Accurate broadband measurement of electromagnetic tissue phantoms using open-ended coaxial systems

[EN] New technologies and devices for wireless communication networks are continually developed. In order to assess their performance, they have to be tested in realistic environments taking into account the influence of the body in wireless communications. Thus, the development of phantoms, which are synthetic materials that can emulate accurately the electromagnetic behaviour of different tissues, is mandatory. An accurate dielectric measurement of these phantoms requires using a measurement method with a low uncertainty. The open-ended coaxial technique is the most spread technique but its accuracy is strongly conditioned by the calibration procedure. A typical calibration is performed using an open circuit, a short circuit and water. However, this basic calibration is not the most accurate approach for measuring all kinds of materials. In this paper, an uncertainty analysis of the calibration process of open-ended coaxial characterization systems when a polar liquid is added to the typical calibration is provided. Measurements are performed on electromagnetically well-known liquids in the 0.5 - 8.5 GHz band. Results show that adding methanol improves the accuracy in the whole solution domain of the system, mainly when measuring phantoms that mimic high water content tissues, whereas ethanol is more suitable for measuring low water content tissue phantoms.This work was supported by the Ministerio de Educacion y Ciencia, Spain (ref. TEC2014-60258-C2-1-R, TEC2014-56469-REDT), by the European FEDER funds.Fornés Leal, A.; Garcia-Pardo, C.; Castelló-Palacios, S.; Vallés Lluch, A.; Cardona Marcet, N. (2007). Accurate broadband measurement of electromagnetic tissue phantoms using open-ended coaxial systems. IEEE. 32-36. https://doi.org/10.1109/ISMICT.2017.7891761S323

Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis

[EN] An in-body sensor network is that in which at least one of the sensors is located inside the human body. Such wireless in-body sensors are used mainly in medical applications, collecting and monitoring important parameters for health and disease treatment. IEEE Standard 802.15.6-2012 for wireless body area networks (WBANs) considers in-body communications in the Medical Implant Communications Service (MICS) band. Nevertheless, high-data-rate communications are not feasible at the MICS band because of its narrow occupied bandwidth. In this framework, ultrawideband (UWB) systems have emerged as a potential solution for in-body highdata-rate communications because of their miniaturization capabilities and low power consumption.This work was supported by the Programa de Ayudas de Investigación y Desarrollo (PAID-01-16) at the Universitat Politècnica de València, Spain; by the Ministerio de Economía y Competitividad, Spain (TEC2014-60258-C2-1-R); and by the European FEDER funds. It was also funded by the European Union’s H2020:MSCA:ITN program for the Wireless In-Body Environ-ment Communication–WiBEC project under grant 675353.Garcia-Pardo, C.; Andreu-Estellés, C.; Fornés Leal, A.; Castelló-Palacios, S.; Pérez-Simbor, S.; Barbi, M.; Vallés Lluch, A.... (2018). Ultrawideband Technology for Medical In-Body Sensor Networks: An Overview of the Human Body as a Propagation Medium, Phantoms, and Approaches for Propagation Analysis. IEEE Antennas and Propagation Magazine. 60(3):19-33. https://doi.org/10.1109/MAP.2018.2818458S193360

Gel Phantoms for Body Microwave Propagation in the (2 to 26.5) GHz Frequency Band

