379 research outputs found

    Models of Neuronal Stimulus-Response Functions: Elaboration, Estimation, and Evaluation

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    Rich, dynamic, and dense sensory stimuli are encoded within the nervous system by the time-varying activity of many individual neurons. A fundamental approach to understanding the nature of the encoded representation is to characterize the function that relates the moment-by-moment firing of a neuron to the recent history of a complex sensory input. This review provides a unifying and critical survey of the techniques that have been brought to bear on this effort thus far—ranging from the classical linear receptive field model to modern approaches incorporating normalization and other nonlinearities. We address separately the structure of the models; the criteria and algorithms used to identify the model parameters; and the role of regularizing terms or “priors.” In each case we consider benefits or drawbacks of various proposals, providing examples for when these methods work and when they may fail. Emphasis is placed on key concepts rather than mathematical details, so as to make the discussion accessible to readers from outside the field. Finally, we review ways in which the agreement between an assumed model and the neuron's response may be quantified. Re-implemented and unified code for many of the methods are made freely available

    Image Restoration

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    This book represents a sample of recent contributions of researchers all around the world in the field of image restoration. The book consists of 15 chapters organized in three main sections (Theory, Applications, Interdisciplinarity). Topics cover some different aspects of the theory of image restoration, but this book is also an occasion to highlight some new topics of research related to the emergence of some original imaging devices. From this arise some real challenging problems related to image reconstruction/restoration that open the way to some new fundamental scientific questions closely related with the world we interact with

    Object Detection in High Resolution Aerial Images and Hyperspectral Remote Sensing Images

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    With rapid developments in satellite and sensor technologies, there has been a dramatic increase in the availability of remotely sensed images. However, the exploration of these images still involves a tremendous amount of human interventions, which are tedious, time-consuming, and inefficient. To help imaging experts gain a complete understanding of the images and locate the objects of interest in a more accurate and efficient way, there is always an urgent need for developing automatic detection algorithms. In this work, we delve into the object detection problems in remote sensing applications, exploring the detection algorithms for both hyperspectral images (HSIs) and high resolution aerial images. In the first part, we focus on the subpixel target detection problem in HSIs with low spatial resolutions, where the objects of interest are much smaller than the image pixel spatial resolution. To this end, we explore the detection frameworks that integrate image segmentation techniques in designing the matched filters (MFs). In particular, we propose a novel image segmentation algorithm to identify the spatial-spectral coherent image regions, from which the background statistics were estimated for deriving the MFs. Extensive experimental studies were carried out to demonstrate the advantages of the proposed subpixel target detection framework. Our studies show the superiority of the approach when comparing to state-of-the-art methods. The second part of the thesis explores the object based image analysis (OBIA) framework for geospatial object detection in high resolution aerial images. Specifically, we generate a tree representation of the aerial images from the output of hierarchical image segmentation algorithms and reformulate the object detection problem into a tree matching task. We then proposed two tree-matching algorithms for the object detection framework. We demonstrate the efficiency and effectiveness of the proposed tree-matching based object detection framework. In the third part, we study object detection in high resolution aerial images from a machine learning perspective. We investigate both traditional machine learning based framework and end-to-end convolutional neural network (CNN) based approach for various object detection tasks. In the traditional detection framework, we propose to apply the Gaussian process classifier (GPC) to train an object detector and demonstrate the advantages of the probabilistic classification algorithm. In the CNN based approach, we proposed a novel scale transfer module that generates enhanced feature maps for object detection. Our results show the efficiency and competitiveness of the proposed algorithms when compared to state-of-the-art counterparts

    Novel Aggregated Solutions for Robust Visual Tracking in TrafïŹc Scenarios

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    This work proposes novel approaches for object tracking in challenging scenarios like severe occlusion, deteriorated vision and long range multi-object reidentiïŹcation. All these solutions are only based on image sequence captured by a monocular camera and do not require additional sensors. Experiments on standard benchmarks demonstrate an improved state-of-the-art performance of these approaches. Since all the presented approaches are smartly designed, they can run at a real-time speed

    Computational approaches for improving treatment and prevention of viral infections

