Adaptive sampling by histogram equalization: theory, algorithms, and applications, 2007

We present the investigation of a novel, progressive, adaptive sampling scheme. This scheme is based on the distribution of already obtained samples. Even spaced sampling of a function with varying slopes or degrees of complexity yields relatively fewer samples from the regions of higher slopes. Hence, a distribution of these samples will exhibit a relatively lower representation of the function values from regions of higher complexity. When compared to even spaced sampling, a scheme that attempts to progressively equalize the histogram of the function values results in a higher concentration of samples in regions of higher complexity. This is a more efficient distri-bution of sample points, hence the term adaptive sampling. This conjecture is confirmed by numerous examples. Compared to existing adaptive sampling schemes, our approach has the unique ability to efficiently obtain expensive samples from a space with no prior knowledge of the relative levels of variation or complexity in the sampled function. This is a requirement in numerous scientific computing applications. Three models are employed to achieve the equalization in the distribution of sampled function values: (1) an active-walker model, containing elements of the random walk theory, and the motion of Brownian particles, (2) an ant model, based on the simulation of the behavior of ants in search of resources, and (3) an evolutionary algorithm model. Their performances are compared on objective basis such as entropy measure of information, and the Nyquist-Shannon minimum sampling rate for band-limited signals. The development of this adaptive sampling scheme was informed by a need to effi-ciently synthesize hyperspectral images used in place of real images. The performance of the adaptive sampling scheme as an aid to the image synthesis process is evaluated. The synthesized images are used in the development of a measure of clutter in hyperspectral images. This process is described, and the results are presented

Clearing the Clouds: Extracting 3D information from amongst the noise

Advancements permitting the rapid extraction of 3D point clouds from a variety of imaging modalities across the global landscape have provided a vast collection of high fidelity digital surface models. This has created a situation with unprecedented overabundance of 3D observations which greatly outstrips our current capacity to manage and infer actionable information. While years of research have removed some of the manual analysis burden for many tasks, human analysis is still a cornerstone of 3D scene exploitation. This is especially true for complex tasks which necessitate comprehension of scale, texture and contextual learning. In order to ameliorate the interpretation burden and enable scientific discovery from this volume of data, new processing paradigms are necessary to keep pace. With this context, this dissertation advances fundamental and applied research in 3D point cloud data pre-processing and deep learning from a variety of platforms. We show that the representation of 3D point data is often not ideal and sacrifices fidelity, context or scalability. First ground scanning terrestrial LIght Detection And Ranging (LiDAR) models are shown to have an inherent statistical bias, and present a state of the art method for correcting this, while preserving data fidelity and maintaining semantic structure. This technique is assessed in the dense canopy of Micronesia, with our technique being the best at retaining high levels of detail under extreme down-sampling (\u3c 1%). Airborne systems are then explored with a method which is presented to pre-process data to preserve a global contrast and semantic content in deep learners. This approach is validated with a building footprint detection task from airborne imagery captured in Eastern TN from the 3D Elevation Program (3DEP), our approach was found to achieve significant accuracy improvements over traditional techniques. Finally, topography data spanning the globe is used to assess past and previous global land cover change. Utilizing Shuttle Radar Topography Mission (SRTM) and Moderate Resolution Imaging Spectroradiometer (MODIS) data, paired with the airborne preprocessing technique described previously, a model for predicting land-cover change from topography observations is described. The culmination of these efforts have the potential to enhance the capabilities of automated 3D geospatial processing, substantially lightening the burden of analysts, with implications improving our responses to global security, disaster response, climate change, structural design and extraplanetary exploration