[EN] Tissue phantoms are widely used for assessing the interaction between the electromagnetic waves and the human body. These are especially key in body area networks, where the body itself acts as the propagation medium since transmission is highly influenced by its diverse dielectric properties. Gels are suitable materials because of their high water content, which is required to mimic the dielectric properties of most tissues. In this paper, PHEA gels are suggested for achieving those properties due to their synthetic nature, which gives them the possibility to be swollen reversibly in more types of mixtures, in addition to water. These gels can be tailored to control the amount of liquid they embed so that they can imitate different body tissues in a wide bandwidth (2¿26.5 GHz), which includes most of the current mobile communication and medical bands. This versatility offers the chance to create heterogeneous models of particular regions of the body, and thus improve the test realism. In addition, they own better mechanical and stability properties than the widely used agar or gelatin.This work was supported in part by the Universitat Politecnica de Valencia-Institut d'Investigacio Sanitaria La Fe (UPV-IIS La Fe) Program [Early Stage Colon Tumour Diagnosis by Electromagnetic Reflection (STuDER), 2016 and Electromagnetic Probe for Early Tumour Detection (EMOTE), 2017], in part by the Universitat Politecnica de Valencia through the Programa de Ayudas de Investigacion y Desarrollo under Grant PAID-01-16, and in part by the European Union's H2020: MSCA: ITN Program for the "mmWave Communications in the Built Environments - WaveComBE" Project under Grant 766231.Castelló-Palacios, S.; Garcia-Pardo, C.; Alloza-Pascual, M.; Fornés Leal, A.; Cardona Marcet, N.; Vallés Lluch, A. (2019). Gel Phantoms for Body Microwave Propagation in the (2 to 26.5) GHz Frequency Band. IEEE Transactions on Antennas and Propagation. 67(10):6564-6573. https://doi.org/10.1109/TAP.2019.2920293S65646573671

Broadband Measurement of Complex Permittivity Using Reflection Method and Coaxial Probes

This paper describes and evaluates a method for determining complex permittivity, and presents results of permittivity measurement of some substances. Complex permittivity of a phantom of biological muscle tissue, of some industrial chemicals and dielectrics is found. A non-destructive and non-invasive method based on reflection coefficient measurement of an open-ended coaxial line attaching the material under test is used. Two coaxial probes are under investigation. Vector measurement of the reflection coefficient on the interface between probes and measured samples is performed with the aid of network analyzer in the frequency range from 300 kHz to 3 GHz. Numerical modeling (FDTD) is compared with measurement. The results indicate that using the coaxial probe with dimensions of N connector the method is suitable in the frequency range approximately from 30 MHz to 1 GHz and using the probe with dimensions of SMA connector in range approximately from 30 MHz to 3 GHz

Development of multi-material phantoms and implanted monopole antennas for bone fracture monitoring

This thesis presents a novel method for monitoring the healing of severe bone fractures. This would be particularly useful during the first two to four weeks after trauma where x-ray and computerised tomography scanning cannot provide an accurate indication regarding the healing status of the fractured bone. The technique involves measuring the radiofrequency transmission from one bone-implanted monopole to another, each one located on either side of the bone fracture. Throughout this thesis, it is envisaged that the monopoles will also act as the screws of an external fixation implanted into patients for the stabilization and alignment of the bone fragments. To replicate a simplified version of a human limb, several multi-material semi-solid phantoms were developed to represent bone marrow, bone cortical, blood and muscle. Medical literature indicates that the amount of blood found at the initial stage of a bone fracture decreases as bone regeneration takes place towards the healed state. The rate of change of the 21 of the implanted monopoles over time was shown to provide a tool that allowed the estimation of the amount of blood (hematoma) inside any bone fracture. In this thesis it has been shown that as the effective dielectric properties of the investigated fractured area shifted from the dielectric properties of blood towards the properties of bone, the 21 of the monopoles increased, thus, this technique can be used to indicate bone healing. The simulated results were validated in measurements using several multi-material phantoms and a real lamb joint. Finally, an analytical model on the approximation of the 21 of the monopoles in the near field inside the multi-material phantoms was developed. The results showed good agreement over the frequency spectrum of 1 to 4GHz and reasonable agreement over the parametric investigation of separation distance between them for the range of 1 to 7cm. This will potentially allow the application of the proposed technique for special types of fractures where the screws of the external fixation are separated by different distances

