8,379 research outputs found

    A Decision Support System for Economic Viability and Environmental Impact Assessment of Vertical Farms

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    Vertical farming (VF) is the practice of growing crops or animals using the vertical dimension via multi-tier racks or vertically inclined surfaces. In this thesis, I focus on the emerging industry of plant-specific VF. Vertical plant farming (VPF) is a promising and relatively novel practice that can be conducted in buildings with environmental control and artificial lighting. However, the nascent sector has experienced challenges in economic viability, standardisation, and environmental sustainability. Practitioners and academics call for a comprehensive financial analysis of VPF, but efforts are stifled by a lack of valid and available data. A review of economic estimation and horticultural software identifies a need for a decision support system (DSS) that facilitates risk-empowered business planning for vertical farmers. This thesis proposes an open-source DSS framework to evaluate business sustainability through financial risk and environmental impact assessments. Data from the literature, alongside lessons learned from industry practitioners, would be centralised in the proposed DSS using imprecise data techniques. These techniques have been applied in engineering but are seldom used in financial forecasting. This could benefit complex sectors which only have scarce data to predict business viability. To begin the execution of the DSS framework, VPF practitioners were interviewed using a mixed-methods approach. Learnings from over 19 shuttered and operational VPF projects provide insights into the barriers inhibiting scalability and identifying risks to form a risk taxonomy. Labour was the most commonly reported top challenge. Therefore, research was conducted to explore lean principles to improve productivity. A probabilistic model representing a spectrum of variables and their associated uncertainty was built according to the DSS framework to evaluate the financial risk for VF projects. This enabled flexible computation without precise production or financial data to improve economic estimation accuracy. The model assessed two VPF cases (one in the UK and another in Japan), demonstrating the first risk and uncertainty quantification of VPF business models in the literature. The results highlighted measures to improve economic viability and the viability of the UK and Japan case. The environmental impact assessment model was developed, allowing VPF operators to evaluate their carbon footprint compared to traditional agriculture using life-cycle assessment. I explore strategies for net-zero carbon production through sensitivity analysis. Renewable energies, especially solar, geothermal, and tidal power, show promise for reducing the carbon emissions of indoor VPF. Results show that renewably-powered VPF can reduce carbon emissions compared to field-based agriculture when considering the land-use change. The drivers for DSS adoption have been researched, showing a pathway of compliance and design thinking to overcome the ‘problem of implementation’ and enable commercialisation. Further work is suggested to standardise VF equipment, collect benchmarking data, and characterise risks. This work will reduce risk and uncertainty and accelerate the sector’s emergence

    TOWARDS AN UNDERSTANDING OF EFFORTFUL FUNDRAISING EXPERIENCES: USING INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS IN FUNDRAISING RESEARCH

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    Physical-activity oriented community fundraising has experienced an exponential growth in popularity over the past 15 years. The aim of this study was to explore the value of effortful fundraising experiences, from the point of view of participants, and explore the impact that these experiences have on people’s lives. This study used an IPA approach to interview 23 individuals, recognising the role of participants as proxy (nonprofessional) fundraisers for charitable organisations, and the unique organisation donor dynamic that this creates. It also bought together relevant psychological theory related to physical activity fundraising experiences (through a narrative literature review) and used primary interview data to substantiate these. Effortful fundraising experiences are examined in detail to understand their significance to participants, and how such experiences influence their connection with a charity or cause. This was done with an idiographic focus at first, before examining convergences and divergences across the sample. This study found that effortful fundraising experiences can have a profound positive impact upon community fundraisers in both the short and the long term. Additionally, it found that these experiences can be opportunities for charitable organisations to create lasting meaningful relationships with participants, and foster mutually beneficial lifetime relationships with them. Further research is needed to test specific psychological theory in this context, including self-esteem theory, self determination theory, and the martyrdom effect (among others)

    Statistical Learning for Gene Expression Biomarker Detection in Neurodegenerative Diseases

