10,778 research outputs found

    Hurdles and signposts on the road to virtual control groups—A case study illustrating the influence of anesthesia protocols on electrolyte levels in rats

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    Introduction: Virtual Control Groups (VCGs) represent the concept of using historical control data from legacy animal studies to replace concurrent control group (CCG) animals. Based on the data curation and sharing activities of the Innovative Medicine Initiatives project eTRANSAFE (enhancing TRANSlational SAFEty Assessment through Integrative Knowledge Management) the ViCoG working group was established with the objectives of i) collecting suitable historical control data sets from preclinical toxicity studies, ii) evaluating statistical methodologies for building adequate and regulatory acceptable VCGs from historical control data, and iii) sharing those control-group data across multiple pharmaceutical companies. During the qualification process of VCGs a particular focus was put on the identification of hidden confounders in the data sets, which might impair the adequate matching of VCGs with the CCG.Methods: During our analyses we identified such a hidden confounder, namely, the choice of the anesthetic procedure used in animal experiments before blood withdrawal. Anesthesia using CO2 may elevate the levels of some electrolytes such as calcium in blood, while the use of isoflurane is known to lower these values. Identification of such hidden confounders is particularly important if the underlying experimental information (e.g., on the anesthetic procedure) is not routinely recorded in the standard raw data files, such as SEND (Standard for Exchange of Non-clinical Data). We therefore analyzed how the replacement of CCGs with VCGs would affect the reproducibility of treatment-related findings regarding electrolyte values (potassium, calcium, sodium, and phosphate). The analyses were performed using a legacy rat systemic toxicity study consisting of a control and three treatment groups conducted according to pertinent OECD guidelines. In the report of this study treatment-related hypercalcemia was reported. The rats in this study were anesthetized with isoflurane.Results: Replacing the CCGs with VCGs derived from studies comprising both anesthetics resulted in a shift of control electrolyte parameters. Instead of the originally reported hypercalcemia the use of VCG led to fallacious conclusions of no observed effect or hypocalcemia.Discussion: Our study highlights the importance of a rigorous statistical analysis including the detection and elimination of hidden confounders prior to the implementation of the VCG concept

    latent Dirichlet allocation method-based nowcasting approach for prediction of silver price

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    Silver is a metal that offers significant value to both investors and companies. The purpose of this study is to make an estimation of the price of silver. While making this estimation, it is planned to include the frequency of searches on Google Trends for the words that affect the silver price. Thus, it is aimed to obtain a more accurate estimate. First, using the Latent Dirichlet Allocation method, the keywords to be analyzed in Google Trends were collected from various articles on the Internet. Mining data from Google Trends combined with the information obtained by LDA is the new approach this study took, to predict the price of silver. No study has been found in the literature that has adopted this approach to estimate the price of silver. The estimation was carried out with Random Forest Regression, Gaussian Process Regression, Support Vector Machine, Regression Trees and Artificial Neural Networks methods. In addition, ARIMA, which is one of the traditional methods that is widely used in time series analysis, was also used to benchmark the accuracy of the methodology. The best MSE ratio was obtained as 0,000227131 ± 0.0000235205 by the Regression Trees method. This score indicates that it would be a valid technique to estimate the price of "Silver" by using Google Trends data using the LDA method

    A Decision Support System for Economic Viability and Environmental Impact Assessment of Vertical Farms

