GEANT4--a simulation toolkikt

Geant4 is a toolkit for simulating the passage of particles through matter. It includes a complete range of functionality including tracking, geometry, physics models and hits. The physics processes offered cover a comprehensive range, including electromagnetic, hadronic and optical processes, a large set of long-lived particles, materials and elements, over a wide energy range starting, in some cases, from 250 eV and extending in others to the TeV energy range. It has been designed and constructed to expose the physics models utilised, to handle complex geometries, and to enable its easy adaptation for optimal use in different sets of applications. The toolkit is the result of a worldwide collaboration of physicists and software engineers. It has been created exploiting software engineering and object-oriented technology and implemented in the C++ programming language. It has been used in applications in particle physics, nuclear physics, accelerator design, space engineering and medical physics

Ami-deu : un cadre sémantique pour des applications adaptables dans des environnements intelligents

Cette thèse vise à étendre l’utilisation de l'Internet des objets (IdO) en facilitant le développement d’applications par des personnes non experts en développement logiciel. La thèse propose une nouvelle approche pour augmenter la sémantique des applications d’IdO et l’implication des experts du domaine dans le développement d’applications sensibles au contexte. Notre approche permet de gérer le contexte changeant de l’environnement et de générer des applications qui s’exécutent dans plusieurs environnements intelligents pour fournir des actions requises dans divers contextes. Notre approche est mise en œuvre dans un cadriciel (AmI-DEU) qui inclut les composants pour le développement d’applications IdO. AmI-DEU intègre les services d’environnement, favorise l’interaction de l’utilisateur et fournit les moyens de représenter le domaine d’application, le profil de l’utilisateur et les intentions de l’utilisateur. Le cadriciel permet la définition d’applications IoT avec une intention d’activité autodécrite qui contient les connaissances requises pour réaliser l’activité. Ensuite, le cadriciel génère Intention as a Context (IaaC), qui comprend une intention d’activité autodécrite avec des connaissances colligées à évaluer pour une meilleure adaptation dans des environnements intelligents. La sémantique de l’AmI-DEU est basée sur celle du ContextAA (Context-Aware Agents) – une plateforme pour fournir une connaissance du contexte dans plusieurs environnements. Le cadriciel effectue une compilation des connaissances par des règles et l'appariement sémantique pour produire des applications IdO autonomes capables de s’exécuter en ContextAA. AmI- DEU inclut également un outil de développement visuel pour le développement et le déploiement rapide d'applications sur ContextAA. L'interface graphique d’AmI-DEU adopte la métaphore du flux avec des aides visuelles pour simplifier le développement d'applications en permettant des définitions de règles étape par étape. Dans le cadre de l’expérimentation, AmI-DEU comprend un banc d’essai pour le développement d’applications IdO. Les résultats expérimentaux montrent une optimisation sémantique potentielle des ressources pour les applications IoT dynamiques dans les maisons intelligentes et les villes intelligentes. Notre approche favorise l'adoption de la technologie pour améliorer le bienêtre et la qualité de vie des personnes. Cette thèse se termine par des orientations de recherche que le cadriciel AmI-DEU dévoile pour réaliser des environnements intelligents omniprésents fournissant des adaptations appropriées pour soutenir les intentions des personnes.Abstract: This thesis aims at expanding the use of the Internet of Things (IoT) by facilitating the development of applications by people who are not experts in software development. The thesis proposes a new approach to augment IoT applications’ semantics and domain expert involvement in context-aware application development. Our approach enables us to manage the changing environment context and generate applications that run in multiple smart environments to provide required actions in diverse settings. Our approach is implemented in a framework (AmI-DEU) that includes the components for IoT application development. AmI- DEU integrates environment services, promotes end-user interaction, and provides the means to represent the application domain, end-user profile, and end-user intentions. The framework enables the definition of IoT applications with a self-described activity intention that contains the required knowledge to achieve the activity. Then, the framework generates Intention as a Context (IaaC), which includes a self-described activity intention with compiled knowledge to be assessed for augmented adaptations in smart environments. AmI-DEU framework semantics adopts ContextAA (Context-Aware Agents) – a platform to provide context-awareness in multiple environments. The framework performs a knowledge compilation by rules and semantic matching to produce autonomic IoT applications to run in ContextAA. AmI-DEU also includes a visual tool for quick application development and deployment to ContextAA. The AmI-DEU GUI adopts the flow metaphor with visual aids to simplify developing applications by allowing step-by-step rule definitions. As part of the experimentation, AmI-DEU includes a testbed for IoT application development. Experimental results show a potential semantic optimization for dynamic IoT applications in smart homes and smart cities. Our approach promotes technology adoption to improve people’s well-being and quality of life. This thesis concludes with research directions that the AmI-DEU framework uncovers to achieve pervasive smart environments providing suitable adaptations to support people’s intentions

