, physicians, and end users to advocate an excellent understanding of FECG signal and its analysis procedures for fetal heart rate monitoring system

Non-invasive Detection and Compression of Fetal Electrocardiogram

Noninvasive detection of fetal electrocardiogram (FECG) from abdominal ECG recordings is highly dependent on typical statistical signal processing techniques such as independent component analysis (ICA), adaptive noise filtering, and multichannel blind deconvolution. In contrast to the previous multichannel FECG extraction methods, several recent schemes for single‐channel FECG extraction such as the extended Kalman filter (EKF), extended Kalman smoother (EKS), template subtraction (TS), and support vector regression (SVR) for detecting R waves on ECG, are evaluated via the quantitative metrics such as sensitivity (SE), positive predictive value (PPV), F‐score, detection error rate (DER), and range of accuracy. A correlation predictor that combines with multivariable gray model (GM) is also proposed for sequential ECG data compression, which displays better percent root mean-square difference (PRD) than those of Sabah’s scheme for fixed and predicted compression ratio (CR). Automatic calculation on fetal heart rate (FHR) on the reconstructed FECG from mixed signals of abdominal ECG recordings is also experimented with sample synthetic ECG data. Sample data on FHR and T/QRS for both physiological case and pathological case are simulated in a 10-min time sequence

Efficient Blind Source Separation Algorithms with Applications in Speech and Biomedical Signal Processing

Blind source separation/extraction (BSS/BSE) is a powerful signal processing method and has been applied extensively in many fields such as biomedical sciences and speech signal processing, to extract a set of unknown input sources from a set of observations. Different algorithms of BSS were proposed in the literature, that need more investigations, related to the extraction approach, computational complexity, convergence speed, type of domain (time or frequency), mixture properties, and extraction performances. This work presents a three new BSS/BSE algorithms based on computing new transformation matrices used to extract the unknown signals. Type of signals considered in this dissertation are speech, Gaussian, and ECG signals. The first algorithm, named as the BSE-parallel linear predictor filter (BSE-PLP), computes a transformation matrix from the the covariance matrix of the whitened data. Then, use the matrix as an input to linear predictor filters whose coefficients being the unknown sources. The algorithm has very fast convergence in two iterations. Simulation results, using speech, Gaussian, and ECG signals, show that the model is capable of extracting the unknown source signals and removing noise when the input signal to noise ratio is varied from -20 dB to 80 dB. The second algorithm, named as the BSE-idempotent transformation matrix (BSE-ITM), computes its transformation matrix in iterative form, with less computational complexity. The proposed method is tested using speech, Gaussian, and ECG signals. Simulation results show that the proposed algorithm significantly separate the source signals with better performance measures as compared with other approaches used in the dissertation. The third algorithm, named null space idempotent transformation matrix (NSITM) has been designed using the principle of null space of the ITM, to separate the unknown sources. Simulation results show that the method is successfully separating speech, Gaussian, and ECG signals from their mixture. The algorithm has been used also to estimate average FECG heart rate. Results indicated considerable improvement in estimating the peaks over other algorithms used in this work