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    Vertical farming (VF) is the practice of growing crops or animals using the vertical dimension via multi-tier racks or vertically inclined surfaces. In this thesis, I focus on the emerging industry of plant-specific VF. Vertical plant farming (VPF) is a promising and relatively novel practice that can be conducted in buildings with environmental control and artificial lighting. However, the nascent sector has experienced challenges in economic viability, standardisation, and environmental sustainability. Practitioners and academics call for a comprehensive financial analysis of VPF, but efforts are stifled by a lack of valid and available data. A review of economic estimation and horticultural software identifies a need for a decision support system (DSS) that facilitates risk-empowered business planning for vertical farmers. This thesis proposes an open-source DSS framework to evaluate business sustainability through financial risk and environmental impact assessments. Data from the literature, alongside lessons learned from industry practitioners, would be centralised in the proposed DSS using imprecise data techniques. These techniques have been applied in engineering but are seldom used in financial forecasting. This could benefit complex sectors which only have scarce data to predict business viability. To begin the execution of the DSS framework, VPF practitioners were interviewed using a mixed-methods approach. Learnings from over 19 shuttered and operational VPF projects provide insights into the barriers inhibiting scalability and identifying risks to form a risk taxonomy. Labour was the most commonly reported top challenge. Therefore, research was conducted to explore lean principles to improve productivity. A probabilistic model representing a spectrum of variables and their associated uncertainty was built according to the DSS framework to evaluate the financial risk for VF projects. This enabled flexible computation without precise production or financial data to improve economic estimation accuracy. The model assessed two VPF cases (one in the UK and another in Japan), demonstrating the first risk and uncertainty quantification of VPF business models in the literature. The results highlighted measures to improve economic viability and the viability of the UK and Japan case. The environmental impact assessment model was developed, allowing VPF operators to evaluate their carbon footprint compared to traditional agriculture using life-cycle assessment. I explore strategies for net-zero carbon production through sensitivity analysis. Renewable energies, especially solar, geothermal, and tidal power, show promise for reducing the carbon emissions of indoor VPF. Results show that renewably-powered VPF can reduce carbon emissions compared to field-based agriculture when considering the land-use change. The drivers for DSS adoption have been researched, showing a pathway of compliance and design thinking to overcome the ‘problem of implementation’ and enable commercialisation. Further work is suggested to standardise VF equipment, collect benchmarking data, and characterise risks. This work will reduce risk and uncertainty and accelerate the sector’s emergence

    Combining shallow-water and analytical wake models for tidal-array micro-siting

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    For tidal-stream energy to become a competitive renewable energy source, clustering multiple turbines into arrays is paramount. Array optimisation is thus critical for achieving maximum power performance and reducing cost of energy. However, ascertaining an optimal array layout is a complex problem, subject to specific site hydrodynamics and multiple inter-disciplinary constraints. In this work, we present a novel optimisation approach that combines an analytical-based wake model, FLORIS, with an ocean model, Thetis. The approach is demonstrated through applications of increasing complexity. By utilising the method of analytical wake superposition, the addition or alteration of turbine position does not require re-calculation of the entire flow field, thus allowing the use of simple heuristic techniques to perform optimisation at a fraction of the computational cost of more sophisticated methods. Using a custom condition-based placement algorithm, this methodology is applied to the Pentland Firth for arrays with turbines of 3.05m/s rated speed, demonstrating practical implications whilst considering the temporal variability of the tide. For a 24-turbine array case, micro-siting using this technique delivered an array 15.8% more productive on average than a staggered layout, despite flow speeds regularly exceeding the rated value. Performance was evaluated through assessment of the optimised layout within the ocean model that treats turbines through a discrete turbine representation. Used iteratively, this methodology could deliver improved array configurations in a manner that accounts for local hydrodynamic effects

    INVESTIGATING THE PERCEPTION OF EXPATRIATES TOWARDS IMMIGRATION SERVICE QUALITY IN SHARJAH, UNITED ARAB EMIRATES THROUGH MIXED METHOD APPROACH

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    The public sectors in UAE are under immense pressure to demonstrate that their services are customer-focused and that continuous performance improvement is being delivered. The United Arab Emirates is a favoured destination for expatriates due to its own citizens form a minority of the population and are barely represented in the private sector workforce. These highly unusual demographics confer high importance on the national immigration services. Recently, increased interest in international migration, specifically within the United Arab Emirates, has been shown both by government agencies and by the governments of industrialised countries. Given the importance of the expatriate labour force to economic stability and growth in the Emirates, this research investigates how immigration services are perceived, with the aim of contributing to their improvement, thus ultimately supporting economic growth. It proposes a service quality perception framework to improve understanding within SID of how to raise levels of service delivered to migrants and other persons directly or indirectly affected by SID services. Qualitative data were collected by means of semi-structured interviews and quantitative data by means of a questionnaire survey based on the abovementioned framework. The survey data, on the variables influencing participants’ experiences and perceptions of SID services, were subjected to statistical analysis. The framework was then used to evaluate quality of service in terms of general impressions, delivery, location, response, SID culture and behaviour. Numerical data were analysed using inferential and descriptive statistics. It was found that service quality positively influenced service behaviour and that this relationship was mediated by SID culture. This research makes an original contribution to knowledge as one of the few studies of immigration to the United Arab Emirates. By examining the workings of one immigration department, it adds to the literature on immigration departments and organisational development in developing countries. It illuminates the mechanics of immigration services and demonstrates their increasing importance to the world economy

