15 research outputs found
Plasticity and Adaptation in Neuromorphic Biohybrid Systems
Neuromorphic systems take inspiration from the principles of biological information processing to form hardware platforms that enable the large-scale implementation of neural networks. The recent years have seen both advances in the theoretical aspects of spiking neural networks for their use in classification and control tasks and a progress in electrophysiological methods that is pushing the frontiers of intelligent neural interfacing and signal processing technologies. At the forefront of these new technologies, artificial and biological neural networks are tightly coupled, offering a novel \u201cbiohybrid\u201d experimental framework for engineers and neurophysiologists. Indeed, biohybrid systems can constitute a new class of neuroprostheses opening important perspectives in the treatment of neurological disorders. Moreover, the use of biologically plausible learning rules allows forming an overall fault-tolerant system of co-developing subsystems. To identify opportunities and challenges in neuromorphic biohybrid systems, we discuss the field from the perspectives of neurobiology, computational neuroscience, and neuromorphic engineering. \ua9 2020 The Author(s
An FPGA platform for real-time simulation of spiking neuronal networks
In the last years, the idea to dynamically interface biological neurons with artificial ones has become more and more urgent. The reason is essentially due to the design of innovative neuroprostheses where biological cell assemblies of the brain can be substituted by artificial ones. For closed-loop experiments with biological neuronal networks interfaced with in silico modeled networks, several technological challenges need to be faced, from the low-level interfacing between the living tissue and the computational model to the implementation of the latter in a suitable form for real-time processing. Field programmable gate arrays (FPGAs) can improve flexibility when simple neuronal models are required, obtaining good accuracy, real-time performance, and the possibility to create a hybrid system without any custom hardware, just programming the hardware to achieve the required functionality. In this paper, this possibility is explored presenting a modular and efficient FPGA design of an in silico spiking neural network exploiting the Izhikevich model. The proposed system, prototypically implemented on a Xilinx Virtex 6 device, is able to simulate a fully connected network counting up to 1,440 neurons, in real-time, at a sampling rate of 10 kHz, which is reasonable for small to medium scale extra-cellular closed-loop experiments
Closed-loop approaches for innovative neuroprostheses
The goal of this thesis is to study new ways to interact with the nervous system in case of damage or pathology. In particular, I focused my effort towards the development of innovative, closed-loop stimulation protocols in various scenarios: in vitro, ex vivo, in vivo
Neural networks-on-chip for hybrid bio-electronic systems
PhD ThesisBy modelling the brains computation we can further our understanding
of its function and develop novel treatments for neurological disorders. The
brain is incredibly powerful and energy e cient, but its computation does
not t well with the traditional computer architecture developed over the
previous 70 years. Therefore, there is growing research focus in developing
alternative computing technologies to enhance our neural modelling capability,
with the expectation that the technology in itself will also bene t from
increased awareness of neural computational paradigms.
This thesis focuses upon developing a methodology to study the design
of neural computing systems, with an emphasis on studying systems suitable
for biomedical experiments. The methodology allows for the design to be
optimized according to the application. For example, di erent case studies
highlight how to reduce energy consumption, reduce silicon area, or to
increase network throughput.
High performance processing cores are presented for both Hodgkin-Huxley
and Izhikevich neurons incorporating novel design features. Further, a complete
energy/area model for a neural-network-on-chip is derived, which is
used in two exemplar case-studies: a cortical neural circuit to benchmark
typical system performance, illustrating how a 65,000 neuron network could
be processed in real-time within a 100mW power budget; and a scalable highperformance
processing platform for a cerebellar neural prosthesis. From
these case-studies, the contribution of network granularity towards optimal
neural-network-on-chip performance is explored
Implantable Micro-Device for Epilepsy Seizure Detection and Subsequent Treatment
RÉSUMÉ L’émergence des micro-dispositifs implantables est une voie prometteuse pour le traitement de troubles neurologiques. Ces systèmes biomédicaux ont été exploités comme traitements non-conventionnels sur des patients chez qui les remèdes habituels sont inefficaces. Les récents progrès qui ont été faits sur les interfaces neuronales directes ont permis aux chercheurs d’analyser l’activité EEG intracérébrale (icEEG) en temps réel pour des fins de traitements. Cette thèse présente un dispositif implantable à base de microsystèmes pouvant capter efficacement des signaux neuronaux, détecter des crises d’épilepsie et y apporter un traitement afin de l’arrêter. Les contributions principales présentées ici ont été rapportées dans cinq articles scientifiques, publiés ou acceptés pour publication dans les revues IEEE, et plusieurs autres tels que «Low Power Electronics» et «Emerging Technologies in Computing». Le microsystème proposé inclus un circuit intégré (CI) à faible consommation énergétique permettant la détection de crises d’épilepsie en temps réel. Cet CI comporte une pré-amplification initiale et un détecteur de crises d’épilepsie. Le pré-amplificateur est constitué d’une nouvelle topologie de stabilisateur d’hacheur réduisant le bruit et la puissance dissipée. Les CI fabriqués ont été testés sur des enregistrements d’icEEG provenant de sept patients épileptiques réfractaires