Cancer diagnosis using deep learning: A bibliographic review

In this paper, we first describe the basics of the field of cancer diagnosis, which includes steps of cancer diagnosis followed by the typical classification methods used by doctors, providing a historical idea of cancer classification techniques to the readers. These methods include Asymmetry, Border, Color and Diameter (ABCD) method, seven-point detection method, Menzies method, and pattern analysis. They are used regularly by doctors for cancer diagnosis, although they are not considered very efficient for obtaining better performance. Moreover, considering all types of audience, the basic evaluation criteria are also discussed. The criteria include the receiver operating characteristic curve (ROC curve), Area under the ROC curve (AUC), F1 score, accuracy, specificity, sensitivity, precision, dice-coefficient, average accuracy, and Jaccard index. Previously used methods are considered inefficient, asking for better and smarter methods for cancer diagnosis. Artificial intelligence and cancer diagnosis are gaining attention as a way to define better diagnostic tools. In particular, deep neural networks can be successfully used for intelligent image analysis. The basic framework of how this machine learning works on medical imaging is provided in this study, i.e., pre-processing, image segmentation and post-processing. The second part of this manuscript describes the different deep learning techniques, such as convolutional neural networks (CNNs), generative adversarial models (GANs), deep autoencoders (DANs), restricted Boltzmann’s machine (RBM), stacked autoencoders (SAE), convolutional autoencoders (CAE), recurrent neural networks (RNNs), long short-term memory (LTSM), multi-scale convolutional neural network (M-CNN), multi-instance learning convolutional neural network (MIL-CNN). For each technique, we provide Python codes, to allow interested readers to experiment with the cited algorithms on their own diagnostic problems. The third part of this manuscript compiles the successfully applied deep learning models for different types of cancers. Considering the length of the manuscript, we restrict ourselves to the discussion of breast cancer, lung cancer, brain cancer, and skin cancer. The purpose of this bibliographic review is to provide researchers opting to work in implementing deep learning and artificial neural networks for cancer diagnosis a knowledge from scratch of the state-of-the-art achievements

Breathing pattern characterization in patients with respiratory and cardiac failure