    Quantitative Study of Predictive Relationships Between English Language Proficiency, Academic Growth, and Academic Achievement Assessments in North Georgia

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    This study examined the predictive relationship between ELs' proficiency levels on the Assessing Comprehension and Communication in English State-to-State for ELs 2.0, students' performance on English language arts Georgia Milestones Assessment System, and academic growth on the Measures of Academic Progress. It was comprised of third through fifth grade English Language Learners. The study compared the percentage of English language learner students at each proficiency level, gender, and grade level and their achievement of English language arts on the Georgia Milestones Assessment System and growth from the beginning of the year to the end of the year on Measure of Academic Progress. The study was evaluated by conducting Pearson correlation coefficients, one-way ANOVA, and mediation analysis. Results for this research question indicated a significant positive relationship between academic achievement and academic growth. There was a significant positive relationship between academic achievement and all eight domains of English proficiency. The results indicated as grade level increased, English proficiency increased, and academic growth and achievement decreased. Results for this research question indicated a significant effect on all eight domains of English proficiency. The results indicated academic achievement is not obtained for almost 77% of ELs scoring in the 4.3 – 4.9 English proficiency level. There were significant results for all eight domains of English proficiency and academic achievement. The three domains of speaking, oral, and composite were mediated by academic growth. Keywords: English Language Proficiency; Academic Growth; Academic Achievement Assessments; English Language Learners; ELLs; EL;ABSTRACT i -- TABLE OF CONTENTS ii -- LIST OF TABLES vi -- LIST OF FIGURES vii -- ACKNOWLEDGMENT viii -- DEDICATION ix -- Chapter I INTRODUCTION 1 -- Overview 1 -- Statement of the Problem 4 -- Purpose 5 -- Research Questions 7 -- Significance of the Study 8 -- Conceptual Framework 9 -- Summary of Methodology 13 -- Limitations 14 -- Summary 14 -- Definitions of Terms 15 -- Chapter II REVIEW OF LITERATURE 17 -- Overview 17 -- ELs 17 -- Accommodations 18 -- Exit Criteria 19 -- Post Exit Monitoring 20 -- ELs in the Classroom: Best Practices 21 -- Challenges in the Classroom 21 -- The Role of Leadership 24 -- State and Federal Mandates 25 -- Standards 26 -- Every Student Succeed Act 26 -- Georgia Standards of Excellence 27 -- World-Class Instructional Design Assessment Consortium 27 -- English Language Proficiency: Years to Proficiency 28 -- Gender 30 -- Reclassifying ELs 31 -- Language Proficiency Assessment 35 -- Academic Achievement Assessment 36 -- Adaptive Academic Assessment 36 -- Summary 37 -- Chapter III METHODOLOGY 39 -- Overview 39 -- Research Questions 40 -- Research Design 40 -- Sample 42 -- Description of the Population 43 -- Data Collection 44 -- Procedures 47 -- Threats to Validity 50 -- Summary 50 -- Chapter IV RESULTS 52 -- Data Analysis 53 -- Descriptive Statistics 54 -- Results by Questions 55 -- Research Question 1 55 -- Research Question 2 64 -- Research Question 3 69 -- Summary 79 -- Chapter V SUMMARY AND DISCUSSION 82 -- Overview 82 -- Overview of the Sample and Data Collection 86 -- Quantitative Findings 87 -- Implications of Findings 89 -- Limitations to the Study 94 -- Recommendations for Future Research 95 -- Summary 96 -- REFERENCES 98 -- Appendix A Institutional Review Board Protocol Exemption Report 109 -- Appendix B Letter of Cooperation 1 111 -- Appendix C Letter of Cooperation 2 113 -- Appendix D Data Collection 115Bochenko, MichaelSakhavat, MammadovHsiao, E-LingHill, D. LaverneEd.D.Education in Leadershi

    Laser Welding

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    Among novel techniques, laser welding is considered an adaptable and rapidly evolving method, finding innumerable applications in engineering industries. It is capable of welding narrow and impassable joints precisely, which can be operated under computer control. This chapter of the welding Handbook reviews the most recent developments in the field of laser welding, which are used for different applications. The first section provides an overview of laser welding basics and then moves on to the developments such as high-power CO2 laser welding, laser micro-welding, and solid-state laser welding technologies. The second section underlines laser welding instruments used for joining different materials such as titanium, aluminum, and magnesium alloys, ceramics, and plastics. The third section highlights the advances in innovative laser welding methods with discussions on the applications of laser welding robots to improve the modeling and simulation of this technique. Lastly, the fourth section focuses on the use of laser welding technology in various industries including aerospace, automotive, railway, etc. The present Handbook is a practical reference for scholars, engineers, and professionals using laser welding techniques or requiring an understanding of the field of laser welding technologies

    Annals [...].

