Process analytical technology in food biotechnology

Biotechnology is an area where precision and reproducibility are vital. This is due to the fact that products are often in form of food, pharmaceutical or cosmetic products and therefore very close to the human being. To avoid human error during the production or the evaluation of the quality of a product and to increase the optimal utilization of raw materials, a very high amount of automation is desired. Tools in the food and chemical industry that aim to reach this degree of higher automation are summarized in an initiative called Process Analytical Technology (PAT). Within the scope of the PAT, is to provide new measurement technologies for the purpose of closed loop control in biotechnological processes. These processes are the most demanding processes in regards of control issues due to their very often biological rate-determining component. Most important for an automation attempt is deep process knowledge, which can only be achieved via appropriate measurements. These measurements can either be carried out directly, measuring a crucial physical value, or if not accessible either due to the lack of technology or a complicated sample state, via a soft-sensor.Even after several years the ideal aim of the PAT initiative is not fully implemented in the industry and in many production processes. On the one hand a lot effort still needs to be put into the development of more general algorithms which are more easy to implement and especially more reliable. On the other hand, not all the available advances in this field are employed yet. The potential users seem to stick to approved methods and show certain reservations towards new technologies.Die Biotechnologie ist ein Wissenschaftsbereich, in dem hohe Genauigkeit und Wiederholbarkeit eine wichtige Rolle spielen. Dies ist der Tatsache geschuldet, dass die hergestellten Produkte sehr oft den Bereichen Nahrungsmitteln, Pharmazeutika oder Kosmetik angehöhren und daher besonders den Menschen beeinflussen. Um den menschlichen Fehler bei der Produktion zu vermeiden, die Qualität eines Produktes zu sichern und die optimale Verwertung der Rohmaterialen zu gewährleisten, wird ein besonders hohes Maß an Automation angestrebt. Die Werkzeuge, die in der Nahrungsmittel- und chemischen Industrie hierfür zum Einsatz kommen, werden in der Process Analytical Technology (PAT) Initiative zusammengefasst. Ziel der PAT ist die Entwicklung zuverlässiger neuer Methoden, um Prozesse zu beschreiben und eine automatische Regelungsstrategie zu realisieren. Biotechnologische Prozesse gehören hierbei zu den aufwändigsten Regelungsaufgaben, da in den meisten Fällen eine biologische Komponente der entscheidende Faktor ist. Entscheidend für eine erfolgreiche Regelungsstrategie ist ein hohes Maß an Prozessverständnis. Dieses kann entweder durch eine direkte Messung der entscheidenden physikalischen, chemischen oder biologischen Größen gewonnen werden oder durch einen SoftSensor. Zusammengefasst zeigt sich, dass das finale Ziel der PAT Initiative auch nach einigen Jahren des Propagierens weder komplett in der Industrie noch bei vielen Produktionsprozessen angekommen ist. Auf der einen Seite liegt dies mit Sicherheit an der Tatsache, dass noch viel Arbeit in die Generalisierung von Algorithmen gesteckt werden muss. Diese müsse einfacher zu implementieren und vor allem noch zuverlässiger in der Funktionsweise sein. Auf der anderen Seite wurden jedoch auch Algorithmen, Regelungsstrategien und eigne Ansätze für einen neuartigen Sensor sowie einen Soft-Sensors vorgestellt, die großes Potential zeigen. Nicht zuletzt müssen die möglichen Anwender neue Strategien einsetzen und Vorbehalte gegenüber unbekannten Technologien ablegen

Proceedings of the 10th International Chemical and Biological Engineering Conference - CHEMPOR 2008

This volume contains full papers presented at the 10th International Chemical and Biological Engineering Conference - CHEMPOR 2008, held in Braga, Portugal, between September 4th and 6th, 2008.FC