au traitement antiépileptique. Le délai moyen de la détection d’une crise est de 13,5 secondes, soit avant le début des manifestations cliniques évidentes. La consommation totale d’énergie mesurée de cette puce est de 51 μW. Un neurostimulateur à boucle fermée (NSBF), quant à lui, détecte automatiquement les crises en se basant sur les signaux icEEG captés par des électrodes intracrâniennes et permet une rétroaction par une stimulation électrique au même endroit afin d’interrompre ces crises. La puce de détection de crises et le stimulateur électrique à base sur FPGA ont été assemblés à des électrodes afin de compléter la prothèse proposée. Ce NSBF a été validé en utilisant des enregistrements d’icEEG de dix patients souffrant d’épilepsie réfractaire. Les résultats révèlent une performance excellente pour la détection précoce de crises et pour l’auto-déclenchement subséquent d’une stimulation électrique. La consommation énergétique totale du NSBF est de 16 mW. Une autre alternative à la stimulation électrique est l’injection locale de médicaments, un traitement prometteur de l’épilepsie. Un système local de livraison de médicament basé sur un nouveau détecteur asynchrone des crises est présenté.----------ABSTRACT Emerging implantable microdevices hold great promise for the treatment of patients with neurological conditions. These biomedical systems have been exploited as unconventional treatment for the conventionally untreatable patients. Recent progress in brain-machine-interface activities has led the researchers to analyze the intracerebral EEG (icEEG) recording in real-time and deliver subsequent treatments. We present in this thesis a long-term safe and reliable low-power microsystem-based implantable device to perform efficient neural signal recording, seizure detection and subsequent treatment for epilepsy. The main contributions presented in this thesis are reported in five journal manuscripts, published or accepted for publication in IEEE Journals, and many others such as Low Power Electronics, and Emerging Technologies in Computing. The proposed microsystem includes a low-power integrated circuit (IC) intended for real-time epileptic seizure detection. This IC integrates a front-end preamplifier and epileptic seizure detector. The preamplifier is based on a new chopper stabilizer topology that reduces noise and power dissipation. The fabricated IC was tested using icEEG recordings from seven patients with drug-resistant epilepsy. The average seizure detection delay was 13.5 sec, well before the onset of clinical manifestations. The measured total power consumption of this chip is 51 µW. A closed-loop neurostimulator (CLNS) is next introduced, which is dedicated to automatically detect seizure based on icEEG recordings from intracranial electrode contacts and provide an electrical stimulation feedback to the same contacts in order to disrupt these seizures. The seizure detector chip and a dedicated FPGA-based electrical stimulator were assembled together with common recording electrodes to complete the proposed prosthesis. This CLNS was validated offline using recording from ten patients with refractory epilepsy, and showed excellent performance for early detection of seizures and subsequent self-triggering electrical stimulation. Total power consumption of the CLNS is 16 mW. Alternatively, focal drug injection is the promising treatment for epilepsy. A responsive focal drug delivery system based on a new asynchronous seizure detector is also presented. The later system with data-dependent computation reduces up to 49% power consumption compared to the previous synchronous neurostimulator
2022 roadmap on neuromorphic computing and engineering
Modern computation based on von Neumann architecture is now a mature cutting-edge science. In the von Neumann architecture, processing and memory units are implemented as separate blocks interchanging data intensively and continuously. This data transfer is responsible for a large part of the power consumption. The next generation computer technology is expected to solve problems at the exascale with 10 calculations each second. Even though these future computers will be incredibly powerful, if they are based on von Neumann type architectures, they will consume between 20 and 30 megawatts of power and will not have intrinsic physically built-in capabilities to learn or deal with complex data as our brain does. These needs can be addressed by neuromorphic computing systems which are inspired by the biological concepts of the human brain. This new generation of computers has the potential to be used for the storage and processing of large amounts of digital information with much lower power consumption than conventional processors. Among their potential future applications, an important niche is moving the control from data centers to edge devices. The aim of this roadmap is to present a snapshot of the present state of neuromorphic technology and provide an opinion on the challenges and opportunities that the future holds in the major areas of neuromorphic technology, namely materials, devices, neuromorphic circuits, neuromorphic algorithms, applications, and ethics. The roadmap is a collection of perspectives where leading researchers in the neuromorphic community provide their own view about the current state and the future challenges for each research area. We hope that this roadmap will be a useful resource by providing a concise yet comprehensive introduction to readers outside this field, for those who are just entering the field, as well as providing future perspectives for those who are well established in the neuromorphic computing community
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A Neural Signal Processor for Low-Latency Spike Inference
