21 research outputs found

    Ultra-low-power circuits and systems for wearable and implantable medical devices

    Get PDF
    Thesis (Ph. D.)--Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2013.Cataloged from PDF version of thesis.Includes bibliographical references (pages 219-231).Advances in circuits, sensors, and energy storage elements have opened up many new possibilities in the health industry. In the area of wearable devices, the miniaturization of electronics has spurred the rapid development of wearable vital signs, activity, and fitness monitors. Maximizing the time between battery recharge places stringent requirements on power consumption by the device. For implantable devices, the situation is exacerbated by the fact that energy storage capacity is limited by volume constraints, and frequent battery replacement via surgery is undesirable. In this case, the design of energy-efficient circuits and systems becomes even more crucial. This thesis explores the design of energy-efficient circuits and systems for two medical applications. The first half of the thesis focuses on the design and implementation of an ultra-low-power, mixed-signal front-end for a wearable ECG monitor in a 0.18pm CMOS process. A mixed-signal architecture together with analog circuit optimizations enable ultra-low-voltage operation at 0.6V which provides power savings through voltage scaling, and ensures compatibility with state-of-the-art DSPs. The fully-integrated front-end consumes just 2.9[mu]W, which is two orders of magnitude lower than commercially available parts. The second half of this thesis focuses on ultra-low-power system design and energy-efficient neural stimulation for a proof-of-concept fully-implantable cochlear implant. First, implantable acoustic sensing is demonstrated by sensing the motion of a human cadaveric middle ear with a piezoelectric sensor. Second, alternate energy-efficient electrical stimulation waveforms are investigated to reduce neural stimulation power when compared to the conventional rectangular waveform. The energy-optimal waveform is analyzed using a computational nerve fiber model, and validated with in-vivo ECAP recordings in the auditory nerve of two cats and with psychophysical tests in two human cochlear implant users. Preliminary human subject testing shows that charge and energy savings of 20-30% and 15-35% respectively are possible with alternative waveforms. A system-on-chip comprising the sensor interface, reconfigurable sound processor, and arbitrary-waveform neural stimulator is implemented in a 0.18[mu]m high-voltage CMOS process to demonstrate the feasibility of this system. The sensor interface and sound processor consume just 12[mu]W of power, representing just 2% of the overall system power which is dominated by stimulation. As a result, the energy savings from using alternative stimulation waveforms transfer directly to the system.by Marcus Yip.Ph.D

    Integrated RF oscillators and LO signal generation circuits

    Get PDF
    This thesis deals with fully integrated LC oscillators and local oscillator (LO) signal generation circuits. In communication systems a good-quality LO signal for up- and down-conversion in transmitters is needed. The LO signal needs to span the required frequency range and have good frequency stability and low phase noise. Furthermore, most modern systems require accurate quadrature (IQ) LO signals. This thesis tackles these challenges by presenting a detailed study of LC oscillators, monolithic elements for good-quality LC resonators, and circuits for IQ-signal generation and for frequency conversion, as well as many experimental circuits. Monolithic coils and variable capacitors are essential, and this thesis deals with good structures of these devices and their proper modeling. As experimental test devices, over forty monolithic inductors and thirty varactors have been implemented, measured and modeled. Actively synthesized reactive elements were studied as replacements for these passive devices. At first glance these circuits show promising characteristics, but closer noise and nonlinearity analysis reveals that these circuits suffer from high noise levels and a small dynamic range. Nine circuit implementations with various actively synthesized variable capacitors were done. Quadrature signal generation can be performed with three different methods, and these are analyzed in the thesis. Frequency conversion circuits are used for alleviating coupling problems or to expand the number of frequency bands covered. The thesis includes an analysis of single-sideband mixing, frequency dividers, and frequency multipliers, which are used to perform the four basic arithmetical operations for the frequency tone. Two design cases are presented. The first one is a single-sideband mixing method for the generation of WiMedia UWB LO-signals, and the second one is a frequency conversion unit for a digital period synthesizer. The last part of the thesis presents five research projects. In the first one a temperature-compensated GaAs MESFET VCO was developed. The second one deals with circuit and device development for an experimental-level BiCMOS process. A cable-modem RF tuner IC using a SiGe process was developed in the third project, and a CMOS flip-chip VCO module in the fourth one. Finally, two frequency synthesizers for UWB radios are presented

    Neurocomputing systems for auditory processing

    Get PDF
    This thesis studies neural computation models and neuromorphic implementations of the auditory pathway with applications to cochlear implants and artiļ¬cial auditory sensory and processing systems. Very low power analogue computation is addressed through the design of micropower analogue building blocks and an auditory preprocessing module targeted at cochlear implants. The analogue building blocks have been fabricated and tested in a standard Complementary Metal Oxide Silicon (CMOS) process. The auditory pre-processing module design is based on the cochlea signal processing mechanisms and low power microelectronic design methodologies. Compared to existing preprocessing techniques used in cochlear implants, the proposed design has a wider dynamic range and lower power consumption. Furthermore, it provides the phase coding as well as the place coding information that are necessary for enhanced functionality in future cochlear implants. The thesis presents neural computation based approaches to a number of signal-processing problems encountered in cochlear implants. Techniques that can improve the performance of existing devices are also presented. Neural network based models for loudness mapping and pattern recognition based channel selection strategies are described. Compared with stateā€”ofā€”theā€”art commercial cochlear implants, the thesis results show that the proposed channel selection model produces superior speech sound qualities; and the proposed loudness mapping model consumes substantially smaller amounts of memory. Aside from the applications in cochlear implants, this thesis describes a biologically plausible computational model of the auditory pathways to the superior colliculus based on current neurophysiological ļ¬ndings. The model encapsulates interaural time difference, interaural spectral difference, monaural pathway and auditory space map tuning in the inferior colliculus. A biologically plausible Hebbian-like learning rule is proposed for auditory space neural map tuning, and a reinforcement learning method is used for map alignment with other sensory space maps through activity independent cues. The validity of the proposed auditory pathway model has been veriļ¬ed by simulation using synthetic data. Further, a complete biologically inspired auditory simulation system is implemented in software. The system incorporates models of the external ear, the cochlea, as well as the proposed auditory pathway model. The proposed implementation can mimic the biological auditory sensory system to generate an auditory space map from 3ā€”D sounds. A large amount of real 3-D sound signals including broadband White noise, click noise and speech are used in the simulation experiments. The eļ¬ect of the auditory space map developmental plasticity is examined by simulating early auditory space map formation and auditory space map alignment with a distorted visual sensory map. Detailed simulation methods, procedures and results are presented