Putting reaction-diffusion systems into port-Hamiltonian framework

Reaction-diffusion systems model the evolution of the constituents distributed in space under the influence of chemical reactions and diffusion [6], [10]. These systems arise naturally in chemistry [5], but can also be used to model dynamical processes beyond the realm of chemistry such as biology, ecology, geology, and physics. In this paper, by adopting the viewpoint of port-controlled Hamiltonian systems [7] we cast reaction-diffusion systems into the portHamiltonian framework. Aside from offering conceptually a clear geometric interpretation formalized by a Stokes-Dirac structure [8], a port-Hamiltonian perspective allows to treat these dissipative systems as interconnected and thus makes their analysis, both quantitative and qualitative, more accessible from a modern dynamical systems and control theory point of view. This modeling approach permits us to draw immediately some conclusions regarding passivity and stability of reaction-diffusion systems. It is well-known that adding diffusion to the reaction system can generate behaviors absent in the ode case. This primarily pertains to the problem of diffusion-driven instability which constitutes the basis of Turing’s mechanism for pattern formation [11], [5]. Here the treatment of reaction-diffusion systems as dissipative distributed portHamiltonian systems could prove to be instrumental in supply of the results on absorbing sets, the existence of the maximal attractor and stability analysis. Furthermore, by adopting a discrete differential geometrybased approach [9] and discretizing the reaction-diffusion system in port-Hamiltonian form, apart from preserving a geometric structure, a compartmental model analogous to the standard one [1], [2] is obtaine

Coping with Algebraic Constraints in Power Networks

In the intuitive modelling of the power network, the generators and the loads are located at different subset of nodes. This corresponds to the so-called structure preserving model which is naturally expressed in terms of differential algebraic equations (DAE). The algebraic constraints in the structure preserving model are associated with the load dynamics. Motivated by the fact the presence of the algebraic constraints hinders the analysis and control of power networks, several aggregated models are reported in the literature where each bus of the grid is associated with certain load and generation. The advantage of these aggregated models is mainly due to the fact that they are described by ordinary differential equations (ODE) which facilitates the analysis of the network. However, the explicit relationship between the aggregated model and the original structure preserved model is often missing, which restricts the validity and applicability of the results. Aiming at simplified ODE description of the model together with respecting the heterogenous structure of the power network has endorsed the use of Kron reduced models; see e.g. [2]. In the Kron reduction method, the variables which are exclusive to the algebraic constraints are solved in terms of the rest of the variables. This results in a reduced graph, the (loopy) Laplaican matrix of which is the Schur complement of the (loopy) Laplacian matrix of the original graph. By construction, the Kron reduction technique restricts the class of the applicable load dynamics to linear loads. The algebraic constraints can also be solved in the case of frequency dependent loads where the active power drawn by each load consists of a constant term and a frequencydependent term [1],[3]. However, in the popular class of constant power loads, the algebraic constraints are “proper”, meaning that they are not explicitly solvable. In this talk, first we revisit the Kron reduction method for the linear case, where the Schur complement of the Laplacian matrix (which is again a Laplacian) naturally appears in the network dynamics. It turns out that the usual decomposition of the reduced Laplacian matrix leads to a state space realization which contains merely partial information of the original power network, and the frequency behavior of the loads is not visible. As a remedy for this problem, we introduce a new matrix, namely the projected pseudo incidence matrix, which yields a novel decomposition of the reduced Laplacian. Then, we derive reduced order models capturing the behavior of the original structure preserved model. Next, we turn our attention to the nonlinear case where the algebraic constraints are not readily solvable. Again by the use of the projected pseudo incidence matrix, we propose explicit reduced models expressed in terms of ordinary differential equations. We identify the loads embedded in the proposed reduced network by unveiling the conserved quantity of the system

Social work with airports passengers

Social work at the airport is in to offer to passengers social services. The main methodological position is that people are under stress, which characterized by a particular set of characteristics in appearance and behavior. In such circumstances passenger attracts in his actions some attention. Only person whom he trusts can help him with the documents or psychologically

Recent Development of Hybrid Renewable Energy Systems

Abstract: The use of renewable energies continues to increase. However, the energy obtained from renewable resources is variable over time. The amount of energy produced from the renewable energy sources (RES) over time depends on the meteorological conditions of the region chosen, the season, the relief, etc. So, variable power and nonguaranteed energy produced by renewable sources implies intermittence of the grid. The key lies in supply sources integrated to a hybrid system (HS)

