Accepting networks of evolutionary picture processors

We extend the study of networks of evolutionary processors accepting words to a similar model, processing rectangular pictures. To this aim, we introduce accepting networks of evolutionary picture processors and investigate their computational power. We show that these networks can accept the complement of any local picture language as well as picture languages that are not recognizable. Some open problems regarding decidability issues and closure properties are finally discussed

Accepting networks of evolutionary picture processors

We extend the study of networks of evolutionary processors accepting words to a similar model, processing rectangular pictures. To this aim, we introduce accepting networks of evolutionary picture processors and investigate their computational power. We show that these networks can accept the complement of any local picture language as well as picture languages that are not recognizable. Some open problems regarding decidability issues and closure properties are finally discussed

Computational Approaches to Drug Profiling and Drug-Protein Interactions

Despite substantial increases in R&D spending within the pharmaceutical industry, denovo drug design has become a time-consuming endeavour. High attrition rates led to a long period of stagnation in drug approvals. Due to the extreme costs associated with introducing a drug to the market, locating and understanding the reasons for clinical failure is key to future productivity. As part of this PhD, three main contributions were made in this respect. First, the web platform, LigNFam enables users to interactively explore similarity relationships between ‘drug like’ molecules and the proteins they bind. Secondly, two deep-learning-based binding site comparison tools were developed, competing with the state-of-the-art over benchmark datasets. The models have the ability to predict offtarget interactions and potential candidates for target-based drug repurposing. Finally, the open-source ScaffoldGraph software was presented for the analysis of hierarchical scaffold relationships and has already been used in multiple projects, including integration into a virtual screening pipeline to increase the tractability of ultra-large screening experiments. Together, and with existing tools, the contributions made will aid in the understanding of drug-protein relationships, particularly in the fields of off-target prediction and drug repurposing, helping to design better drugs faster

Microbial community dynamics and methane cycling in rewetted temperate fens

Changes in land use and climate influence the methane balance of fen peatlands, and the peat microbial communities involved in methane transformation. Microbial communities, however, have rarely been studied in fens in this context. In this thesis, I used high-throughput 16S rRNA gene amplicon sequencing of DNA and cDNA, qPCR, and geochemical analyses to assess how rewetting and drying of fens influences methane producers (methanogens) and consumers (methanotrophs). Fen rewetting promoted the establishment of methanogens, while short-term drought promoted methanotroph establishment

A technology acceptance model for empirically testing new end-user information systems : theory and results

Thesis (Ph. D.)--Massachusetts Institute of Technology, Sloan School of Management, 1986.MICROFICHE COPY AVAILABLE IN ARCHIVES AND DEWEY.Bibliography: leaves 233-250.by Fred D. Davis, Jr.Ph.D

Proceedings of the 26th International Symposium on Theoretical Aspects of Computer Science (STACS'09)

The Symposium on Theoretical Aspects of Computer Science (STACS) is held alternately in France and in Germany. The conference of February 26-28, 2009, held in Freiburg, is the 26th in this series. Previous meetings took place in Paris (1984), Saarbr¨ucken (1985), Orsay (1986), Passau (1987), Bordeaux (1988), Paderborn (1989), Rouen (1990), Hamburg (1991), Cachan (1992), W¨urzburg (1993), Caen (1994), M¨unchen (1995), Grenoble (1996), L¨ubeck (1997), Paris (1998), Trier (1999), Lille (2000), Dresden (2001), Antibes (2002), Berlin (2003), Montpellier (2004), Stuttgart (2005), Marseille (2006), Aachen (2007), and Bordeaux (2008). ..

Hadron models and related New Energy issues

The present book covers a wide-range of issues from alternative hadron models to their likely implications in New Energy research, including alternative interpretation of lowenergy reaction (coldfusion) phenomena. The authors explored some new approaches to describe novel phenomena in particle physics. M Pitkanen introduces his nuclear string hypothesis derived from his Topological Geometrodynamics theory, while E. Goldfain discusses a number of nonlinear dynamics methods, including bifurcation, pattern formation (complex GinzburgLandau equation) to describe elementary particle masses. Fu Yuhua discusses a plausible method for prediction of phenomena related to New Energy development. F. Smarandache discusses his unmatter hypothesis, and A. Yefremov et al. discuss Yang-Mills field from Quaternion Space Geometry. Diego Rapoport discusses theoretical link between Torsion fields and Hadronic Mechanic. A.H. Phillips discusses semiconductor nanodevices, while V. and A. Boju discuss Digital Discrete and Combinatorial methods and their likely implications in New Energy research. Pavel Pintr et al. describe planetary orbit distance from modified Schrödinger equation, and M. Pereira discusses his new Hypergeometrical description of Standard Model of elementary particles. The present volume will be suitable for researchers interested in New Energy issues, in particular their link with alternative hadron models and interpretation

Investigation of binary polar solvent mixtures, solubilized ferroelectric salts and paraffin-based derivatives using dielectric spectroscopy

Water properties are the subject of investigations in physics, chemistry, biology and different applied fields of natural science. Liquid dosage forms, generally based on aqueous solutions, take an important role in drug administration e.g. as parenteral preparations, ophthalmic formulations or as oral solutions for children and elderly patients. Sufficient drug solubility in water is a prerequisite for orally administrated solid dosage forms such as tablets, capsules, etc. to show a sufficient bioavailability. The solubility of a drug is determined by intermolecular forces. While these can be reasonably well characterized in gaseous and solid material, no satisfying description has yet been found for liquid systems, especially for nonideal solutions. The presence of several types of intermolecular interactions let water show rather a complex associated structure due to which it has a number of its abnormal properties. In part A of this work, the intermolecular forces in pure solvents and binary mixtures at 298.2 K (25°C) are investigated, using quasistatic low-frequency and AC highfrequency broadband (0.2-20 GHz) dielectric spectroscopy. The data were interpreted using for the low frequency measurements the modified Clausius-Mossotti-Debye equation according to Leuenberger and Kirkwood-Fröhlich equation. For the description of the dielectric relaxation in the high frequency range there are different models available which describe the relaxation behaviour of a polar liquid. The most simple equation is the Debye equation, which will be described and will be compared with the other models in the theory chapter. It has to be kept in mind that the resulting relaxation times

Aerospace Medicine and Biology: A cumulative index to the 1982 issues

This publication is a cumulative index to the abstracts contained in the Supplements 229 through 240 of Aerospace Medicine and Biology: A continuing Bibliography. It includes three indexes: subject, personal author, and corporate source