El objetivo principal de la tesis es estudiar los patrones respiratorios de pacientes en proceso de extubación y pacientes con insuficiencia cardiaca crónica (CHF), a partirde la señal de flujo respiratorio. La información obtenida de este estudio puede contribuir a la comprensión de los procesos fisiológicos subyacentes,y ayudar en el diagnóstico de estos pacientes. Uno de los problemas más desafiantes en unidades de cuidados intensivos es elproceso de desconexión de pacientes asistidos mediante ventilación mecánica. Más del 10% de pacientes que se extuban tienen que ser reintubados antes de 48 horas. Una prueba fallida puede ocasionar distrés cardiopulmonar y una mayor tasa de mortalidad. Se caracterizó el patrón respiratorio y la interacción dinámica entre la frecuenciacardiaca y frecuencia respiratoria, para obtener índices no invasivos que proporcionen una mayor información en el proceso de destete y mejorar el éxito de la desconexión.Las señales de flujo respiratorio y electrocardiográfica utilizadas en este estudio fueron obtenidas durante 30 minutos aplicando la prueba de tubo en T. Se compararon94 pacientes que tuvieron éxito en el proceso de extubación (GE), 39 pacientes que fracasaron en la prueba al mantener la respiración espontánea (GF), y 21 pacientes quesuperaron la prueba con éxito y fueron extubados, pero antes de 48 horas tuvieron que ser reintubados (GR). El patrón respiratorio se caracterizó a partir de las series temporales. Se aplicó la dinámica simbólica conjunta a las series correspondientes a las frecuencias cardiaca y respiratoria, para describir las interacciones cardiorrespiratoria de estos pacientes. Técnicas de "clustering", ecualización del histograma, clasificación mediante máquinasde soporte vectorial (SVM) y técnicas de validación permitieron seleccionar el conjunto de características más relevantes. Se propuso una nueva métrica B (índice de equilibrio) para la optimización de la clasificación con muestras desbalanceadas. Basado en este nuevo índice, aplicando SVM, se seleccionaron las mejores características que mantenían el mejor equilibrio entre sensibilidad y especificidad en todas las clasificaciones. El mejor resultado se obtuvo considerando conjuntamente la precisión y el valor de B, con una clasificación del 80% entre los grupos GE y GF, con 6 características. Clasificando GE vs. el resto de los pacientes, el mejor resultado se obtuvo con 9 características, con 81%. Clasificando GR vs. GE y GR vs. el resto de pacientes la precisión fue del 83% y 81% con 9 y 10 características, respectivamente. La tasa de mortalidad en pacientes con CHF es alta y la estratificación de estospacientes en función del riesgo es uno de los principales retos de la cardiología contemporánea. Estos pacientes a menudo desarrollan patrones de respiraciónperiódica (PB) incluyendo la respiración de Cheyne-Stokes (CSR) y respiración periódica sin apnea. La respiración periódica en estos pacientes se ha asociadocon una mayor mortalidad, especialmente en pacientes con CSR. Por lo tanto, el estudio de estos patrones respiratorios podría servir como un marcador de riesgo y proporcionar una mayor información sobre el estado fisiopatológico de pacientes con CHF. Se pretende identificar la condición de los pacientes con CHFde forma no invasiva mediante la caracterización y clasificación de patrones respiratorios con PBy respiración no periódica (nPB), y patrón de sujetos sanos, a partir registros de 15minutos de la señal de flujo respiratorio. Se caracterizó el patrón respiratorio mediante un estudio tiempo-frecuencia estacionario y no estacionario, de la envolvente de la señal de flujo respiratorio. Parámetros relacionados con la potencia espectral de la envolvente de la señal presentaron losmejores resultados en la clasificación de sujetos sanos y pacientes con CHF con CSR, PB y nPB. Las curvas ROC validan los resultados obtenidos. Se aplicó la "correntropy" para una caracterización tiempo-frecuencia mas completa del patrón respiratorio de pacientes con CHF. La "corretronpy" considera los momentos estadísticos de orden superior, siendo más robusta frente a los "outliers". Con la densidad espectral de correntropy (CSD) tanto la frecuencia de modulación como la dela respiración se representan en su posición real en el eje frecuencial. Los pacientes con PB y nPB, presentan diferentesgrados de periodicidad en función de su condición, mientras que los sujetos sanos no tienen periodicidad marcada. Con único parámetro se obtuvieron resultados del 88.9% clasificando pacientes PB vs. nPB, 95.2% para CHF vs. sanos, 94.4% para nPB vs. sanos.The main objective of this thesis is to study andcharacterize breathing patterns through the respiratory flow signal applied to patients on weaning trials from mechanicalventilation and patients with chronic heart failure (CHF). The aim is to contribute to theunderstanding of the underlying physiological processes and to help in the diagnosis of these patients. One of the most challenging problems in intensive care units is still the process ofdiscontinuing mechanical ventilation, as over 10% of patients who undergo successfulT-tube trials have to be reintubated in less than 48 hours. A failed weaning trial mayinduce cardiopulmonary distress and carries a higher mortality rate. We characterize therespiratory pattern and the dynamic interaction between heart rate and breathing rate toobtain noninvasive indices that provide enhanced information about the weaningprocess and improve the weaning outcome. This is achieved through a comparison of 94 patients with successful trials (GS), 39patients who fail to maintain spontaneous breathing (GF), and 21 patients who successfully maintain spontaneous breathing and are extubated, but require thereinstitution of mechanical ventilation in less than 48 hours because they are unable tobreathe (GR). The ECG and the respiratory flow signals used in this study were acquired during T-tube tests and last 30 minute. The respiratory pattern was characterized by means of a number of respiratory timeseries. Joint symbolic dynamics applied to time series of heart rate and respiratoryfrequency was used to describe the cardiorespiratory interactions of patients during theweaning trial process. Clustering, histogram equalization, support vector machines-based classification (SVM) and validation techniques enabled the selection of the bestsubset of input features. We defined a new optimization metric for unbalanced classification problems, andestablished a new SVM feature selection method, based on this balance index B. The proposed B-based SVM feature selection provided a better balance between sensitivityand specificity in all classifications. The best classification result was obtained with SVM feature selection based on bothaccuracy and the balance index, which classified GS and GFwith an accuracy of 80%, considering 6 features. Classifying GS versus the rest of patients, the best result wasobtained with 9 features, 81%, and the accuracy classifying GR versus GS, and GR versus the rest of the patients was 83% and 81% with 9 and 10 features, respectively.The mortality rate in CHF patients remains high and risk stratification in these patients isstill one of the major challenges of contemporary cardiology. Patients with CHF oftendevelop periodic breathing patterns including Cheyne-Stokes respiration (CSR) and periodic breathing without apnea. Periodic breathing in CHF patients is associated withincreased mortality, especially in CSR patients. Therefore it could serve as a risk markerand can provide enhanced information about thepathophysiological condition of CHF patients. The main goal of this research was to identify CHF patients' condition noninvasively bycharacterizing and classifying respiratory flow patterns from patients with PB and nPBand healthy subjects by using 15-minute long respiratory flow signals. The respiratory pattern was characterized by a stationary and a nonstationary time-frequency study through the envelope of the respiratory flow signal. Power-related parameters achieved the best results in all of the classifications involving healthy subjects and CHF patients with CSR, PB and nPB and the ROC curves validated theresults obtained for the identification of different respiratory patterns. We investigated the use of correntropy for the spectral characterization of respiratory patterns in CHF patients. The correntropy function accounts for higher-order moments and is robust to outliers. Due to the former property, the respiratory and modulationfrequencies appear at their actual locations along the frequency axis in the correntropy spectral density (CSD). The best results were achieved with correntropy and CSD-related parameters that characterized the power in the modulation and respiration discriminant bands, definedas a frequency interval centred on the modulation and respiration frequency peaks,respectively. All patients, i.e. both PB and nPB, exhibit various degrees of periodicitydepending on their condition, whereas healthy subjects have no pronounced periodicity.This fact led to excellent results classifying PB and nPB patients 88.9%, CHF versushealthy 95.2%, and nPB versus healthy 94.4% with only one parameter.Postprint (published version