암 진단 및 치료에 적용 가능한 마이크로파 능동 집적 탐침에 관한 연구

학위논문 (박사)-- 서울대학교 대학원 : 전기·컴퓨터공학부, 2015. 2. 권영우.본 논문에서는 암 진단 및 치료에 적용 가능한 초소형 마이크로파 능동 집적 탐침에 대해 기술하였다. 생체 조직의 광대역 측정과 저전력 온열 치료에 적용 하기 위해 유전율 측정 회로를 평면형 동축 탐침에 집적하였고, 마이크로파 발생 회로를 어플리케이터에 집적하였다. MEMS 기술과 MMIC 기술을 적용함으로써 단일 플랫폼에 집적된 시스템으로 구현하여 집적도를 향상 시키고, 시스템을 소형화 하였다. 먼저 multi-state reflectometer를 이용하여 암 진단에 활용 가능한복소 유전율 측정 기술에 대해 제안하였다. 2, 16 GHz에서 동작하는 광대역 reflectometer는 이중 대역 위상 고정 루프 (PLL), 임피던스 튜너, RF 전력 검출기 등의 MMIC와 MEMS 기반의 방향성 결합기, 평면형 탐침을 집적하여 구현하였다. 제작한 능동 집적 탐침 시스템을 이용하여 생체 조직과 암 조직 등의 유전율을 측정함으로써 유용함을 확인하였고, 측정된 유전율과 표준값을 비교하여 시스템의 측정 정확도를 검증하였다. 또한 저전력 마이크로파 온열 치료 요법을 위한 능동 집적 탐침을 개발하였다. MEMS 공정을 통해 제작한 평면형 실리콘 탐침에 전압 제어 발진기, 구동 증폭기, 전력 증폭기를 집적하여 능동 집적 탐침 시스템을 제작하였다. 치료를 진행하는 동안, 마이크로파의 전력을 측정할 수 있도록 전력 검출기와 방향성 결합기도 함께 집적하였다. 암, 근육 등 다양한 생체 조직을 이용한 실험의 결과로부터 Ku 대역의 주파수에서 저전력 마이크로파 온열 치료가 가능함을 확인하였다. 마지막으로 자성 나노입자를 이용한 온열 치료에 적용하기 위해 능동 집적 탐침을 개발하였다. 자성 나노입자가 온열 치료 요법에 미치는 영향을 분석하기 위해 전자기-열 결합 해석을 수행하였고, 이로부터 자성 나노입자의 선택도 향상을 위한 최적의 주파수를 결정하였다. 발진기와 전력 증폭기 MMIC와 이중 채널 로그 전력 검출기, 방향성 결합기를 탐침에 집적하여 시스템을 제작하였다. 이를 이용한 실험 결과로부터 능동 집적 탐침의 성능을 확인하였으며, 자성 나노입자가 저전력 및 암 특이 마이크로파 온열 치료의 효율과 선택도를 향상시키는데 유용함을 검증하였다.This thesis presents miniaturized microwave active integrated probe systems applicable to cancer detection and treatment. To realize broadband detection and low-power hyperthermia, planar-type coaxial probes and heat applicators have been integrated with active circuits for permittivity measurement and microwave generation, respectively. Each integrated system is implemented on a single platform using Microelectromechanical Systems (MEMS) and monolithic microwave integrated circuit (MMIC) technologies for miniaturization and integration. First, a complex permittivity measurement technique using an integrated multi-state reflectometer (MSR) is proposed for cancer detection application. The broadband MSR covering both 2 and 16 GHz bands consists of a dual-band phase-locked loop, a directional coupler, an impedance tuner, two RF power detectors, and a micromachined silicon planar probe with an open-ended coaxial aperture. All the active and passive circuit components have been integrated on the micromachined probe platform in a small form factor of 6.8 mm × 50 mm × 0.6 mm. The performance of the fabricated integrated probe has been evaluated by comparing the measured permittivities of 0.9% saline, pork muscle, fat, and xenografted human breast cancer with the reference data. For low-power microwave hyperthermia, a Ku-band active integrated heat applicator is demonstrated. A planar-type coaxial applicator has been fabricated using silicon micromachining technology, on which a Ku-band voltage controlled oscillator (VCO), a driver amplifier, and a power amplifier (PA) have been integrated. A directional