2,023 research outputs found

    Architectures and dynamic bandwidth allocation algorithms for next generation optical access networks

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    Bioinspired robotic rehabilitation tool for lower limb motor learning after stroke

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    Mención Internacional en el título de doctorEsta tesis doctoral presenta, tras repasar la marcha humana, las principales patologíıas y condiciones que la afectan, y los distintos enfoques de rehabilitación con la correspondiente implicación neurofisiológica, el camino de investigación que desemboca en la herramienta robótica de rehabilitación y las terapias que se han desarrollado en el marco de los proyectos europeos BioMot: Smart Wearable Robots with Bioinspired Sensory-Motor Skills y HANK: European advanced exoskeleton for rehabilitation of Acquired Brain Damage (ABD) and/or spinal cord injury’s patients, y probado bajo el paraguas del proyecto europeo ASTONISH: Advancing Smart Optical Imaging and Sensing for Health y el proyecto nacional ASSOCIATE: A comprehensive and wearable robotics based approach to the rehabilitation and assistance to people with stroke and spinal cord injury.This doctoral thesis presents, after reviewing human gait, the main pathologies and conditions that affect it, and the different rehabilitation approaches with the corresponding neurophysiological implications, the research journey that leads to the development of the rehabilitation robotic tool, and the therapies that have been designed, within the framework of the European projects BioMot: Smart Wearable Robots with Bioinspired Sensory-Motor Skills and HANK: European advanced exoskeleton for rehabilitation of Acquired Brain Damage (ABD) and/or spinal cord injury’s patients and tested under the umbrella of the European project ASTONISH: Advancing Smart Optical Imaging and Sensing for Health and the national project ASSOCIATE: A comprehensive and wearable robotics based approach to the rehabilitation and assistance to people with stroke and spinal cord injury.This work has been carried out at the Neural Rehabilitation Group (NRG), Cajal Institute, Spanish National Research Council (CSIC). The research presented in this thesis has been funded by the Commission of the European Union under the BioMot project - Smart Wearable Robots with Bioinspired Sensory-Motor Skills (Grant Agreement number IFP7-ICT - 611695); under HANK Project - European advanced exoskeleton for rehabilitation of Acquired Brain Damage (ABD) and/or spinal cord injury’s patients (Grant Agreements number H2020-EU.2. - PRIORITY ’Industrial leadership’ and H2020-EU.3. - PRIORITY ’Societal challenges’ - 699796); also under the ASTONISH Project - Advancing Smart Optical Imaging and Sensing for Health (Grant Agreement number H2020-EU.2.1.1.7. - ECSEL - 692470); with financial support of Spanish Ministry of Economy and Competitiveness (MINECO) under the ASSOCIATE project - A comprehensive and wearable robotics based approach to the rehabilitation and assistance to people with stroke and spinal cord injury (Grant Agreement number 799158449-58449-45-514); and with grant RYC-2014-16613, also by Spanish Ministry of Economy and Competitiveness.Programa de Doctorado en Ingeniería Eléctrica, Electrónica y Automática por la Universidad Carlos III de MadridPresidente: Fernando Javier Brunetti Fernández.- Secretario: Dorin Sabin Copaci.- Vocal: Antonio Olivier

    WDM/TDM PON bidirectional networks single-fiber/wavelength RSOA-based ONUs layer 1/2 optimization

