Applications of Artificial Intelligence in Battling Against Covid-19: A Literature Review

© 2020 Elsevier Ltd. All rights reserved.Colloquially known as coronavirus, the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), that causes CoronaVirus Disease 2019 (COVID-19), has become a matter of grave concern for every country around the world. The rapid growth of the pandemic has wreaked havoc and prompted the need for immediate reactions to curb the effects. To manage the problems, many research in a variety of area of science have started studying the issue. Artificial Intelligence is among the area of science that has found great applications in tackling the problem in many aspects. Here, we perform an overview on the applications of AI in a variety of fields including diagnosis of the disease via different types of tests and symptoms, monitoring patients, identifying severity of a patient, processing covid-19 related imaging tests, epidemiology, pharmaceutical studies, etc. The aim of this paper is to perform a comprehensive survey on the applications of AI in battling against the difficulties the outbreak has caused. Thus we cover every way that AI approaches have been employed and to cover all the research until the writing of this paper. We try organize the works in a way that overall picture is comprehensible. Such a picture, although full of details, is very helpful in understand where AI sits in current pandemonium. We also tried to conclude the paper with ideas on how the problems can be tackled in a better way and provide some suggestions for future works.Peer reviewe

Exploring the Impact of Different Potential Update Rules on the Performance of Spiking Neural Networks

Yüksek Lisans Bitirme TeziSon yıllarda, spiking sinir ağlar (SNN'ler), gerçek nöronların faaliyetini taklit edebilme yetenekleri nedeniyle popülerlik kazanmış ve geniş bir makine öğrenimi uygulama yelpazesine uygun hale gelmiştir. Bu çalışmada, farklı potansiyel güncelleme kurallarının SNN'lerin COVID-19 sınıflandırması için performansına olan etkisini araştırıyoruz. COVID-19 pandemisi, sağlık sistemine eşi benzeri görülmemiş zorluklar getirmiş olup, hastalığın yayılmasını kontrol etmek için erken teşhis önemlidir. CT tarama görüntüleme, hastalıkla ilişkili akciğer anormalliklerini gösteren yüksek çözünürlüklü görüntüler sunması nedeniyle COVID-19 teşhisi için güçlü bir araç olarak ortaya çıkmıştır. Bu doğrultuda, farklı sinir hücresi modelleri kullanarak SNN tabanlı bir model oluşturmayı denedik ve çeşitli derin öğrenme paketlerini kullandık. Özellikle, klasik İF modeli ve sunmuş olduğumuz birkaç üstel entegre-et ve ateşleme modelinin farklı potansiyel güncelleme kurallarını inceliyoruz. SNN'ler kullanarak CT tarama resimlerinden özellikler çıkarıyor ve denetimli bi

The Role of 3D CT Imaging in the Accurate Diagnosis of Lung Function in Coronavirus Patients

Early grading of coronavirus disease 2019 (COVID-19), as well as ventilator support machines, are prime ways to help the world fight this virus and reduce the mortality rate. To reduce the burden on physicians, we developed an automatic Computer-Aided Diagnostic (CAD) system to grade COVID-19 from Computed Tomography (CT) images. This system segments the lung region from chest CT scans using an unsupervised approach based on an appearance model, followed by 3D rotation invariant Markov–Gibbs Random Field (MGRF)-based morphological constraints. This system analyzes the segmented lung and generates precise, analytical imaging markers by estimating the MGRF-based analytical potentials. Three Gibbs energy markers were extracted from each CT scan by tuning the MGRF parameters on each lesion separately. The latter were healthy/mild, moderate, and severe lesions. To represent these markers more reliably, a Cumulative Distribution Function (CDF) was generated, then statistical markers were extracted from it, namely, 10th through 90th CDF percentiles with 10% increments. Subsequently, the three extracted markers were combined together and fed into a backpropagation neural network to make the diagnosis. The developed system was assessed on 76 COVID-19-infected patients using two metrics, namely, accuracy and Kappa. In this paper, the proposed system was trained and tested by three approaches. In the first approach, the MGRF model was trained and tested on the lungs. This approach achieved 95.83% accuracy and 93.39% kappa. In the second approach, we trained the MGRF model on the lesions and tested it on the lungs. This approach achieved 91.67% accuracy and 86.67% kappa. Finally, we trained and tested the MGRF model on lesions. It achieved 100% accuracy and 100% kappa. The results reported in this paper show the ability of the developed system to accurately grade COVID-19 lesions compared to other machine learning classifiers, such as k-Nearest Neighbor (KNN), decision tree, naïve Bayes, and random forest

Explainable, Domain-Adaptive, and Federated Artificial Intelligence in Medicine

Artificial intelligence (AI) continues to transform data analysis in many domains. Progress in each domain is driven by a growing body of annotated data, increased computational resources, and technological innovations. In medicine, the sensitivity of the data, the complexity of the tasks, the potentially high stakes, and a requirement of accountability give rise to a particular set of challenges. In this review, we focus on three key methodological approaches that address some of the particular challenges in AI-driven medical decision making. (1) Explainable AI aims to produce a human-interpretable justification for each output. Such models increase confidence if the results appear plausible and match the clinicians expectations. However, the absence of a plausible explanation does not imply an inaccurate model. Especially in highly non-linear, complex models that are tuned to maximize accuracy, such interpretable representations only reflect a small portion of the justification. (2) Domain adaptation and transfer learning enable AI models to be trained and applied across multiple domains. For example, a classification task based on images acquired on different acquisition hardware. (3) Federated learning enables learning large-scale models without exposing sensitive personal health information. Unlike centralized AI learning, where the centralized learning machine has access to the entire training data, the federated learning process iteratively updates models across multiple sites by exchanging only parameter updates, not personal health data. This narrative review covers the basic concepts, highlights relevant corner-stone and state-of-the-art research in the field, and discusses perspectives.Comment: This paper is accepted in IEEE CAA Journal of Automatica Sinica, Nov. 10 202