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    Pedometrics: innovation in tropics; Legacy data: how turn it useful?; Advances in soil sensing; Pedometric guidelines to systematic soil surveys.Evento online. Coordenado por: Waldir de Carvalho Junior, Helena Saraiva Koenow Pinheiro, Ricardo Simão Diniz Dalmolin

    Cultivating Agrobiodiversity in the U.S.: Barriers and Bridges at Multiple Scales

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    The diversity of crops grown in the United States (U.S.) is declining, causing agricultural landscapes to become more and more simplified. This trend is concerning for the loss of important plant, insect, and animal species, as well as the pollution and degradation of our environment. Through three separate but related studies, this dissertation addresses the need to increase the diversity of these agricultural landscapes in the U.S., particularly through diversifying the type and number of crops grown. The first study uses multiple, openly accessible datasets related to agricultural land use and policies to document and visualize change over recent decades. Through this, I show that U.S. agriculture has gradually become more specialized in the crops grown, crop production is heavily concentrated in certain areas, and crop diversity is continuing to decline. Meanwhile, federal agricultural policy, while having become more influential over how U.S. agriculture operates, incentivizes this specialization. The second study uses nonlinear statistical modeling to identify and compare social, political, and ecological factors that best predict crop diversity across nine regions in the U.S. Factors of climate, prior land use, and farm inputs best predict diversity across regions, but regions show key differences in how factors are important, indicating that patterns at the regional scale constrain and enable further diversification. Finally, the third study relied on interviews with farmers and key informants in southern Idaho’s Magic Valley – a cluster of eight counties that is known to be agriculturally diverse. Interviews gauge what farmers are currently doing to manage crop diversity (the present) and how they imagine alternative landscapes (the imaginary). We found that farmers in the Magic Valley manage current diversity mainly through cover cropping and diverse crop rotations, but daily struggles and political barriers make experimenting with and imagining alternative landscapes difficult and unlikely to occur. Together, these three studies provide an integrated view of how and why U.S. agriculture landscapes simplify or diversify, as well as the barriers and bridges such pathways of diversification

    The Impact of a Play Intervention on the Social-Emotional Development of Preschool Children in Riyadh, Saudi Arabia

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    Practitioners working with children have emphasized that play is vital to children’s development, Links between children’s social-emotional development and play have been widely documented. However, rigorous research evidence of these links remains limited. This study’s objectives were to measure the impact of play on children’s social-emotional development in the kingdom of Saudi Arabia; identify teachers’ viewpoints around the use of play intervention; and understand the children’s experience of play intervention. Fifty-nine children aged between five and six years, with mean age of 5.5 (SD 3.376) and eight teachers participated in the study. The study used a mixed-method strategy including questionnaires, interviews, and focus group discussions. Children’s social-emotional development was measured by using the Strengths and Difficulties Questioner (SDQ). A pre-/post-test counterbalanced design was used to measure the impact of the play intervention on children’s development. Teachers’ perspectives on play were obtained by interviewing eight teachers. Children’s views were gathered through focus group discussions. Repeated measures ANOVA was conducted to determine the differences in the SDQ score over three time points. Results showed that using unstructured loose parts play had positively impacted children’s social-emotional development. After participation in the play intervention, scores from the SDQ indicated that children demonstrated significantly less problematic emotional, conduct and peer relationship issues. They also scored significantly higher in their positive prosocial behaviour. These positive effects were sustained after six weeks of stopping the intervention. The play intervention did not however impact children’s hyperactivity level. The interviews analysis illustrates four main themes: concept and characteristics of play, play functions, developmental benefits of play, and play and practice. Regarding children’s discussion, affordance emerged as a main theme; this includes emotional, social, and functional affordances. Unstructured loose parts play intervention was demonstrated to have positive impacts on children’s social-emotional development. The study’s findings support the view that play is a way to increase children’s development
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