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    This Thesis proposes the design and the optimization of a hybrid WDM/TDM PON at the L1 (PHY) and L2 (MAC) layers, in terms of minimum deployment cost and enhanced performance for Greenfield NGPON. The particular case of RSOA-based ONUs and ODN using a single-fibre/single-wavelength is deeply analysed. In this WDM/TDM PON relevant parameters are optimized. Special attention has been given at the main noise impairment in this type of networks: the Rayleigh Backscattering effect, which cannot be prevented. To understand its behaviour and mitigate its effects, a novel mathematical model for the Rayleigh Backscattering in burst mode transmission is presented for the first time, and it has been used to optimize the WDM/TDM RSOA based PON. Also, a cost-effective, simple design SCM WDM/TDM PON with rSOA-based ONU, was optimized and implemented. This prototype was successfully tested showing high performance, robustness, versatility and reliability. So, the system is able to give coverage up to 1280 users at 2.5 Gb/s / 1.25 Gb/s downstream/upstream, over 20 Km, and being compatible with the GPON ITU-T recommendation. This precedent has enabled the SARDANA network to extend the design, architecture and capabilities of a WDM/TDM PON for a long reach metro-access network (100 km). A proposal for an agile Transmission Convergence sub-layer is presented as another relevant contribution of this work. It is based on the optimization of the standards GPON and XG-PON (for compatibility), but applied to a long reach metro-access TDM/WDM PON rSOA-based network with higher client count. Finally, a proposal of physical implementation for the SARDANA layer 2 and possible configurations for SARDANA internetworking, with the metro network and core transport network, are presented

    Integrated control platform for converged optical and wireless networks

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    Simulations of recoiling black holes: adaptive mesh refinement and radiative transfer

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    (Abridged) We here continue our effort to model the behaviour of matter when orbiting or accreting onto a generic black hole by developing a new numerical code employing advanced techniques geared solve the equations of in general-relativistic hydrodynamics. The new code employs a number of high-resolution shock-capturing Riemann-solvers and reconstruction algorithms, exploiting the enhanced accuracy and the reduced computational cost of AMR techniques. In addition, the code makes use of sophisticated ray-tracing libraries that, coupled with general-relativistic radiation-transfer calculations, allow us to compute accurately the electromagnetic emissions from such accretion flows. We validate the new code by presenting an extensive series of stationary accretion flows either in spherical or axial symmetry and performed either in 2D or 3D. In addition, we consider the highly nonlinear scenario of a recoiling black hole produced in the merger of a supermassive black hole binary interacting with the surrounding circumbinary disc. In this way we can present, for the first time, ray-traced images of the shocked fluid and the light-curve resulting from consistent general-relativistic radiation-transport calculations from this process. The work presented here lays the ground for the development of a generic computational infrastructure employing AMR techniques to deal accurately and self-consistently with accretion flows onto compact objects. In addition to the accurate handling of the matter, we provide a self-consistent electromagnetic emission from these scenarios by solving the associated radiative-transfer problem. While magnetic fields are presently excluded from our analysis, the tools presented here can have a number of applications to study accretion flows onto black holes or neutron stars.Comment: 20 pages, 20 figures, accepted for publication in A&

    Numerically exact, time-dependent treatment of vibrationally coupled electron transport in single-molecule junctions

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    The multilayer multiconfiguration time-dependent Hartree (ML-MCTDH) theory within second quantization representation of the Fock space, a novel numerically exact methodology to treat many-body quantum dynamics for systems containing identical particles, is applied to study the effect of vibrational motion on electron transport in a generic model for single-molecule junctions. The results demonstrate the importance of electronic-vibrational coupling for the transport characteristics. For situations where the energy of the bridge state is located close to the Fermi energy, the simulations show the time-dependent formation of a polaron state that results in a pronounced suppression of the current corresponding to the phenomenon of phonon blockade. We show that this phenomenon cannot be explained solely by the polaron shift of the energy but requires methods that incorporate the dynamical effect of the vibrations on the transport. The accurate results obtained with the ML-MCTDH in this parameter regime are compared to results of nonequilibrium Green's function (NEGF) theory.Comment: 39 pages, 11 figure

    In vivo SPECT/CT molecular imaging of LFA-1 in atherosclerotic inflammatory development with radiolabeled DANBIRT