Design of High-Speed Power-Efficient A/D Converters for Wireline ADC-Based Receiver Applications

Serial input/output (I/O) data rates are increasing in order to support the explosion in network traffic driven by big data applications such as the Internet of Things (IoT), cloud computing and etc. As the high-speed data symbol times shrink, this results in an increased amount of inter-symbol interference (ISI) for transmission over both severe low-pass electrical channels and dispersive optical channels. This necessitates increased equalization complexity and consideration of advanced modulation schemes, such as four-level pulse amplitude modulation (PAM-4). Serial links which utilize an analog-to-digital converter (ADC) receiver front-end offer a potential solution, as they enable more powerful and flexible digital signal processing (DSP) for equalization and symbol detection and can easily support advanced modulation schemes. Moreover, the DSP back-end provides robustness to process, voltage, and temperature (PVT) variations, benefits from improved area and power with CMOS technology scaling and offers easy design transfer between different technology nodes and thus improved time-to-market. However, ADC-based receivers generally consume higher power relative to their mixed-signal counterparts because of the significant power consumed by conventional multi-GS/s ADC implementations. This motivates exploration of energy-efficient ADC designs with moderate resolution and very high sampling rates to support data rates at or above 50Gb/s. This dissertation presents two power-efficient designs of ≥25GS/s time-interleaved ADCs for ADC-based wireline receivers. The first prototype includes the implementation of a 6b 25GS/s time-interleaved multi-bit search ADC in 65nm CMOS with a soft-decision selection algorithm that provides redundancy for relaxed track-and-hold (T/H) settling and improved metastability tolerance, achieving a figure-of-merit (FoM) of 143fJ/conversion step and 1.76pJ/bit for a PAM-4 receiver design. The second prototype features the design of a 52Gb/s PAM-4 ADC-based receiver in 65nm CMOS, where the front-end consists of a 4-stage continuous-time linear equalizer (CTLE)/variable gain amplifier (VGA) and a 6b 26GS/s time-interleaved SAR ADC with a comparator-assisted 2b/stage structure for reduced digital-to-analog converter (DAC) complexity and a 3-tap embedded feed-forward equalizer (FFE) for relaxed ADC resolution requirement. The receiver front-end achieves an efficiency of 4.53bJ/bit, while compensating for up to 31dB loss with DSP and no transmitter (TX) equalization