    Collective analog bioelectronic computation

    Get PDF
    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2009.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student submitted PDF version of thesis.Includes bibliographical references (p. 677-710).In this thesis, I present two examples of fast-and-highly-parallel analog computation inspired by architectures in biology. The first example, an RF cochlea, maps the partial differential equations that describe fluid-membrane-hair-cell wave propagation in the biological cochlea to an equivalent inductor-capacitor-transistor integrated circuit. It allows ultra-broadband spectrum analysis of RF signals to be performed in a rapid low-power fashion, thus enabling applications for universal or software radio. The second example exploits detailed similarities between the equations that describe chemical-reaction dynamics and the equations that describe subthreshold current flow in transistors to create fast-and-highly-parallel integrated-circuit models of protein-protein and gene-protein networks inside a cell. Due to a natural mapping between the Poisson statistics of molecular flows in a chemical reaction and Poisson statistics of electronic current flow in a transistor, stochastic effects are automatically incorporated into the circuit architecture, allowing highly computationally intensive stochastic simulations of large-scale biochemical reaction networks to be performed rapidly. I show that the exponentially tapered transmission-line architecture of the mammalian cochlea performs constant-fractional-bandwidth spectrum analysis with O(N) expenditure of both analysis time and hardware, where N is the number of analyzed frequency bins. This is the best known performance of any spectrum-analysis architecture, including the constant-resolution Fast Fourier Transform (FFT), which scales as O(N logN), or a constant-fractional-bandwidth filterbank, which scales as O (N2).(cont.) The RF cochlea uses this bio-inspired architecture to perform real-time, on-chip spectrum analysis at radio frequencies. I demonstrate two cochlea chips, implemented in standard 0.13m CMOS technology, that decompose the RF spectrum from 600MHz to 8GHz into 50 log-spaced channels, consume < 300mW of power, and possess 70dB of dynamic range. The real-time spectrum analysis capabilities of my chips make them uniquely suitable for ultra-broadband universal or software radio receivers of the future. I show that the protein-protein and gene-protein chips that I have built are particularly suitable for simulation, parameter discovery and sensitivity analysis of interaction networks in cell biology, such as signaling, metabolic, and gene regulation pathways. Importantly, the chips carry out massively parallel computations, resulting in simulation times that are independent of model complexity, i.e., O(1). They also automatically model stochastic effects, which are of importance in many biological systems, but are numerically stiff and simulate slowly on digital computers. Currently, non-fundamental data-acquisition limitations show that my proof-of-concept chips simulate small-scale biochemical reaction networks at least 100 times faster than modern desktop machines. It should be possible to get 103 to 106 simulation speedups of genome-scale and organ-scale intracellular and extracellular biochemical reaction networks with improved versions of my chips. Such chips could be important both as analysis tools in systems biology and design tools in synthetic biology.by Soumyajit Mandal.Ph.D

    A Switched-Capacitor degenerated, scalable gm - C filter-bank for acoustic front-ends

    Get PDF
    Ā© 2016 IEEE. Filter-banks based on a gm-C topology are popular in acoustic sensor systems targeting spectral analysis. Their benefits lie in a very low power consumption and center-frequency scalability through gm-tuning to cover the audio frequency range. However the linear signal swing at the output of the filter is limited due to the inherent non-linearity of the input transistors in a differential pair. This work assesses the impact of noise and center-frequency specifications on the power consumption of 2 OTA base gm-C bandpass filters, both from a theoretical and practical point of view. Next, we introduce a novel scalable switched-capacitor based degeneration technique that enhances the linear signal swing at the filter output. Simulation results in 90nm CMOS demonstrate a power consumption of only 44nW for a bandpass filter with Q-factor of 1 with 63 dB dynamic range (< 2% THD) and a center-frequency of 100Hz. This scales to only 1. Ī¼W for a center-frequency at 3.2kHz. These power consumption numbers compare favorably with the state-of-the-art and enhance the Figure of Merit by more than 1.5X for a similar dynamic range.status: publishe

    Low Power Memory/Memristor Devices and Systems

    Get PDF
    This reprint focusses on achieving low-power computation using memristive devices. The topic was designed as a convenient reference point: it contains a mix of techniques starting from the fundamental manufacturing of memristive devices all the way to applications such as physically unclonable functions, and also covers perspectives on, e.g., in-memory computing, which is inextricably linked with emerging memory devices such as memristors. Finally, the reprint contains a few articles representing how other communities (from typical CMOS design to photonics) are fighting on their own fronts in the quest towards low-power computation, as a comparison with the memristor literature. We hope that readers will enjoy discovering the articles within
    corecore