10,511 research outputs found
Bioinformatics and the politics of innovation in the life sciences: Science and the state in the United Kingdom, China, and India
The governments of China, India, and the United Kingdom are unanimous in their belief that bioinformatics should supply the link between basic life sciences research and its translation into health benefits for the population and the economy. Yet at the same time, as ambitious states vying for position in the future global bioeconomy they differ considerably in the strategies adopted in pursuit of this goal. At the heart of these differences lies the interaction between epistemic change within the scientific community itself and the apparatus of the state. Drawing on desk-based research and thirty-two interviews with scientists and policy makers in the three countries, this article analyzes the politics that shape this interaction. From this analysis emerges an understanding of the variable capacities of different kinds of states and political systems to work with science in harnessing the potential of new epistemic territories in global life sciences innovation
Evolution and Biogeography of Haemonchus contortus: Linking Faunal Dynamics in Space and Time
History is the foundation that informs about the nuances of faunal assembly that are essential in understanding the dynamic nature of the host-parasite interface. All of our knowledge begins and ends with evolution, ecology and biogeography, as these interacting facets determine the history of biodiverse systems. These components, relating to Haemonchus, can inform about the complex history of geographical distribution, host association and the intricacies of host-parasite associations that are played out in physiological and behavioural processes that influence the potential for disease and our capacity for effective control in a rapidly changing world. Origins and evolutionary diversification among species of the genus Haemonchus and Hae- monchus contortus occurred in a complex crucible defined by shifts in environmental structure emerging from cycles of climate change and ecological perturbation during the late Tertiary and through the Quaternary. A history of sequential host colonization associated with waves of dispersal bringing assemblages of ungulates from Eurasia into Africa and processes emerging from ecosystems in collision and faunal turnover defined the arena for radiation among 12 recognized species of Haemonchus. Among congeners, the host range for H. contortus is exceptionally broad, including species among artiodactyls of 40 genera representing 5 families (and within 12 tribes of Bovi- dae). Broad host range is dramatically reflected in the degree to which translocation, introduction and invasion with host switching, has characterized an expanding distribution over time in North America, South America, southern Eurasia, Australia and New Zealand, coincidental with agriculture, husbandry and global colonization by human populations driven particularly by European exploration after the 1500s. African origins in xeric to mesic habitats of the African savannah suggest that historical constraints linked to ecological adaptations (tolerances and developmental thresholds defined by temperature and humidity for larval stages) will be substantial determinants in the potential outcomes for widespread geographical and host colonization which are predicted to unfold over the coming century. Insights about deeper evolutionary events, ecology and biogeography are critical as understanding history informs us about the possible range of responses in complex systems under new regimes of environmental forcing, especially, in this case, ecological perturbation linked to climate change. A deeper history of perturbation is relevant in understanding contemporary systems that are now strongly structured by events of invasion and colonization. The relaxation of abiotic and biotic controls on the occurrence of H. contortus, coincidental with inception and dissemination of anthelmintic resistance may be synergistic, serving to exacerbate challenges to control parasites or to limit the socioeconomic impacts of infection that can influence food security and availability. Studies of haemonchine nematodes contribute directly to an expanding model about the nature of diversity and the evolutionary trajectories for faunal assembly among complex hosteparasite systems across considerable spatial and temporal scales
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A legacy handbook for manufacturing
Legacy Handbook reviewing emda's experience of manufacturing activity. Identifies key achievements and draws out lessons learned that may be relevant to successor bodies active in this area
La bioética en el época del ‘big data’: la salud y más allá
La ciència del ‘big data’ (o dades massives) comporta un enorme potencial per a la recerca biomèdica, i promet ocasionar una gran transformació en l’àmbit de la salut i l'assistència mèdica. Al mateix temps, l'ús de dades de salut en recerca presenta diversos reptes ètics. En aquest article, analitzaré els aspectes ètics de l'arribada del ‘big data’ a l'àmbit de la salut. Encara que el discurs públic i regulador s'ha focalitzat principalment en l'ús de les dades personals, bregar amb els nous desafiaments que comporten la irrupció de les dades massives requereix enfocaments alternatius a l'ètica de la recerca, com ara el model del “contracte social”. A més, cal pensar més enllà de l'ús de dades per a recerques en salut i tenir en compte les conseqüències socials de l'epistemologia i la pràctica del ‘big data’ i les implicacions morals de la ‘datificació’ d’allò que és humà.‘Big data’ and data-intensive research approaches are rapidly gaining momentum in health and biomedical research, with potential to transform health at all levels from personal to public. The use of ‘big data’ for health research, however, raises a number of ethical challenges. In this paper I discuss ethical aspects of the advent of big data in health. I argue that although public discourse has focused on immediate concerns relating to use of individuals’ information, ‘big health data’ requires us to explore alternative conceptual approaches to research ethics, including the ‘social contract’ model. Further, we need to think beyond health research uses of data to the social consequences of big data epistemology and practice, and the moral implications of ‘datafying’ the human.La ciencia de ‘big data’ (o datos masivos) lleva mucho potencial para la investigación biomédica, y promete una transformación en la salud y la asistencia médica. Al mismo tiempo, el uso de datos de salud en investigación presenta varios retos éticos. En este artículo, exploraré aspectos éticos de la llegada del ‘big data’ al ámbito de la salud. Aunque el discurso público y regulatorio se ha focalizado mucho en el uso de datos del individuo, lidiar con los nuevos desafíos de datos masivos requiere considerar enfoques alternativos a la ética de la investigación, tal como el modelo del “contrato social”. Hay que pensar más allá del uso de datos para investigaciones en salud y contemplar las consecuencias sociales de la epistemología y la práctica de ‘big data’ y las implicancias morales de la ‘datificación’ del humano