coupler and power detectors are employed for power monitoring. The fully integrated heat applicator has been realized in a small footprint of 8 mm × 56 mm. In-vitro and in-vivo ablation experiments on pork muscle, fat, and human-cancer xenografted nude mouse demonstrate the feasibility of low-power hyperthermia using Ku-band microwaves. Finally, an active integrated heat applicator for magnetic nanoparticle (MNP)-assisted hyperthermia is developed. The effect of the MNP on microwave hyperthermia has been analyzed by a coupled electromagnetic-thermal analysis. The optimum frequency for hyperthermia is determined by the coupled analysis. A 2-GHz source module consisting of a VCO and a PA has been implemented in MMICs and integrated on the heat applicator platform. A dual-channel log detector and a directional coupler have been also employed to monitor the power levels during hyperthermia. Experiment results show not only sufficient heating performance of the integrated applicator, but also the effectiveness of the MNP for low-power and cancer-specific microwave hyperthermia.Abstract i Contents iv List of Figures viii List of Tables xv 1. Introduction 1 1.1 Motivation 1 1.2 Microwave Cancer Detection 4 1.3 Microwave Hyperthermia 5 1.4 Outline of Thesis 7 2. Active Integrated Probe for Cancer Detection 9 2.1 Introduction 9 2.2 Principle of Operation 13 2.2.1 Multi-State Reflectometer 14 2.2.2 Governing Equation for Complex Permittivity 15 2.2.3 Determination of Complex Permittivity 17 2.2.4 Calibration 19 2.3 Design and Fabrication 21 2.3.1 Micromachined Planar Coaxial Probe 21 2.3.2 Impedance Tuner 30 2.3.3 Directional Coupler 34 2.3.4 Power Detector 37 2.3.5 Signal Source 39 2.3.6 Active Integrated Probe System 43 2.4 Measurement Results 46 2.5 Summary 52 3. Ku-Band Active Integrated Heat Applicator for Cancer Ablation 54 3.1 Introduction 54 3.2 Design and Fabrication 57 3.2.1 Micromachined Planar Coaxial Applicator 58 3.2.2 Microwave Source 63 3.2.3 Power Monitoring Circuits 67 3.2.4 Ku-Band Active Integrated Applicator System 67 3.3 Experiment Results 70 3.4 Summary 77 4. Active Integrated Heat Applicator for Magnetic Nanoparticle-Assisted Hyperthermia 79 4.1 Introduction 79 4.2 Magnetic Nanoparticle (MNP) 82 4.2.1 Heating mechanism of MNP 83 4.2.2 Permeability of MNP 84 4.3 Coupled Electromagnetic-Thermal Analysis 88 4.3.1 Coupled Electromagnetic-Thermal Problems 88 4.3.2 Electromagnetic Analysis 92 4.3.3 Thermal Analysis 94 4.3.4 Analysis Results 96 4.4 Design and Fabrication 103 4.4.1 Spiral Applicator 104 4.4.2 Microwave Source 107 4.4.3 Power Monitoring Circuits 111 4.4.4 Active Integrated Applicator for MNP-Assisted Hyperthermia 119 4.5 Experiment Results 122 4.6 Summary 132 5. Conclusion 134 Bibliography 137 Abstract in Korean 152Docto

