70,499 research outputs found
Beyond A/B Testing: Sequential Randomization for Developing Interventions in Scaled Digital Learning Environments
Randomized experiments ensure robust causal inference that are critical to
effective learning analytics research and practice. However, traditional
randomized experiments, like A/B tests, are limiting in large scale digital
learning environments. While traditional experiments can accurately compare two
treatment options, they are less able to inform how to adapt interventions to
continually meet learners' diverse needs. In this work, we introduce a trial
design for developing adaptive interventions in scaled digital learning
environments -- the sequential randomized trial (SRT). With the goal of
improving learner experience and developing interventions that benefit all
learners at all times, SRTs inform how to sequence, time, and personalize
interventions. In this paper, we provide an overview of SRTs, and we illustrate
the advantages they hold compared to traditional experiments. We describe a
novel SRT run in a large scale data science MOOC. The trial results
contextualize how learner engagement can be addressed through inclusive
culturally targeted reminder emails. We also provide practical advice for
researchers who aim to run their own SRTs to develop adaptive interventions in
scaled digital learning environments
SAFS: A Deep Feature Selection Approach for Precision Medicine
In this paper, we propose a new deep feature selection method based on deep
architecture. Our method uses stacked auto-encoders for feature representation
in higher-level abstraction. We developed and applied a novel feature learning
approach to a specific precision medicine problem, which focuses on assessing
and prioritizing risk factors for hypertension (HTN) in a vulnerable
demographic subgroup (African-American). Our approach is to use deep learning
to identify significant risk factors affecting left ventricular mass indexed to
body surface area (LVMI) as an indicator of heart damage risk. The results show
that our feature learning and representation approach leads to better results
in comparison with others
Dennis Littky, the Educational Activist: Can His Model Revamp the Public Educational System?
When an individual observes a classroom of today, he will see many elements that are recognizable to anyone who attended school during the last one hundred years, students working from textbooks, repetitive worksheets, and rows of desks holding students completing tasks directed by the teacher. Even though societal and technological advancements are increasing rapidly, our school system has stayed stagnant. What this means for students is the lack of individuality, teachers’ non acceptance of personal interests, lack of personal voice, and in many cases, a non relationship between teacher and student beyond the classroom assignment (Castleman & Littky, 2007)
Advances in computational modelling for personalised medicine after myocardial infarction
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide. Determining which patients will experience heart failure and sudden cardiac death after an acute MI is notoriously difficult for clinicians. The extent of heart damage after an acute MI is informed by cardiac imaging, typically using echocardiography or sometimes, cardiac magnetic resonance (CMR). These scans provide complex data sets that are only partially exploited by clinicians in daily practice, implying potential for improved risk assessment. Computational modelling of left ventricular (LV) function can bridge the gap towards personalised medicine using cardiac imaging in patients with post-MI. Several novel biomechanical parameters have theoretical prognostic value and may be useful to reflect the biomechanical effects of novel preventive therapy for adverse remodelling post-MI. These parameters include myocardial contractility (regional and global), stiffness and stress. Further, the parameters can be delineated spatially to correspond with infarct pathology and the remote zone. While these parameters hold promise, there are challenges for translating MI modelling into clinical practice, including model uncertainty, validation and verification, as well as time-efficient processing. More research is needed to (1) simplify imaging with CMR in patients with post-MI, while preserving diagnostic accuracy and patient tolerance (2) to assess and validate novel biomechanical parameters against established prognostic biomarkers, such as LV ejection fraction and infarct size. Accessible software packages with minimal user interaction are also needed. Translating benefits to patients will be achieved through a multidisciplinary approach including clinicians, mathematicians, statisticians and industry partners
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