32,870 research outputs found

    FORGE: An eLearning Framework for Remote Laboratory Experimentation on FIRE Testbed Infrastructure

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    The Forging Online Education through FIRE (FORGE) initiative provides educators and learners in higher education with access to world-class FIRE testbed infrastructure. FORGE supports experimentally driven research in an eLearning environment by complementing traditional classroom and online courses with interactive remote laboratory experiments. The project has achieved its objectives by defining and implementing a framework called FORGEBox. This framework offers the methodology, environment, tools and resources to support the creation of HTML-based online educational material capable accessing virtualized and physical FIRE testbed infrastruc- ture easily. FORGEBox also captures valuable quantitative and qualitative learning analytic information using questionnaires and Learning Analytics that can help optimise and support student learning. To date, FORGE has produced courses covering a wide range of networking and communication domains. These are freely available from FORGEBox.eu and have resulted in over 24,000 experiments undertaken by more than 1,800 students across 10 countries worldwide. This work has shown that the use of remote high- performance testbed facilities for hands-on remote experimentation can have a valuable impact on the learning experience for both educators and learners. Additionally, certain challenges in developing FIRE-based courseware have been identified, which has led to a set of recommendations in order to support the use of FIRE facilities for teaching and learning purposes

    From Social Simulation to Integrative System Design

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    As the recent financial crisis showed, today there is a strong need to gain "ecological perspective" of all relevant interactions in socio-economic-techno-environmental systems. For this, we suggested to set-up a network of Centers for integrative systems design, which shall be able to run all potentially relevant scenarios, identify causality chains, explore feedback and cascading effects for a number of model variants, and determine the reliability of their implications (given the validity of the underlying models). They will be able to detect possible negative side effect of policy decisions, before they occur. The Centers belonging to this network of Integrative Systems Design Centers would be focused on a particular field, but they would be part of an attempt to eventually cover all relevant areas of society and economy and integrate them within a "Living Earth Simulator". The results of all research activities of such Centers would be turned into informative input for political Decision Arenas. For example, Crisis Observatories (for financial instabilities, shortages of resources, environmental change, conflict, spreading of diseases, etc.) would be connected with such Decision Arenas for the purpose of visualization, in order to make complex interdependencies understandable to scientists, decision-makers, and the general public.Comment: 34 pages, Visioneer White Paper, see http://www.visioneer.ethz.c

    The Boston University Photonics Center annual report 2013-2014

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    This repository item contains an annual report that summarizes activities of the Boston University Photonics Center in the 2013-2014 academic year. The report provides quantitative and descriptive information regarding photonics programs in education, interdisciplinary research, business innovation, and technology development. The Boston University Photonics Center (BUPC) is an interdisciplinary hub for education, research, scholarship, innovation, and technology development associated with practical uses of light.This annual report summarizes activities of the Boston University Photonics Center in the 2013–2014 academic year.This has been a good year for the Photonics Center. In the following pages, you will see that the center’s faculty received prodigious honors and awards, generated more than 100 notable scholarly publications in the leading journals in our field, and attracted 14.5Minnewresearchgrantsandcontractsthisyear.Facultyandstaffalsoexpandedtheireffortsineducationandtraining,throughNationalScienceFoundationsponsoredsitesforResearchExperiencesforUndergraduatesandforTeachers.Asacommunity,wehostedacompellingseriesofdistinguishedinvitedspeakers,andemphasizedthethemeofInnovationsattheIntersectionsofMicro/NanofabricationTechnology,Biology,andBiomedicineatourannualFutureofLightSymposium.Wetookaleadershiproleinrunningnationalworkshopsonemergingphotonicfields,includinganOSAIncubatoronControlledLightPropagationthroughComplexMedia,andanNSFWorkshoponNoninvasiveImagingofBrainFunction.HighlightsofourresearchachievementsfortheyearincludeadistinctivePresidentialEarlyCareerAwardforScientistsandEngineers(PECASE)forAssistantProfessorXueHan,anambitiousnewDoDsponsoredgrantforMultiScaleMultiDisciplinaryModelingofElectronicMaterialsledbyProfessorEnricoBellotti,launchofourNIHsponsoredCenterforInnovationinPointofCareTechnologiesfortheFutureofCancerCareledbyProfessorCathyKlapperich,andsuccessfulcompletionoftheambitiousIARPAfundedcontractforNextGenerationSolidImmersionMicroscopyforFaultIsolationinBackSideCircuitAnalysisledbyProfessorBennettGoldberg.Thesethreeprograms,whichrepresentmorethan14.5M in new research grants and contracts this year. Faculty and staff also expanded their efforts in education and training, through National Science Foundation–sponsored sites for Research Experiences for Undergraduates and for Teachers. As a community, we hosted a compelling series of distinguished invited speakers, and emphasized the theme of Innovations at the Intersections of Micro/Nanofabrication Technology, Biology, and Biomedicine at our annual Future of Light Symposium. We took a leadership role in running national workshops on emerging photonic fields, including an OSA Incubator on Controlled Light Propagation through Complex Media, and an NSF Workshop on Noninvasive Imaging of Brain Function. Highlights of our research achievements for the year include a distinctive Presidential Early Career Award for Scientists and Engineers (PECASE) for Assistant Professor Xue Han, an ambitious new DoD-sponsored grant for Multi-Scale Multi-Disciplinary Modeling of Electronic Materials led by Professor Enrico Bellotti, launch of our NIH-sponsored Center for Innovation in Point of Care Technologies for the Future of Cancer Care led by Professor Cathy Klapperich, and successful completion of the ambitious IARPA-funded contract for Next Generation Solid Immersion Microscopy for Fault Isolation in Back-Side Circuit Analysis led by Professor Bennett Goldberg. These three programs, which represent more than 20M in research funding for the University, are indicative of the breadth of Photonics Center research interests: from fundamental modeling of optoelectronic materials to practical development of cancer diagnostics, from exciting new discoveries in optogenetics for understanding brain function to the achievement of world-record resolution in semiconductor circuit microscopy. Our community welcomed an auspicious cohort of new faculty members, including a newly hired assistant professor and a newly hired professor (and Chair of the Mechanical Engineering Department). The Industry/University Cooperative Research Center—the centerpiece of our translational biophotonics program—continues to focus on advancing the health care and medical device industries, and has entered its fourth year of operation with a strong record of achievement and with the support of an enthusiastic industrial membership base