Dwarna : a blockchain solution for dynamic consent in biobanking
Dynamic consent aims to empower research partners and facilitate active participation in the research process. Used within
the context of biobanking, it gives individuals access to information and control to determine how and where their
biospecimens and data should be used. We present Dwarna—a web portal for ‘dynamic consent’ that acts as a hub
connecting the different stakeholders of the Malta Biobank: biobank managers, researchers, research partners, and the
general public. The portal stores research partners’ consent in a blockchain to create an immutable audit trail of research
partners’ consent changes. Dwarna’s structure also presents a solution to the European Union’s General Data Protection
Regulation’s right to erasure—a right that is seemingly incompatible with the blockchain model. Dwarna’s transparent
structure increases trustworthiness in the biobanking process by giving research partners more control over which research
studies they participate in, by facilitating the withdrawal of consent and by making it possible to request that the biospecimen
and associated data are destroyed.peer-reviewe
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From commercialising intellectual property to facilitating open innovation: the evolution of UK biotechnology incubators
This paper investigates the changing landscape of biotechnology incubators in the UK and evidences their evolution from 1999 to 2017. We highlight the changing policy environment for biotechnology incubators and begin to investigate the evolution of UK biotechnology incubators from facilities that primarily support the commercialisation of intellectual property derived from universities to facilities that reuse former pharmaceutical research and development laboratories and collocate with operational pharmaceutical companies. This study uses two desk-based surveys that provide snap-shots of 21 biotechnology incubators taken in December 2012 and December 2017. The surveys provide a detailed examination of the characteristics of UK biotechnology incubators and their tenant companies. We observe the appearance of biotechnology incubators with an economic regeneration remit, funded by and working in partnership with regional government (BioPark Hertfordshire & BioCity Nottingham). We also observe the appearance of corporate biotechnology incubators (Akcomak, 2009) co-located on operational pharmaceutical research and development sites with an open innovation remit e.g. Astra Zeneca (Manchester), GlaxoSmithKline (Stevenage) and Boots (Nottingham). We propose that regional and national policy initiatives and changes in the business model of large pharmaceutical companies have been the main drivers for the evolution of biotechnology incubators in the UK
Marine Biotechnology Task Force Report
Marine biotechnology is a rapidly growing area that is recognised, by policy makers and
the enterprise sector, as offering significant potential to develop market opportunities for
new products and processes by enabling greater utilisation of marine biological resources.
Current research funding activity, supporting efforts to create a sustainable bioeconomy, is
likely to lead to a growth in marine biotechnology research and commercial activities. Irish
and international financial support for this research is aimed at as yet largely unexplored
and underexploited marine resources for use as food, functional foods and nutraceuticals;
cosmetics and cosmeceuticals; human and animal health – including pharmaceuticals,
biocompatible materials and medical devices; materials technology; environmental
bioremediation; and marine model organisms, including the use of marine derived
materials in bioprocessing. Research within these areas has resulted in an array of new
products and processes which offer benefits to society and support economic growth.
The Marine Institute established a Task Force to advise on the steps required to strengthen
Ireland’s capability to use marine biotechnology to exploit the value of its extensive
marine bioresources. The Task Force, comprising academic and industry members,
considered the various national strategies and plans for science, technology, research
and economic development, and identified market opportunity areas and Irish marine
biotechnology research capabilities. In supporting the work of the Task Force, the Marine
Institute completed a number of information-gathering exercises to fill various knowledge
gaps identified by the Task Force. Following the preparation of a draft report, the Task
Force, with the support of the Marine Institute, held a workshop attended by researchers
and companies. This final report of the Task Force takes account of feedback from this
workshop in developing its recommendations
Economic Fundamentals Of the Knowledge Society
This article provides an introduction to fundamental issues in the development of new knowledge-based economies. After placing their emergence in historical perspective and proposing a theoretical framework that distinguishes knowledge from information, the authors characterize the specific nature of such economies. They go on to deal with some of the major issues concerning the new skills and abilities required for integration into the knowledge-based economy; the new geography that is taking shape (where physical distance ceases to be such an influential constraint); the conditions governing access to both information and knowledge, not least for developing countries; the uneven development of scientific, technological (including organizational) knowledge across different sectors of activity; problems concerning intellectual property rights and the privatization of knowledge; and the issues of trust, memory and the fragmentation of knowledge. This monograph is concerned with the nature of the process of macroeconomic growth that has characterized the U. S. experience, and manifested itself in the changing pace and sources of the continuing rise real output per capita over the course of the past two hundred years. A key observation that emerges from the long-term quantitative economic record is that the proximate sources of increases in real GDP per head in the century between 1889 and 1999 were quite different from those which obtained during the first hundred years of American national experience. Baldly put, the economy's ascent to a position of twentieth century global industrial leadership entailed a transition from growth based upon the interdependent development and extensive exploitation of its natural resources and the substitution of tangible capital for labor, towards a the maintenance of an productivity leadership through rising rates of intangible investment in the formation and exploitation of technological and organizational knowledge.
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