This thesis describes the development of a system that can assign identities to a population of single-units, in multi-electrode recordings, at single-spike resolution with low-latency. The system has two parts. The first is a Field-Programmable Gate Array (FPGA)-based Neural Signal Processor (NSP) that receives raw input and generates labelled spikes as output, a process referred to as real-time spike inference. The second is a piece of software (Spiketag) that runs on a PC, communicates with the NSP, and generates a spike-sorted model to guide the real-time spike inference. The NSP provides clocks and control signals to five 32-channel INTAN RHD2132 chips to manage the acquisition of 160 channels of raw neural data. In parallel, the NSP further filters, detects and extracts extracellular spike waveforms from the raw neural data recorded by tetrodes or silicon probes and assigns single-unit identity to each detected spike. A set of Python application programming interfaces (APIs) was developed in Spiketag to enable the communication between the NSP and the PC. These APIs allow the NSP to obtain a model from the PC, which holds parameters such as reference channels, spike detection thresholds, spike feature transformation matrix and vector quantized clusters generated by spike sorting a short recording session. Using the spike-sorted model, the NSP performs data acquisition and real-time spike inference simultaneously. Algorithmic modules were implemented in the FPGA and pipelined to compute during 40 ms acquisition intervals. At the output end of the FPGA NSP, the real-time assigned single-unit identity (spike-id) is packaged with the timestamp, the electrode group, and the spike features as a spike-id packet. Spike-id packets are asynchronously transmitted through a low-latency Peripheral Component Interconnect Express (PCIe) interface to the PC, producing the real-time spike trains. The real-time spike trains can be used for further processing, such as real-time decoding. Several types of ground-truth data, including intracellular/extracellular paired recordings, synthesized
tetrode extracellular waveforms with ground-truth spike timing and high-channel-count silicon probe recordings with ground-truth animal positions during navigation were used to validate the low-latency (1 ms) and high-accuracy (as high as state-of-the-art offline sorting and decoding algorithms) of the NSP’s real-time spike inference and the NSP-based
real-time population decoding performance
De animais a máquinas : humanos tecnicamente melhores nos imaginários de futuro da convergência tecnológica
Dissertação (mestrado)—Universidade de BrasÃlia, Instituto de Ciências Sociais, Departamento de Sociologia, 2020.O tema desta investigação é discutir os imaginários sociais de ciência e tecnologia que emergem
a partir da área da neuroengenharia, em sua relação com a Convergência Tecnológica de quatro
disciplinas: Nanotecnologia, Biotecnologia, tecnologias da Informação e tecnologias Cognitivas -
neurociências- (CT-NBIC). Estas áreas desenvolvem-se e são articuladas por meio de discursos
que ressaltam o aprimoramento das capacidades fÃsicas e cognitivas dos seres humanos, com
o intuito de construir uma sociedade melhor por meio do progresso cientÃfico e tecnológico, nos
limites das agendas de pesquisa e desenvolvimento (P&D).
Objetivos:
Os objetivos nesse cenário, são discutir as implicações éticas, econômicas, polÃticas e sociais
deste modelo de sistema sociotécnico. Nos referimos, tanto as aplicações tecnológicas, quanto
as consequências das mesmas na formação dos imaginários sociais, que tipo de relações se
estabelecem e como são criadas dentro desse contexto.
Conclusão:
ConcluÃmos na busca por refletir criticamente sobre as propostas de aprimoramento humano
mediado pela tecnologia, que surgem enquanto parte da agenda da Convergência Tecnológica
NBIC. No entanto, as propostas de melhoramento humano vão muito além de uma agenda de
investigação. Há todo um quadro de referências filosóficas e polÃticas que defendem o
aprimoramento da espécie, vertentes estas que se aliam a movimentos trans-humanistas e pós-
humanistas, posições que são ao mesmo tempo éticas, polÃticas e econômicas. A partir de nossa
análise, entendemos que ciência, tecnologia e polÃtica estão articuladas, em coprodução, em
relação às expectativas de futuros que são esperados ou desejados. Ainda assim, acreditamos
que há um espaço de diálogo possÃvel, a partir do qual buscamos abrir propostas para o debate
público sobre questões de ciência e tecnologia relacionadas ao aprimoramento da espécie
humana.Conselho Nacional de Desenvolvimento CientÃfico e Tecnológico (CNPq)The subject of this research is to discuss the social imaginaries of science and technology that
emerge from the area of neuroengineering in relation with the Technological Convergence of four
disciplines: Nanotechnology, Biotechnology, Information technologies and Cognitive technologies
-neurosciences- (CT-NBIC). These areas are developed and articulated through discourses that
emphasize the enhancement of human physical and cognitive capacities, the intuition it is to build
a better society, through the scientific and technological progress, at the limits of the research
and development (R&D) agendas.
Objectives:
The objective in this scenery, is to discuss the ethic, economic, politic and social implications of
this model of sociotechnical system. We refer about the technological applications and the
consequences of them in the formation of social imaginaries as well as the kind of social relations
that are created and established in this context.
Conclusion:
We conclude looking for critical reflections about the proposals of human enhancement mediated
by the technology. That appear as a part of the NBIC technologies agenda. Even so, the
proposals of human enhancement go beyond boundaries that an investigation agenda. There is
a frame of philosophical and political references that defend the enhancement of the human
beings. These currents that ally to the transhumanism and posthumanism movements, positions
that are ethic, politic and economic at the same time. From our analysis, we understand that
science, technology and politics are articulated, are in co-production, regarding the expected and
desired futures. Even so, we believe that there is a space of possible dialog, from which we look
to open proposals for the public discussion on questions of science and technology related to
enhancement of human beings