93,133 research outputs found

    Ontology-assisted database integration to support natural language processing and biomedical data-mining

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    Successful biomedical data mining and information extraction require a complete picture of biological phenomena such as genes, biological processes, and diseases; as these exist on different levels of granularity. To realize this goal, several freely available heterogeneous databases as well as proprietary structured datasets have to be integrated into a single global customizable scheme. We will present a tool to integrate different biological data sources by mapping them to a proprietary biomedical ontology that has been developed for the purposes of making computers understand medical natural language

    Technology Integration around the Geographic Information: A State of the Art

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    One of the elements that have popularized and facilitated the use of geographical information on a variety of computational applications has been the use of Web maps; this has opened new research challenges on different subjects, from locating places and people, the study of social behavior or the analyzing of the hidden structures of the terms used in a natural language query used for locating a place. However, the use of geographic information under technological features is not new, instead it has been part of a development and technological integration process. This paper presents a state of the art review about the application of geographic information under different approaches: its use on location based services, the collaborative user participation on it, its contextual-awareness, its use in the Semantic Web and the challenges of its use in natural languge queries. Finally, a prototype that integrates most of these areas is presented

    Nucleotide second messengers in bacterial decision making

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    Since the initial discovery of bacterial nucleotide second messengers (NSMs), we have made huge progress towards understanding these complex signalling networks. Many NSM networks contain dozens of metabolic enzymes and binding targets, whose activity is tightly controlled at every regulatory level. They function as global regulators and in specific signalling circuits, controlling multiple aspects of bacterial behaviour and development. Despite these advances there is much still to discover, with current research focussing on the molecular mechanisms of signalling circuits, the role of the environment in controlling NSM pathways and attempts to understand signalling at the whole cell/community level. Here we examine recent developments in the NSM signalling field and discuss their implications for understanding this important driver of microbial behaviour

    How can heat maps of indexing vocabularies be utilized for information seeking purposes?

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    The ability to browse an information space in a structured way by exploiting similarities and dissimilarities between information objects is crucial for knowledge discovery. Knowledge maps use visualizations to gain insights into the structure of large-scale information spaces, but are still far away from being applicable for searching. The paper proposes a use case for enhancing search term recommendations by heat map visualizations of co-word relation-ships taken from indexing vocabulary. By contrasting areas of different "heat" the user is enabled to indicate mainstream areas of the field in question more easily.Comment: URL workshop proceedings: http://ceur-ws.org/Vol-1311

    Stone tools and the linguistic capabilities of earlier hominids

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    The evolution of human manipulative abilities may be clearly linked to the evolution of speech motor control Both creativity and complexity in vocal and manipulative gestures may be closely linked to a single dimension of brain evolution — the evolution of absolute brain size. Inferring the linguistic capabilities of earlier hominids from their lithic artefacts, however, required us to take account of domain-specific constraints on manipulative skill In this article we report on a pilot flint-knapping experiment designed to identify such constraints ‘in action’

    Designing as Construction of Representations: A Dynamic Viewpoint in Cognitive Design Research

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    This article presents a cognitively oriented viewpoint on design. It focuses on cognitive, dynamic aspects of real design, i.e., the actual cognitive activity implemented by designers during their work on professional design projects. Rather than conceiving de-signing as problem solving - Simon's symbolic information processing (SIP) approach - or as a reflective practice or some other form of situated activity - the situativity (SIT) approach - we consider that, from a cognitive viewpoint, designing is most appropriately characterised as a construction of representations. After a critical discussion of the SIP and SIT approaches to design, we present our view-point. This presentation concerns the evolving nature of representations regarding levels of abstraction and degrees of precision, the function of external representations, and specific qualities of representation in collective design. Designing is described at three levels: the organisation of the activity, its strategies, and its design-representation construction activities (different ways to generate, trans-form, and evaluate representations). Even if we adopt a "generic design" stance, we claim that design can take different forms depending on the nature of the artefact, and we propose some candidates for dimensions that allow a distinction to be made between these forms of design. We discuss the potential specificity of HCI design, and the lack of cognitive design research occupied with the quality of design. We close our discussion of representational structures and activities by an outline of some directions regarding their functional linkages
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