Different profiles of immune reconstitution in children and adults with HIV-infection after highly active antiretroviral therapy

BACKGROUND: Recent advances in characterizing the immune recovery of HIV-1-infected people have highlighted the importance of the thymus for peripheral T-cell diversity and function. The aim of this study was to investigate differences in immune reconstitution profiles after highly active antiretroviral therapy (HAART) between HIV-children and adults. METHODS: HIV patients were grouped according to their previous clinical and immunological status: 9 HIV-Reconstituting-adults (HIV-Rec-adults) and 10 HIV-Reconstituting-children (HIV-Rec-children) on HAART with viral load (VL) ≤400 copies/ml and CD4(+ )≥500 cells/μL at least during 6 months before the study and CD4(+ )≤300 cells/μL anytime before. Fifteen healthy-adults and 20 healthy-children (control subjects) were used to calculate Z-score values to unify value scales between children and adults to make them comparable. RESULTS: HIV-Rec-children had higher T-cell receptor excision circles (TREC) and lower interleukin (IL)-7 levels than HIV-Rec-adults (p < 0.05). When we analyzed Z-score values, HIV-Rec-children had higher TREC Z-score levels (p = 0.03) than HIV-Rec-adults but similar IL-7 Z-score levels. Regarding T-cell subsets, HIV-Rec-children had higher naïve CD4(+ )(CD4(+)CD45RA (hi+)CD27(+)), naïve CD8(+ )(CD8(+)CD45RA (hi+)CD27(+)), and memory CD8(+ )(CD8(+)CD45RO(+)) cells/μl than HIV-Rec-adults, but similar memory CD4(+ )(CD4(+)CD45RO(+)) counts. HIV-Rec-children had lower naïve CD8(+ )Z-score values than HIV-Rec-adults (p = 0.05). CONCLUSION: Our data suggest that HIV-Rec-children had better thymic function than HIV-Rec-adults and this fact affects the peripheral T-cell subsets. Thus, T-cell recovery after HAART in HIV-Rec-adults could be the consequence of antigen-independent peripheral T-cell expansion while in HIV-Rec-children thymic output could play a predominant role in immune reconstitution

Explicit diversification of event aspects for temporal summarization

During major events, such as emergencies and disasters, a large volume of information is reported on newswire and social media platforms. Temporal summarization (TS) approaches are used to automatically produce concise overviews of such events by extracting text snippets from related articles over time. Current TS approaches rely on a combination of event relevance and textual novelty for snippet selection. However, for events that span multiple days, textual novelty is often a poor criterion for selecting snippets, since many snippets are textually unique but are semantically redundant or non-informative. In this article, we propose a framework for the diversification of snippets using explicit event aspects, building on recent works in search result diversification. In particular, we first propose two techniques to identify explicit aspects that a user might want to see covered in a summary for different types of event. We then extend a state-of-the-art explicit diversification framework to maximize the coverage of these aspects when selecting summary snippets for unseen events. Through experimentation over the TREC TS 2013, 2014, and 2015 datasets, we show that explicit diversification for temporal summarization significantly outperforms classical novelty-based diversification, as the use of explicit event aspects reduces the amount of redundant and off-topic snippets returned, while also increasing summary timeliness

Recombination Effects on Supernova Light Curves

The light curves of type-II supernovae (SNe) are believed to be highly affected by recombination of hydrogen that takes place in their envelopes. In this work, we analytically investigate the transition from a fully ionized envelope to a partially recombined one and its effects on the SN light curve. The motivation is to establish the underlying processes that dominate the evolution at late times when recombination takes place in the envelope, yet early enough so that $^{56}$Ni decay is a negligible source of energy. We consider the diffusion of photons through the envelope while analyzing the ionization fraction and the coupling between radiation and gas, and find that the main effect of recombination is on the evolution of the observed temperature. Before recombination the temperature decreases relatively fast, while after recombination starts it significantly reduces the rate at which the observed temperature drops with time. This behaviour is the main cause for the observed flattening in the optical bands, where for a typical red supergiant explosion, the recombination wave affects the bolometric luminosity only mildly during most of the photospheric phase. Moreover, the plateau phase observed in some type-II SNe is not a generic result of recombination, and it also depends on the density structure of the progenitor. This is one possible explanation to the different light curve decay rates observed in type II (P and L) SNe.Comment: Submitted to ApJ, after first referee report. This is a major revision of arXiv:1404.631

Evaluating epistemic uncertainty under incomplete assessments

The thesis of this study is to propose an extended methodology for laboratory based Information Retrieval evaluation under incomplete relevance assessments. This new methodology aims to identify potential uncertainty during system comparison that may result from incompleteness. The adoption of this methodology is advantageous, because the detection of epistemic uncertainty - the amount of knowledge (or ignorance) we have about the estimate of a system's performance - during the evaluation process can guide and direct researchers when evaluating new systems over existing and future test collections. Across a series of experiments we demonstrate how this methodology can lead towards a finer grained analysis of systems. In particular, we show through experimentation how the current practice in Information Retrieval evaluation of using a measurement depth larger than the pooling depth increases uncertainty during system comparison

Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia

We previously demonstrated prolonged, profound CD4+ T-lymphopenia in rheumatoid arthritis (RA) patients following lymphocyte-depleting therapy. Poor reconstitution could result either from reduced de novo T-cell production through the thymus or from poor peripheral expansion of residual T-cells. Interleukin-7 (IL-7) is known to stimulate the thymus to produce new T-cells and to allow circulating mature T-cells to expand, thereby playing a critical role in T-cell homeostasis. In the present study we demonstrated reduced levels of circulating IL-7 in a cross-section of RA patients. IL-7 production by bone marrow stromal cell cultures was also compromised in RA. To investigate whether such an IL-7 deficiency could account for the prolonged lymphopenia observed in RA following therapeutic lymphodepletion, we compared RA patients and patients with solid cancers treated with high-dose chemotherapy and autologous progenitor cell rescue. Chemotherapy rendered all patients similarly lymphopenic, but this was sustained in RA patients at 12 months, as compared with the reconstitution that occurred in cancer patients by 3–4 months. Both cohorts produced naïve T-cells containing T-cell receptor excision circles. The main distinguishing feature between the groups was a failure to expand peripheral T-cells in RA, particularly memory cells during the first 3 months after treatment. Most importantly, there was no increase in serum IL-7 levels in RA, as compared with a fourfold rise in non-RA control individuals at the time of lymphopenia. Our data therefore suggest that RA patients are relatively IL-7 deficient and that this deficiency is likely to be an important contributing factor to poor early T-cell reconstitution in RA following therapeutic lymphodepletion. Furthermore, in RA patients with stable, well controlled disease, IL-7 levels were positively correlated with the T-cell receptor excision circle content of CD4+ T-cells, demonstrating a direct effect of IL-7 on thymic activity in this cohort

Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure

Extracellular heat-shock protein 72 (eHsp72) concentration increases during exercise-heat stress when conditions elicit physiological strain. Differences in severity of environmental and exercise stimuli have elicited varied response to stress. The present study aimed to quantify the extent of increased eHsp72 with increased exogenous heat stress, and determine related endogenous markers of strain in an exercise-heat model. Ten males cycled for 90 min at 50% O2peak in three conditions (TEMP, 20°C/63% RH; HOT, 30.2°C/51%RH; VHOT, 40.0°C/37%RH). Plasma was analysed for eHsp72 pre, immediately post and 24-h post each trial utilising a commercially available ELISA. Increased eHsp72 concentration was observed post VHOT trial (+172.4%) (P<0.05), but not TEMP (-1.9%) or HOT (+25.7%) conditions. eHsp72 returned to baseline values within 24hrs in all conditions. Changes were observed in rectal temperature (Trec), rate of Trec increase, area under the curve for Trec of 38.5°C and 39.0°C, duration Trec ≥ 38.5°C and ≥ 39.0°C, and change in muscle temperature, between VHOT, and TEMP and HOT, but not between TEMP and HOT. Each condition also elicited significantly increasing physiological strain, described by sweat rate, heart rate, physiological strain index, rating of perceived exertion and thermal sensation. Stepwise multiple regression reported rate of Trec increase and change in Trec to be predictors of increased eHsp72 concentration. Data suggests eHsp72 concentration increases once systemic temperature and sympathetic activity exceeds a minimum endogenous criteria elicited during VHOT conditions and is likely to be modulated by large, rapid changes in core temperature

Modelling User Preferences using Word Embeddings for Context-Aware Venue Recommendation

Venue recommendation aims to assist users by making personalised suggestions of venues to visit, building upon data available from location-based social networks (LBSNs) such as Foursquare. A particular challenge for this task is context-aware venue recommendation (CAVR), which additionally takes the surrounding context of the user (e.g. the user’s location and the time of day) into account in order to provide more relevant venue suggestions. To address the challenges of CAVR, we describe two approaches that exploit word embedding techniques to infer the vector-space representations of venues, users’ existing preferences, and users’ contextual preferences. Our evaluation upon the test collection of the TREC 2015 Contextual Suggestion track demonstrates that we can significantly enhance the effectiveness of a state-of-the-art venue recommendation approach, as well as produce context-aware recommendations that are at least as effective as the top TREC 2015 systems

B-mode polarization induced by gravitational waves from kinks on infinite cosmic strings

We investigate the effect of the stochastic gravitational wave (GW) background produced by kinks on infinite cosmic strings, whose spectrum was derived in our previous work, on the B-mode power spectrum of the cosmic microwave background (CMB) anisotropy. We find that the B-mode polarization due to kinks is comparable to that induced by the motion of the string network and hence the contribution of GWs from kinks is important for estimating the B-mode power spectrum originating from cosmic strings. If the tension of cosmic strings \mu is large enough i.e., G\mu >~ 10^{-8}, B-mode polarization induced by cosmic strings can be detected by future CMB experiments.Comment: 13 pages, 1 figur