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    In this work, statistical learning approaches are used to detect biomarkers for neurodegenerative diseases (NDs). NDs are becoming increasingly prevalent as populations age, making understanding of disease and identification of biomarkers progressively important for facilitating early diagnosis and the screening of individuals for clinical trials. Advancements in gene expression profiling has enabled the exploration of disease biomarkers at an unprecedented scale. The work presented here demonstrates the value of gene expression data in understanding the underlying processes and detection of biomarkers of NDs. The value of novel approaches to previously collected -omics data is shown and it is demonstrated that new therapeutic targets can be identified. Additionally, the importance of meta-analysis to improve power of multiple small studies is demonstrated. The value of blood transcriptomics data is shown in applications to researching NDs to understand underlying processes using network analysis and a novel hub detection method. Finally, after demonstrating the value of blood gene expression data for investigating NDs, a combination of feature selection and classification algorithms were used to identify novel accurate biomarker signatures for the diagnosis and prognosis of Parkinson’s disease (PD) and Alzheimer’s disease (AD). Additionally, the use of feature pools based on previous knowledge of disease and the viability of neural networks in dimensionality reduction and biomarker detection is demonstrated and discussed. In summary, gene expression data is shown to be valuable for the investigation of ND and novel gene biomarker signatures for the diagnosis and prognosis of PD and AD

    Karttatypografia: luettavuuden parantaminen kirjainmuotoilun keinoin topografisissa kartoissa