    Toward a Standardized Strategy of Clinical Metabolomics for the Advancement of Precision Medicine

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    Despite the tremendous success, pitfalls have been observed in every step of a clinical metabolomics workflow, which impedes the internal validity of the study. Furthermore, the demand for logistics, instrumentations, and computational resources for metabolic phenotyping studies has far exceeded our expectations. In this conceptual review, we will cover inclusive barriers of a metabolomics-based clinical study and suggest potential solutions in the hope of enhancing study robustness, usability, and transferability. The importance of quality assurance and quality control procedures is discussed, followed by a practical rule containing five phases, including two additional "pre-pre-" and "post-post-" analytical steps. Besides, we will elucidate the potential involvement of machine learning and demonstrate that the need for automated data mining algorithms to improve the quality of future research is undeniable. Consequently, we propose a comprehensive metabolomics framework, along with an appropriate checklist refined from current guidelines and our previously published assessment, in the attempt to accurately translate achievements in metabolomics into clinical and epidemiological research. Furthermore, the integration of multifaceted multi-omics approaches with metabolomics as the pillar member is in urgent need. When combining with other social or nutritional factors, we can gather complete omics profiles for a particular disease. Our discussion reflects the current obstacles and potential solutions toward the progressing trend of utilizing metabolomics in clinical research to create the next-generation healthcare system.11Ysciescopu

