15,144 research outputs found
A unified theory of the dynamics of closed-loop supply chains
This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordWe investigate the dynamics of a closed-loop supply chain with first-order auto-regressive (AR(1)) demand and return processes. We assume these two processes are cross-correlated. The remanufacturing process is subject to a random triage yield. Remanufactured products are considered as-good-as-new and used to partially satisfy market demand; newly manufactured products make up the remainder. We derive the optimal linear policy in our closed-loop supply chain setting to minimise the manufacturer's inventory costs. We show that the lead-time paradox can emerge in many cases. In particular, the auto- and cross-correlation parameters and variances of the error terms in the demand and the returns, as well as the remanufacturing lead time, all influence the existence of the lead-time paradox. Finally, we propose managerial recommendations for manufacturers.JSPS KAKENH
A unified theory of the dynamics of closed-loop supply chains
We investigate the dynamics of a closed-loop supply chain with first-order auto-regressive (AR(1)) demand and return processes. We assume these two processes are cross-correlated. The remanufacturing process is subject to a random triage yield. Remanufactured products are considered as-goodas- new and used to partially satisfy market demand; newly manufactured products make up the remainder. We derive the optimal linear policy in our closed-loop supply chain setting to minimise the manufacturer’s inventory costs. We show that the lead-time paradox can emerge in many cases. In particular, the auto- and cross-correlation parameters and variances of the error terms in the demand and the returns, as well as the remanufacturing lead time, all influence the existence of the lead-time paradox. Finally, we propose managerial recommendations for manufacturers
Building Resilience in Closed-Loop Supply Chains through Information-Sharing Mechanisms
In this paper we reflect on the role of information sharing on increasing the resilience of
supply chains. Specifically, we highlight the lack of studies addressing this relevant topic in closed-loop
supply chains. Then, we introduce the works covered by the Special Issue “Information Sharing
on Sustainable and Resilient Supply Chains” to investigate the relationships between information
sharing and resilience in sustainable supply chains.Universidad de Sevilla V PPIT-USDICAR-UniCT (Dpto. Ing. Civil y Arqu. Univ. Catania) Plan de investigación Departamental 2016-201
Eco‐Holonic 4.0 Circular Business Model to Conceptualize Sustainable Value Chain Towards Digital Transition
The purpose of this paper is to conceptualize a circular business model based on an Eco-Holonic Architecture, through the integration of circular economy and holonic principles. A conceptual model is developed to manage the complexity of integrating circular economy principles, digital transformation, and tools and frameworks for sustainability into business models. The proposed architecture is multilevel and multiscale in order to achieve the instantiation of the sustainable value chain in any territory. The architecture promotes the incorporation of circular economy and holonic principles into new circular business models. This integrated perspective of business model can support the design and upgrade of the manufacturing companies in their respective industrial sectors. The conceptual model proposed is based on activity theory that considers the interactions between technical and social systems and allows the mitigation of the metabolic rift that exists between natural and social metabolism. This study contributes to the existing literature on circular economy, circular business models and activity theory by considering holonic paradigm concerns, which have not been explored yet. This research also offers a unique holonic architecture of circular business model by considering different levels, relationships, dynamism and contextualization (territory) aspects
Kinesin Is an Evolutionarily Fine-Tuned Molecular Ratchet-and-Pawl Device of Decisively Locked Direction
Conventional kinesin is a dimeric motor protein that transports membranous
organelles toward the plus-end of microtubules (MTs). Individual kinesin dimers
show steadfast directionality and hundreds of consecutive steps, yetthe
detailed physical mechanism remains unclear. Here we compute free energies for
the entire dimer-MT system for all possible interacting configurations by
taking full account of molecular details. Employing merely first principles and
several measured binding and barrier energies, the system-level analysis
reveals insurmountable energy gaps between configurations, asymmetric ground
state caused by mechanically lifted configurational degeneracy, and forbidden
transitions ensuring coordination between both motor domains for alternating
catalysis. This wealth of physical effects converts a kinesin dimer into a
molecular ratchet-and-pawl device, which determinedly locks the dimer's
movement into the MT plus-end and ensures consecutive steps in hand-over-hand
gait.Under a certain range of extreme loads, however, the ratchet-and-pawl
device becomes defective but not entirely abolished to allow consecutive
back-steps. This study yielded quantitative evidence that kinesin's multiple
molecular properties have been evolutionarily adapted to fine-tune the
ratchet-and-pawl device so as to ensure the motor's distinguished performance.Comment: 10 printed page
Recommended from our members
On the dynamics of closed-loop supply chains with capacity constraints
In this paper, we investigate the dynamic behavior of a closed-loop supply chain with capacity restrictions both in the manufacturing and remanufacturing lines. We assume it operates in a context of a twofold uncertainty by considering stochastic demand and return processes. From a bullwhip perspective, we evaluate how the four relevant factors (specifically, two capacities and two sources of uncertainty) interact and determine the operational performance of the system by measuring the variability of the manufacturing and remanufacturing lines and the net stock. Interestingly, while the manufacturing capacity only impacts on the forward flow of materials, the remanufacturing capacity affects the dynamics of the whole system. From a managerial viewpoint, this work suggests that capacity constraints in both remanufacturing and manufacturing lines can be adopted as a fruitful bullwhip-dampening method, even if they need to be properly regulated for avoiding a reduction in the system capacity to fulfill customer demand in a cost-effective manner
The effect of returns volume uncertainty on the dynamic performance of closed-loop supply chains
We investigate the dynamics of a hybrid manufacturing/remanufacturing system (HMRS) by exploring the impact of the average return yield and uncertainty in returns volume. Through modelling and simulation techniques, we measure the long-term variability of end-product inventories and orders issued, given its negative impact on the operational performance of supply chains, as well as the average net stock and the average backlog, in order to consider the key trade-off between service level and holding requirements. In this regard, prior studies have observed that returns may positively impact the dynamic behaviour of the HMRS. We demonstrate that this occurs as long as the intrinsic uncertainty in the volume of returns is low —increasing the return yield results in decreased fluctuations in production, which enhances the operation of the closed-loop system. Interestingly, we observe a U-shaped relationship between the inventory performance and the return yield. However, the dynamics of the supply chain may significantly suffer from returns volume uncertainty through the damaging Bullwhip phenomenon. Under this scenario, the relationship between the average return yield and the intrinsic returns volume variability determines the operational performance of closed-loop supply chains in comparison with traditional (open-loop) systems. In this sense, this research adds to the still very limited literature on the dynamic behaviour of closed-loop supply chains, whose importance is enormously growing in the current production model evolving from a linear to a circular architecture
- …