Tailor-Made Tissue Phantoms Based on Acetonitrile Solutions for Microwave Applications up to 18 GHz

(c) 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.Tissue-equivalent phantoms play a key role in the development of new wireless communication devices that are tested on such phantoms prior to their commercialization. However, existing phantoms cover a small number of tissues and do not reproduce them accurately within wide frequency bands. This paper aims at enlarging the number of mimicked tissues as well as their working frequency band. Thus, a variety of potential compounds are scanned according to their relative permittivity from 0.5 to 18 GHz. Next, a combination of these compounds is characterized so the relation between their dielectric properties and composition is provided. Finally, taking advantage of the previous analysis, tailor-made phantoms are developed for different human tissues up to 18 GHz and particularized for the main current body area network (BAN) operating bands. The tailor-made phantoms presented here exhibit such a high accuracy as would allow researchers and manufacturers to test microwave devices at high frequencies for large bandwidths as well as the use of heterogeneous phantoms in the near future. The key to these phantoms lies in the incorporation of acetonitrile to aqueous solutions. Such compounds have a suitable behavior to achieve the relative permittivity values of body tissues within the studied frequency band.This work was supported by the Ministerio de Economia y Competitividad, Spain (TEC2014-60258-C2-1-R) and by the European FEDER Funds.Castelló-Palacios, S.; García Pardo, C.; Fornés Leal, A.; Cardona Marcet, N.; Vallés Lluch, A. (2016). Tailor-Made Tissue Phantoms Based on Acetonitrile Solutions for Microwave Applications up to 18 GHz. IEEE Transactions on Microwave Theory and Techniques. 64(11):3987-3994. https://doi.org/10.1109/TMTT.2016.2608890S39873994641

Microwave Breast Imaging Techniques and Measurement Systems

Electromagnetic waves at microwave frequencies allow penetration into many optically non-transparent mediums such as biological tissues. Over the past 30 years, researchers have extensively investigated microwave imaging (MI) approaches including imaging algorithms, measurement systems and applications in biomedical fields, such as breast tumor detection, brain stroke detection, heart imaging and bone imaging. Successful clinical trials of MI for breast imaging brought worldwide excitation, and this achievement further confirmed that the MI has potential to become a low-risk and cost-effective alternative to existing medical imaging tools such as X-ray mammography for early breast cancer detection. This chapter offers comprehensive descriptions of the most important MI approaches for early breast cancer detection, including reconstruction procedures and measurement systems as well as apparatus

Dielectric Characterization of In Vivo Abdominal and Thoracic Tissues in the 0.5 26.5 GHz Frequency Band for Wireless Body Area Networks

(c) 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.[EN] The dielectric properties of biological tissues are of utmost importance in the development of wireless body area networks (WBANs), especially for implanted devices. The early design stages of medical devices like capsule endoscopy, pacemakers, or physiological sensors rely on precise knowledge of the dielectric properties of the tissues present in their surrounding medium. Many of these applications make use of electromagnetic phantoms, which are software or physical models that imitate the shape and the electromagnetic properties of the tissues. They are used for designing devices in software simulations and for testing them in laboratory trials, aiding in both the development of WBAN antennas or in communication link evaluations. The existing reports about dielectric in vivo properties are limited and have drawbacks like: low variety of characterized tissues, lacking some relevant ones, and limitations and inhomogeneity in the measured frequency range. This paper aims at filling that gap by providing a new database of dielectric properties of biological tissues measured in vivo . In particular, it is focused on the tissues of the thoracic and the abdominal regions, measured at the same wide frequency band, on the same animal specimen, and under the same conditions. The properties have been obtained by measuring porcine tissues in the 0.5¿26.5 GHz band with the open-ended coaxial technique. In this paper, we focus on those tissues that have been scarcely characterized so far in the literature, like heart, esophagus, stomach, and pancreas. The Cole¿Cole fitting parameters of the measured tissues and their uncertainties are provided.This work was supported in part by UPV-IIS LaFe Program (STuDER, 2016, and EMOTE, 2018), in part by the Programa de Ayudas de Investigacion y Desarrollo (PAID-01-16) from the Universitat Politecnica de Valencia, in part by the European Union's H2020: MSCA: ITN Programs for the "Wireless In-Body Environment Communication-WiBEC'' Project, under Grant 675353, and in part by the "mmWave Communications in the Built Environments-WaveComBE'' Project, under Grant 766231.Fornés Leal, A.; Cardona Marcet, N.; Frasson, M.; Castelló-Palacios, S.; Nevárez, A.; Pons Beltrán, V.; Garcia-Pardo, C. (2019). Dielectric Characterization of In Vivo Abdominal and Thoracic Tissues in the 0.5 26.5 GHz Frequency Band for Wireless Body Area Networks. IEEE Access. 7:31854-31864. https://doi.org/10.1109/ACCESS.2019.2903481S3185431864