Perspective—Challenges in Developing Wearable Electrochemical Sensors for Longitudinal Health Monitoring

Wearable electrochemical sensors have the potential to overcome the problem of infrequent clinical visits that leads to transient events of potential diagnostic importance being unduly overlooked. The promise of real-time, personalized health care has driven multidisciplinary work on fabricating various forms of wearable sensors. Although remarkable advances in device form factor and integrated circuit design have been achieved, notable hurdles, such as shelf life, reuseability, flex and sweat resistance, and longitudinal performance, remain unaddressed. This perspective seeks to summarize major advances in current wearable electrochemical sensors and to highlight the most pressing challenges that will benefit from collective research endeavors

Using ontologies to support and critique decisions

Supporting decision making in the working environment has long being pursued by practitioners across a variety of fields, ranging from sociology and operational research to cognitive and computer scientists. A number of computer-supported systems and various technologies have been used over the years, but as we move into more global and flexible organisational structures, new technologies and challenges arise. In this paper, I argue for an ontology-based solution and present some of the early prototypes we have been developing, assess their impact on the decision making process and elaborate on the costs involved

Scalable Planning and Learning for Multiagent POMDPs: Extended Version

Online, sample-based planning algorithms for POMDPs have shown great promise in scaling to problems with large state spaces, but they become intractable for large action and observation spaces. This is particularly problematic in multiagent POMDPs where the action and observation space grows exponentially with the number of agents. To combat this intractability, we propose a novel scalable approach based on sample-based planning and factored value functions that exploits structure present in many multiagent settings. This approach applies not only in the planning case, but also in the Bayesian reinforcement learning setting. Experimental results show that we are able to provide high quality solutions to large multiagent planning and learning problems

Development of an Extended Product Lifecycle Management through Service Oriented Architecture.

Organised by: Cranfield UniversityThe aim of this work is to define new business opportunities through the concept of Extended Product Lifecycle Management (ExtPLM), analysing its potential implementation within a Service Oriented Architecture. ExtPLM merges the concepts of Extended Product, Avatar and PLM. It aims at allowing a closer interaction between enterprises and their customers, who are integrated in all phases of the life cycle, creating new technical functionalities and services, improving both the practical (e.g. improving usage, improving safety, allowing predictive maintenance) and the emotional side (e.g. extreme customization) of the product.Mori Seiki – The Machine Tool Company; BAE Systems; S4T – Support Service Solutions: Strategy and Transitio

Panel on future challenges in modeling methodology

This panel paper presents the views of six researchers and practitioners of simulation modeling. Collectively we attempt to address a range of key future challenges to modeling methodology. It is hoped that the views of this paper, and the presentations made by the panelists at the 2004 Winter Simulation Conference will raise awareness and stimulate further discussion on the future of modeling methodology in areas such as modeling problems in business applications, human factors and geographically dispersed networks; rapid model development and maintenance; legacy modeling approaches; markup languages; virtual interactive process design and simulation; standards; and Grid computing

Early aspects: aspect-oriented requirements engineering and architecture design

This paper reports on the third Early Aspects: Aspect-Oriented Requirements Engineering and Architecture Design Workshop, which has been held in Lancaster, UK, on March 21, 2004. The workshop included a presentation session and working sessions in which the particular topics on early aspects were discussed. The primary goal of the workshop was to focus on challenges to defining methodical software development processes for aspects from early on in the software life cycle and explore the potential of proposed methods and techniques to scale up to industrial applications

On the emergent Semantic Web and overlooked issues

The emergent Semantic Web, despite being in its infancy, has already received a lotof attention from academia and industry. This resulted in an abundance of prototype systems and discussion most of which are centred around the underlying infrastructure. However, when we critically review the work done to date we realise that there is little discussion with respect to the vision of the Semantic Web. In particular, there is an observed dearth of discussion on how to deliver knowledge sharing in an environment such as the Semantic Web in effective and efficient manners. There are a lot of overlooked issues, associated with agents and trust to hidden assumptions made with respect to knowledge representation and robust reasoning in a distributed environment. These issues could potentially hinder further development if not considered at the early stages of designing Semantic Web systems. In this perspectives paper, we aim to help engineers and practitioners of the Semantic Web by raising awareness of these issues

A domain-specific language based approach to component composition, error-detection, and fault prediction

Current methods of software production are resource-intensive and often require a number of highly skilled professionals. To develop a well-designed and effectively implemented system requires a large investment of resources, often numbering into millions of pounds. The time required may also prove to be prohibitive. However, many parts of the new systems being currently developed already exist, either in the form of whole or parts of existing systems. It is therefore attractive to reuseexisting code when developing new software, in order to reduce the time andresources required. This thesis proposes the application of a domain-specific language (DSL) to automatic component composition, testing and fault-prediction. The DSL ISinherently based on a domain-model which should aid users of the system m knowing how the system is structured and what responsibilities the system fulfils. The DSL structure proposed in this thesis uses a type system and grammar hence enabling the early detection of syntactically incorrect system usage. Each DSL construct's behaviour can also be defined in a testing DSL, described here as DSL-test. This can take the form of input and output parameters, which should suffice for specifying stateless components, or may necessitate the use of a special method call, described here as a White-Box Test (WBT), which allows the external observer to view the abstract state of a component. Each DSL-construct can be mapped to its implementing components i.e. the component, or amalgamation of components, that implement(s) the behaviour as prescribed by the DSL-construct. User-requirements are described using the DS Land appropriate implementing components (if sufficient exist) are automatically located and integrated. That is to say, given a requirement described in terms of the DSL and sufficient components, the architecture (which was named Hydra) will be able to generate an executable which should behave as desired. The DSL-construct behaviour description language (DSL-test) is designed in such a way that it can be translated into a computer programming language, and so code can be inserted between the system automatically to verify that the implementing component is acting in a way consistent with the model of its expected behaviour. Upon detection of an error, the system examines available data (i.e. where the error occurred, what sort of error was it, and what was the structure of the executable), to attempt to predict the location of the fault and, where possible, make remedialaction. A number of case studies have been investigated and it was found that, if applied to the appropriate problem domain, the approach proposed in this thesis shows promise in terms of full automation and integration of black-box or grey-box software. However, further work is required before it can be claimed that this approach should be used in real scale systems

Green process for adipic acid synthesis: oxidation by hydrogen peroxide in water micromelusions using Benzalkonium Chloride C12-14 surfactant

Adipic acid was synthesized by the oxidation of cyclohexene using 30% hydrogen peroxide in a microemulsion in the presence of sodium tungstate as catalyst. The proposed green process is environmentally friendly since catalyst and surfactant are recycled and pure adipic acid is produced in high yield (70% to 79%). Microemulsions are used as a “green solvent” and give a better contact between the phases. Alkyldimethylbenzylammonium chloride (C12-C14) was used as a surfactant for the generation of the microemulsion since it enables the use of harmful organic solvents and phase-transfer catalysts to be avoided. Optimised operating conditions (temperature, reaction time, separation process) have been defined and applied to evaluate the industrial practicability. The main interest of the present work is the easy recovery of pure adipic acid and the reuse of the reaction media (surfactant and catalyst). This shows promise for developing a future green industrial process that will enable greenhouse gas emissions (N2O), among others, to be reduced