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    The treatment of infections with HIV or HCV is challenging. Thus, novel drugs and new computational approaches that support the selection of therapies are required. This work presents methods that support therapy selection as well as methods that advance novel antiviral treatments. geno2pheno[ngs-freq] identifies drug resistance from HIV-1 or HCV samples that were subjected to next-generation sequencing by interpreting their sequences either via support vector machines or a rules-based approach. geno2pheno[coreceptor-hiv2] determines the coreceptor that is used for viral cell entry by analyzing a segment of the HIV-2 surface protein with a support vector machine. openPrimeR is capable of finding optimal combinations of primers for multiplex polymerase chain reaction by solving a set cover problem and accessing a new logistic regression model for determining amplification events arising from polymerase chain reaction. geno2pheno[ngs-freq] and geno2pheno[coreceptor-hiv2] enable the personalization of antiviral treatments and support clinical decision making. The application of openPrimeR on human immunoglobulin sequences has resulted in novel primer sets that improve the isolation of broadly neutralizing antibodies against HIV-1. The methods that were developed in this work thus constitute important contributions towards improving the prevention and treatment of viral infectious diseases.Die Behandlung von HIV- oder HCV-Infektionen ist herausfordernd. Daher werden neue Wirkstoffe, sowie neue computerbasierte Verfahren benötigt, welche die Therapie verbessern. In dieser Arbeit wurden Methoden zur UnterstĂŒtzung der Therapieauswahl entwickelt, aber auch solche, welche neuartige Therapien vorantreiben. geno2pheno[ngs-freq] bestimmt, ob Resistenzen gegen Medikamente vorliegen, indem es Hochdurchsatzsequenzierungsdaten von HIV-1 oder HCV Proben mittels Support Vector Machines oder einem regelbasierten Ansatz interpretiert. geno2pheno[coreceptor-hiv2] bestimmt den HIV-2 Korezeptorgebrauch dadurch, dass es einen Abschnitt des viralen OberflĂ€chenproteins mit einer Support Vector Machine analysiert. openPrimeR kann optimale Kombinationen von Primern fĂŒr die Multiplex-Polymerasekettenreaktion finden, indem es ein MengenĂŒberdeckungsproblem löst und auf ein neues logistisches Regressionsmodell fĂŒr die Vorhersage von Amplifizierungsereignissen zurĂŒckgreift. geno2pheno[ngs-freq] und geno2pheno[coreceptor-hiv2] ermöglichen die Personalisierung antiviraler Therapien und unterstĂŒtzen die klinische Entscheidungsfindung. Durch den Einsatz von openPrimeR auf humanen Immunoglobulinsequenzen konnten PrimersĂ€tze generiert werden, welche die Isolierung von breit neutralisierenden Antikörpern gegen HIV-1 verbessern. Die in dieser Arbeit entwickelten Methoden leisten somit einen wichtigen Beitrag zur Verbesserung der PrĂ€vention und Therapie viraler Infektionskrankheiten

    Signal and data processing for machine olfaction and chemical sensing: A review

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    Signal and data processing are essential elements in electronic noses as well as in most chemical sensing instruments. The multivariate responses obtained by chemical sensor arrays require signal and data processing to carry out the fundamental tasks of odor identification (classification), concentration estimation (regression), and grouping of similar odors (clustering). In the last decade, important advances have shown that proper processing can improve the robustness of the instruments against diverse perturbations, namely, environmental variables, background changes, drift, etc. This article reviews the advances made in recent years in signal and data processing for machine olfaction and chemical sensing

    Data Mining

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    The availability of big data due to computerization and automation has generated an urgent need for new techniques to analyze and convert big data into useful information and knowledge. Data mining is a promising and leading-edge technology for mining large volumes of data, looking for hidden information, and aiding knowledge discovery. It can be used for characterization, classification, discrimination, anomaly detection, association, clustering, trend or evolution prediction, and much more in fields such as science, medicine, economics, engineering, computers, and even business analytics. This book presents basic concepts, ideas, and research in data mining

    Brain Computer Interfaces and Emotional Involvement: Theory, Research, and Applications

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    This reprint is dedicated to the study of brain activity related to emotional and attentional involvement as measured by Brain–computer interface (BCI) systems designed for different purposes. A BCI system can translate brain signals (e.g., electric or hemodynamic brain activity indicators) into a command to execute an action in the BCI application (e.g., a wheelchair, the cursor on the screen, a spelling device or a game). These tools have the advantage of having real-time access to the ongoing brain activity of the individual, which can provide insight into the user’s emotional and attentional states by training a classification algorithm to recognize mental states. The success of BCI systems in contemporary neuroscientific research relies on the fact that they allow one to “think outside the lab”. The integration of technological solutions, artificial intelligence and cognitive science allowed and will allow researchers to envision more and more applications for the future. The clinical and everyday uses are described with the aim to invite readers to open their minds to imagine potential further developments
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