Opportunistic deep learning powered calcium scoring in oncologic patients with very high coronary artery calcium (≥ 1000) undergoing 18F-FDG PET/CT

Our aim was to identify and quantify high coronary artery calcium (CAC) with deep learning (DL)-powered CAC scoring (CACS) in oncological patients with known very high CAC (≥ 1000) undergoing 18F-FDG-PET/CT for re-/staging. 100 patients were enrolled: 50 patients with Agatston scores ≥ 1000 (high CACS group), 50 patients with Agatston scores < 1000 (negative control group). All patients underwent oncological 18F-FDG-PET/CT and cardiac SPECT myocardial perfusion imaging (MPI) by 99mTc-tetrofosmin within 6 months. CACS was manually performed on dedicated non-contrast ECG-gated CT scans obtained from SPECT-MPI (reference standard). Additionally, CACS was performed fully automatically with a user-independent DL-CACS tool on non-contrast, free-breathing, non-gated CT scans from 18F-FDG-PET/CT examinations. Image quality and noise of CT scans was assessed. Agatston scores obtained by manual CACS and DL tool were compared. The high CACS group had Agatston scores of 2200 ± 1620 (reference standard) and 1300 ± 1011 (DL tool, average underestimation of 38.6 ± 26%) with an intraclass correlation of 0.714 (95% CI 0.546, 0.827). Sufficient image quality significantly improved the DL tool's capability of correctly assigning Agatston scores ≥ 1000 (p = 0.01). In the control group, the DL tool correctly assigned Agatston scores < 1000 in all cases. In conclusion, DL-based CACS performed on non-contrast free-breathing, non-gated CT scans from 18F-FDG-PET/CT examinations of patients with known very high (≥ 1000) CAC underestimates CAC load, but correctly assigns an Agatston scores ≥ 1000 in over 70% of cases, provided sufficient CT image quality. Subgroup analyses of the control group showed that the DL tool does not generate false-positives

PICACS: self-consistent modelling of galaxy cluster scaling relations

In this paper, we introduce PICACS, a physically-motivated, internally consistent model of scaling relations between galaxy cluster masses and their observable properties. This model can be used to constrain simultaneously the form, scatter (including its covariance) and evolution of the scaling relations, as well as the masses of the individual clusters. In this framework, scaling relations between observables (such as that between X-ray luminosity and temperature) are modelled explicitly in terms of the fundamental mass-observable scaling relations, and so are fully constrained without being fit directly. We apply the PICACS model to two observational datasets, and show that it performs as well as traditional regression methods for simply measuring individual scaling relation parameters, but reveals additional information on the processes that shape the relations while providing self-consistent mass constraints. Our analysis suggests that the observed combination of slopes of the scaling relations can be described by a deficit of gas in low-mass clusters that is compensated for by elevated gas temperatures, such that the total thermal energy of the gas in a cluster of given mass remains close to self-similar expectations. This is interpreted as the result of AGN feedback removing low entropy gas from low mass systems, while heating the remaining gas. We deconstruct the luminosity-temperature (LT) relation and show that its steepening compared to self-similar expectations can be explained solely by this combination of gas depletion and heating in low mass systems, without any additional contribution from a mass dependence of the gas structure. Finally, we demonstrate that a self-consistent analysis of the scaling relations leads to an expectation of self-similar evolution of the LT relation that is significantly weaker than is commonly assumed.Comment: Updated to match published version. Improvements to presentation of results, and treatment of scatter and covariance. Main conclusions unchange

Review of selection criteria for sensor and actuator configurations suitable for internal combustion engines

This literature review considers the problem of finding a suitable configuration of sensors and actuators for the control of an internal combustion engine. It takes a look at the methods, algorithms, processes, metrics, applications, research groups and patents relevant for this topic. Several formal metric have been proposed, but practical use remains limited. Maximal information criteria are theoretically optimal for selecting sensors, but hard to apply to a system as complex and nonlinear as an engine. Thus, we reviewed methods applied to neighboring fields including nonlinear systems and non-minimal phase systems. Furthermore, the closed loop nature of control means that information is not the only consideration, and speed, stability and robustness have to be considered. The optimal use of sensor information also requires the use of models, observers, state estimators or virtual sensors, and practical acceptance of these remains limited. Simple control metrics such as conditioning number are popular, mostly because they need fewer assumptions than closed-loop metrics, which require a full plant, disturbance and goal model. Overall, no clear consensus can be found on the choice of metrics to define optimal control configurations, with physical measures, linear algebra metrics and modern control metrics all being used. Genetic algorithms and multi-criterial optimisation were identified as the most widely used methods for optimal sensor selection, although addressing the dimensionality and complexity of formulating the problem remains a challenge. This review does present a number of different successful approaches for specific applications domains, some of which may be applicable to diesel engines and other automotive applications. For a thorough treatment, non-linear dynamics and uncertainties need to be considered together, which requires sophisticated (non-Gaussian) stochastic models to establish the value of a control architecture