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    The objective of this thesis project is to assess inflammatory leukocyte presence and accumulation in vascular atherosclerotic plaque using [111In] In-DANBIRT as a non-invasive diagnostic imaging tool. ApoE-/-mice were fed either normal or high fat diet (HFD) for 8 weeks. Sprague Dawley male rats were exposed to filtered air and ozone for 4 hours. SPECT/CT imaging was performed at baseline, 4 and 8 weeks. 3D autoradiography was performed after 8 weeks. Leukocyte isolation methods were performed for neutrophil and peripheral blood mononuclear cell (PBMC) separations post-incubation with [68Ga] Ga-DANBIRT and [111In] In-DANBIRT. Whole blood isolation correlated these findings showing increased specific uptake by neutrophils in the ozone-exposed group. Radioisotopic dilution methods evidence a saturation of binding sites in isolated neutrophil samples starting at a 10-fold dilution from initial concentration of [111In] In-DANBIRT. Longitudinal molecular imaging evidenced an increased uptake in HFD fed mice, consistent with increased immune response to vascular injury in cardiovascular and immune tissues. Histologic analysis illustrated atherosclerotic plaque disease progression and increased vascular lesion area in HFD fed mice

    Directly Phase Modulated Transmitters and Coherent Recivers for Future Passive Optical Networks (PON)

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    En los últimos años, el tráfico de dato transmitido en las redes ópticas de acceso ha crecido exponencialmente debido a nuevos servicios como pueden ser la computación en la nube, el video online, la realidad virtual y aumentada, el internet de las cosas (IoT) y la convergencia entre las redes ópticas y redes inalámbricas en el paradigma del 5G. Estos nuevos servicios endurecen los requerimientos de las redes ópticas de acceso, como pueden ser unas tasas de datos más altas, un mayor alcance y un mayor número de usuarios. Para abordar estos requerimientos, esta tesis ha investigado, desarrollado y analizado nuevas tecnologías para transmisores y receptores orientadas a los dos tipos de redes ópticas de acceso que la comunidad científica ha identificado como posibles candidatas. Estos dos tipos de redes ópticas son las redes uDWDM y las redes TWDM como las redes NG-PON2 y sus evoluciones.Las redes uDWDM están basadas en la transmisión de tasas de datos relativamente bajas, por debajo de 2.5 Gbps, que son dedicadas en su totalidad a los usuarios finales. Estas tasas de datos relativamente bajas son multiplexadas en longitud de onda usando intervalos frecuenciales estrechos, del orden de 12.5 GHz o 6.25 GHz. En esta tesis, los transmisores modulados directamente en fase se han propuesto como posibles candidatos para estas redes uDWDM. En concreto, se han propuesto un DFB modulado directamente en fase con una tasa de datos de 1 Gbps; un RSOA bombeado por un VCSEL y modulado directamente en fase con una tasa de datos de 1 Gbps; y un VCSEL modulado directamente en fase con una tasa de datos de 1.25 Gbps y 2.5 Gbps. Estas señales moduladas directamente en fase son recibidas con un receptor heterodino con un único fotodiodo (PD) para mantener el coste tan bajo como sea posible. La combinación de estos transmisores modulados directamente en fase con el receptor heterodino con un único PD ha sido probada como unos candidatos muy prometedores para las redes ópticas de acceso basadas en redes uDWDM. Estas combinaciones proveen sensibilidades que varían entre -39.5 dBm y -52 dBm, que se traducen en balances de potencia que van desde 38.5 dB a 51 dB y por lo tanto en ratios de división o número de usuarios de entre 128 y 1024 después de una transmisión de 50 km a través de fibra monomodo estándar (SSMF).Además, los links de 1 Gbps formados por la modulación directa de DFBs o de RSOAs bombeados por VCSELs y el receptor heterodino con un único PD son usados como enlace de subida en canales bidireccionales. Estos enlaces de subida son combinados con enlaces de bajada basados en Nyquist-DPSK generada con un MZM y recibidos con un receptor heterodino de un único PD. Como parte de análisis de los canales bidireccionales, se ha analizado el estudio de la viabilidad del uso de LOs de bajo coste, como DFBs o VCSELs, en los receptores heterodinos con un único PD. Estos