Atti del XXXV Convegno Nazionale di Idraulica e Costruzioni Idrauliche

La XXXV edizione del Convegno Nazionale di Idraulica e Costruzioni Idrauliche (IDRA16), co-organizzata dal Gruppo Italiano di Idraulica (GII) e dal Dipartimento di Ingegneria Civile, Chimica, Ambientale, e dei Materiali (DICAM) dell’Alma Mater Studiorum - Università di Bologna, si è svolta a Bologna dal 14 al 16 settembre 2016. Il Convegno Nazionale è tornato pertanto ad affacciarsi all’ombra del “Nettuno”, dopo l’edizione del 1982 (XVIII edizione). Il titolo della XXXV edizione, “Ambiente, Risorse, Energia: le sfide dell’Ingegneria delle acque in un mondo che cambia”, sottolinea l’importanza e la complessità delle tematiche che rivestono la sfera dello studio e del governo delle risorse idriche. Le sempre più profonde interconnessioni tra risorse idriche, sviluppo economico e benessere sociale, infatti, spronano sia l’Accademia che l’intera comunità tecnico-scientifica nazionale ed internazionale all’identificazione ed alla messa in atto di strategie di gestione innovative ed ottimali: sfide percepite quanto mai necessarie in un contesto ambientale in continua evoluzione, come quello in cui viviamo. La XXXV edizione del Convegno di Idraulica e Costruzioni Idrauliche, pertanto, si è posta come punto d’incontro della comunità tecnico-scientifica italiana per la discussione a tutto tondo di tali problematiche, offrendo un programma scientifico particolarmente ricco e articolato, che ha coperto tutti gli ambiti riconducibili all’Ingegneria delle Acque. L’apertura dei lavori del Convegno si è svolta nella storica cornice della Chiesa di Santa Cristina, uno dei luoghi più caratteristici e belli della città ed oggi luogo privilegiato per l’ascolto della musica classica, mentre le attività di presentazione e discussione scientifica si sono svolte principalmente presso la sede della Scuola di Ingegneria e Architettura dell’Università di Bologna sita in Via Terracini. Il presente volume digitale ad accesso libero (licenza Creative Commons 4.0) raccoglie le memorie brevi pervenute al Comitato Scientifico di IDRA16 ed accettate per la presentazione al convegno a valle di un processo di revisione tra pari. Il volume articola dette memorie in sette macro-tematiche, che costituiscono i capitoli del volume stesso: I. meccanica dei fluidi; II. ambiente marittimo e costiero; III. criteri, metodi e modelli per l’analisi dei processi idrologici e la gestione delle acque; IV. gestione e tutela dei corpi idrici e degli ecosistemi; V. valutazione e mitigazione del rischio idrologico e idraulico; VI. dinamiche acqua-società: sviluppo sostenibile e gestione del territorio; VII. monitoraggio, open-data e software libero. Ciascuna macro-tematica raggruppa più sessioni specialistiche autonome sviluppatesi in parallelo durante le giornate del Convegno, i cui titoli vengono richiamati all’interno del presente volume. La vastità e la diversità delle tematiche affrontate, che ben rappresentano la complessità delle numerose sfide dell’Ingegneria delle Acque, appaiono evidenti dalla consultazione dell’insieme di memorie brevi presentate. La convinta partecipazione della Comunità Scientifica Italiana è dimostrata dalle oltre 350 memorie brevi, distribuite in maniera pressoché uniforme tra le sette macro-tematiche di riferimento. Dette memorie sono sommari estesi di lunghezza variabile redatti in lingua italiana, o inglese. In particolare, la possibilità di stesura in inglese è stata concessa con l’auspicio di portare la visibilità del lavoro presentato ad un livello sovranazionale, grazie alla pubblicazione open access del volume degli Atti del Convegno. Il volume si divide in tre parti: la parte iniziale è dedicata alla presentazione del volume ed all’indice generale dei contributi divisi per macro-tematiche; la parte centrale raccoglie le memorie brevi; la terza parte riporta l’indice analitico degli Autori, che chiude il volume