Proceedings of The Multi-Agent Logics, Languages, and Organisations Federated Workshops (MALLOW 2010)

http://ceur-ws.org/Vol-627/allproceedings.pdfInternational audienceMALLOW-2010 is a third edition of a series initiated in 2007 in Durham, and pursued in 2009 in Turin. The objective, as initially stated, is to "provide a venue where: the cost of participation was minimum; participants were able to attend various workshops, so fostering collaboration and cross-fertilization; there was a friendly atmosphere and plenty of time for networking, by maximizing the time participants spent together"

European Distance and E-Learning Network (EDEN). Conference Proceedings

Erasmus+ Programme of the European UnionThe powerful combination of the information age and the consequent disruption caused by these unstable environments provides the impetus to look afresh and identify new models and approaches for education (e.g. OERs, MOOCs, PLEs, Learning Analytics etc.). For learners this has taken a fantastic leap into aggregating, curating and co-curating and co-producing outside the boundaries of formal learning environments – the networked learner is sharing voluntarily and for free, spontaneously with billions of people.Supported by Erasmus+ Programme of the European Unioninfo:eu-repo/semantics/publishedVersio

Incorporating standardised drift-tube ion mobility to enhance non-targeted assessment of the wine metabolome (LC×IM-MS)

Liquid chromatography with drift-tube ion mobility spectrometry-mass spectrometry (LCxIM-MS) is emerging as a powerful addition to existing LC-MS workflows for addressing a diverse range of metabolomics-related questions [1,2]. Importantly, excellent precision under repeatability and reproducibility conditions of drift-tube IM separations [3] supports the development of non-targeted approaches for complex metabolome assessment such as wine characterisation [4]. In this work, fundamentals of this new analytical metabolomics approach are introduced and application to the analysis of 90 authentic red and white wine samples originating from Macedonia is presented. Following measurements, intersample alignment of metabolites using non-targeted extraction and three-dimensional alignment of molecular features (retention time, collision cross section, and high-resolution mass spectra) provides confidence for metabolite identity confirmation. Applying a fingerprinting metabolomics workflow allows statistical assessment of the influence of geographic region, variety, and age. This approach is a state-of-the-art tool to assess wine chemodiversity and is particularly beneficial for the discovery of wine biomarkers and establishing product authenticity based on development of fingerprint libraries

La bioinformática al servicio de la genómica

Este trabajo de tesis aborda distintos ámbitos de aplicación de técnicas bioinformáticas a la resolución de problemas surgidos del manejo, análisis, almacenamiento y consulta de grandes volúmenes de datos genómicos. Los principales retos a los que esta tesis ha tratado de dar respuesta han sido los siguientes: - Procesar la información más básica de las tecnologías de genotipado de alto rendimiento, a fin de permitir obtener de manera rápida y sencilla una serie de parámetros y estadísticas básicas características de un experimento independientemente de la tecnología elegida. - Facilitar la publicación y consulta de resultados de genotipado a baja y media escala, tanto de SNPs como de STRs, así como su interacción con los repositorios de variabilidad accesibles públicamente. - Estudiar la viabilidad de gestionar localmente un repositorio propio de variabilidad humana basado en los recursos disponibles, tanto de información externa como de infraestructura interna. - Transferir el conocimiento obtenido. Aportar herramientas existentes o soluciones ad hoc a los problemas que pueda presentar la investigación genética en el campo de la biología computacional