canales bidireccionales son también unos candidatos prometedores para las futuras redes uDWDM, ya que en esta tesis se ha probado que pueden proveer enlaces full-duplex de 1 Gbps usando intervalos frecuenciales tan pequeños como 6.25 GHz o 5 GHz. Estos canales bidireccionales tienen balances de potencia que van desde 37 dB a 42 dB y tienen posibles ratios de división de 128 o 256 después de una transmisión de 50 km a través de SSMF.Esta tesis también ha investigado y desarrollado receptores quasicoherentes para redes NG-PON2 y sus evoluciones. Este tipo de redes están basadas en altas tasas de datos, como 10 Gbps para redes NG-PON2 y 25 Gbps para las futuras evoluciones de NG-PON2, en entornos multi longitud de onda donde los usuarios son multiplexados en tiempo y longitud de onda (TWDM). El receptor quasicoherente usa la amplificación coherente gracias a la recepción heterodina y por tanto la sensibilidad del receptor es mejorada en comparación con los esquemas de detección directa. El receptor quasicoherente es independiente a la polarización, lo cual es una característica importante para los receptores coherentes. Además, el receptor quasicoherente permite seleccionar el canal de trabajo sin la necesidad de filtros ópticos y es un receptor independiente de la longitud de onda debido a que el canal de trabajo se puede elegir ajustando la longitud de onda del LO. El receptor quasicoherente de 10 Gbps muestra una sensibilidad -35.2 dBm y por tanto permite un balance de potencias de 35.64 dB y un ratio de división de 128 después de una transmisión de 40 km a través de SSMF.La combinación del receptor quasicoherente con un ecualizador FFE/DFE permite combatir la dispersión cromática de la banda C y conseguir un link de 25 Gbps con un alcance de 20 km a través de SSMF. El receptor quasicoherente a 25 Gbps con ecualización FFE/DFE muestra una mejor sensibilidad de -30.5 dBm con el llamado ecualizador de altas prestaciones, lo que lleva a un balance de potencias de25 dB. Si se utilizada el llamado ecualizador de baja complejidad, la sensibilidad cae a -27 dBm y el balance de potencias cae a 23 dBm. En ambos casos, el receptor quasicoherente a 25 Gbps con ecualización FFE/DFE permite un ratio de división de 32 después de una transmisión de 20 km a través de SSMF.En conclusión, esta tesis ha presentado transmisores (DFB, RSOA y VCSEL) modulados directamente en fase combinados con un receptor heterodino con un único PD como potenciales candidatos para las redes uDWDM. Esta tesis también ha presentados los receptores quasicoherentes como unos candidatos muy prometedores para las redes NG-PON2 y sus futuras evoluciones.<br /

    Modern day monitoring and control challenges outlined on an industrial-scale benchmark fermentation process

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    This paper outlines real-world control challenges faced by modern-day biopharmaceutical facilities through the extension of a previously developed industrial-scale penicillin fermentation simulation (IndPenSim). The extensions include the addition of a simulated Raman spectroscopy device for the purpose of developing, evaluating and implementation of advanced and innovative control solutions applicable to biotechnology facilities. IndPenSim can be operated in fixed or operator controlled mode and generates all the available on-line, off-line and Raman spectra for each batch. The capabilities of IndPenSim were initially demonstrated through the implementation of a QbD methodology utilising the three stages of the PAT framework. Furthermore, IndPenSim evaluated a fault detection algorithm to detect process faults occurring on different batches recorded throughout a yearly campaign. The simulator and all data presented here are available to download at www.industrialpenicillinsimulation.com and acts as a benchmark for researchers to analyse, improve and optimise the current control strategy implemented on this facility. Additionally, a highly valuable data resource containing 100 batches with all available process and Raman spectroscopy measurements is freely available to download. This data is highly suitable for the development of big data analytics, machine learning (ML) or artificial intelligence (AI) algorithms applicable to the biopharmaceutical industry
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