Peramorphosis, an evolutionary developmental mechanism in neotropical bat skull diversity

Background The neotropical leaf‐nosed bats (Chiroptera, Phyllostomidae) are an ecologically diverse group of mammals with distinctive morphological adaptations associated with specialized modes of feeding. The dramatic skull shape changes between related species result from changes in the craniofacial development process, which brings into focus the nature of the underlying evolutionary developmental processes. Results In this study, we use three‐dimensional geometric morphometrics to describe, quantify, and compare morphological modifications unfolding during evolution and development of phyllostomid bats. We examine how changes in development of the cranium may contribute to the evolution of the bat craniofacial skeleton. Comparisons of ontogenetic trajectories to evolutionary trajectories reveal two separate evolutionary developmental growth processes contributing to modifications in skull morphogenesis: acceleration and hypermorphosis. Conclusion These findings are consistent with a role for peramorphosis, a form of heterochrony, in the evolution of bat dietary specialists

An underwater image quality assessment metric

Various image enhancement algorithms are adopted to improve underwater images that often suffer from visual distortions. It is critical to assess the output quality of underwater images undergoing enhancement algorithms, and use the results to optimise underwater imaging systems. In our previous study, we created a benchmark for quality assessment of underwater image enhancement via subjective experiments. Building on the benchmark, this paper proposes a new objective metric that can automatically assess the output quality of image enhancement, namely UWEQM. By characterising specific underwater physics and relevant properties of the human visual system, image quality attributes are computed and combined to yield an overall metric. Experimental results show that the proposed UWEQM metric yields good performance in predicting image quality as perceived by human subjects

Machine Learning Methods for Classifying Human Physical Activity from On-Body Accelerometers

The use of on-body wearable sensors is widespread in several academic and industrial domains. Of great interest are their applications in ambulatory monitoring and pervasive computing systems; here, some quantitative analysis of human motion and its automatic classification are the main computational tasks to be pursued. In this paper, we discuss how human physical activity can be classified using on-body accelerometers, with a major emphasis devoted to the computational algorithms employed for this purpose. In particular, we motivate our current interest for classifiers based on Hidden Markov Models (HMMs). An example is illustrated and discussed by analysing a dataset of accelerometer time series

Cage Active Contours for image warping and morphing

Cage Active Contours (CACs) have shown to be a framework for segmenting connected objects using a new class of parametric region-based active contours. The CAC approach deforms the contour locally by moving cage's points through affine transformations. The method has shown good performance for image segmentation, but other applications have not been studied. In this paper, we extend the method with new energy functions based on Gaussian mixture models to capture multiple color components per region and extend their applicability to RGB color space. In addition, we provide an extended mathematical formalization of the CAC framework with the purpose of showing its good properties for segmentation, warping, and morphing. Thus, we propose a multiple-step combined method for segmenting images, warping the correspondences of the object cage points, and morphing the objects to create new images. For validation, both quantitative and qualitative tests are used on different datasets. The results show that the new energies produce improvements over the previously developed energies for the CAC. Moreover, we provide examples of the application of the CAC in image segmentation, warping, and morphing supported by our theoretical conclusions

Deep Learning in Cardiology

The medical field is creating large amount of data that physicians are unable to decipher and use efficiently. Moreover, rule-based expert systems are inefficient in solving complicated medical tasks or for creating insights using big data. Deep learning has emerged as a more accurate and effective technology in a wide range of medical problems such as diagnosis, prediction and intervention. Deep learning is a representation learning method that consists of layers that transform the data non-linearly, thus, revealing hierarchical relationships and structures. In this review we survey deep learning application papers that use structured data, signal and imaging modalities from cardiology. We discuss the advantages and limitations of applying deep learning in cardiology that also apply in medicine in general, while proposing certain directions as the most viable for clinical use.Comment: 27 pages, 2 figures, 10 table