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    This thesis examines the legibility of type on maps and aims to find out ways to improve it through type design. As type often is an integral part of maps – something that helps the map user navigate, understand, and perceive a wide range of information in an effective way – type design and legibility must be regarded as important design elements. However, even though cartography and typography have extensive theoretical bases, the subject of legibility has not been comprehensively researched in cartographic context. Thus, by combining type design theory and scientific legibility studies with cartographic theory, the legibility of type on maps could be improved. The topic is first studied by an extensive literature review to cover existing concepts and theories of cartography, cartographic typography, and typography. After a competent knowledge basis of these concepts and theories is acquired, the findings are utilised in the design component. The design component is a type family designed specifically to be used with topographic maps: it consists of two elements, a project description that follows the design process of the type family, relating design choices to the theoretical findings and perspectives presented in the literary review, and the finished type family. In conclusion of the design component, several visual studies are made both to compare the design component (type family) to other relevant typefaces, and to validate the possible functionality of the design component in the chosen cartographic application (topographic map). A broad understanding of the topics of the literature review was formed. Cartographic theory observed the overall nature of maps and specified the various map elements and their intended uses. Cartographic typography deepened the understanding of type on maps – it highlighted the specific needs that must be taken into consideration, demonstrated the diversity of typographic situations that might occur, and presented a large set of guidelines to help the mapmaker to achieve better results. Typography and type design focused on the micro-level of type: how the minor design choices affect the whole, and furthermore, through legibility studies, validated certain views and brought new topics into consideration. By combining theoretical literature from these domains, this thesis helped to form a foundation for an improved framework for type de-sign for (topographic) maps. Furthermore, the domains of cartographic typography and typography and type design gave clear suggestions on how the legibility of type on topographic maps can be improved: legibility of type in this context constitutes from multiple components that must be both taken into consideration and be applied to processes of mapmaking and type design.TĂ€ssĂ€ opinnĂ€ytetyössĂ€ tutkitaan karttatypografiaa ja pyritÀÀn löytĂ€mÀÀn keinoja parantaa luettavuutta kirjainmuotoilun keinoin. Teksti on usein elimellinen osa karttoja: se helpottaa kartan kĂ€yttĂ€jÀÀ navigoimaan ja sisĂ€istĂ€mÀÀn suuren mÀÀrĂ€n informaatiota tehokkaasti. SiispĂ€ kirjainmuotoilua ja luettavuutta tulee pitÀÀ tĂ€rkeinĂ€ karttasuunnittelun työkaluina. Vaikka sekĂ€ kartografiassa ettĂ€ typografiassa on olemassa laajat teoreettiset perustat, luettavuutta ei ole kattavasti tutkittu kartografisessa kontekstissa. YhdistĂ€mĂ€llĂ€ kirjainmuotoilun ja tieteelliset luettavuustutkimukset kartografiseen teoriaan, karttatekstien luettavuutta voidaan parantaa. Aluksi tutustutaan olemassa oleviin konsepteihin ja kartografisiin teorioihin kattavan kirjallisuuskatsauksen avulla. Kun tarpeellinen tietopohja on rakennettu, saavutettua tietĂ€mystĂ€ hyödynnetÀÀn opinnĂ€ytetyön projektiosassa, joka tĂ€ssĂ€ tapauksessa on topografisten karttojen yhteydessĂ€ kĂ€ytettĂ€vĂ€ kirjainperhe. Projektiosio on kaksijakoinen ja pitÀÀ sisĂ€llÀÀn sekĂ€ valmiin kirjainperheen, ettĂ€ projektikuvauksen. Projektikuvaus seuraa suunnitteluprosessia ja peilaa tehtyjĂ€ valintoja kirjallisuuskatsauksessa esiteltyihin löydöksiin. Projektiosion pÀÀtelmĂ€ssĂ€ tutkitaan visuaalisesti kirjainperheen toimintaa ja kĂ€yttökelpoisuutta topografisessa karttaympĂ€ristössĂ€, sekĂ€ verrataan kirjainperheen toimivuutta suhteessa muihin kirjaintyyppeihin. Tutkimuksen perusteella muodostuu laaja ymmĂ€rrys aiheesta. Kartografinen teoria valottaa yleisesti karttojen olemusta ja toimintaa, sekĂ€ esittelee erilaisia karttalementtejĂ€ ja niiden toimintatapoja. Karttatypografian teoria syventÀÀ ymmĂ€rrystĂ€ tekstin kĂ€yttĂ€ytymisestĂ€ karttaympĂ€ristössĂ€, esittelee karttatypografian erityispiirteitĂ€, ja tarjoaa laajan karttatypografisen ohjeiston. Typografian ja kirjainmuotoilun teoria keskittyy mikrotason aiheisiin: kuinka vĂ€hĂ€pĂ€töisiltĂ€ vaikuttavat suunnitteluvalinnat vaikuttavat kokonaisuuteen, ja kuinka luettavuustutkimukset auttavat nĂ€kemÀÀn asioita uudessa valossa. TĂ€mĂ€ opinnĂ€ytetyö auttaa parantamaan kirjainmuotoilua (topografisessa) karttaympĂ€ristössĂ€ yhdistĂ€mĂ€llĂ€ edellĂ€ mainittujen alojen teorioita keskenÀÀn ja pohjustamalla paranneltuja suunniteluvalintoja. Yhdistetty teoria viittaa selkeĂ€sti siihen, ettĂ€ luettavuus karttaympĂ€ristössĂ€ koostuu lukuisista osatekijöistĂ€ – nĂ€mĂ€ osatekijĂ€t tulee ymmĂ€rtÀÀ, ottaa huomioon, ja soveltaa sekĂ€ karttojen ettĂ€ niille suunniteltujen kirjaintyyppien suunnitteluprosesseissa

    Antibody Targeting of HIV-1 Env: A Structural Perspective

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    A key component of contemporary efforts toward a human immunodeficiency virus 1 (HIV-1) vaccine is the use of structural biology to understand the structural characteristics of antibodies elicited both from human patients and animals immunized with engineered 'immunogens,' or early vaccine candidates. This thesis will report on projects characterizing both types of antibodies against HIV-1. Chapter 1 will introduce relevant topics, including the reasons HIV-1 is particularly capable of evading the immune system in natural infection and after vaccination, the 20+ year history of unsuccessful HIV-1 vaccine large-scale efficacy trials, an introduction to broadly neutralizing antibodies (bNAbs), and a review of common strategies utilized in HIV-1 immunogen design today. Chapter 2 describes the isolation, high-resolution structural characterization, and in vitro resistance profile of a new bNAb, 1-18, that is both very broad and potent, as well as able to restrict HIV-1 escape in vivo. Chapter 3 reports the results of an epitope-focusing immunogen design and immunization experiment carried out in wild type mice, rabbits, and non-human primates where it was shown that B cells targeting the desired epitope were expanded after a single prime immunization with immunogen RC1 or a variant, RC1-4fill. Chapter 4 describes Ab1245, an off-target non-neutralizing monoclonal antibody isolated in a macaque that had been immunized with a series of sequential immunogens after the prime immunization reported in Chapter 3. The antibody structure describes a specific type of distracting response as it binds in a way that causes a large structural change in Env, resulting in the destruction of the neutralizing fusion peptide epitope. Chapter 5 is adapted from a review about how antibodies differentially recognize the viruses HIV-1, SARS-CoV-2, and Zika virus. This review serves as an introduction to the virus SARS-CoV-2, which is the topic of the final chapter, Chapter 6. In this chapter, structures of many neutralizing antibodies isolated from SARS-CoV-2 patients were used to define potentially therapeutic classes of neutralizing receptor-binding domain (RBD) antibodies based on their epitopes and binding profiles

