Respiratory organ motion in interventional MRI : tracking, guiding and modeling

Respiratory organ motion is one of the major challenges in interventional MRI, particularly in interventions with therapeutic ultrasound in the abdominal region. High-intensity focused ultrasound found an application in interventional MRI for noninvasive treatments of different abnormalities. In order to guide surgical and treatment interventions, organ motion imaging and modeling is commonly required before a treatment start. Accurate tracking of organ motion during various interventional MRI procedures is prerequisite for a successful outcome and safe therapy. In this thesis, an attempt has been made to develop approaches using focused ultrasound which could be used in future clinically for the treatment of abdominal organs, such as the liver and the kidney. Two distinct methods have been presented with its ex vivo and in vivo treatment results. In the first method, an MR-based pencil-beam navigator has been used to track organ motion and provide the motion information for acoustic focal point steering, while in the second approach a hybrid imaging using both ultrasound and magnetic resonance imaging was combined for advanced guiding capabilities. Organ motion modeling and four-dimensional imaging of organ motion is increasingly required before the surgical interventions. However, due to the current safety limitations and hardware restrictions, the MR acquisition of a time-resolved sequence of volumetric images is not possible with high temporal and spatial resolution. A novel multislice acquisition scheme that is based on a two-dimensional navigator, instead of a commonly used pencil-beam navigator, was devised to acquire the data slices and the corresponding navigator simultaneously using a CAIPIRINHA parallel imaging method. The acquisition duration for four-dimensional dataset sampling is reduced compared to the existing approaches, while the image contrast and quality are improved as well. Tracking respiratory organ motion is required in interventional procedures and during MR imaging of moving organs. An MR-based navigator is commonly used, however, it is usually associated with image artifacts, such as signal voids. Spectrally selective navigators can come in handy in cases where the imaging organ is surrounding with an adipose tissue, because it can provide an indirect measure of organ motion. A novel spectrally selective navigator based on a crossed-pair navigator has been developed. Experiments show the advantages of the application of this novel navigator for the volumetric imaging of the liver in vivo, where this navigator was used to gate the gradient-recalled echo sequence

A Bayesian approach for energy-based estimation of acoustic aberrations in high intensity focused ultrasound treatment

High intensity focused ultrasound is a non-invasive method for treatment of diseased tissue that uses a beam of ultrasound to generate heat within a small volume. A common challenge in application of this technique is that heterogeneity of the biological medium can defocus the ultrasound beam. Here we reduce the problem of refocusing the beam to the inverse problem of estimating the acoustic aberration due to the biological tissue from acoustic radiative force imaging data. We solve this inverse problem using a Bayesian framework with a hierarchical prior and solve the inverse problem using a Metropolis-within-Gibbs algorithm. The framework is tested using both synthetic and experimental datasets. We demonstrate that our approach has the ability to estimate the aberrations using small datasets, as little as 32 sonication tests, which can lead to significant speedup in the treatment process. Furthermore, our approach is compatible with a wide range of sonication tests and can be applied to other energy-based measurement techniques

Blind MultiChannel Identification and Equalization for Dereverberation and Noise Reduction based on Convolutive Transfer Function

This paper addresses the problems of blind channel identification and multichannel equalization for speech dereverberation and noise reduction. The time-domain cross-relation method is not suitable for blind room impulse response identification, due to the near-common zeros of the long impulse responses. We extend the cross-relation method to the short-time Fourier transform (STFT) domain, in which the time-domain impulse responses are approximately represented by the convolutive transfer functions (CTFs) with much less coefficients. The CTFs suffer from the common zeros caused by the oversampled STFT. We propose to identify CTFs based on the STFT with the oversampled signals and the critical sampled CTFs, which is a good compromise between the frequency aliasing of the signals and the common zeros problem of CTFs. In addition, a normalization of the CTFs is proposed to remove the gain ambiguity across sub-bands. In the STFT domain, the identified CTFs is used for multichannel equalization, in which the sparsity of speech signals is exploited. We propose to perform inverse filtering by minimizing the $\ell_1$-norm of the source signal with the relaxed $\ell_2$-norm fitting error between the micophone signals and the convolution of the estimated source signal and the CTFs used as a constraint. This method is advantageous in that the noise can be reduced by relaxing the $\ell_2$-norm to a tolerance corresponding to the noise power, and the tolerance can be automatically set. The experiments confirm the efficiency of the proposed method even under conditions with high reverberation levels and intense noise.Comment: 13 pages, 5 figures, 5 table