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Data compressions on machines with limited memory
We consider two problems in which machines with limited internal memory are used to compress and decompress data. In the first application, a powerful encoder transmits a coded file to a decoder that has severely constrained memory. A data structure that achieves minimum storage is presented, and alternative methods that sacrifice a small amount of storage to attain faster decoding are described. The second problem we address is that of encoding and decoding in limited memory. Methods for representing context models succinctly are described. These methods provide compression performance that is superior to state-of-the-art techniques, and competitive with newer approaches that use five times as much internal memory
Applying autonomy to distributed satellite systems: Trends, challenges, and future prospects
While monolithic satellite missions still pose significant advantages in terms of accuracy and
operations, novel distributed architectures are promising improved flexibility, responsiveness,
and adaptability to structural and functional changes. Large satellite swarms, opportunistic satellite
networks or heterogeneous constellations hybridizing small-spacecraft nodes with highperformance
satellites are becoming feasible and advantageous alternatives requiring the adoption
of new operation paradigms that enhance their autonomy. While autonomy is a notion that
is gaining acceptance in monolithic satellite missions, it can also be deemed an integral characteristic
in Distributed Satellite Systems (DSS). In this context, this paper focuses on the motivations
for system-level autonomy in DSS and justifies its need as an enabler of system qualities. Autonomy
is also presented as a necessary feature to bring new distributed Earth observation functions
(which require coordination and collaboration mechanisms) and to allow for novel structural
functions (e.g., opportunistic coalitions, exchange of resources, or in-orbit data services). Mission
Planning and Scheduling (MPS) frameworks are then presented as a key component to implement
autonomous operations in satellite missions. An exhaustive knowledge classification explores the
design aspects of MPS for DSS, and conceptually groups them into: components and organizational
paradigms; problem modeling and representation; optimization techniques and metaheuristics;
execution and runtime characteristics and the notions of tasks, resources, and constraints.
This paper concludes by proposing future strands of work devoted to study the trade-offs of
autonomy in large-scale, highly dynamic and heterogeneous networks through frameworks that
consider some of the limitations of small spacecraft technologies.Postprint (author's final draft
Neural Network and Bioinformatic Methods for Predicting HIV-1 Protease Inhibitor Resistance
This article presents a new method for predicting viral resistance to seven protease inhibitors from the HIV-1 genotype, and for identifying the positions in the protease gene at which the specific nature of the mutation affects resistance. The neural network Analog ARTMAP predicts protease inhibitor resistance from viral genotypes. A feature selection method detects genetic positions that contribute to resistance both alone and through interactions with other positions. This method has identified positions 35, 37, 62, and 77, where traditional feature selection methods have not detected a contribution to resistance.
At several positions in the protease gene, mutations confer differing degress of resistance, depending on the specific amino acid to which the sequence has mutated. To find these positions, an Amino Acid Space is introduced to represent genes in a vector space that captures the functional similarity between amino acid pairs. Feature selection identifies several new positions, including 36, 37, and 43, with amino acid-specific contributions to resistance. Analog ARTMAP networks applied to inputs that represent specific amino acids at these positions perform better than networks that use only mutation locations.Air Force Office of Scientific Research (F49620-01-1-0423); National Geospatial-Intelligence Agency (NMA 201-01-1-2016); National Science Foundation (SBE-0354378); Office of Naval Research (N00014-01-1-0624
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