The Prominence of Artificial Intelligence in COVID-19

In December 2019, a novel virus called COVID-19 had caused an enormous number of causalities to date. The battle with the novel Coronavirus is baffling and horrifying after the Spanish Flu 2019. While the front-line doctors and medical researchers have made significant progress in controlling the spread of the highly contiguous virus, technology has also proved its significance in the battle. Moreover, Artificial Intelligence has been adopted in many medical applications to diagnose many diseases, even baffling experienced doctors. Therefore, this survey paper explores the methodologies proposed that can aid doctors and researchers in early and inexpensive methods of diagnosis of the disease. Most developing countries have difficulties carrying out tests using the conventional manner, but a significant way can be adopted with Machine and Deep Learning. On the other hand, the access to different types of medical images has motivated the researchers. As a result, a mammoth number of techniques are proposed. This paper first details the background knowledge of the conventional methods in the Artificial Intelligence domain. Following that, we gather the commonly used datasets and their use cases to date. In addition, we also show the percentage of researchers adopting Machine Learning over Deep Learning. Thus we provide a thorough analysis of this scenario. Lastly, in the research challenges, we elaborate on the problems faced in COVID-19 research, and we address the issues with our understanding to build a bright and healthy environment.Comment: 63 pages, 3 tables, 17 figure

Adversarial Machine Learning For Advanced Medical Imaging Systems

Although deep neural networks (DNNs) have achieved significant advancement in various challenging tasks of computer vision, they are also known to be vulnerable to so-called adversarial attacks. With only imperceptibly small perturbations added to a clean image, adversarial samples can drastically change models’ prediction, resulting in a significant drop in DNN’s performance. This phenomenon poses a serious threat to security-critical applications of DNNs, such as medical imaging, autonomous driving, and surveillance systems. In this dissertation, we present adversarial machine learning approaches for natural image classification and advanced medical imaging systems. We start by describing our advanced medical imaging systems to tackle the major challenges of on-device deployment: automation, uncertainty, and resource constraint. It is followed by novel unsupervised and semi-supervised robust training schemes to enhance the adversarial robustness of these medical imaging systems. These methods are designed to tackle the unique challenges of defending against adversarial attacks on medical imaging systems and are sufficiently flexible to generalize to various medical imaging modalities and problems. We continue on developing novel training scheme to enhance adversarial robustness of the general DNN based natural image classification models. Based on a unique insight into the predictive behavior of DNNs that they tend to misclassify adversarial samples into the most probable false classes, we propose a new loss function as a drop-in replacement for the cross-entropy loss to improve DNN\u27s adversarial robustness. Specifically, it enlarges the probability gaps between true class and false classes and prevents them from being melted by small perturbations. Finally, we conclude the dissertation by summarizing original contributions and discussing our future work that leverages DNN interpretability constraint on adversarial training to tackle the central machine learning problem of generalization gap

Automatic classification between COVID-19 and Non-COVID-19 pneumonia using symptoms, comorbidities, and laboratory findings : the Khorshid COVID cohort study

Coronavirus disease-2019, also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was a disaster in 2020. Accurate and early diagnosis of coronavirus disease-2019 (COVID-19) is still essential for health policymaking. Reverse transcriptase-polymerase chain reaction (RT-PCR) has been performed as the operational gold standard for COVID-19 diagnosis. We aimed to design and implement a reliable COVID-19 diagnosis method to provide the risk of infection using demographics, symptoms and signs, blood markers, and family history of diseases to have excellent agreement with the results obtained by the RT-PCR and CT-scan. Our study primarily used sample data from a 1-year hospital-based prospective COVID-19 open-cohort, the Khorshid COVID Cohort (KCC) study. A sample of 634 patients with COVID-19 and 118 patients with pneumonia with similar characteristics whose RT-PCR and chest CT scan were negative (as the control group) (dataset 1) was used to design the system and for internal validation. Two other online datasets, namely, some symptoms (dataset 2) and blood tests (dataset 3), were also analyzed. A combination of one-hot encoding, stability feature selection, over-sampling, and an ensemble classifier was used. Ten-fold stratified cross-validation was performed. In addition to gender and symptom duration, signs and symptoms, blood biomarkers, and comorbidities were selected. Performance indices of the cross-validated confusion matrix for dataset 1 were as follows: sensitivity of 96% [confidence interval, CI, 95%: 94–98], specificity of 95% [90–99], positive predictive value (PPV) of 99% [98–100], negative predictive value (NPV) of 82% [76–89], diagnostic odds ratio (DOR) of 496 [198–1,245], area under the ROC (AUC) of 0.96 [0.94–0.97], Matthews Correlation Coefficient (MCC) of 0.87 [0.85–0.88], accuracy of 96% [94–98], and Cohen's Kappa of 0.86 [0.81–0.91]. The proposed algorithm showed excellent diagnosis accuracy and class-labeling agreement, and fair discriminant power. The AUC on the datasets 2 and 3 was 0.97 [0.96–0.98] and 0.92 [0.91–0.94], respectively. The most important feature was white blood cell count, shortness of breath, and C-reactive protein for datasets 1, 2, and 3, respectively. The proposed algorithm is, thus, a promising COVID-19 diagnosis method, which could be an amendment to simple blood tests and screening of symptoms. However, the RT-PCR and chest CT-scan, performed as the gold standard, are not 100% accurate.Peer ReviewedPostprint (published version