    AIUCD 2022 - Proceedings

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    L’undicesima edizione del Convegno Nazionale dell’AIUCD-Associazione di Informatica Umanistica ha per titolo Culture digitali. Intersezioni: filosofia, arti, media. Nel titolo ù presente, in maniera esplicita, la richiesta di una riflessione, metodologica e teorica, sull’interrelazione tra tecnologie digitali, scienze dell’informazione, discipline filosofiche, mondo delle arti e cultural studies

    Chinese Benteng Women’s Participation in Local Development Affairs in Indonesia: Appropriate means for struggle and a pathway to claim citizen’ right?

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    It had been more than two decades passing by aftermath the devastating Asia’s Financial Crisis in 1997, subsequently followed by Suharto’s step down from his presidential throne which he occupied for more than three decades. The financial turmoil turned to a political disaster furthermore has led to massive looting that severely impacted Indonesians of Chinese descendant, including unresolved mystery of the most atrocious sexual violation against women and covert killings of students and democracy activists in this country. Since then, precisely aftermath May 1998, which publicly known as “Reformasi”1, Indonesia underwent political reform that eventually corresponded positively to its macroeconomic growth. Twenty years later, in 2018, Indonesia captured worldwide attention because it has successfully hosted two internationally renowned events, namely the Asian Games 2018 – the most prestigious sport events in Asia – conducted in Jakarta and Palembang; and the IMF/World Bank Annual Meeting 2018 in Bali. Particularly in the IMF/World Bank Annual Meeting, this event has significantly elevated Indonesia’s credibility and international prestige in the global economic powerplay as one of the nations with promising growth and openness. However, the narrative about poverty and inequality, including increasing racial tension, religious conservatism, and sexual violation against women are superseded by friendly climate for foreign investment and eventually excessive glorification of the nation’s economic growth. By portraying the image of promising new economic power, as rhetorically promised by President Joko Widodo during his presidential terms, Indonesia has swept the growing inequality in this highly stratified society that historically compounded with religious and racial tension under the carpet of digital economy.Arte y Humanidade

    Platform protocol place: a practice-based study of critical media art practice (2007-2020)

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    This practice-based research project focuses on critical media art practices in contemporary digital culture. The theoretical framework employed in this inquiry draws from the work of the Frankfurt School, in particular Theodor Adorno and Max Horkheimer’s The Culture Industry: Enlightenment as Mass Deception. Using Adorno & Horkheimer’s thesis as a theoretical guide, this research project formulates the concept of the digital culture industry - a concept that refers to the contemporary era of networked capitalism, an era defined by the unprecedented extraction, accumulation and manipulation of data and the material and digital infrastructures that facilitate it. This concept is used as a framing mechanism that articulates certain techno-political concerns within networked capitalism and responds to them through practice. The second concept formulated within this research project is Platform Protocol Place. The function of this second concept is to frame and outline the body of practice-based work developed in this study. It is also used to make complex technological issues accessible and to communicate these issues through public exhibition and within this written thesis. The final concept developed in this research project is tactical media archaeology. This concept describes the techniques and approaches employed in the development of the body of practice-based work that are the central focus of this research project. This approach is a synthesis of two subfields of media art practice and theory, tactical media and media archaeology. Through practice, tactical media archaeology critiques the geopolitical machinations and systems beneath the networked devices and interfaces of the digital culture industry
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