    The Boston University Photonics Center annual report 2013-2014

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    This repository item contains an annual report that summarizes activities of the Boston University Photonics Center in the 2013-2014 academic year. The report provides quantitative and descriptive information regarding photonics programs in education, interdisciplinary research, business innovation, and technology development. The Boston University Photonics Center (BUPC) is an interdisciplinary hub for education, research, scholarship, innovation, and technology development associated with practical uses of light.This annual report summarizes activities of the Boston University Photonics Center in the 2013–2014 academic year.This has been a good year for the Photonics Center. In the following pages, you will see that the center’s faculty received prodigious honors and awards, generated more than 100 notable scholarly publications in the leading journals in our field, and attracted 14.5Minnewresearchgrantsandcontractsthisyear.Facultyandstaffalsoexpandedtheireffortsineducationandtraining,throughNationalScienceFoundationsponsoredsitesforResearchExperiencesforUndergraduatesandforTeachers.Asacommunity,wehostedacompellingseriesofdistinguishedinvitedspeakers,andemphasizedthethemeofInnovationsattheIntersectionsofMicro/NanofabricationTechnology,Biology,andBiomedicineatourannualFutureofLightSymposium.Wetookaleadershiproleinrunningnationalworkshopsonemergingphotonicfields,includinganOSAIncubatoronControlledLightPropagationthroughComplexMedia,andanNSFWorkshoponNoninvasiveImagingofBrainFunction.HighlightsofourresearchachievementsfortheyearincludeadistinctivePresidentialEarlyCareerAwardforScientistsandEngineers(PECASE)forAssistantProfessorXueHan,anambitiousnewDoDsponsoredgrantforMultiScaleMultiDisciplinaryModelingofElectronicMaterialsledbyProfessorEnricoBellotti,launchofourNIHsponsoredCenterforInnovationinPointofCareTechnologiesfortheFutureofCancerCareledbyProfessorCathyKlapperich,andsuccessfulcompletionoftheambitiousIARPAfundedcontractforNextGenerationSolidImmersionMicroscopyforFaultIsolationinBackSideCircuitAnalysisledbyProfessorBennettGoldberg.Thesethreeprograms,whichrepresentmorethan14.5M in new research grants and contracts this year. Faculty and staff also expanded their efforts in education and training, through National Science Foundation–sponsored sites for Research Experiences for Undergraduates and for Teachers. As a community, we hosted a compelling series of distinguished invited speakers, and emphasized the theme of Innovations at the Intersections of Micro/Nanofabrication Technology, Biology, and Biomedicine at our annual Future of Light Symposium. We took a leadership role in running national workshops on emerging photonic fields, including an OSA Incubator on Controlled Light Propagation through Complex Media, and an NSF Workshop on Noninvasive Imaging of Brain Function. Highlights of our research achievements for the year include a distinctive Presidential Early Career Award for Scientists and Engineers (PECASE) for Assistant Professor Xue Han, an ambitious new DoD-sponsored grant for Multi-Scale Multi-Disciplinary Modeling of Electronic Materials led by Professor Enrico Bellotti, launch of our NIH-sponsored Center for Innovation in Point of Care Technologies for the Future of Cancer Care led by Professor Cathy Klapperich, and successful completion of the ambitious IARPA-funded contract for Next Generation Solid Immersion Microscopy for Fault Isolation in Back-Side Circuit Analysis led by Professor Bennett Goldberg. These three programs, which represent more than 20M in research funding for the University, are indicative of the breadth of Photonics Center research interests: from fundamental modeling of optoelectronic materials to practical development of cancer diagnostics, from exciting new discoveries in optogenetics for understanding brain function to the achievement of world-record resolution in semiconductor circuit microscopy. Our community welcomed an auspicious cohort of new faculty members, including a newly hired assistant professor and a newly hired professor (and Chair of the Mechanical Engineering Department). The Industry/University Cooperative Research Center—the centerpiece of our translational biophotonics program—continues to focus on advancing the health care and medical device industries, and has entered its fourth year of operation with a strong record of achievement and with the support of an enthusiastic industrial membership base

    Implementation of Systems Engineering Approach in Academic Projects: Software Defined Radio Technology Development as a Case Study

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    Each year, federal and private agencies spend billions of dollars on research projects that academic institutions conduct for them. However, the communication language between these agencies as clients and academia as hosts, is not very efficient and well-established. This has resulted in lack of clarity in clients’ description of what exactly to be expected and in hosts’ description of their capabilities and challenges. In addition, many of these projects are essentially interdisciplinary and demand the involvement of diverse research teams from different university departments. Lack of cohesive collaboration among these diverse teams results in mismatches between different compartments of project output, and consequently, generation of superfluous product prototypes. Finally, for their real-time tracking and later retrieval, the current situation of documentation of academic projects needs to be significantly altered. We suggest that the presence of a systems engineering team should be an indispensable part of a large academic research project, in order to monitor and manage the various aspects and phases from initiation to completion.For this purpose, we proposed a systems engineering model specific for academic research projects, which considers both strengths and challenges of universities as host research institutes. As a case study, we applied this proposed systems engineering approach on a NASA-funded project at Morgan State University (MSU) which was about design and implementation of software defined radio (SDR) for space exploration. Application of this model significantly improved the professional dialogue and technical clarifications between NASA and MSU partners, as well as within MSU teams. Moreover, the sub-system compatibility among different modules of the implemented product was notably enhanced. Overall, application of systems engineering approach in academic projects can result in mutual benefits for the institution and either federal or private client
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