Recent trends, technical concepts and components of computer-assisted orthopedic surgery systems: A comprehensive review

Computer-assisted orthopedic surgery (CAOS) systems have become one of the most important and challenging types of system in clinical orthopedics, as they enable precise treatment of musculoskeletal diseases, employing modern clinical navigation systems and surgical tools. This paper brings a comprehensive review of recent trends and possibilities of CAOS systems. There are three types of the surgical planning systems, including: systems based on the volumetric images (computer tomography (CT), magnetic resonance imaging (MRI) or ultrasound images), further systems utilize either 2D or 3D fluoroscopic images, and the last one utilizes the kinetic information about the joints and morphological information about the target bones. This complex review is focused on three fundamental aspects of CAOS systems: their essential components, types of CAOS systems, and mechanical tools used in CAOS systems. In this review, we also outline the possibilities for using ultrasound computer-assisted orthopedic surgery (UCAOS) systems as an alternative to conventionally used CAOS systems.Web of Science1923art. no. 519

Intelligent Tools for Multitrack Frequency and Dynamics Processing

PhDThis research explores the possibility of reproducing mixing decisions of a skilled audio engineer with minimal human interaction that can improve the overall listening experience of musical mixtures, i.e., intelligent mixing. By producing a balanced mix automatically musician and mixing engineering can focus on their creativity while the productivity of music production is increased. We focus on the two essential aspects of such a system, frequency and dynamics. This thesis presents an intelligent strategy for multitrack frequency and dynamics processing that exploit the interdependence of input audio features, incorporates best practices in audio engineering, and driven by perceptual models and subjective criteria. The intelligent frequency processing research begins with a spectral characteristic analysis of commercial recordings, where we discover a consistent leaning towards a target equalization spectrum. A novel approach for automatically equalizing audio signals towards the observed target spectrum is then described and evaluated. We proceed to dynamics processing, and introduce an intelligent multitrack dynamic range compression algorithm, in which various audio features are proposed and validated to better describe the transient nature and spectral content of the signals. An experiment to investigate the human preference on dynamic processing is described to inform our choices of parameter automations. To provide a perceptual basis for the intelligent system, we evaluate existing perceptual models, and propose several masking metrics to quantify the masking behaviour within the multitrack mixture. Ultimately, we integrate previous research on auditory masking, frequency and dynamics processing, into one intelligent system of mix optimization that replicates the iterative process of human mixing. Within the system, we explore the relationship between equalization and dynamics processing, and propose a general frequency and dynamics processing framework. Various implementations of the intelligent system are explored and evaluated objectively and subjectively through listening experiments.China Scholarship Council

Speech Recognition

Chapters in the first part of the book cover all the essential speech processing techniques for building robust, automatic speech recognition systems: the representation for speech signals and the methods for speech-features extraction, acoustic and language modeling, efficient algorithms for searching the hypothesis space, and multimodal approaches to speech recognition. The last part of the book is devoted to other speech processing applications that can use the information from automatic speech recognition for speaker identification and tracking, for prosody modeling in emotion-detection systems and in other speech processing applications that are able to operate in real-world environments, like mobile communication services and smart homes